Patents Represented by Attorney, Agent or Law Firm Justin D. Karjala
  • Isolated human kinase proteins, nucleic acid molecules encoding human kinase proteins, and uses thereof
    Patent number: 6835562
    Abstract: The present invention provides amino acid sequences of peptides that are encoded by genes within the human genome, the kinase peptides of the present invention. The present invention specifically provides isolated peptide and nucleic acid molecules, methods of identifying orthologs and paralogs of the kinase peptides, and methods of identifying modulators of the kinase peptides.
    Type: Grant
    Filed: October 23, 2003
    Date of Patent: December 28, 2004
    Assignee: Applera Corporation
    Inventors: Ming-Hui Wei, Valentina Di Francesco, Ellen M. Beasley
  • Isolated human kinase proteins, nucleic acid molecules encoding human kinase proteins, and uses thereof
    Patent number: 6830911
    Abstract: The present invention provides amino acid sequences of peptides that are encoded by genes within the human genome, the kinase peptides of the present invention. The present invention specifically provides isolated peptide and nucleic acid molecules, methods of identifying orthologs and paralogs of the kinase peptides, and methods of identifying modulators of the kinase peptides.
    Type: Grant
    Filed: February 8, 2002
    Date of Patent: December 14, 2004
    Assignee: Applera Corporation
    Inventor: Zhaoxi Ke
  • Isolated human kinase proteins, nucleic acid molecules encoding human kinase proteins and uses thereof
    Patent number: 6830912
    Abstract: The present invention provides amino acid sequences of peptides that are encoded by genes within the human genome, the kinase peptides of the present invention. The present invention specifically provides isolated peptide and nucleic acid molecules, methods of identifying orthologs and paralogs of the kinase peptides, and methods of identifying modulators of the kinase peptides.
    Type: Grant
    Filed: October 31, 2003
    Date of Patent: December 14, 2004
    Assignee: Applera Corporation
    Inventors: Douglas Rusch, Karen A. Ketchum, Valentina Di Francesco, Ellen M. Beasley
  • Polymorphisms in known genes associated with osteoporosis, methods of detection and uses thereof
    Patent number: 6825336
    Abstract: The present invention is based on the discovery of novel polymorphisms (SNPs) in the genes known in the art to contribute to osteoporosis. Such polymorphisms can lead to a variety of disorders that are mediated/modulated by a variant osteoporosis associated protein. The present invention provides reagents used for detecting and expressing the variant nucleic acid/protein sequence as well as methods of identifying and using these variants.
    Type: Grant
    Filed: September 10, 2001
    Date of Patent: November 30, 2004
    Assignee: Applera Corporation
    Inventors: J. Craig Venter, Jinghui N. Zhang, Xiangjun Liu, William Rowe, Anibal Cravchik, Francis Kalush, Ashwinikumar Naik, Gangadharan Subramanian, Trevor Woodage
  • Isolated nucleic acid molecules encoding human synthase proteins, and uses thereof
    Patent number: 6825026
    Abstract: The present invention provides amino acid sequences of peptides that are encoded by genes within the human genome, the enzyme peptides of the present invention. The present invention specifically provides isolated peptide and nucleic acid molecules, methods of identifying orthologs and paralogs of the enzyme peptides, and methods of identifying modulators of the enzyme peptides.
    Type: Grant
    Filed: July 21, 2003
    Date of Patent: November 30, 2004
    Assignee: Applera Corporation
    Inventors: Fangcheng Gong, Chunhua Yan, Valentina Di Francesco, Ellen M. Beasley
  • Isolated human zinc metalloprotease, nucleic acid molecules encoding said enzymes, and uses thereof
    Patent number: 6825025
    Abstract: The present invention provides amino acid sequences of peptides that are encoded by genes within the human genome, the enzyme peptides of the present invention. The present invention specifically provides isolated peptide and nucleic acid molecules, methods of identifying orthologs and paralogs of the enzyme peptides, and methods of identifying modulators of the enzyme peptides.
    Type: Grant
    Filed: October 9, 2003
    Date of Patent: November 30, 2004
    Assignee: Applera Corporation
    Inventors: Ming-Hui Wei, Chunhua Yan, Valentina Di Francesco, Ellen M. Beasley
  • Isolated human kinase proteins, nucleic acid molecules encoding human kinase proteins, and uses thereof
    Patent number: 6821765
    Abstract: The present invention provides amino acid sequences of peptides that are encoded by genes within the human genome, the kinase peptides of the present invention. The present invention specifically provides isolated peptide and nucleic acid molecules, methods of identifying orthologs and paralogs of the kinase peptides, and methods of identifying modulators of the kinase peptides.
    Type: Grant
    Filed: September 23, 2003
    Date of Patent: November 23, 2004
    Assignee: Applera Corporation
    Inventors: Jane Ye, Chunhua Yan, Valentina Di Francesco, Ellen M Beasley
  • Nucleic acid molecules encoding human secreted hemopexin-related proteins
    Patent number: 6815181
    Abstract: The present invention provides amino acid sequences of peptides that are encoded by genes within the human genome, the secreted peptides of the present invention. The present invention specifically provides isolated peptide and nucleic acid molecules, methods of identifying orthologs and paralogs of the secreted peptides, and methods of identifying modulators of the secreted peptides.
    Type: Grant
    Filed: July 9, 2001
    Date of Patent: November 9, 2004
    Assignee: Applera Corporation
    Inventors: Toni Ceccardi, Emanuel Langit, Min Zhong, Istvan Ladunga
  • Isolated human kinase proteins, nucleic acid molecules encoding human kinase proteins and uses thereof
    Patent number: 6812014
    Abstract: The present invention provides amino acid sequences of peptides that are encoded by genes within the human genome, the kinase peptides of the present invention. The present invention specifically provides isolated peptide and nucleic acid molecules, methods of identifying orthologs and paralogs of the kinase peptides, and methods of identifying modulators of the kinase peptides.
    Type: Grant
    Filed: October 31, 2003
    Date of Patent: November 2, 2004
    Assignee: Applera Corporation
    Inventors: Ming-Hui Wei, Karen A. Ketchum, Valentina Di Francesco, Ellen M. Beasley
  • Polymorphisms in known genes associated with human disease, methods of detection and uses thereof
    Patent number: 6812339
    Abstract: The present invention is based on the discovery of novel polymorphisms (SNPs) in the genes known in the art to contribute to human disease. Such polymorphisms can lead to a variety of disorders that are mediated/modulated by a variant human disease associated protein. The present invention provides reagents used for detecting and expressing the variant nucleic acid/protein sequence as well as methods of identifying and using these variants.
    Type: Grant
    Filed: September 10, 2001
    Date of Patent: November 2, 2004
    Assignee: Applera Corporation
    Inventors: J. Craig Venter, Jinghui N. Zhang, Xiangjun Liu, William Rowe, Anibal Cravchik, Francis Kalush, Ashwinikumar Naik, Gangadharan Subramanian, Trevor Woodage
  • Isolated human kinase proteins, nucleic acid molecules encoding human kinase proteins, and uses thereof
    Patent number: 6808912
    Abstract: The present invention provides amino acid sequences of peptides that are encoded by genes within the human genome, the kinase peptides of the present invention. The present invention specifically provides isolated peptide and nucleic acid molecules, methods of identifying orthologs and paralogs of the kinase peptides, and methods of identifying modulators of the kinase peptides.
    Type: Grant
    Filed: August 13, 2003
    Date of Patent: October 26, 2004
    Assignee: Applera Corporation
    Inventors: Ming-Hui Wei, Ishwar Chandramouliswaran, Jane Ye, Karen A. Ketchum, Valentina Di Francesco, Ellen M. Beasley
  • Isolated human kinase proteins, nucleic acid molecules encoding human kinase proteins, and uses thereof
    Patent number: 6808911
    Abstract: The present invention provides amino acid sequences of peptides that are encoded by genes within the human genome, the kinase peptides of the present invention. The present invention specifically provides isolated peptide and nucleic acid molecules, methods of identifying orthologs and paralogs of the kinase peptides, and methods of identifying modulators of the kinase peptides.
    Type: Grant
    Filed: October 21, 2002
    Date of Patent: October 26, 2004
    Assignee: Applera Corporation
    Inventors: Marion Webster, Ming-Hui Wei, Chunhua Yan, Valentina Di Francesco, Ellen M. Beasley
  • Isolated human kinase proteins, nucleic acid molecules encoding human kinase proteins, and uses thereof
    Patent number: 6806072
    Abstract: The present invention provides amino acid sequences of peptides that are encoded by genes within the human genome, the kinase peptides of the present invention. The present invention specifically provides isolated peptide and nucleic acid molecules, methods of identifying orthologs and paralogs of the kinase peptides, and methods of identifying modulators of the kinase peptides.
    Type: Grant
    Filed: January 16, 2003
    Date of Patent: October 19, 2004
    Assignee: Applera Corporation
    Inventors: Jane Ye, Chunhua Yan, Valentina Di Francesco, Ellen M. Beasley
  • Isolated human casein kinase proteins, nucleic acid molecules encoding human casein kinase proteins, and uses thereof
    Patent number: 6800283
    Abstract: The present invention provides amino acid sequences of peptides that are encoded by genes within the human genome, the kinase peptides of the present invention. The present invention specifically provides isolated peptide and nucleic acid molecules, methods of identifying orthologs and paralogs of the kinase peptides, and methods of identifying modulators of the kinase peptides.
    Type: Grant
    Filed: July 22, 2002
    Date of Patent: October 5, 2004
    Assignee: Applera Corporation
    Inventors: Fangcheng Gong, Ming-Hui Wei, Valentina Di Francesco, Ellen M. Beasley
  • Isolated human kinase proteins, nucleic acid molecules encoding human kinase proteins, and uses thereof
    Patent number: 6800471
    Abstract: The present invention provides amino acid sequences of peptides that are encoded by genes within the human genome, the kinase peptides of the present invention. The present invention specifically provides isolated peptide and nucleic acid molecules, methods of identifying orthologs and paralogs of the kinase peptides, and methods of identifying modulators of the kinase peptides.
    Type: Grant
    Filed: September 25, 2003
    Date of Patent: October 5, 2004
    Assignee: Applera Corporation
    Inventors: Chunhua Yan, Ming-Hui Wei, Karen Ketchum, Gennady Merkulov, Ellen M Beasley
  • Isolated human enzyme proteins, nucleic acid molecules encoding human enzyme proteins, and uses thereof
    Patent number: 6787344
    Abstract: The present invention provides amino acid sequences of peptides that are encoded by genes within the human genome, the enzyme peptides of the present invention. The present invention specifically provides isolated peptide and nucleic acid molecules, methods of identifying orthologs and paralogs of the enzyme peptides, and methods of identifying modulators of the enzyme peptides.
    Type: Grant
    Filed: February 21, 2003
    Date of Patent: September 7, 2004
    Assignee: Applera Corporation
    Inventors: Ellen M. Beasley, Gennady V. Merkulov, Valentina Di Francesco
  • Isolated human kinase proteins, nucleic acid molecules encoding human kinase proteins, and uses thereof
    Patent number: 6780626
    Abstract: The present invention provides amino acid sequences of peptides that are encoded by genes within the human genome, the kinase peptides of the present invention. The present invention specifically provides isolated peptide and nucleic acid molecules, methods of identifying orthologs and paralogs of the kinase peptides, and methods of identifying modulators of the kinase peptides.
    Type: Grant
    Filed: January 10, 2003
    Date of Patent: August 24, 2004
    Assignee: Applera Corporation
    Inventors: Jiayin Li, Karl Guegler, Ellen M. Beasley, Karen A. Ketchum, Valentina Di Francesco
  • Isolated human Ras-like proteins, nucleic acid molecules encoding these human Ras-like proteins, and uses thereof
    Patent number: 6773904
    Abstract: The present invention provides amino acid sequences of polypeptides that are encoded by genes within the human genome, the Ras-like protein polypeptides of the present invention. The present invention specifically provides isolated polypeptide and nucleic acid molecules, methods of identifying orthologs and paralogs of the Ras-like protein polypeptides, and methods of identifying modulators of the Ras-like protein polypeptides.
    Type: Grant
    Filed: April 9, 2002
    Date of Patent: August 10, 2004
    Assignee: Applera Corporation
    Inventors: Chunhua Yan, Karen A. Ketchum, Ellen M. Beasley
  • Nucleic acid encoding retinoic acid receptor
    Patent number: 6756213
    Abstract: The present invention provides amino acid sequences of peptides that are encoded by genes within the human genome, the nuclear hormone receptor peptides of the present invention. The present invention specifically provides isolated peptide and nucleic acid molecules, methods of identifying orthologs and paralogs of the nuclear hormone receptor peptides, and methods of identifying modulators of the nuclear hormone receptor peptides.
    Type: Grant
    Filed: October 19, 2000
    Date of Patent: June 29, 2004
    Assignee: Applera Corporation
    Inventors: Ming-Hui Wei, Jane Ye, Chunhua Yan, Karen A. Ketchum, Valentina Di Francesco, Ellen M. Beasley
  • Isolated human kinase proteins, nucleic acid molecules encoding human kinase proteins, and uses thereof
    Patent number: 6753175
    Abstract: The present invention provides amino acid sequences of peptides that are encoded by genes within the human genome, the kinase peptides of the present invention. The present invention specifically provides isolated peptide and nucleic acid molecules, methods of identifying orthologs and paralogs of the kinase peptides, and methods of identifying modulators of the kinase peptides.
    Type: Grant
    Filed: July 31, 2002
    Date of Patent: June 22, 2004
    Assignee: Applera Corporation
    Inventors: Jane Abu-Threideh, Fangcheng Gong, Karen A. Ketchum, Valentina Di Francesco, Ellen M. Beasley