Abstract: The present invention relates to cosmetic compositions that comprise: a) a safe and effective amount of a cyclic imidocarbonate bonding agent having the structure wherein X represents a cosmetic benefit agent that may or may not be attached to a chemical linker and R represents NH or O; and b) a cosmetically acceptable carrier for the bonding agent wherein the composition is administered topically to mammalian proteinaceous substrates and wherein the bonding agent reacts with a protein contained in the substrate such that the bonding agent, and thus the cosmetic benefit agent, is covalently attached to the substrate. The invention further relates to methods of using the compositions described above as well as various products that include the claimed compositions.

Abstract: Disclosed are anhydrous antiperspirant and deodorant compositions comprising from about 0.1% to about 30% by weight of an underarm active (antiperspirant and/or deodorant active); from about 0.01% to about 10% by weight of a solid, encapsulated, water-soluble, d-pantothenate salt such as calcium pantothenate; from about 0.1% to about 40% by weight of a suspending agent; and from about 10% to about 99% by weight of an anhydrous carrier liquid. Also disclosed are methods of controlling perspiration wetness and/or odor through the topical application to the underarm, especially shaven underarms, of an underarm active and a solid pantothenate salt. The anhydrous compositions are mild to the skin and can help sooth or heal skin irritated or damaged underarm skin, especially when such irritation and damage is the result of occasional or routine shaving of the underarmn.

Abstract: According to the present invention there is provided a visually clear, dentrifice gel comprising; a) sufficient tetrasodium pyrophosphate to provide from 0.2% to 5% pyrophosphate anion; b) a silica dental abrasive having a refractive index of from 1.445 to 1.47; c) from 0.7% to 3% sodium alkyl sulphate; and d) an aqueous liquid carrier. The gel has excellent clarity, high anticalculus efficiency and good foaming. According to a further aspect of the invention there is provided a process for making a clear dentifrice gel comprising the step of adding anhydrous tetrasodium pyrophosphate to an aqueous carrier, the gel comprising: a) a silica dental abrasive having a refractive index of from 1.445 to 1.47; and b) an aqueous liquid carrier comprising less than 27% total water. The use of anhydrous tetrasodium pyrophosphate allows greater formulation flexibility at the processing stage by freeing up water for the dissolution and/or hydration of other dentrifice components.

Abstract: The present invention relates to a dispensing device (1) for a fluid (10), the dispensing device (1) comprising a reservoir (11), a shaft (12), a back seal (13), a damper (14), a piston (151) and a one-way valve (16), the back seal (13) sealing a first end of the reservoir and being displaceable along the shaft, the valve being on the second end of the reservoir, the piston being fixed to one end of the shaft, the piston being located between the valve and the damper, the damper being also fixed to the shaft, the damper being located between the piston and the back seal, whereby the piston has an opened position (151) and a closed position (152), the open position allowing fluid communication between the valve and the pat of the reservoir between the piston and the back seal, the displacement of the piston between the opened and the closed position being induced by a displacement of the shaft along its own axis, the pressure in the area comprised between the valve and the piston reducing when the piston is mo

Abstract: Dehydrated potato flakes prepared from potato slices, slivers and/or nubbins suitable for use in dough compositions used to make fabricated products. The dehydrated flakes are prepared such that the physical properties in the flake are controlled during processing. The resulting flakes can be used to prepare a more cohesive, non-adhesive, machineable dough.

Abstract: The present invention relates to Proteinase K variants having a modified amino acid sequence of wild-type Proteinase K amino acid sequence, the wild-type amino acid sequence comprising a first loop region, a second loop region, a third loop region, a fourth loop region, a fifth loop region and a sixth loop region; wherein the modified amino acid sequence comprises different amino acids than that occurring in wild-type Proteinase K (i.e., substitution) at specifically identified positions in one or more of the loop regions whereby the Proteinase K variant has decreased adsorption to, and increased hydrolysis of, an insoluble substrate as compared to the wild-type Proteinase K. The present invention also relates to DNA sequences encoding such Proteinase K variants. The present invention also relates to compositions comprising such Proteinase K variants for cleaning a variety of surfaces.

Abstract: The present invention relates to subtilisin BPN′ variants comprising at least one or more amino acid positions having a different amino acid than that occurring in wild-type subtilisin BPN′ (i.e., substitution) at specifically identified positions, whereby the BPN′ variant has decreased adsorption to, and increased hydrolysis of, an insoluble substrate as compared to wild-type subtilisin BPN′. The present invention further relates to various cleaning compositions comprising such BPN′ variants.

Abstract: The present invention relates to subtilisin BPN′ variants having a modified amino acid sequence of wild-type BPN′ amino acid sequence, the wild-type amino acid sequence comprising a first loop region, a second loop region, a third loop region, a fourth loop region and a fifth loop region; wherein the modified amino acid sequence comprises different amino acids than that occurring in wild-type subtilisin BPN′ (i.e., substitution) at specifically identified positions in one or more of the loop regions whereby the BPN′ variant has decreased adsorption to, and increased hydrolysis of, an insoluble substrate as compared to the wild-type subtilisin BPN′. The present invention also relates to the genes encoding such subtilisin BPN′ variants. The present invention also relates to compositions comprising such subtilisin BPN′ variants for cleaning a variety of surfaces.

Abstract: Snacks made from dough composition comprising starch-based material, water, and an emulsifier-lipid composition. The emulsifier-lipid composition comprises a specific blend of (1) a monoglyceride component, (2) a polyglycerol ester component, and (3) a fat component. Use of the emulsifier-lipid composition in the dough provides textural and flavor advantages in the finished snack.

Abstract: A throat drop comprises from 60% to 95% of an edible shell and from 5% to 40% of an aqueous filling, by weight of the drop. The filling contains a throat relief agent, from 8% to 95%, by weight, water and from 0.001% to 10%, by weight, of a vesicle-forming agent which encapsulates the throat relief agents with vesicles which are dispersed within the filling. The vesicles have a number average particle size of from about 1 to about 100 &mgr;m.

Abstract: Dough compositions used to prepare reduced-calorie and low-calorie farinaceous snacks. The snacks made from the dough compositions have a high degree of mouth-melt, less waxiness and increased crispness. The organoleptical improvements are obtained by incorporating a modified starch and/or high amylopectin flour or starch into the dough composition.

Abstract: A toothbrush, having a handle (12) and at one end thereof a bristle-bearing head (11), wherein the head (11) is in the form of two or more segments (15) flexibly and/or resiliently linked to each other and/or to the handle (12), one or more of the segments (15) being bristle bearing.

Abstract: Disclosed are improved food preparation compositions. The compositions can include an anti-stick agent, a flavor enhancing agent, and an anti-foam agent. The compositions can be used in relatively low levels when preparing food, yet provide improved flavor, texture and aroma compared to results achieved using greater amounts of conventional food preparation compositions.

Abstract: The invention provides compounds of formula as described in the claims, or an optical isomer, diastereomer or enantiomer thereof, or a pharmaceutically-acceptacle salt, or biohydrolyzable amide, ester, or imide thereof are useful as inhibitors of metalloproteases. Also disclosed are pharmaceutical compositions and methods of treating diseases, disorders and conditions characterized by metalloprotease activity using these compounds or the pharmaceutical compositions containing them.

Abstract: Snacks made from dough compositions comprising starch-based material, water, and an emulsifier-lipid composition. The emulsifier-lipid composition comprises a specific blend of (1) a monoglyceride component, (2) a polyglycerol ester component, and (3) a fat component. Use of the emulsifier-lipid composition in the dough provides textural and flavor advantages in the finished snack.

Abstract: This invention involves compounds having the following structure: as described in the Claims; and enantiomers, optical isomers, stereoisomers, diastereomers, tautomers, addition salts, biohydrolyzable amides and esters thereof, as well as pharmaceutical compositions comprising such novel compounds. The invention also relates to the use of such compounds for preventing or treating disorders modulated by alpha-2 adrenoceptors.

Abstract: Oral compositions containing therapeutical agents wherein the undesirable consumer aesthetics associated with these agents are mitigated using coolants and sweeteners.

Abstract: Substituted heterocyclic compounds are disclosed. The compounds are useful for treating multidrug resistance. The compounds can be formulated in compositions with a carrier and, optionally, a therapeutic agent.

Abstract: The present invention relates to products, including preservative systems and compositions (e.g., foods, beverages, health care products, personal care products, herbicidal products, and containment devices). The products comprise a constituent comprising an isothiocyanate compound. The products may further comprise a preservative selected from sorbate preservatives, benzoate preservatives, and mixtures thereof. The present invention further relates to methods of preserving products comprising incorporating the foregoing preservative systems into such products.

Abstract: The present invention relates to color and flavor improvements in iron and zinc supplemented dry beverage powders having fruit and/or botanical flavor. Vitamins such as the B vitamins, vitamin A, vitamin C, and vitamin E can be added to the dry beverage mix. The supplemented dry beverage mix can also contain iodine, niacin and folic acid. In particular, methods for fortifying dry beverage mixes with certain bioavailable zinc and iron compounds without producing reconstituted beverages having undesirable color or flavor are disclosed. Also disclosed are beverages and foods fortified preferably with amino acid chelated iron that do not impart objectionable color due to the inclusion of a ferric ion reducing agent such as ascorbic acid and/or an agent such as citric acid that is capable of preferentially complexing ferric ion in the presence of polyphenols or flavonoids that are typically present in these beverages or foods.