Abstract: The present invention relates to wettable silicone hydrogels comprising the reaction product of at least one siloxane containing component and at least one reactive, hydrophilic polymeric internal wetting agent. The present invention further relates to silicone hydrogel contact lenses comprising at least one oxygen permeable component, and an amount of reactive, hydrophilic polymeric internal wetting agent sufficient to impart wettability to said device.

Abstract: The present invention relates to biomedical devices, and particularly contact lenses comprising a polymer having entangled therein at least one acyclic polyamide.

Abstract: This invention includes a wettable biomedical device containing a high molecular weight hydrophilic polymer and a hydroxyl-functionalized silicone-containing monomer.

Abstract: The present invention is a composition, which may be used to form contact lenses, comprising at least one silicone containing component, at least one hydrophilic component, at least one high molecular weight hydrophilic polymer and at least one diluent with an alpha value of about 0.5 to about 1 and a Hansen solubility parameter of less than about 10.

Abstract: The present invention provides ophthalmic devices comprising at least one photochromic material which is an indeno-fused naphthopyran having a pi-conjugation extending group bonded to the 11-position of the indeno-fused naphthopyran, the pi-conjugation extending group having at least one pendent halo-substituted group bonded thereto. The pi-conjugation extending group extends the pi-conjugation system of said indeno-fused naphthopyran. The 13-position of the indeno-fused naphthopyran is substantially free of spiro-substituents. The invention further provides photochromic materials of specified structure, photochromic compositions, photochromic articles and optical elements that include the photochromic materials. Other non-limiting embodiments relate to methods of making the ophthalmic devices comprising photochromic materials.

Abstract: The present invention relates to a process comprising forming a monomer mixture comprising at least one monofunctional silicone containing component which comprises at least one difunctional byproduct and adding to said monomer mixture a normalizing amount of said at least one difunctional byproduct and curing said monomer mixture to form a biomedical device.

Abstract: The present invention relates to biomedical devices, and particularly contact lenses comprising a polymer having entangled therein at least one acyclic polyamide.

Abstract: This invention relates to ophthalmic devices and methods for their production where the ophthalmic device contain a polymer and at least one heterocyclic compound comprising at least one N—Cl and/or N—Br bond.

Abstract: This invention relates to solutions for packaging ophthalmic devices comprising at least one antimicrobial metal salt which prevent the loss of said antimicrobial metal salt during autoclaving and storage.

Abstract: Biomedical devices with antimicrobial coatings are provided. One or more surfaces of the device are coated with a cationic peptide, cationic proteins, or mixtures thereof to impart antimicrobial properties to the surface.

Abstract: The present invention relates to compositions comprising a polymeric substrate comprising at least one volume excluding polymer. In one embodiment, the present invention provides polymeric articles that are capable of acting as osmotic drivers. The articles are capable of maintaining a desired water balance by moving water in or out of a substrate to maintain cation concentration equilibrium between the substrate and its environment.

Abstract: The present invention relates to contact lenses comprising at least one ionizable antimicrobial metal compound and a polymer formed from a reaction mixture comprising at least one hydrophobic component and hydrophilic components in a concentration to provide a hydrophilicity index of at least 42.

Abstract: Lactam polymers has been modified with sodium borohydride (NaBH4) to yield lactam polymers bearing hydroxyl functional groups. These functional groups are useful for the covalent attachment of reactive groups, fluorescent probes, antimicrobial agents, bioactive factors, and drugs. The resulting as components for medical devices, specifically ophthalmic devices and more specifically contact lenses. Hydrogels based on these polymers are also useful for biomedical applications in the areas of drug delivery, tissue engineering, and implantable devices.

Abstract: This invention relates to ophthalmic devices and methods for their production where the ophthalmic device contain a polymer and at least one heterocyclic compound comprising at least one N—Cl and/or N—Br bond.

Abstract: This invention includes a wettable biomedical device containing a high molecular weight hydrophilic polymer and a hydroxyl-functionalized silicone-containing monomer.

Abstract: This invention includes a wettable biomedical device containing a high molecular weight hydrophilic polymer and a hydroxyl-functionalized silicone-containing monomer.

Abstract: The present invention relates to soft contact lenses having an overall comfort preference of at least about 2 to 1 as compared to an Acuvue® contact lens and measured after one week of daily wear. The present invention further relates to a soft contact lens comprising an oxygen transmissibility greater than about 70 barrers/mm and physical properties suitable to provide wearer comfort over at least about 9 hours in at least about 80% of wearers, as measured in a randomized, double masked clinical study.

Abstract: The invention is the method of preparing macromer for use in making ophthalmic lenses comprising combining two or more monomers and using a macromer-forming catalyst, wherein the macromer-forming catalyst comprises triethylamine or bismuth.

Abstract: The present invention relates to (meth)acrylamide monomers of the formula: wherein R is H or CH3, R1 is selected from H, substituted and unsubstituted alkyl groups having 1 to 8 carbon atoms, substituted and unsubstituted benzene and toluene groups and and R2, R3 and R4 are independently selected from alkyl groups having 1 to 8 carbon atoms, substituted and unsubstituted benzene and toluene groups, and —OSiR5R6R7 wherein R5, R6 and R7 are independently selected from the group consisting of straight or branched alkyl groups having 1 to 4 carbon atoms. Polymers made therefrom are also disclosed.

Abstract: The present invention relates to a promotional aid comprising a substantially flat plastic film sample which comprises at least one quality which is substantially similar to at least one quality of a medical device. The promotional aids of the present invention may be sent directly to consumers.