Patents Represented by Attorney Kelly L. McDow
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Patent number: 6358544Abstract: The present invention relates to color and flavor improvements in iron and zinc supplemented dry beverage powders having fruit and/or botanical flavor. Vitamins such as the B vitamins, vitamin A, vitamin C, and vitamin E can be added to the dry beverage mix. The supplemented dry beverage mix can also contain iodine, niacin and folic acid. In particular, methods for fortifying dry beverage mixes with certain bioavailable zinc and iron compounds without producing reconstituted beverages having undesirable color or flavor are disclosed. Also disclosed are beverages and foods fortified preferably with amino acid chelated iron that do not impart objectionable color due to the inclusion of a ferric ion reducing agent such as ascorbic acid and/or an agent such as citric acid that is capable of preferentially complexing ferric ion in the presence of polyphenols or flavonoids that are typically present in these beverages or foods.Type: GrantFiled: December 9, 1999Date of Patent: March 19, 2002Assignee: The Procter & Gamble Co.Inventors: William John Henry, Jr., Xiaobing Xi, Michel Lucien Hubert Lannelongue Favre, Haile Mehansho, Renee Irvine Mellican, Jianjun Li
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Patent number: 6326040Abstract: Disclosed are beverage products with improved vitamin stability. The beverage products include an effective amount of a aminopolycarboxylic acid as well as an effective amount of a polyphosphate, and can be enriched with one or more vitamins or other nutrients. In one embodiment, the beverage products include added water, fruit juice, ascorbic acid, ethylene diamine tetra-acetic acid (EDTA), sodium hexametaphosphate, and potassium sorbate. The beverage can be packaged in relatively inexpensive HDPE-type containers which are generally oxygen permeable, and do not require the use of special oxygen barrier packaging to preserve the vitamins and flavor oils from oxidation.Type: GrantFiled: February 22, 2000Date of Patent: December 4, 2001Assignee: The Procter & Gamble Co.Inventors: Donald Raymond Kearney, Sanford Theodore Kirksey, Jr., Donald Joseph Cox
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Patent number: 6306622Abstract: The present invention relates to an isolated BMP, (bone morphogonic protein) receptor kinase protein or soluble fragment thereof, a DNA sequence coding for the BMP receptor kinase protein or the soluble fragment thereof, a recombinant expression vector comprising the DNA sequence, a host cell comprising the recombinant expression vector, and a method of expressing the BMP receptor kinase protein or soluble fragment thereof.Type: GrantFiled: November 4, 1994Date of Patent: October 23, 2001Assignee: The Procter & Gamble Co.Inventors: Jan Susan Rosenbaum, Tsutomu Nohno
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Patent number: 6307049Abstract: The present disclosure describes novel compounds and compositions which are particularly useful for treating hair loss in mammals, including arresting and/or reversing hair loss and promoting hair growth. The present compounds and compositions may also be useful against a variety of disorders including, for example, multi-drug resistance, human immunodeficiency virus (HIV), cardiac injury, and neurological disorders, and may be useful for controlling parasites and invoking immunosuppression.Type: GrantFiled: September 21, 1999Date of Patent: October 23, 2001Assignee: The Procter & Gamble Co.Inventors: John McMillan McIver, Charles Raymond Degenhardt, David Joseph Eickhoff
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Patent number: 6294214Abstract: The noncarbonated beverage products have a pH of between 2.5 and 4.5 and contain from about 300 ppm to about 3000 ppm of a polyphosphate; from about 100 ppm to about 1000 ppm of a preservative such as sorbic acid, benzoic acid, alkali metal salts thereof and mixtures thereof; from about 0.1% to about 40% by weight of fruit juice; and from about 80% to about 99% by weight of added water, the added water contains from 0 ppm to about 60 ppm of hardness, and preferably contains from 0 ppm to about 300 ppm of alkalinity. These noncarbonated beverage products can be stored at ambient temperatures for at least about 10 days, without substantial microbial proliferation therein after exposure to beverage spoilage organisms.Type: GrantFiled: July 14, 1997Date of Patent: September 25, 2001Assignee: The Procter & Gamble Co.Inventors: Jonathan Javier Calderas, Thomas Ray Graumlich, Leonard Jenkins, Robert Phillip Sabin
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Patent number: 6268003Abstract: The noncarbonated beverage products have a pH of between 2.5 and 4.5 and contain from about 300 ppm to about 3000 ppm of a polyphosphate; from about 100 ppm to about 1000 ppm of a preservative selected from sorbic acid, benzoic acid, alkali metal salts thereof and mixtures thereof; from about 0.1% to about 20% by weight of fruit juice; and from about 80% to about 99% by weight of added water, wherein the added water contains from 0 ppm to about 60 ppm of hardness, and preferably contains from 0 ppm to about 300 ppm of alkalinity. These noncarbonated beverage products can be stored at ambient temperatures for at least about 10 days, without substantial microbial proliferation therein after exposure to beverage spoilage organisms.Type: GrantFiled: August 29, 1997Date of Patent: July 31, 2001Assignee: The Procter & Gamble CompanyInventors: Jonathan Javier Calderas, Thomas Ray Graumlich, Leonard Jenkins, Robert Phillip Sabin
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Patent number: 6265008Abstract: Disclosed are noncarbonated beverage products with improved microbial stability, and processes for preparing them. The noncarbonated beverage products have a pH of between 2.5 and 4.5 and comprise from about 300 ppm to about 3000 ppm of a polyphosphate having an average chain length ranging from about 17 to about 60: from about 100 ppm to about 1000 ppm of a preservative selected from the group consisting of sorbic acid, benzoic acid, alkali metal salts thereof and mixtures thereof; from about 0.1% to about 40% by weight of fruit juice; and from about 80% to about 99% by weight of added water, wherein the added water contains from 61 ppm to about 220 ppm of hardness. These noncarbonated beverage products can be stored at ambient temperatures for at least about 28 days without substantial microbial proliferation therein after exposure to beverage spoilage organisms.Type: GrantFiled: November 9, 1999Date of Patent: July 24, 2001Assignee: The Procter & Gamble Co.Inventors: James Arthur Smith, Thomas Ray Graumlich, Robert Phillip Sabin, Judith Wells Vigar
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Patent number: 6261619Abstract: The noncarbonated beverage products have a pH of between 2.5 and 4.5 and contain from about 300 ppm to about 3000 ppm of a polyphosphate; from about 100 ppm to about 1000 ppm of a preservative selected from sorbic acid, benzoic acid, alkali metal salts thereof and mixtures thereof; from about 0.1% to about 40% by weight of fruit juice; and from about 80% to about 99% by weight of added water, wherein the added water contains from 0 ppm to about 60 ppm of hardness, and preferably contains from 0 ppm to about 300 ppm of alkalinity. These noncarbonated beverage products can be stored at ambient temperatures for at least about 10 days, without substantial microbial proliferation therein after exposure to beverage spoilage organisms.Type: GrantFiled: September 10, 1999Date of Patent: July 17, 2001Assignee: The Procter & Gamble Co.Inventors: Jonathan Javier Calderas, Thomas Ray Graumlich, Leonard Jenkins, Robert Phillip Sabin
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Patent number: 6211186Abstract: The present invention relates to compounds, compositions, and methods which are useful for the prevention and treatment of adverse health, skin, hair, and oral conditions. The compounds, compositions, and methods are also widely applicable for use in health, skin, hair, oral, beauty, and personal care applications. In particular, the present invention relates to compounds having the structure: and the tautomers, acceptable salts, and biohydrolyzable amides, esters, and imides thereof, wherein A, Q, n, P, L1, L2, L3, L4, Z, X, B1, and B2 are defined herein.Type: GrantFiled: February 16, 2000Date of Patent: April 3, 2001Assignee: The Procter & Gamble CompanyInventors: John McMillan McIver, Todd Laurence Underiner, Timothy Bates
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Patent number: 6197316Abstract: The present invention relates to kits and films formed from the kits which are useful as cosmetic or therapeutic agents, as well as methods of their use. The films and kits herein are particularly useful as polishes for mammalian nails. More particularly, the present invention relates to kits and films which, when applied to mammalian nails exhibit long wear.Type: GrantFiled: May 1, 1998Date of Patent: March 6, 2001Assignee: The Procter & Gamble CompanyInventors: Peter Christopher Ellingson, Edward Dewey Smith, III, Katherine Eleanor Flynn, Michel Joseph Giret, Stevan David Jones
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Patent number: 6136356Abstract: Antimicrobial combinations containing a sorbate preservative, natamycin and a dialkyl dicarbonate at levels below the taste threshold for each of these antimicrobials but such that combination is effective against food spoilage microorganisms. These antimicrobial combinations are useful in treating beverages, especially dilute juice beverages, calcium fortified beverages, beverages containing tea solids, and beverages containing milk solids and proteins, as well as other acidified, high water activity food and beverage products such as cheese, sausage, ready-to-spread frostings, salad dressings, mayonnaise, and the like, that are susceptible to food spoilage microorganisms, including yeasts such as Zygosaccharomyces bailii.Type: GrantFiled: April 14, 1999Date of Patent: October 24, 2000Assignee: The Procter & Gamble CompanyInventors: John Robert Bunger, Athula Ekanayake
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Patent number: 6136300Abstract: The present invention relates to kits and films formed from the kits which are useful as cosmetic or therapeutic agents, as well as methods of their use. The films and kits herein are particularly useful as polishes for mammalian nails. More particularly, the present invention relates to kits and films which, when applied to mammalian nails exhibit long wear. When applied to mammalian nails, the present kits provide films exhibiting Peak Adhesive Strengths of greater than about 15 g/mm and exhibiting a Toughness Value of greater than about 1.2 MPa or a Wear Value of greater than about 1000 (MPa).sup.2. The present invention further relates to methods of coating mammalian nails with kits and films formed from the kits which exhibit Peak Adhesive Strengths of greater than about 15 g/mm and exhibit Toughness Values of greater than about 1.2 MPa or Wear Values of greater than about 1000 (MPa).sup.2.Type: GrantFiled: May 1, 1998Date of Patent: October 24, 2000Assignee: The Procter & Gamble CompanyInventors: Peter Christopher Ellingson, Edward Dewey Smith, III
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Patent number: 6132787Abstract: Antimicrobial combinations comprising a sorbate preservative, natamycin and a dialkyl dicarbonate at levels below the taste threshold for each of these antimicrobials but such that combination is effective against food spoilage microorganisms. These antimicrobial combinations are useful in treating beverages, especially dilute juice beverages, calcium fortified beverages, beverages containing tea solids, and beverages containing milk solids and proteins, as well as other acidified, high water activity food and beverage products such as cheese, sausage, ready-to-spread frostings, salad dressings, mayonnaise, and the like, that are susceptible to food spoilage microorganisms, including yeasts such as Zygosaccharomyces balii.Type: GrantFiled: April 25, 1997Date of Patent: October 17, 2000Assignee: The Procter & Gamble CompanyInventors: John Robert Bunger, Athula Ekanayake
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Patent number: 6126980Abstract: Disclosed are noncarbonated beverage products with improved microbial stability, and processes for preparing them. The noncarbonated beverage products have a pH of between 2.5 and 4.5 and comprise from about 300 ppm to about 3000 ppm of a polyphosphate having an average chain length ranging from about 17 to about 60; from about 100 ppm to about 1000 ppm of a preservative selected from the group consisting of sorbic acid, benzoic acid, alkali metal salts thereof and mixtures thereof; from about 0.1% to about 40% by weight of fruit juice; and from about 80% to about 99% by weight of added water, wherein the added water contains from 61 ppm to about 220 ppm of hardness. These noncarbonated beverage products can be stored at ambient temperatures for at least about 28 days without substantial microbial proliferation therein after exposure to beverage spoilage organisms.Type: GrantFiled: August 29, 1997Date of Patent: October 3, 2000Assignee: The Procter & Gamble CompanyInventors: James Arthur Smith, Thomas Ray Graumlich, Robert Phillip Sabin, Judith Wells Vigar
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Patent number: 6126960Abstract: The present invention relates to oral compositions having enhanced organoleptic characteristics of fattiness, creaminess, soothing, satisfaction, and full mouthfeel, and comprises acylglycerol compounds having substituents R.sub.1, R.sub.2, and R.sub.3 attached at the positions of the OH.sup.- groups of a glycerol backbone. The substituents R.sub.1 and R.sub.2 are independently selected from conjugated polyunsaturated fatty acids having from 16 carbon atoms to 22 carbon atoms and R.sub.3 is selected from the group consisting of R.sub.1, OH, PO.sub.3 HR.sub.4, and C.sub.6 -C.sub.12 carboxylic acids, wherein R.sub.4 is selected from the group consisting of OH, choline, inositol, serine, and ethanolamine. The oral compositions of the present invention being substantially free of free conjugated polyunsaturated fatty acids.Type: GrantFiled: January 19, 1999Date of Patent: October 3, 2000Assignee: The Procter & Gamble CompanyInventors: Stephen James Nilsen, Gary Lyle Walden
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Patent number: 6080414Abstract: The present invention relates to kits and films formed from the kits which are useful as cosmetic or therapeutic agents, as well as methods of their use. The films and kits herein are particularly useful as polishes for mammalian nails. More particularly, the present invention relates to kits and films which, when applied to mammalian nails exhibit long wear, particularly at the tip of the nail. When applied to mammalian nails, the present kits and films exhibit Tip Wear Indices, Total Wear Indices, and/or Jagged Indices of less than about 0.90. The present invention further relates to methods of coating mammalian nails with kits and films which exhibit Tip Wear Indices, Total Wear Indices, and/or Jagged Indices of less than about 0.90.Type: GrantFiled: May 1, 1998Date of Patent: June 27, 2000Assignee: The Proctor & Gamble CompanyInventors: Edward Dewey Smith, III, Peter Christopher Ellingson, Michel Joseph Giret, Stevan David Jones
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Patent number: 6080413Abstract: The present invention relates to compositions useful as cosmetic or therapeutic agents, as well as methods of their use. The compositions herein are particularly useful as coatings for mammalian nails. More particularly, the present invention relates to compositions which, when applied to mammalian nails exhibit long wear properties including excellent adhesion to the nail.Type: GrantFiled: May 1, 1998Date of Patent: June 27, 2000Assignee: The Procter & Gamble CompanyInventors: Peter Christopher Ellingson, Katherine Eleanor Flynn, Alice Jean Michels, Edward Dewey Smith, III
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Patent number: 6066673Abstract: The present invention relates to compounds, compositions, and methods which are useful for the prevention and treatment of adverse health, skin, hair, and oral conditions. The compounds, compositions, and methods are also widely applicable for use in health, skin, hair, oral, beauty, and personal care applications.In particular, the present invention relates to compounds having the structure: ##STR1## and the tautomers, acceptable salts, and biohydrolyzable amides, esters, and imides thereof, wherein A, Q, n, P, L.sub.1, L.sub.2, L.sub.3, L.sub.4, Z, X, B.sub.1, and B.sub.2 are defined herein.Type: GrantFiled: March 12, 1998Date of Patent: May 23, 2000Assignee: The Procter & Gamble CompanyInventors: John McMillan McIver, Todd Laurence Underiner, Timothy Bates
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Patent number: 6030933Abstract: The present invention relates to detergent compositions comprising one or more enzymes which are immobilized by a covalent binding on an activated polymer. Such enzymes are preferably bound to the activated polymer via a spacer molecule. The enzymes are selected from a variety of enzymes including, for example, cellulases, hemicellulases, peroxidases, proteases, glucoamylases, amylases, lipases, cutinases, pectinases, reductases, oxidases, phenoloxidases, lipoxygenases, laccases, ligninases, pullulanases, xylanases, tannases, pentosanases, manlanases, .beta.-glucanases, arabinosidases, and mixtures thereof. The polymer is selected from a variety of polymers. A preferred polymer for use in the present invention is polyethylene glycol.Type: GrantFiled: June 29, 1998Date of Patent: February 29, 2000Assignee: The Procter & Gamble CompanyInventors: Ivan Maurice Alfons Jan Herbots, Madeleine Petronella Jansen, Andre Cesar Baeck, Jean Wevers
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Patent number: 6020148Abstract: A technique for in vitro testing of ocular and dermal irritants is disclosed. The process involves the topical application of liquid, solid granular or gel-like materials (e.g. cosmetics) to a cell culture and then evaluating the cytotoxicity of the material. Cell cultures of human skin without a stratum corneum and having a histologic similarity to the eye are used. Irritation is evaluated by measuring cell viability using MTT assay (based on the reduction of a tetrazolium dye by functional mitochondria), or release of LDH or PGE.sub.2. A unique method of applying test materials which are not water soluble is described.Type: GrantFiled: June 18, 1997Date of Patent: February 1, 2000Assignee: The Procter & Gamble CompanyInventors: Rosemarie Osborne, Mary Ann Perkins, Deirdre Anne Roberts