Abstract: The compounds of formula I are useful in treating gastrointestinal disorders associated with antagonizing the motilin receptor disorders. The compounds compete with erythromycin and motilin for the motilin receptor. In addition the compounds are antagonists of the contractile smooth muscle response to those ligands.

Abstract: An improved solid pharmaceutical composition comprising a lyophilized liposomal KL4 pulmonary surfactant composition comprising:(a) about 1 to about 10 percent weight KL4 polypeptide; and(b) 50 to about 100 weight percent phospholipid comprised of about 3 parts DPPC to about 1 part POPG.A facile process for the production of the lyophilized solid composition is also provided.

Abstract: The invention relates to benzimidazole antibacterial compounds of the Formula I: ##STR1## as described herein, pharmaceutical compositions containing the compounds, and methods for their production and use. These compounds are effective in inhibiting the action of a bacterial histidine protein kinase and are useful as anti-infective agents against a variety of bacterial organisms, including organisms which are resistant to other known antibiotics.

Abstract: Compounds of Formula I ##STR1## wherein, R.sub.1 through R.sub.7 are described herein. These compounds inhibit the production of arachidonic acid products associated with 5-lipoxygenase and cyclooxygenase and are useful in the treatment of inflammatory disorders.

Abstract: Calcium carbonate liquid antacid compositions containing one or more pH adjusting agents to maintain the pH above 9.0, preferably above 9.5. The resultant antacid liquid possesses superior resistance to microbial attack and enhanced taste properties.

Abstract: The invention is a child resistant and easy to use blister package for containing a solid medicament that utilizes a push and peel mechanism as an opening feature. The multi-section blister card package has an opening mechanism which features a pre-formed second cavity in the blister container sheet which is adjacent to the cavity containing the product and a corresponding full score or cut in both the backing closure sheet and the container sheet. A land area or notch of material that is not cut through is maintained in the score area to add break away resistance for hindering child access. An unsealed area in the closure sheet encompasses the pre-formed second cavity and score area allowing for easy separation of materials.

Abstract: The invention is a child resistant and easy to use blister package for containing a solid medicament that utilizes a push through and peel mechanism as an opening feature. The multi-section blister card package has an opening mechanism featuring a cut-out in the blister container sheet which is adjacent to the cavity containing the product and a corresponding weakened area such as a perforation or score in the closure sheet positioned slightly inside and adjacent to the edge of the cut-out in the container sheet. The blister is opened by pushing through the closure sheet at the perforation to form a pull-tab which can be used to peel the closure sheet from the container sheet towards the product cavity thereby exposing the product cavity to remove the product.

Abstract: The invention relates to triphenylalkyl antibacterial compounds of the general formula: ##STR1## pharmaceutical compositions containing the compounds, and methods for their production and use. These compounds are effective in inhibiting the action of a bacterial histidine protein kinase and are thus useful as anti-infective agents against a variety of bacterial organisms, including organisms which are resistant to other known antibiotics.

Abstract: Compounds of Formula I ##STR1## useful in the treatment of inflammatory disorders.

Abstract: The invention is a child resistant and easy to use blister package for containing a solid medicament that utilizes a dual compartment cavity assist mechanism as an opening feature. The multi-section blister card package has an opening feature comprising a pre-formed dual compartment cavity in the blister container sheet which is adjacent to the cavity containing the product and a corresponding weakened area such as perforation or score in the backing closure sheet in the area covering the dual compartment cavity. The blister is opened by applying pressure on the dual compartment cavity at the underside of the backing score line. The pre-formed second cavity assists in forming a pull tab on the opposite side of the blister, allowing for easy access to separate and pull the backing material towards the product cavity and thus exposing the product cavity for product removal.

Abstract: The invention relates to benzoxazine and pyrido-oxazine antibacterial compounds of the general formula: ##STR1## wherein the moiety Q is a fused phenyl or fused pyridyl moiety as herein described, pharmaceutical compositions containing the compounds, methods for their production and their use in treating bacterial infections.

Abstract: Compounds of Formula I ##STR1## useful in the treatment of inflammatory disorders.

Abstract: A liposome-based formulation with good skin penetration of the effective substance, particularly calcitriol, is described. This formulation is well suited for the treatment of psoriasis.

Abstract: A pharmaceutical composition for oral administration comprising a film coated tablet exhibiting enhanced disintegration characteristics, said film coating comprising a hydrophilic film forming polymer such as hydroxypropyl methylcellulose and an alkaline agent wherein the alkaline agent reduces the disintegration time of the film coating by increasing the rate of removal of the film coating polymers.

Abstract: New antibacterial agents produced by fungal culture 07F275, of which the compound designated 07F275 alpha having the following structure: ##STR1## is representative. Methods for the fermentation, recovery and purification from crude solutions are also disclosed.

Abstract: 2,5-Disubstituted thiophene derivatives, and more particularly, to 2-aryloxy-5-alkansulfonamido-thiophenes of the general formula: ##STR1## Wherein, R.sub.2 is CF.sub.3, C.sub.1 -C.sub.10 alkyl, or phenyl;X is O, S, or CH.sub.2 ; andR is aryl, C.sub.1 -C.sub.10 alkyl, or C.sub.3 -C.sub.8 cycloalkyl; which compounds are pharmacologically active in alleviating inflammation, asthma, arthritis, hypersensitivity, myocardial ischemia and dermatological conditions, such as, psoriasis and dermatitis, and gastrointestinal inflammatory conditions, such as, inflammatory bowel syndrome.

Abstract: The invention relates to diaryl antimicrobial compounds of the general formula: ##STR1## where G, E L, J, q, m, X, Ar, W, p, n and A are as described herein, pharmaceutical compositions containing the compounds, methods for their production and their use in treating bacterial infections.

Abstract: The invention relates to cyclohexenyl antibacterial compounds of the formula I: ##STR1## and pharmaceutical compositions containing the compounds, methods for their production and use.

Abstract: Diaza-18-crown-6 compounds of the formula I: ##STR1## wherein X is a phenol, naphthol or quinolinol moiety selected from those of the formulae: ##STR2## R.sub.1, R.sub.2, R.sub.3, R.sub.4 and R.sub.5 are independently selected from hydrogen, halo, cyano, nitro, (C.sub.1 -C.sub.6) alkyl, (C.sub.2 -C.sub.8) acyl, acetamido, mercapto, alkyl or arylsulfonyl, trifluoromethyl, aryl, and substituted aryl wherein the aryl moiety is selected from phenyl and naphthyl and the aryl substituent is selected from halo, cyano, nitro, (C.sub.1 -C.sub.6) alkyl, (C.sub.2 -C.sub.8) acyl, phenyl, acetamido, mercapto, alkyl or arylsulfonyl and trifluoromethyl; provided that when R.sub.1, R.sub.2, R.sub.3 and R.sub.5 are hydrogen and X is phenol, R.sub.4 is not nitro; and provided that when X is phenol and R.sub.5 is hydrogen, R.sub.1 (or R.sub.2) and R.sub.4 are not both nitro.

Abstract: The invention relates to a method of manufacturing pulmonary surfactant protein by solubilizing the protein in ethanol by treatment with a fluorinated alcohol so that the protein may be formulated into liposomes by ethanolic injection.