Abstract: Composition for cleaning cooking surfaces comprises, by weight, from about 0.5% to about 10% of a surfactant selected from the group consisting of polyhydroxy fatty acid amide surfactants having the formula: ##STR1## wherein R.sub.1 is H, methyl, ethyl, propyl, butyl, 2-hydroxyl ethyl or 2-hydroxy propyl; R.sub.2 is a C.sub.5 -C.sub.31 hydrocarbyl; and Z is a polyhydroxyhydrocarbyl having a linear hydrocarbyl chain with at least 3 hydroxyls directly connected to the chain, or an alkoxylated derivative of the polyhydroxyhydrocarbyl wherein at least one of the hydroxyls is alkoxylated; from about 0% to about 10% of a surfactant selected from the group consisting of amine oxide surfactants having the formula:R.sub.3 R.sub.4 R.sub.5 N.fwdarw.Owherein R.sub.3 is an alkyl having from about 8 to about 16 carbon atoms, and R.sub.4 and R.sub.5 are each independently methyl or ethyl; and mixtures thereof; from about 0.
Type:
Grant
Filed:
March 18, 1997
Date of Patent:
July 6, 1999
Assignee:
The Procter & Gamble Company
Inventors:
Thomas James Wierenga, James August Weikel, David Charles Underwood
Abstract: The present invention relates to fat free corn chips comprising corn masa and fat free filler selected from the group consisting of starch, protein and nondigestible fiber, and mixtures thereof; nondigestible fat substitute; and other essentially fat free ingredients selected from the group consisting of salt, emulsifiers and fat free seasonings and combinations thereof.
Type:
Grant
Filed:
March 27, 1996
Date of Patent:
May 18, 1999
Assignee:
The Procter & Gamble Company
Inventors:
John Michael Jensen, David Thomas Biedermann, Robert William Johnston, Robert Daniel Rece
Abstract: Nutritional iron compositions comprising bioavailable sources of iron selected from ferrous fumarate and ferrous succinate where the iron source is preferably spread on the surface of a lecithin coated edible carrier such as sucrose. These nutritional iron compositions are particularly useful in food and beverage products such as chocolate flavored edible mixes, especially chocolate flavored beverages, that are additionally fortified with other minerals and vitamins, especially multi-mineral and vitamin combinations involving, iodine, vitamin A, vitamin C, riboflavin, and folic acid to avoid developing an undesirable color, off-flavor, astringency, particularly when the edible and/or beverage mix is reconstituted with water or milk.
Abstract: A process for preparing nut spreads having a sugar level of from about 15 to about 50% and especially flavored nut spreads having such relatively high levels of sugar. A substantially homogeneous blend is prepared from a fluid suspension consisting essentially of an intimate mixture of sugar, liquid oil and lecithin as a surfactant to improve the fluidity of the suspension, a nut solids-containing mixture and a flavorant that is preferably added to the fluid suspension. The resulting flavored nut spreads are more fluid and softer than products made without using the fluid suspension.
Type:
Grant
Filed:
October 27, 1997
Date of Patent:
March 23, 1999
Assignee:
The Procter & Gamble Company
Inventors:
Vincent York-Leung Wong, Richard Joseph Sackenheim
Abstract: Nut spreads, especially peanut butters, having a relatively low viscosity of about 2000 centipoise or less that have significantly reduced stickiness and increased nut flavor intensity. These nut spreads are obtained by milling a mixture of nut solids, oil, particulate water-soluble solids such as sugar and salt, optionally but preferably nut butter stabilizer and emulsifier, such that the water soluble solids have a mean particle size of about 20 microns or less to reduce grittiness. This milled mixture is combined with a nut paste prepared without excessively reducing the particle size of the nut solids.
Type:
Grant
Filed:
June 20, 1997
Date of Patent:
March 23, 1999
Assignee:
The Procter & Gamble Company
Inventors:
Vincent York-Leung Wong, Richard Joseph Sackenheim
Abstract: Green tea extracts having improved clarity and color. These extracts are obtained by treating the green tea extract with an amount of a food grade cation exchange resin effective to remove metal cations present in the extract. The treated extract is then contacted nanofiltration membrane while the treated extract is at a temperature of from about 100.degree. to about 140.degree. F. (from about 37.8.degree. to about 60.degree. C.) to provide a filtered green tea extract as the permeate. These green tea extracts can be included in a variety of beverages and are especially useful in suppressing the characteristic aftertaste of aspartame in diet beverages.
Type:
Grant
Filed:
September 18, 1997
Date of Patent:
March 9, 1999
Assignee:
The Procter & Gamble Company
Inventors:
Athula Ekanayake, John Robert Bunger, Marvin Joseph Mohlenkamp, Jr.
Abstract: The present invention provides methods of treating a human or other animal subject afflicted with arthritis, including rheumatoid, arthritis and osteoarthritis, comprising a sixty (60)-day treatment period, comprised of an optional NSAID administration regimen and a phosphonate administration regimen, wherein(a) said optional NSAID administration regimen which comprises the administration to said subject of NSAIDs at a level of from 20% to 80%, preferably 20% to 70%, most preferably 20% to 50% of the conventionally prescribed daily dose on each day that said NSAID is administered; provided that said NSAID is administered in sufficient quantities and on a sufficient number of days to alleviate symptoms of inflammation, and wherein(b) said phosphonate administration regimen comprises the administration to said subject of a phosphonate at a dose equivalent to a systemic level of from about 0.0005 mgP/kg to about 1.
Type:
Grant
Filed:
June 7, 1995
Date of Patent:
February 9, 1999
Assignee:
The Proctor & Gamble Company
Inventors:
Kristine Hovancik, Marion David Francis, Richard Allen Underwood
Abstract: The present invention relates to thio-substituted, nitrogen-containing heterocyclic phosphonate compounds, including bisphosphonates, phosphonoalkylphosphinates, phosphonocarboxylates, and phosphonosulfonates, and the pharmaceutically-acceptable salts and esters thereof useful for the treatment and prevention of osteoporosis and arthritis. These compounds have the general structure: ##STR1## (a) Z is a monocyclic or polycyclic heterocyclic ring moiety containing one or more heteroatoms selected from O, S, or N, at least one of which is N;(b) Q is covalent bond; O, S, N, or NR.sub.1 ;(c) R is COOH, SO.sub.3 H, PO.sub.3 H.sub.2, or P(O)(OH)R.sup.4, wherein R.sup.4 is substituted or unsubstituted C.sub.1 -C.sub.8 alkyl;(d) each R1 is independently selected from --SR.sup.6 ; --R.sup.8 SR.sup.6 ; nil; hydrogen; unsubstituted or substituted C.sub.1 -C.sub.8 alkyl; unsubstituted or substituted aryl; hydroxy; --CO.sub.2 R.sup.3 ; --O.sub.2 CR.sup.3 ; --NR.sup.3.sub.2 ; --OR.sup.3 ; --C(O)N(R.sup.3).sub.2 ; --N(R.sup.
Type:
Grant
Filed:
May 9, 1994
Date of Patent:
January 5, 1999
Assignee:
The Procter & Gamble Company
Inventors:
Susan Mary Kaas, Frank Hallock Ebetino, Marion David Francis
Abstract: The present invention provides a process for making an improved thermally insulated microwave silicate foam susceptor. The process for making the improved microwave susceptor comprises the following steps:a) preparing pourable aqueous alkali metal dielectric sodium silicate slurry,b) pouring said slurry into a smooth surface substrate mold,c) heating said poured slurry at an effective elevated temperature to foam the slurry in said mold;d) drying said foam at an effective elevated temperature to provide said dry silicate foam substrate having a substantially smooth surface;e) coating at least a portion of said substantially smooth surface with an effective amount of a flowable microwave active material coating (MAC) and drying said flowable coating at an effective temperature to form a dry layer of said MAC.
Type:
Grant
Filed:
December 29, 1995
Date of Patent:
December 29, 1998
Assignee:
The Procter & Gamble Company
Inventors:
Paul Ralph Bunke, Robert Lawrence Prosise, Phillip Floyd Pflaumer
Abstract: The present invention relates to new 14-aminosteroids, pharmaceutical compositions containing the new compounds and methods of treatment for humans or other mammals afflicted with congestive heart failure.
Type:
Grant
Filed:
February 20, 1997
Date of Patent:
December 15, 1998
Assignee:
The Procter & Gamble Company
Inventors:
Paul Michael Dybas, Roland Norman Johnson, Randy Stuart Muth, Song Liu, David Edward Portlock
Abstract: Compounds of the formula ##STR1## where m and n are integers 0 to 10 and m+n equals 0 to 10, (a) X is O or S(b) Z is a covalent bond; a monocyclic or polycyclic carbocycle ring moiety; or a monocyclic or polycyclic heterocyclic ring moiety containing one or more heteroatoms selected from O, S, or N;(c) Q is covalent bond; O; or S;(d) R is COOH, SO.sub.3 H, PO.sub.3 H.sub.2, or P(O)(OH)R.sup.4, wherein R.sup.4 is C.sub.1 -C.sub.8 alkyl;(e) R.sup.1, R.sup.2 and R.sup.5 are as defined in the claims.are useful in the treatment of calcium and phosphate elated disorders, such as arthritis and the like.
Type:
Grant
Filed:
September 7, 1994
Date of Patent:
October 20, 1998
Assignee:
The Procter & Gamble Company
Inventors:
Marion David Francis, Susan Mary Kaas, Frank Hallock Ebetino
Abstract: The present invention relates to a pharmaceutical composition in a unit dosage form for peroral administration in a human or lower animal, having a gastrointestinal tract comprising a small intestine and a colon with a lumen therethrough having an inlet to the colon from the small intestine, comprising:a. a safe and effective amount of a therapeutically active agent incorporated into or coated on the surface of a dosage form selected from the group consisting of a spherical substrate, an elliptical substrate, a hard capsule, or a compressed tablet, with a maximum diameter of about 3 mm to about 10 mm; andb. an enteric polymer coating material;wherein the dosage form has a smooth surface free from edges or sharp curves; the elliptical substrate and the hard capsule have a ratio of the long to short diameters of no greater than about 1.
Abstract: The present invention relates to a method for making a compound of the structure: ##STR1## comprising the steps: (a) adding 6-deoxy-.alpha.-L-mannopyranosyl bromide, 2,3,4-tri-O-benzoate; DMSO; a base, selected from the group including tertiary amines, amidines, bicarbonates, carbonates, heteroaryl amine, and a solvent, hydrocarbons, esters, and ethers, in a slurry heated to 50.degree.-150.degree. C.;(b) stirring the reaction mixture at 50.degree.-150.degree. C. for 5 minutes to 30 minutes,(c) pouring the reaction mixture over ice water; and(d) extracting the product with a solvent selected from the group consisting of chlorinated solvents, aromatic hydrocarbons, esters, ethers, and evaporating said layer to give a solid.
Type:
Grant
Filed:
June 5, 1995
Date of Patent:
July 21, 1998
Assignee:
Procter & Gamble Pharmaceuticals, Inc.
Inventors:
Song Liu, David Edward Portlock, Gilles Yves Genain, Jean-Jacques Koenig, Jacques de Rostolan, Randy Stuart Muth
Abstract: The present invention relates to color and shelf stable beverage compositions comprising:a) from about 0.4% to about 1.5% tea extract wherein the level of caffeine is from about 0.85% to about 3.2%; and the tea solids content is from about 12% to about 60%;b) from about 10 ppm to about 40 ppm colorant;c) from about 300 ppm to about 1500 ppm erythorbic acid or ascorbic acid;d) from about 0.5% to about 8.0% citric acid;e) an effective amount of sweetener; andf) water; andwherein the tea extract contains unoxidized flavanols.
Type:
Grant
Filed:
January 3, 1996
Date of Patent:
July 14, 1998
Assignee:
The Procter & Gamble Company
Inventors:
Sanford Theodore Kirksey, Athula Ekanayake, Edmund Paul Pultinas, Jr., Judith Ann Jones, Richard Fiske Stradling, Jr.
Abstract: The present invention relates to quaternary nitrogen-containing phosphate compounds, and the pharmaceutically-acceptable salts and esters thereof having the general structure: ##STR1## wherein: Z is a saturated, unsaturated, or aromatic, monocyclic or polycyclic carbocycle or monocyclic or polycyclic heterocycle containing one or more heteroatoms selected from O, S, or N;Y is N.sup.+ (R.sup.8).sub.2 or C(R.sup.1).sub.2 and when Y is C(R.sup.1).sub.2, at least one R.sup.2 must be N.sup.+ (R.sup.8).sub.3 ;R.sup.1, R.sup.2, R.sup.5, and R.sup.8 are defined in claim 1, m and n are integers from 0 to 10; m+n is from 0 to 10;R is COOH; PO.sub.3 H.sub.2 ; SO.sub.3 H; or P(O)(OH)R.sub.4, wherein R.sub.4 is substituted or unsubstituted alkyl of 1-8 carbons atoms.The present invention further relates to pharmaceutical compostions containing a safe and effective amount of a compound of the present invention, and pharmaceutically-acceptable excipients.
Type:
Grant
Filed:
November 3, 1994
Date of Patent:
June 23, 1998
Assignee:
The Procter & Gamble Company
Inventors:
Frank Hallock Ebetino, Susan Mary Kaas, Marion David Francis, Dennis George Anthony Nelson, John Michael Janusz
Abstract: Methods for the solventless transesterification of a polyol comprise reacting polyol with fatty acid alkyl ester in the presence of a basic catalyst to produce polyol fatty acid polyester product and lower alkyl alcohol by-product, wherein a majority of the polyol is fully esterified. The reaction is conducted in a reactor at a temperature in the range of from about 60.degree. to about 180.degree. C. and at atmospheric or superatmospheric pressure. An inert gas is sparged through the reactor with sufficient mass transfer surface area contact between the inert gas and reactor liquid to transfer the lower alkyl alcohol by-product from a liquid mixture of reactant and product to the inert gas and promote full esterification of a majority of the polyol without the use of vacuum pressure.
Type:
Grant
Filed:
July 19, 1996
Date of Patent:
June 16, 1998
Assignee:
The Procter & Gamble Company
Inventors:
Richard Gerard Schafermeyer, Patrick Joseph Corrigan, Corey James Kenneally, James Earl Trout
Abstract: The present invention relates to thio-substituted cyclic phosphonate compounds including bisphosphonates and phosphonoalkylphosphinates, and the pharmaceutically-acceptable salts and esters thereof. The present invention further relates to pharmaceutical compositions containing a safe and effective amount of a compound of the present invention, and pharmaceutically-acceptable excipients. Finally, the present invention relates to methods for treating or preventing pathological conditions characterized by abnormal calcium and phosphate metabolism in humans or other mammals including treating or preventing osteoporosis and arthritis, especially rheumatoid arthritis and osteoarthritis. The compounds may be monocyclic or bicyclic and have the following general structure: ##STR1## wherein (a) X and Y are independently selected from nil, O, S, and N;(b) R is PO.sub.3 H.sub.2 or P(O)(OH)R.sup.4, wherein R.sup.4 is substituted or unsubstituted C.sub.1 -C.sub.
Type:
Grant
Filed:
April 30, 1993
Date of Patent:
June 9, 1998
Assignee:
The Procter & Gamble Company
Inventors:
Susan Mary Kaas, Frank Hallock Ebetino, Marion David Francis
Abstract: Disclosed are quaternary nitrogen-containing, saturated or unsaturated monocyclic and bicyclic ring-containing bisphosphonate compounds, and pharmaceutically-acceptable salts and esters thereof. These compounds, which are useful for treating or preventing disorders of calcium and phosphate metabolism, have the following general structure: ##STR1## wherein (a) each X and Y are independently selected from nil, O, S, NR.sup.1 and N.sup.+ (R.sup.2).sub.2 ; if no R.sup.1 is N.sup.+ (R.sup.2).sub.2, then at least one of X or Y must be N.sup.+ (R.sup.2).sub.2 ;(b) m and n and m+n are integers from 0 to 5; p and q and p+q are integers from 0 to 3;(c) s is an integer from 0 to 2 and when m+n=0 and X is nil, s=2;(d) each R.sup.1 is independently selected from the group consisting of nil, N.sup.+ (R.sup.2).sub.2, R.sup.9 SR.sup.6, SR.sup.6, hydrogen, hydroxy; unsubstituted or substituted C.sub.1 -C.sub.8 alkyl, --OR.sup.3, --CO.sub.2 R.sup.3, --O.sub.2 CR.sup.3, NR.sup.3.sub.2, --N(R.sup.3)C(O)R.sup.3, --C(O)N(R.sup.3).
Type:
Grant
Filed:
April 30, 1993
Date of Patent:
May 19, 1998
Assignee:
The Procter & Gamble Company
Inventors:
Frank Hallock Ebetino, Marion David Francis, Susan Mary Kaas
Abstract: Disclosed are 14-aminosteroid compounds, including pharmaceutically acceptable acid salts and esters thereof, useful in treating individuals afflicted with congestive heart failure, which compounds have the general formula: ##STR1## wherein R.sub.3 is a deoxy or oxygen-substituted monosaccharide sugar residue and R.sub.1, R.sub.2 and R.sub.4 are various other substituents as defined herein.
Type:
Grant
Filed:
June 2, 1995
Date of Patent:
February 24, 1998
Assignee:
The Procter & Gamble Company
Inventors:
Song Liu, David Edward Portlock, Gilles Yves Genain, Jean-Jacques Koenig, Jacques de Rostolan
Abstract: The present invention relates to oligosaccharide-containing 14-aminosteroid compounds and the pharmaceutically-acceptable acid salts or esters thereof of the general formula: ##STR1## wherein a) R.sub.1 is(i) COOR.sub.5, whereR.sub.5 is hydrogen, a 1-6 carbon lower alkyl; a 1-6 carbon lower alkyl substituted by an amino group; an arylalkyl or heteroarylalkyl or a carbocyclic ring, or(ii) CHR.sub.6 OH, whereR.sub.6 is a hydrogen atom or 1-6 carbon lower alkyl group, or(iii) COR'", where R'" is hydrogen; 1-6 carbon lower alkyl; 1-6 carbon lower alkyl substituted amino; amino or dialkylamino; andb) R.sub.2 is --NR.sub.7 R.sub.8, whereR.sub.7 and R.sub.8, which may be the same or different, are hydrogen atoms or a 1-6 carbon lower alkyl; andc) R.sub.3 is an oligosaccharide sugar residue; andd) R.sub.4 is(i) OH, or(ii) H, or(iii) OR.sub.13, whereR.sub.13 is a monosaccharide sugar residue; acetoxy; benzoxy; arylalkyl or heteroarylalkyl; ande) Z is(i) --CH--, wherea and b are single bonds, or(ii) .dbd.
Type:
Grant
Filed:
June 2, 1995
Date of Patent:
January 20, 1998
Assignee:
The Procter & Gamble Company
Inventors:
Paul Michael Dybas, Roland Norman Johnson, Randy Stuart Muth, Song Liu