Patents Represented by Attorney, Agent or Law Firm Kenneth J. Dow
  • Substituted N-[[2-(aminocarbonyl)phenylamino]thioxomethyl]benzamides
    Patent number: 5001157
    Abstract: New substituted N-[[2-(aminocarbonyl)phenylamino]-thioxomethyl]benzamides which are useful as congnition stimulators in mammals.
    Type: Grant
    Filed: February 2, 1989
    Date of Patent: March 19, 1991
    Assignee: American Cyanamid Company
    Inventors: William J. Fanshawe, Joseph W. Epstein
  • Synthesis of cisplatin analogs
    Patent number: 4996337
    Abstract: This disclosure sets forth a novel process for producing cisplatin analogs which possess antitumor activity.
    Type: Grant
    Filed: March 13, 1990
    Date of Patent: February 26, 1991
    Assignee: American Cyanamid Company
    Inventors: Panayota Bitha, Joseph J. Hlavka, Yang-I Lin
  • 2-,4- or 5-substituted thiazole derivatives
    Patent number: 4990520
    Abstract: Pharmaceutical compounds and compositions which may be represented by the following structural formulae: ##STR1## where R is hydrogen or lower alkyl and NR'" is amino, (C.sub.1 -C.sub.6) alkylamino, dialkylamino, or trialkylamino, pyrrolidino or piperidino. The compounds are useful in treating central cholinergic disfunction in mammals.
    Type: Grant
    Filed: February 2, 1990
    Date of Patent: February 5, 1991
    Assignee: American Cyanamid Company
    Inventors: Eugene J. Trybulski, Herbert J. Brabander
  • Substituted dibenzothiophenes
    Patent number: 4965284
    Abstract: This disclosure described novel derivatives of dibenzothiophene, dibenzothiophene sulfoxide, dibenzothiophene sulfone, thioxanthene, thioxanthene sulfoxide and thioxanthene sulfone which are active as modulators of the mammalian immune response system.
    Type: Grant
    Filed: April 25, 1989
    Date of Patent: October 23, 1990
    Assignee: American Cyanamid Company
    Inventors: Vijay G. Nair, Ramson B. Conrow, Bosco S. Wang, V. M. Ruszala-Mallon
  • 1-substitute-1,2-dihydro-4-((substituted)phenyl)imidazo-[1,5-a] pyrimidine-8-carbonitriles
    Patent number: 4963552
    Abstract: This disclosure describes 1-substituted-1,2-dihydro-4-[substituted)phenyl]imidazo[1,5-a]pyrimidine-8 -carbonitriles which are useful as antihypertensive agents and/or as antidepressant agents in mammals.
    Type: Grant
    Filed: August 28, 1989
    Date of Patent: October 16, 1990
    Assignee: American Cyanamid Company
    Inventors: Shin S. Tseng, Herbert J. Brabander, Jannie S. Baker, Joseph W. Epstein
  • 3- or 4-substituted oxotremorine derivatives and a method of treating central chloinergic dsyfunction therewith
    Patent number: 4952600
    Abstract: This disclosure describes novel 3 or 4 substituted oxotremorine derivatives having polar substituted oxygen or sulfur groups. The compounds have cholinergic activity. Also disclosed are methods for treating diseases of the central nervous system in mammals employing the compounds, pharmaceutical preparations containing the compounds and processes for the production of the compounds.
    Type: Grant
    Filed: February 20, 1990
    Date of Patent: August 28, 1990
    Assignee: American Cyanamid Company
    Inventors: Eugene J. Trybulski, Richard H. Kramss, Herbert J. Brabander
  • 8-fluoro and 7, 8, 10-trifluoro-9-(substituted)-6-oxo-6H-benzo-(C)quinolizine-5-carboxylic acids
    Patent number: 4948894
    Abstract: Novel substituted quinolinecarboxylic acid derivatives of the formula: ##STR1## wherein R.sup.1 is hydrogen, alkali metal, alkaline earth metal or lower alkyl; R.sub.2 is hydrogen, benzyl or alkyl (C.sub.1 -C.sub.3); X is hydrogen or fluoro; which have antibacterial activity, intermediates useful in the preparation of the compounds, methods of producing and using the compounds to treat bacterial infections in animals.
    Type: Grant
    Filed: December 6, 1989
    Date of Patent: August 14, 1990
    Assignee: American Cyanamid Company
    Inventors: Daniel B. Moran, Yang-I Lin, Carl B. Ziegler
  • Synthesis of cisplatin analogs
    Patent number: 4937358
    Abstract: This disclosure sets forth a novel process for producing cisplatin analogs which possess antitumor activity.
    Type: Grant
    Filed: December 8, 1988
    Date of Patent: June 26, 1990
    Assignee: American Cyanamid Company
    Inventors: Panayota Bitha, Joseph J. Hlavka, Yang-I Lin
  • 3- or 4-substituted oxotremorine derivatives
    Patent number: 4937235
    Abstract: This disclosure describes novel 3 or 4 substituted oxotremorine derivatives having polar substituted oxygen or sulfur groups. The compounds have cholinergic activity. Also disclosed are methods for treating diseases of the central nervous system in mammals employing the compounds, pharmaceutical preparations containing the compounds and processes for the production of the compounds.
    Type: Grant
    Filed: January 23, 1989
    Date of Patent: June 26, 1990
    Assignee: American Cyanamid Company
    Inventors: Eugene J. Trybulski, Richard H. Kramss, Herbert J. Brabander
  • 8-fluoro and 7,8,10-trifluoro-9-(substituted)-6-oxo-6H-benzo(C)quinolizine-5-carboxyl ic acids
    Patent number: 4923868
    Abstract: Novel substituted quinolinecarboxylic acid derivatives of the formula: ##STR1## wherein R.sup.1 is hydrogen, alkali metal, alkaline earth metal or lower alkyl; R.sub.2 is hydrogen, benzyl or alkyl(C.sub.1 -C.sub.3); X is hydrogen or fluoro; which have antibacterial activity, intermediates useful in the preparation of the compounds, methods of producing and using the compounds to treat bacterial infections in animals.
    Type: Grant
    Filed: February 21, 1989
    Date of Patent: May 8, 1990
    Assignee: American Cyanamid Company
    Inventors: Daniel B. Moran, Yang-I Lin, Carl B. Ziegler
  • Process for producing thiotepa
    Patent number: 4918199
    Abstract: This disclosure describes an improved process for preparing N,N', N"-triethylenethiophosphoramide by the in situ generation of ethyleneimine.
    Type: Grant
    Filed: January 21, 1988
    Date of Patent: April 17, 1990
    Assignee: American Cyanamid Company
    Inventor: John Kazan
  • 5-(Substituted-amino)-8-(phenyl or substituted-phenyl)-3H,6H-1,4,5A,8A-tetraazaacenaphthylen-3-ones and treatment of neural behavior disorders
    Patent number: 4916137
    Abstract: This disclosure described novel 5-(substituted-amino)-8-(substituted-phenyl)-3H,6H, -1,-4,5a,8a-tetraazaacenaphthylen-3-ones useful for the treatment of cognitive and related neural behavioral disorders in mammals.
    Type: Grant
    Filed: November 30, 1988
    Date of Patent: April 10, 1990
    Assignee: American Cyanamid Company
    Inventors: Joseph W. Epstein, Jeremy I. Levin, Shin S. Tseng
  • Substituted-6H,8H-pyrimido-[1,2,3-cd]purine-8,10-(9H)-diones and substituted-6H,10H-pyrimido[1,2-cd]purin-10-ones
    Patent number: 4904658
    Abstract: Substituted-6H,8H-pyrimido[1,2,3-cd]purine-8,10(9H)-diones and substituted-6H,10H-pyrimido[1,2-cd]purin-10-ones which are useful as cognition enhancing agents, anxiolytic agents and/or antihypertensive agents in the treatment of cognitive and relative neutral behavioral problems, anxiety and hypertension in mammals.
    Type: Grant
    Filed: April 15, 1988
    Date of Patent: February 27, 1990
    Assignee: American Cyanamid Company
    Inventors: Shin S. Tseng, Joseph W. Epstein, Jeremy I. Levin
  • (2,2-bis(aminomethyl)-1,3-propranediol-N,N')platinum complexes
    Patent number: 4900756
    Abstract: Organic-platinum complexes useful as anti-cancer agents in the treatment of tumors sensitive to the subject compounds are described.
    Type: Grant
    Filed: July 15, 1988
    Date of Patent: February 13, 1990
    Assignee: American Cyanamid Company
    Inventors: Ralph G. Child, Panayota Bitha, Joseph J. Hlavka, Yang-I Lin
  • Stable ophthalmic preparations containing acetazolamide
    Patent number: 4888168
    Abstract: There is provided a stable, ophthalmic aqueous composition for topical administration, comprising (a) acetazolamide and either (b) a pre-formed, pharmaceutically acceptable, aqueous gel or (c) an aqueous gel-forming liquid capable of forming a pharmaceutically acceptable gel in situ when applied topically to a patient; said composition having a pH of less than 5.0.
    Type: Grant
    Filed: December 2, 1987
    Date of Patent: December 19, 1989
    Assignee: American Cyanamid Company
    Inventors: Angela C. Potts, Mark Gibson
  • Novel 1,4-bis(substituted-amino(-5,8-dihydroxyanthraquinones and leuco bases thereof
    Patent number: 4888137
    Abstract: This disclosure describes symmetrical 1,4-bis(substituted-amino)-5,8-dihydroxyanthraquinones useful as chelating agents and for inducing regression and/or palliation of cancer diseases in mammals.
    Type: Grant
    Filed: April 27, 1987
    Date of Patent: December 19, 1989
    Assignee: American Cyanamid Company
    Inventors: Keith C. Murdock, Frederick E. Durr
  • 4,8-disubstituted-1,2-dihydro and 1,2,3,4-tetrahydroimidazo-[1,5-a] pyrimidines
    Patent number: 4888345
    Abstract: This disclosure describes novel 4,8-disubstituted-1,2-dihydro- and -1,2,3,4-tetrahydro -imidazo-[1,5-a] pyrimidines useful as antihypertensive agents and/or as anxiolytic agents in mammals and as intermediates for the synthesis of biologically active compounds.
    Type: Grant
    Filed: February 24, 1988
    Date of Patent: December 19, 1989
    Assignee: American Cyanamid Company
    Inventors: Shin S. Tseng, John P. Dusza, Joseph W. Epstein
  • 4,5,6-substituted-N-(substituted-phenyl)-2-pyrimidinamines
    Patent number: 4876252
    Abstract: This disclosure describes novel 4,5,6-substituted-N-(substituted-phenyl)-2-pyrimidinamines having antiasthmatic activity.
    Type: Grant
    Filed: May 17, 1988
    Date of Patent: October 24, 1989
    Assignee: American Cyanamid Company
    Inventors: Lawrence W. Torley, Bernard D. Johnson, John P. Dusza
  • Antibiotic LL-C19004
    Patent number: 4870019
    Abstract: A new antibacterial agent designated LL-C19004 is described, which antibacterial agent is produced through microbiological fermentation, under controlled conditions using a new species of Saccharothrix, Saccharothrix espanaensis (NRRL 15764).
    Type: Grant
    Filed: November 21, 1986
    Date of Patent: September 26, 1989
    Assignee: American Cyanamid Company
    Inventors: Jane P. Kirby, Donald B. Borders, May D. Lee, William M. Maiese, Raymond T. Testa, David P. Labeda