Abstract: The invention relates to a substance from the calcitonin group, which substance can be isolated from the human body or can be obtained in a different manner, but clearly differs from the known human calcitonin-(1-32), the said substance having hypocalcaemic activity.

Abstract: A closed system for emptying liquid chemical containers comprising a first, container-mating device adapted to have a variable length probe coupled to its lower end; the first device having a two-way valve for filling and emptying the container, and providing a separate path for flushing the container; a second, extracting device, adapted to mate with the first device and to be utilized for actuating the valve so as to permit withdrawal of liquid from the container, and for enabling the intake of flushing liquid.

Abstract: These is described a process for producing sulfonylureas of the formula ##STR1## wherein G is an unsubstituted or substituted furanyl, thienyl, pyrrolyl, pyridinyl or phenyl radical,X is alkyl, haloalkyl, alkoxy, alkylthio, halogen, haloalkoxy, alkylamino or dialkylamino,Y is alkyl, alkoxy or haloalkoxy,Z is a nitrogen atom or the methyne group --CH.dbd..This novel process comprises reacting a sulfonamide of the formulaG--SO.sub.2 --NH.sub.2,in the presence of a base, with a chloroformic acid ester of the formulaCl--CO--Q--T,or a sulfonyl chloride of the formulaG--SO.sub.2 Cl,in the presence of a base, with a urethane of the formulaH.sub.2 N--CO--Q--T;and converting the formed carbamate of the formulaG--SO.sub.2 --NH--CO--Q--Tby reaction with an amine of the formula ##STR2## into the sulfonylurea of the above formula. There are also described novel sulfonylcarbamates of the above formula as intermediates.

Abstract: The invention relates to a novel microorganism of the genus Rhodococcus, to the use thereof in a process for the microbiological degradation of amino-s-triazines and cyanuric acid in wastewaters, as well as to a process for the microbiological degradation of s-triazine derivatives to biomass or to degradation products such as NH.sup.30.sub.4 and/or chloride, which comprises the combined use of said microorganism with Pseudomonas spp.

Abstract: N-acyl-N-alkyl-2,6-dialkyl-3-chloroanilines of the formula ##STR1## wherein R.sub.1 is methyl or ethyl, R.sub.2 is alkoxymethyl, chloromethyl or 2-tetrahydrofuryl, R.sub.3 is alkoxymethyl, carboxy or alkoxycarbonyl and R.sub.4 is hydrogen or methyl and, if R.sub.3 is carboxy or alkoxycarbonyl, R.sub.4 is also 2-alkoxyethyl and 2-alkoxypropyl, and R.sub.3 and R.sub.4, together with the carbon atom to which both radicals are attached, may also form a 2-oxotetrahydro-3-furyl radical or a 2-oxo-5-methyltetrahydro-3-furyl radical, are prepared by reacting a 2,6-dialkylaniline of the formula ##STR2## with a halide of the formula ##STR3## wherein X is chlorine or bromine, to give an N-alkyl-2,6-dialkylaniline of the formula ##STR4## then converting said compound by further reaction with an acylating agent of the formulaX.sub.1 --CO--R.sub.2wherein X.sub.1 is chlorine, bromine or -O-CO-R.sub.

Abstract: A process for the preparation of sulfonated aromatic amines starting with the corresponding aromatic amine sulfate salt which employes a rotating reactor in which there is maintained a rapidly moving heated cascading bed of solid particles composed largely of the final product whose temperature is above or brought above the rearrangement temperature. The reactants are fed to the bed at such a rate that the cascading movement of the bed is unaffected. The heat imparted to the amino hydrogen sulfate within the bed by the surrounding particles orient the desired rearrangement to take place along with the vaporization and elimination of water.

Abstract: There is described a process for producing sulfonylureas of the formula ##STR1## wherein G is an unsubstituted or substituted furanyl, thienyl, pyrrolyl, pyridinyl or phenyl radical,X is alkyl, haloalkyl, alkoxy, alkylthio, halogen, haloalkoxy, alkylamino or dialkylamino,Y is alkyl, alkoxy or haloalkoxy,Z is a nitrogen atom or the methyne group --CH.dbd..This novel process comprises reacting a sulfonamide of the formulaG--SO.sub.2 --NH.sub.2,in the presence of a base, with a chloroformic acid ester of the formulaCl--CO--Q--T,or a sulfonyl chloride of the formulaG--SO.sub.2 Cl,in the presence of a base, with a urethane of the formulaH.sub.2 N--CO--Q--T;and converting the formed carbamate of the formulaG--SO.sub.2 --NH--CO--Q--Tby reaction with an amine of the formula ##STR2## into the sulfonylurea of the above formula. There are also described novel sulfonylcarbamates of the above formula as intermediates.

Abstract: The invention relates to lipopeptides of the formula I, ##STR1## in which each of R.sub.a.sup.1 and R.sub.b.sup.1, independently of the other, represents an aliphatic or cycloaliphatic-aliphatic hydrocarbon radical having from 7 to 21 carbon atoms that is optionally substituted by oxygen functions, orone of the radicals R.sub.a.sup.1 --CO-- and R.sub.b.sup.1 --CO-- represents hydrogen and the other of the radicals R.sub.a.sup.1 --CO-- and R.sub.b.sup.1 --CO-- represents an acyl radical, wherein R.sub.a.sup.1 and R.sub.b.sup.1 have the meanings given above,R.sup.2 represents an aliphatic or cycloaliphatic-aliphatic hydrocarbon radical having from 1 to 21 carbon atoms that is optionally substituted by oxygen functions,n=0 or 1,As.degree. represents a radical of the formula --O--Kw--CO-- or --NH--Kw--CO-- wherein Kw represents an aliphatic hydrocarbon radical having a maximum of 12 carbon atoms,As.sup.1 represents a D- or L-.alpha.-amino acid,each of Z.sup.1 and Z.sup.

Abstract: A process for preparing dry dye granules is disclosed. The process involves the preparation of a controlled moisture content slurry of the dye. Then introducing the slurry into a turbogranulator to form solid spherical particles whose size is controlled by the moisture content of the slurry. Then drying the particles in a fluidized bed dryer by heated air. Most of the fines are removed during the drying stage in the exit air stream from the dryer. The remaining fines and over sized particles are recovered on screening and are combined and ground and used to control the moisture content of the initial slurry. The final solid granules have good strength as compared to the previously marketed spray-dried materials which were in the form of porous hollow spheres. They are more readily dispersible and more rapidly dissolving.

Abstract: The invention relates to a process for the manufacture of novel benzazole derivatives of the formula I ##STR1## in which R.sub.1 represents an optionally 4-substituted piperazino group or a group of the formula R.sub.2 --alk--X.sub.2 --,R.sub.2 represents optionally esterified carboxy or represents hydroxymethyl,alk represents lower alkylene or lower alkylidene,X.sub.1 and X.sub.2, independently of one another, each represents oxygen or sulphur,Ph represents 1,2-phenylene optionally substituted as well as by the group R.sub.1 --C(.dbd.X.sub.1)--NH--,X.sub.3 represents oxygen, sulphur or optionally substituted imino, andR.sub.3 represents optionally fluorine-substituted lower alkyl or cycloalkyl,and their salts.The compounds of the formula I, which have proved to be excellent micro- and macrofilaricides and schistosomacides, are manufactured according to methods known per se.

Abstract: The present invention relates to a novel four-step process for the preparation of herbicidal and plant growth regulating 2-nitro-5-(2-pyridinyloxy)acetophenone oxime ether derivatives of formula I ##STR1## wherein R.sup.1 is hydrogen, cyano, halogen, nitro, C.sub.1 -C.sub.4 alkyl or C.sub.1 -C.sub.4 haloalkyl,R.sup.2 is hydrogen or halogen,R.sup.3 is C.sub.1 -C.sub.4 alkyl andR.sup.4 is C.sub.1 -C.sub.4 alkyl, C.sub.1 -C.sub.4 cyanoalkyl, C.sub.3 -C.sub.5 alkenyl, C.sub.3 -C.sub.5 -haloalkenyl, C.sub.3 -C.sub.5 alkynyl, or C.sub.1 -C.sub.4 alkyl which is substituted by C.sub.1 -C.sub.4 alkoxy, halogen, C.sub.1 -C.sub.4 alkoxycarbonyl, C.sub.1 -C.sub.4 alkylaminocarbonyl or di(C.sub.1 -C.sub.4)alkylaminocarbonyl,which process comprises converting a phenol of formula II ##STR2## by reaction with a compound of formulaH.sub.2 N--O--R.sup.

Abstract: A process is disclosed for the preparation of concentrated stable liquid dye solutions of CI Direct Yellow 11 starting with the tetrasodium complex of the stilbeneazo(xy) based-catalyzed condensation of 4-nitro-toluene-2-sulfonic acid, the wet-cake or the dried technical grade of the condensed tetrasodium complex. The process comprises the steps of forming an aqueous suspension of the starting materials which are admixed with the extended surface silica filter aid and the resulting slurry is acidified with a strong inorganic acid to pH below about 2.

Abstract: A process is disclosed for the preparation of concentrated stable liquid dye solutions of CI Direct Yellow 11 starting with the product of the basic condensation of para-nitrotoluene-ortho-sulfonic acid in the form of its tetrasodium reaction mass or the wet filter cake separation of the solids from said mass and the reaction liquids or the dry technical grade sodium complex which is the dried filter cake. The solid starting material is suspended in a lower alkanol/water medium; the suspension is acidified to a pH below about 2.5 to acidify each sulfo moiety on the chromophore and to form the free inorganic salt; this acidified suspension is heated to assure completion of the metathetical salt-forming reaction; after sufficient heating, the mixture of the acidified chromophore and the salt is neutralized to a pH in the range 6.0 to 7.

Abstract: Compounds of the formula I ##STR1## in which n represents 1, 2 or 3, Ar represents a carbocyclic or heterocyclic aryl radical, Ac represents the acyl radical of an acid, Z represents a radical --OR.sub.7 or --NR.sub.8 R.sub.9, R.sub.1 represents hydrogen, unsubstituted or substituted lower alkyl, a carbocyclic or heterocyclic aryl radical or free, etherified or esterified hydroxy, R.sub.2 and R.sub.3, independently of one another, each represents hydrogen, unsubstituted or substituted lower alkyl, formyl or functionally modified formyl, carboxy or functionally modified carboxy, a carbocyclic or heterocyclic aryl radical or unsubstituted or mono- or di-substituted amino, R.sub.4 represents hydrogen or lower alkyl, R.sub.5 and R.sub.6, independently of one another, each represents hydrogen, unsubstituted or substituted lower alkyl or a carbocyclic or heterocyclic aryl radical, R.sub.7, R.sub.8 and R.sub.

Abstract: The present invention relates to an improved process for the manufacture of (3S)-3,4-trans-disubstituted azetidinones of the formula ##STR1## in which R.sub.1 represents hydrogen or lower alkyl,R.sub.2 represents hydrogen or a hydroxy-protecting group,Y represents the group --S(.dbd.O)--R.sub.3 or --S(.dbd.O).sub.2 --R.sub.3 wherein R.sub.3 represents an organic radical bonded to the sulphur atom by a carbon atom that is not bonded to hydrogen, or the group --C(.dbd.O)--O--R.sub.3 ' wherein R.sub.3 ' represents an organic radical bonded to the oxygen atom of the carboxy group by a carbon atom that is not bonded to hydrogen, or a carboxy-protecting group, andR.sub.4 represents hydrogen or an amino-protecting group R.sub.4 '.The process according to the invention is carried out under particularly favorable reaction conditions and yields compounds (I) in particularly high yields.

Abstract: A process for the production of N-(2-methyl-4-chlorophenyl)-formamidine derivatives of formula ##STR1## wherein R.sub.1 is hydrogen or an alkyl radical having 1 to 4 carbon atoms and R.sub.2 is an alkyl radical having 1 to 4 carbon atoms is disclosed which comprises reacting an N-substituted formamide with an inorganic acid chloride, such as phosphorus oxychloride, thionylchloride and phosgene, condensing the intermediate formed with o-toluidine and subsequently chlorinating the N-(2-methylphenyl)-formamidine derivative formed, all reaction steps involved in said process being carried out in the same solvent which is selected from the group of halogenated hydrocarbons.

Abstract: Novel substituted 2-mercaptoimidazoles of the formula ##STR1## in which at least one of the radicals R.sub.1 and R.sub.2 is a substituted or unsubstituted heteroaryl group and the other is a substituted or unsubstituted aryl group, R.sub.3 is hydrogen or lower alkyl, n is 0, 1 or 2 and R.sub.4 is a substituted or unsubstituted aliphatic hydrocarbon radical and their pharmaceutically usable salts exhibit anti-inflammatory, anti-nociceptive and/or antithrombotic activity.

Abstract: A novel process for the preparation of 3,4-dihydro-2,2-dioxo-3-methyl-1,2-benzoxathiin-8-ylsulfonamide of the formula I ##STR1## reacting a 5-halo-2,3-dihydro-2-methylbenzo[b]furan of the formula II ##STR2## wherein Hal is chlorine or bromine, with chlorosulfonic acid to give a 6-halo-2,2-dioxo-3-methyl-1,2-benzoxathiin-8-ylsulfonyl chloride of formula III ##STR3## wherein Hal is chlorine or bromine, converting this sulfonyl chloride with ammonia into a 6-halo-2,2-dioxo-3-methyl-1,2-benzoxathiin-8-ylsulfonamide of formula IV ##STR4## wherein Hal is chlorine or bromine, dehalogenating this sulfonamide with hydrogen in the presence of a tertiary amine and a noble metal catalyst, and hydrogenating the resultant 2,2-dioxo-3-methyl-1,2-benzoxathiin-8-ylsulfonamide of formula V ##STR5## with hydrogen in the presence of a noble metal catalyst.

Abstract: Cyclic octapeptides of the formula ##STR1## in which Aaa represents a radical of a straight-chained .alpha.,.omega.-diaminoalkanoic acid having from 4 to 7 carbon atoms,trp represents a radical L-Trp or, especially, D-Trp, or a radical derived therefrom, which carries a halogen atom in the indole nucleus,Ac.sub.A represents an acyl radical Ac of an optionally substituted carboxylic acid which is positioned at the .omega.-amino group, or represents an amidino group or hydrogen, andAc.sub.B represents an acyl radical Ac.sup.1 of an amino acid or of an oligopeptide which is positioned at the .epsilon.-amino group, or, preferably, represents hydrogen,as well as physiologically tolerable salts and therapeutically acceptable complexes thereof can be used as antidiabetics and for the treatment of gastro-intestinal bleeding in an analogous manner to somatostatin. They can be obtained by conventional processes of peptide chemistry, especially by the cyclization of corresponding linear peptides.

Abstract: Indoles of the formula I which are unsubstituted in the 2- and 3-positions: ##STR1## wherein Z is hydrogen or a group --COR, and X and Y have the meanings defined in claim 1, can be produced by a novel, simple and economical process which comprises reacting a compound of the formula II ##STR2## at a temperature of between 0.degree. and 120.degree. C., in the presence of a mercury or palladium catalyst, with benzoic acid vinyl ester, or with the vinyl ester of an aliphatic C.sub.1 -C.sub.4 -monocarboxylic acid; and optionally saponifying compounds of the formula I in which Z is --COR. The compounds of the formula I can be used for example for producing indigo dyes, or they can be used as pharmaceutical or agricultural active substances.