Abstract: A melt processible Polyether Ether Ketone (PEEK) polymer with novel end-group structure is synthesized electrophilically using Methane Sulfonic Acid containing Methane Sulfonic Anhydride or Phosphorous Pentoxide. The product so obtained shows controlled structure with elimination of reactive end group like —COOH and is therefore melt processible by conventional techniques and exhibits high thermal and mechanical properties making it useful high temperature engineering and specialty plastics. It can be extruded into a rod, film and can also be molded into commercially useful products.
Abstract: This invention relates to oligonucleotides complementary to the thioredoxin and thioredoxin reductase genes which modulate tumor cell growth in mammals. This invention is also related to methods of using such compounds in inhibiting the growth of tumor cells in mammals. This invention also relates to pharmaceutical compositions comprising a pharmaceutically acceptable excipient and an effective amount of a compound of this invention.
Type:
Grant
Filed:
October 18, 2000
Date of Patent:
May 20, 2003
Assignee:
GeneSense Technologies Inc.
Inventors:
Jim A. Wright, Aiping H. Young, Yoon S. Lee
Abstract: A substantially non-toxic fraction isolated from the venom of Vipera xanthina is disclosed which fraction has an analgesic effect. The fraction is preferably purified on an ion exchange column from Vipera xanthina palestinae. Also described are a pharmaceutical composition for use as an analgesic comprising the non-toxic fraction, and a method for the relief of pain comprising administrating the non-toxic fraction.
Type:
Grant
Filed:
November 2, 2000
Date of Patent:
April 29, 2003
Assignee:
S.I.S. Shulov Institute for Science Ltd.
Abstract: The present invention relates to a composition for use as an immunomodulator comprising small molecular weight components of less than 3000 daltons, and having the following properties: a) is extractable from bile of animals; b) is capable of stimulating monocytes and macrophages in vitro; c) is capable of modulating tumor necrosis factor production; d) contains no measurable IL-1a, IL-1b, TNF, IL-6, IL-8, IL-4, GM-CSF or IFN-gamma; e) has an anti-proliferative effect in a malignant mouse hybridoma cell line; f) shows no cytotoxicity to human peripheral blood mononuclear cells; and g) is not an endotoxin. The invention also relates to a method of preparing the composition and its use as an immunomodulator.
Abstract: The N-oxides of the compounds of formula (I), in which R1, R2, R3, R31, R4, R5, R51 and R6 have the meanings indicated in the description, arm novel active bronchial therapeutics.
Abstract: The N-oxides of the compounds of formula (I), in which R1, R2, R3, R31, R4, R5, R51 and R6 have the meanings indicated in the description, are novel active bronchial therapeutics.
Abstract: Compounds of formula (I), in which R1, R2, R3, R31, R4, R5, R51 and R6 have the meanings indicated in the description, are novel active bronchial therapeutics.
Abstract: Method of thin layer preparation for a radionuclide source comprising the following steps:
deposition of a drop of a radionuclide dissolved in a solvent onto a on a support substrate,
placing said support substrate with said drop in a confined space with a reduced pressure,
directing at least one flow of a hot gas onto the drop,
rotating the source relative to the hot gas jet creating turbulences inside the drop,
evaporating the solvent and obtaining a thin layer of dry radionuclide.
Abstract: The present invention relates to methods of controlling iron overload in a patient in need thereof. The present invention particularly relates to methods of treating hemochromatosis and other causes of iron overload.
Type:
Grant
Filed:
December 14, 2001
Date of Patent:
January 21, 2003
Assignee:
Marshall University Research Corporation
Abstract: A heat exchanger for use in controlling subject's body temperature during a medical procedure comprises a flexible garment adapted for enveloping portions of the subject's body surface with dedicated sections for enveloping different body parts. Defined within the garment is a continuous, fluid tight space, wherein a flow path for heat-control fluid is defined between fluid inlet and fluid outlet. The inner faces of the garment's internal and external layers are made of a heat-weldable material and are point-welded to one another at a plurality of locations throughout the garment with a distance between two adjacent points being between about 8 to about 20 mm.
Abstract: Combinations of N-(3,5-dichloropyrid)-3-cyclopropylmethoxy-4-difluoromethoxybenzamide, its pharmacologically tolerable salts or its N-oxide, with PDE3 inhibitors, and methods of use thereof, are disclosed for therapeutic purposes.
Abstract: A method and device for determining a thickness of a layer in an object. For each of a plurality of frequencies, a continuous vibrational wave is generated at a surface of the layer and an energy of a steady state echo wave produced in the object in response to the generated vibrational wave is measured. The thickness of the layer is then calculated based upon the measured energies of the steady state echoes.
Abstract: This invention relates to lamp fuel composition for colored flames and manufacturing method thereof, comprising solvents, coloring agents, capillary linkers, supporters, and flavors. The lamp fuel composition for colored flames presented by this invention provides sustained powerful flames of various colors, such as green, red, yellow, blue, or pink, producing a decorative lighting, wherein the said composition is prepared through a series of process, such as stirred-blending, heating, and then cooling.
Abstract: The invention relates to a method for the disposal of waste products containing hydrocarbons and/or halogenated waste products, wherein the waste products are made to react in a hydroxide molten bath in the absence of oxygen at temperatures of 400-900° C.
Abstract: The present disclosure relates to novel compositions which provide improved nutritional support for premenopausal and menopausal women and/or relief from symptoms associated with menopause, as well as prophylactic effects, and methods for using same.
Type:
Grant
Filed:
September 30, 1999
Date of Patent:
November 12, 2002
Assignee:
Drugtech Corporation
Inventors:
R. Saul Levinson, Marc S. Hermelin, Mitchell I. Kirschner
Abstract: Compounds of formula (I), in which R1, R2, R3, R31, R4, R5, R51 and Ar have the meanings indicated in the description, are novel active bronchial therapeutics.
Abstract: Compounds of formula (I), in which R1, R2, R3, R31, R4, R5, R51, R6, R13 and R20 have the meaning indicated in the description, are novel active bronchial therapeutics
Abstract: The present invention relates to a method of cosmetic treatment for combating the effects of skin ageing and to novel cosmetic compositions which are particularly suitable for carrying it out. According to the invention, at least one agent for promoting the adhesion of the keratinocytes of the epidermal baseal layer to the dermo-epidermal junction, especially to the collagen IV of said junction, such as, in particular, a divalent metal salt or complex, preferably magnesium aspartate or magnesium chloride, is used, optionally in association with a stimulant of collagen IV synthesis and/or a stimulant of collagen VII synthesis. The application is for the preparation of cosmetic compositions with anti-wrinkle activity.
Type:
Grant
Filed:
November 28, 2000
Date of Patent:
October 29, 2002
Assignee:
LVMH Recherche
Inventors:
Frédéric Bonte, Marc Dumas, Catherine Heusele, Jacques Le Blay
Abstract: The present invention relates to a means for creating a mass having structural integrity, including a rapidly disintegratable tablet for administration with or without the use of water. The present invention has a wide variety of different uses and applications. One embodiment is a tablet intended for oral administration. The tablet comprises at least one active ingredient and a mixture of excipients. The excipients provide desired characteristics and physical properties and when the tablet is sintered or heated, excellent tablet binding characteristics are obtained. The tablet is intended primarily for oral administration and dissolves in the presence of water. Also disclosed is a process for the preparation of a rapidly disintegratable tablet for administration with or without the use of water.
Type:
Grant
Filed:
July 12, 2001
Date of Patent:
October 15, 2002
Assignee:
Drugtech Corporation
Inventors:
Yury Lagoviyer, R. Saul Levinson, Denis Stotler, Thomas C. Riley
Abstract: A catalyst comprising an organoaluminum compound and a vanadium chelate compound having the lability to cause olefins to undergo living coordination polymerization is contacted with a terminal diolefin to obtain a catalyst for living polymer production. When the above contact is:conducted in the presence of a cycloolefin or an internal olefin, the yield of a living polymer can be improved. By modifying all ends of the living polymer obtained, a telechelic olefin polymer is obtained in which all the polymer chains are modified with functional groups.
Type:
Grant
Filed:
March 3, 2000
Date of Patent:
September 24, 2002
Assignees:
Japan as represented by Director General of Agency of
Industrial Science and Technology, Japan Chemical Innovation Institute