Abstract: Oral dosage forms of a risedronate comprised of a safe and effective amount of a pharmaceutical composition comprising risedronate, a chelating agent, and, means for effecting delayed release of the risedronate and the chelating agent in the small intestine provide immediate release of the pharmaceutical composition to the small intestine of the mammal subject and pharmaceutically effective absorption of the bisphosphonate with or without food or beverages. The present invention substantially alleviates the interaction between risedronate and food or beverages, which interaction results in the bisphosphonate active ingredient not being available for absorption. The resulting oral dosage form may thus be taken with or without food. Further, the present invention effects delivery of risedronate and the chelating agent to the small intestine, substantially alleviating the upper GI irritation associated with bisphosphonate therapies.

Abstract: Oral dosage forms of a bisphosphonate comprised of a safe and effective amount of a pharmaceutical composition comprising a bisphosphonate, a chelating agent, and, means for effecting delayed release of the bisphosphonate and the chelating agent in the lower gastrointestinal tract provide delivery of the pharmaceutical composition to the lower gastrointestinal tract of the mammal subject and pharmaceutically effective absorption of the bisphosphonate with or without food or beverages. The present invention substantially alleviates the interaction between bisphosphonates and food or beverages, which interaction results in the bisphosphonate active ingredient not being available for absorption. The resulting oral dosage form may thus be taken with or without food. Further, the present invention effects delivery of the bisphosphonate and the chelating agent to the lower GI tract, substantially alleviating the upper GI irritation associated with bisphosphonate therapies.

Abstract: A nut that includes a body having an aperture disposed within the body, threads located within the aperture of the body, and a plurality of gripping areas disposed along a circumference of the body. The plurality of gripping areas provides visual and tactile directional signals as to the rotational direction required to attach or detach the nut to or from a threaded member. The nut may be used for attaching a water filter system to a water faucet.

Abstract: A filter for producing potable water filter comprises a housing including a water inlet and a water outlet, and a filter material arranged within the housing. The filter material comprises activated carbon particles, and a plurality of carbon nanofilaments disposed on the surface of the activated carbon particles. The filter is operable to provide potable water by removing contaminants from a liquid water stream flowing from the water inlet to the water outlet of the housing.