Patents Represented by Attorney, Agent or Law Firm Justin D. Karjala
  • Isolated human kinase proteins, nucleic acid molecules encoding human kinase proteins, and uses thereof
    Patent number: 6537788
    Abstract: The present invention provides amino acid sequences of peptides that are encoded by genes within the human genome, the kinase peptides of the present invention. The present invention specifically provides isolated peptide and nucleic acid molecules, methods of identifying orthologs and paralogs of the kinase peptides, and methods of identifying modulators of the kinase peptides.
    Type: Grant
    Filed: March 8, 2001
    Date of Patent: March 25, 2003
    Assignee: Applera Corporation
    Inventors: Jane Ye, Chunhua Yan, Valentina Di Francesco, Ellen M. Beasley
  • Isolated nucleic acid molecules encoding transferase enzymes
    Patent number: 6537780
    Abstract: The present invention provides amino acid sequences of peptides that are encoded by genes within the human genome, the enzyme peptides of the present invention. The present invention specifically provides isolated peptide and nucleic acid molecules, methods of identifying orthologs and paralogs of the enzyme peptides, and methods of identifying modulators of the enzyme peptides.
    Type: Grant
    Filed: March 28, 2001
    Date of Patent: March 25, 2003
    Assignee: Applera Corporation
    Inventors: Ellen M. Beasley, Karen A. Ketchum, Valentina Di Francesco
  • Isolated human kinase proteins, nucleic acid molecules encoding human kinase proteins, and uses thereof
    Patent number: 6534299
    Abstract: The present invention provides amino acid sequences of peptides that are encoded by genes within the human genome, the kinase peptides of the present invention. The present invention specifically provides isolated peptide and nucleic acid molecules, methods of identifying orthologs and paralogs of the kinase peptides, and methods of identifying modulators of the kinase peptides.
    Type: Grant
    Filed: March 26, 2001
    Date of Patent: March 18, 2003
    Assignee: Applera Corporation
    Inventors: Ming-Hui Wei, Ishwar Chandramouliswaran, Jane Ye, Karen A. Ketchum, Valentina Di Francesco, Ellen M. Beasley
  • Isolated human kinase proteins, nucleic acid molecules encoding human kinase proteins, and uses thereof
    Patent number: 6528294
    Abstract: The present invention provides amino acid sequences of peptides that are encoded by genes within the human genome, the kinase peptides of the present invention. The present invention specifically provides isolated peptide and nucleic acid molecules, methods of identifying orthologs and paralogs of the kinase peptides, and methods of identifying modulators of the kinase peptides.
    Type: Grant
    Filed: February 1, 2002
    Date of Patent: March 4, 2003
    Assignee: Applera Corporation
    Inventors: Jiayin Li, Karl Guegler, Ellen M. Beasley, Karen A. Ketchum, Valentina Di Francesco
  • Isolated human kinase proteins, nucleic acid molecules encoding human kinase proteins, and uses thereof
    Patent number: 6500656
    Abstract: The present invention provides amino acid sequences of peptides that are encoded by genes within the human genome, the kinase peptides of the present invention. The present invention specifically provides isolated peptide and nucleic acid molecules, methods of identifying orthologs and paralogs of the kinase peptides, and methods of identifying modulators of the kinase peptides.
    Type: Grant
    Filed: June 5, 2001
    Date of Patent: December 31, 2002
    Assignee: Applera Corporation
    Inventors: Marion Webster, Chunhua Yan, Valentina Di Francesco, Ellen Beasley
  • Isolated human kinase proteins, nucleic acid molecules encoding human kinase proteins, and uses thereof
    Patent number: 6492155
    Abstract: The present invention provides amino acid sequences of peptides that are encoded by genes within the human genome, the kinase peptides of the present invention. The present invention specifically provides isolated peptide and nucleic acid molecules, methods of identifying orthologs and paralogs of the kinase peptides, and methods of identifying modulators of the kinase peptides.
    Type: Grant
    Filed: March 9, 2001
    Date of Patent: December 10, 2002
    Assignee: Applera Corporation
    Inventors: Jane Ye, Chunhua Yan, Valentina Di Francesco, Ellen M Beasley
  • Isolated human kinase proteins, nucleic acid molecules encoding human kinase proteins, and uses thereof
    Patent number: 6492154
    Abstract: The present invention provides amino acid sequences of peptides that are encoded by genes within the human genome, the kinase peptides of the present invention. The present invention specifically provides isolated peptide and nucleic acid molecules, methods of identifying orthologs and paralogs of the kinase peptides, and methods of identifying modulators of the kinase peptides.
    Type: Grant
    Filed: March 9, 2001
    Date of Patent: December 10, 2002
    Assignee: Applera Corporation
    Inventors: Chunhua Yan, Karen A Ketchum, Valentina Di Francesco, Ellen M Beasley
  • Isolated human kinase proteins, nucleic acid molecules encoding human kinase proteins, and uses thereof
    Patent number: 6492153
    Abstract: The present invention provides amino acid sequences of peptides that are encoded by genes within the human genome, the kinase peptides of the present invention. The present invention specifically provides isolated peptide and nucleic acid molecules, methods of identifying orthologs and paralogs of the kinase peptides, and methods of identifying modulators of the kinase peptides.
    Type: Grant
    Filed: January 16, 2001
    Date of Patent: December 10, 2002
    Assignee: Applera Corporation
    Inventors: Jane Abu-Threideh, Fangcheng Gong, Karen A. Ketchum, Valentina Di Francesco, Ellen M. Beasley
  • Isolated human kinase proteins, nucleic acid molecules encoding human kinase proteins, and uses thereof
    Patent number: 6482935
    Abstract: The present invention provides amino acid sequences of peptides that are encoded by genes within the human genome, the kinase peptides of the present invention. The present invention specifically provides isolated peptide and nucleic acid molecules, methods of identifying orthologs and paralogs of the kinase peptides, and methods of identifying modulators of the kinase peptides.
    Type: Grant
    Filed: October 18, 2000
    Date of Patent: November 19, 2002
    Assignee: Applera Corporation
    Inventors: Ming-Hui Wei, Shiaoping Zhu, Trevor Woodage, Valentina Di Francesco, Ellen M. Beasley
  • Isolated human kinase proteins, nucleic acid molecules encoding human kinase proteins, and uses thereof
    Patent number: 6479269
    Abstract: The present invention provides amino acid sequences of peptides that are encoded by genes within the human genome, the kinase peptides of the present invention. The present invention specifically provides isolated peptide and nucleic acid molecules, methods of identifying orthologs and paralogs of the kinase peptides, and methods of identifying modulators of the kinase peptides.
    Type: Grant
    Filed: March 13, 2001
    Date of Patent: November 12, 2002
    Assignee: Applera Corporation
    Inventors: Marion Webster, Chunhua Yan, Valentina Di Francesco, Ellen M. Beasley
  • Methods and kits for obtaining DNA end sequence information for large cloned inserts and uses thereof
    Patent number: 6475731
    Abstract: The present invention provides a method of producing a cloned insert that is representative of the ends of a large segment of DNA from the genome of an organism. Specifically, the present invention provides a clone insert sequencing strategy that comprising the steps of isolating a nucleic acid molecule that is at least 20 kb, ligating the nucleic acid molecule into a plasmid vector molecule to produce a closed circle, cutting the ligated vector with a restriction endonuclease that cuts the ligated 20 kb nucleic acid molecule in at least two sites but does not cut the vector DNA, ligating the cut nucleic acid molecule to produce a deletion in the 20 kb nucleic acid molecule and determining the sequence of the ends of the nucleic acid insert and the sequence from the restriction endonuclease site.
    Type: Grant
    Filed: July 3, 2000
    Date of Patent: November 5, 2002
    Assignee: Applera Corporation
    Inventors: Robert Holt, Hamilton O. Smith, Cynthia Pfannkoch
  • Isolated nucleic acid molecules encoding human enzyme proteins, and uses thereof
    Patent number: 6461843
    Abstract: The present invention provides amino acid sequences of peptides that are encoded by genes within the human genome, the enzyme peptides of the present invention. The present invention specifically provides isolated peptide and nucleic acid molecules, methods of identifying orthologs and paralogs of the enzyme peptides, and methods of identifying modulators of the enzyme peptides.
    Type: Grant
    Filed: February 16, 2001
    Date of Patent: October 8, 2002
    Assignee: Applera Corporation
    Inventors: Ming-Hui Wei, Jane Ye, Karen A. Ketchum, Valentina Di Francesco, Ellen M. Beasley
  • Isolated human kinase proteins, nucleic acid molecules encoding human kinase proteins, and uses thereof
    Patent number: 6455291
    Abstract: The present invention provides amino acid sequences of peptides that are encoded by genes within the human genome, the kinase peptides of the present invention. The present invention specifically provides isolated peptide and nucleic acid molecules, methods of identifying orthologs and paralogs of the kinase peptides, and methods of identifying modulators of the kinase peptides.
    Type: Grant
    Filed: March 19, 2001
    Date of Patent: September 24, 2002
    Assignee: PE Corporation (NY)
    Inventors: Chunhua Yan, Jane Ye, Karen A. Ketchum, Valentina Di Francesco, Ellen M. Beasley
  • Isolated nucleic acid molecules encoding human synthase proteins, and uses thereof
    Patent number: 6436692
    Abstract: The present invention provides amino acid sequences of peptides that are encoded by genes within the human genome, the enzyme peptides of the present invention. The present invention specifically provides isolated peptide and nucleic acid molecules, methods of identifying orthologs and paralogs of the enzyme peptides, and methods of identifying modulators of the enzyme peptides.
    Type: Grant
    Filed: March 29, 2001
    Date of Patent: August 20, 2002
    Assignee: Applera Corporation
    Inventors: Fangcheng Gong, Chunhua Yan, Valentina Di Francesco, Ellen M. Beasley
  • Isolated nucleic acid molecules encoding human protease proteins, and uses thereof
    Patent number: 6436689
    Abstract: The present invention provides amino acid sequence of peptides that are encoded by genes within the human genome, the protease peptides of the present invention. The present invention specifically provides isolated peptide and nucleic acid molecules, methods of identify orthologs and paralogs of the protease peptides, and methods of identifying modulators of the protease peptides.
    Type: Grant
    Filed: December 21, 2000
    Date of Patent: August 20, 2002
    Assignee: PE Corporation (NY)
    Inventors: Karl Guegler, Marion Webster, Chunhua Yan, Wei Shao, Karen A. Ketchum, Valentina Di Francesco, Ellen M. Beasley
  • Isolated human kinase proteins, nucleic acid molecules encoding human kinase proteins, and uses thereof
    Patent number: 6426206
    Abstract: The present invention provides amino acid sequences of peptides that are encoded by genes within the human genome, the kinase peptides of the present invention. The present invention specifically provides isolated peptide and nucleic acid molecules, methods of identifying orthologs and paralogs of the kinase peptides, and methods of identifying modulators of the kinase peptides.
    Type: Grant
    Filed: December 6, 2000
    Date of Patent: July 30, 2002
    Assignee: PE Corporation (NY)
    Inventors: Ming-Hui Wei, Valentina Di Francesco, Ellen M. Beasley
  • Isolated human kinase proteins, nucleic acid molecules encoding human kinase proteins, and uses thereof
    Patent number: 6423521
    Abstract: The present invention provides amino acid sequences of peptides that are encoded by genes within the human genome, the kinase peptides of the present invention. The present invention specifically provides isolated peptide and nucleic acid molecules, methods of identifying orthologs and paralogs of the kinase peptides, and methods of identifying modulators of the kinase peptides.
    Type: Grant
    Filed: December 28, 2000
    Date of Patent: July 23, 2002
    Assignee: PE Corporation (NY)
    Inventors: Ishwar Chandramouliswaran, Karl Guegler, Marion Webster, Chunhua Yan, Valentina Di Francesco, Ellen M. Beasley
  • Isolated human kinase proteins, nucleic acid molecules encoding human kinase proteins, and uses thereof
    Patent number: 6416990
    Abstract: The present invention provides amino acid sequences of peptides that are encoded by genes within the human genome, the kinase peptides of the present invention. The present invention specifically provides isolated peptide and nucleic acid molecules, methods of identifying orthologs and paralogs of the kinase peptides, and methods of identifying modulators of the kinase peptides.
    Type: Grant
    Filed: December 8, 2000
    Date of Patent: July 9, 2002
    Assignee: PE Corporation (NY)
    Inventors: Ming-Hui Wei, Karl Guegler, Karen A. Ketchum, Gennady V. Merkulov, Trevor Woodage, Valentina Di Francesco, Ellen M. Beasley
  • Isolated human kinase proteins, nucleic acid molecules encoding human kinase proteins, and uses thereof
    Patent number: 6413756
    Abstract: The present invention provides amino acid sequences of peptides that are encoded by genes within the human genome, the kinase peptides of the present invention. The present invention specifically provides isolated peptide and nucleic acid molecules, methods of identifying orthologs and paralogs of the kinase peptides, and methods of identifying modulators of the kinase peptides.
    Type: Grant
    Filed: December 19, 2000
    Date of Patent: July 2, 2002
    Assignee: PE Corporation (NY)
    Inventors: Chunhua Yan, Jane Abu-Threideh, Wei Shao, Gennady V. Merkulov, Valentina Di Francesco, Ellen M. Beasley
  • Isolated human kinase proteins, nucleic acid molecules encoding human kinase proteins, and uses thereof
    Patent number: 6410294
    Abstract: The present invention provides amino acid sequences of peptides that are encoded by genes within the human genome, the kinase peptides of the present invention. The present invention specifically provides isolated peptide and nucleic acid molecules, methods of identifying orthologs and paralogs of the kinase peptides, and methods of identifying modulators of the kinase peptides.
    Type: Grant
    Filed: December 13, 2000
    Date of Patent: June 25, 2002
    Assignee: PE Corporation (NY)
    Inventors: Karl Guegler, Karen A. Ketchum, Valentina Di Francesco, Ellen M. Beasley