Abstract: A method for lowering serum uric acid is disclosed which comprises administering to a human for its uricosuric activity a pharmaceutical composition comprising 7-chloro-2-methyl-3,3a-dihydro-2H,9H-isoxazolo (3,2-b) (1,3)-benzoxazin-9-one.7-chloro-2-methyl-3,3a-dihydro-2H,9H-isoxazolo (3,2-b) (1,3) benzoxazin-9-one is a useful compound having valuable pharmacological properties, for example, it is a valuable anti-inflammatory agent, as evidenced by its ability to inhibit the local edema formation characteristic of inflammatory states when administered systemically to warm-blooded animals.
Abstract: The compound 7-chloro-2-methyl-3,3a-dihydro-2H,9H-isoxazolo(3,2-b)(1,3)-benzoxazin-9-on e is produced by reacting a mixture of tetrahydrofuran and crotonaldehyde with 5-chlorosalicylhydroxamic acid. The compound has demonstrated utility as a uricosuric agent.
Abstract: Method of inhibiting perspiration with antiperspirant compositions containing trivalent metal salts of trifluoromethanesulfonic acid of the formula:Me (CF.sub.3 SO.sub.3).sub.3wherein Me is aluminum, lanthanum, cerium or didymium obtained by reacting trifluoromethanesulfonic acid with the appropriate metal carbonate or sulfide or by the exchange reaction of the appropriate metal sulfate with barium trifluoromethanesulfonate.
Type:
Grant
Filed:
December 1, 1977
Date of Patent:
August 26, 1980
Inventors:
Gianluigi Soldati, James W. Stitley, Ronald J. Wulf, Herman E. Jass
Abstract: A process for the production of 2-methyl-2-sec. butyl-1,3-propanediol from crotyl alcohol is disclosed. The diol obtained is useful in the manufacture of 2-methyl-2-(1-methylpropyl)-1,3-propanediol dicarbamate a valuable antihypertensive agent.
Abstract: A method for suppressing the release of histamine from sensitized leukocytes in warm blooded animals which comprises administering internally to said animals compounds of the formula: ##STR1## wherein n is a whole integer from 1 to 4; X is halogen and Z is COOH, CH.sub.2 OR or ##STR2## R being a lower alkyl chain of from 1 to 6 carbon atoms and pharmaceutically acceptable salts of those compounds wherein Z is COOH, in sufficient amount to suppress the release of histamine from said cells.
Type:
Grant
Filed:
February 18, 1977
Date of Patent:
November 7, 1978
Assignee:
Carter-Wallace, Inc.
Inventors:
David B. Reisner, Bernard J. Ludwig, George M. Fukui, Frank M. Berger
Abstract: Sulfonylureas are prepared by reacting a hydroxyethyl carbamate with an alkali metal salt of a substituted benzene sulfonamide, the alkali metal being selected from the group comprising sodium, potassium and lithium.
Abstract: An apparatus is disclosed for providing a digital indication of characteristic data measurements of a centrifuge centrifugal head for examining the contents of test vessels, characterized by an indicator capable of showing directly, according to the adjustment of a selector switch, the acceleration, number of revolutions per unit of time and rotor characteristic data.
Abstract: Novel 2,3-disubstituted-1,2,4-benzothiadiazine 1,1-dioxides of the formula: ##STR1## wherein X is hydrogen or chlorine. The novel compositions have been obtained by an unexpected side chain chlorination and have been found to be useful in medicinal chemistry as antihypertensives.
Abstract: Chemical compounds of the formula: ##STR1## wherein X is hydrogen, hydroxy, halogen, lower alkyl, lower alkoxy, nitro, amino, acetamido, sulfonamido or trifluoromethyl, and each R is selected from the group consisting of hydrogen and lower alkyl. Said compounds have valuable anti-inflammatory activity in standard laboratory animals.
Type:
Grant
Filed:
May 8, 1972
Date of Patent:
May 17, 1977
Assignee:
Carter-Wallace, Inc.
Inventors:
David B. Reisner, Bernard J. Ludwig, Harold M. Bates, Frank M. Berger
Abstract: N-methyl-4-piperidinyl.alpha.-benzoyloxy-.alpha.-cyclopentylphenylacetate. The novel ester in the form of its free base or as a salt has been found to be an effective inhibitor of perspiration.
Type:
Grant
Filed:
July 18, 1975
Date of Patent:
May 10, 1977
Assignee:
Carter-Wallace, Inc.
Inventors:
Gianluigi Soldati, Paul Finkelstein, David A. Schlichting, William Oroshnik
Abstract: Polyethylenimine mono-and difluorophosphates are obtained by the reaction of solutions of polyethylenimines with monofluorophosphoric acid or difluorophosphoric acid at low temperatures. The novel polyethylenimine salts have demonstrated valuable properties in the prevention of dental caries.
Type:
Grant
Filed:
January 29, 1975
Date of Patent:
April 26, 1977
Inventors:
Gianluigi Soldati, Ralph G. Eilberg, Helga Melger, William M. Wooding
Abstract: Novel alkylamine fluorophosphates of the formula: ##STR1## wherein R is a linear or branched alkyl group containing 1-20 carbon atoms; R.sub.1 is lower alkyl or hydrogen, R.sub.2 is alkyl or hydrogen; X is 1 or 2; Y is 1 when X=1; Y is 1 or 2 when X=2; m and n are positive whole integers whose sum is 3. When R, R.sub.1 and R.sub.2 are alkyl they can be substituted with an hydroxy group. The novel fluorophosphates have been found to be effective in reducing the acid solubility of tooth enamel.
Type:
Grant
Filed:
October 20, 1975
Date of Patent:
March 8, 1977
Assignee:
Carter-Wallace, Inc.
Inventors:
Gianluigi Soldati, Ralph G. Eilberg, Helga Melger, David A. Schlichting
Abstract: A process for preparing p-[5-chloro-2-methoxy-benzamidoethyl]-benzene sulfonamide consisting of treating 5-chlorosalicylic acid or its ester by methylating and aminolysis to form N-phenethyl-5-chloro-2-methoxybenzamide followed by chlorosulfonation and aminolysis.