Abstract: The present invention relates, in general, to a pharmacologic system to modulate the biology of platelets based upon a nucleic acid ligand that can interact with and modulate the activity of platelet glycoprotein GPVI to regulate platelet function. These nucleic acid ligands are also actively reversible using a modulator that inhibits the activity of the nucleic acid ligand to neutralize this pharmacologic effect and thereby restore GPVI function, including collagen binding, platelet adhesion, collagen-induced platelet activation, and collagen-induced platelet aggregation. The invention further relates to compositions comprising the nucleic acid ligand, the ligand and a modulator, methods to generate the nucleic acid ligand and its modulator, as well as methods of using these agents and compositions in medical therapeutic and diagnostic procedures.

Abstract: A process, device and system for mapping usage data from a plurality of utility usage nodes, such as electricity usage meters, to one or more utility distribution nodes, such as a transformer, in which utility usage data collected at a collection device from the plurality of utility usage nodes at predetermined intervals is received, and utility distribution data collected at the collection device from the utility distribution node at the predetermined intervals is likewise received. Aggregate usage data from one or more of the plurality of utility usage nodes is compared to distribution data from the utility distribution node during one or more of the same predetermined intervals to determine, using a computer, which of the plurality of utility usage nodes is connected to the utility distribution node.

Abstract: Systems and methods are described herein for analyzing neural response data that can be assigned to multiple classes. The systems and methods begin with a set of training data from which optimal weight factors are derived. The derived weight factors are used in a classifier which is then applied to test data from test subjects. The classifier filters out the effects of less relevant data in the test data and provides a result in the form of probabilities associated with classes for the test data.

Abstract: Systems and methods are described herein for performing three-dimensional imaging using backscattered photons generated from a positron-electron annihilation. The systems and methods are implemented using the pair of photons created from a positron-electron annihilation. The trajectory and emission time of one of the photons is detected near the annihilation event. Using this collected data, the trajectory of the second photon can be determined. The second photon is used as a probe photon and is directed towards a target for imaging. The interaction of the second probe photon with the target produces back scattered photons that can be detected and used to create a three-dimensional image of the target. The systems and methods described herein are particularly advantageous because they permit imaging with a system from a single side of the target, as opposed to requiring imaging equipment on both sides of the target.

Abstract: A light fixture includes multiple LED modules, with each LED module including a substrate on which one or more LED's are disposed. The LED modules can interface with one another in a variety of different configurations such that when adjacent LED modules interface with one another, there is a substantially continuous array of LED's across the LED modules. Electrical connectors or other means for powering the LED modules are disposed such that they do not impact the continuity of light across adjacent LED modules.

Abstract: A photocontroller operates one or more lamps, such as a GU24 compact fluorescent lamp, based on ambient light to provide dusk-to-dawn operation. The photocontroller includes a photosensor for detecting the level of ambient light. The photosensor provides a signal to a photocontrol circuit that controls a switching device to selectively provide power to the lamp based on the level of ambient light detected by the photosensor. A fault detection circuit monitors the level of ambient light and the status of the lamp to determine whether the photocontroller is operating properly. The fault detection circuit determines the status of the lamp based on current flow to the lamp as determined by a current sensor. In addition, the photocontroller can include a processor for performing certain photocontrol and fault monitoring functions.

Abstract: An extremely dilute mixture of a liquid in a flowing fluid stream is prepared by forming tiny droplets of the liquid and injecting the droplets individually into the flowing stream. The rate at which liquid is added to the flowing stream is determined by the number of droplet forming units that are provided and upon the frequency with which the units are activated, allowing a precise digital control of the concentration of the liquid in the flowing fluid stream.

Abstract: This disclosure generally relates to assigning and simultaneously running multiple client-side experiments on client devices. A file includes information regarding experiments that are available, including information regarding “layers,” which are logical, imaginary containers in which each experiment “resides.” Each experiment is associated with one layer. For each experiment, the file includes information regarding a location and size of the experiment within the layer. When the client device takes an action, a software module identifies a value of an identifier associated with the action. Each such identifier is associated with one or more of the layers. The software module can calculate, for each of the associated layers, a location within the layer based on the identifier value. The computer software module can identify, based on the information in the file, each experiment that overlaps with the calculated location within each layer and cause each identified experiment to be activated.

Abstract: A method and kit for assaying a cell sample for the presence of at least a threshold number of cells of a given type are disclosed. The kit includes an assay device having a sample chamber for receiving the cell sample and an elongate collection chamber containing a selected-density and/or viscosity medium and having along its length, a plurality of cell-collection regions, and particles which are capable of specific attachment to cells of the selected cell type, and which are effective, when attached to the cells, to increase the density or magnetic susceptibility of the cells. In operation, particle-bound cells and particles in the cell sample are drawn through the elongate collection chamber under the influence of a gravitational or selected centrifugal or magnetic-field force until the particle-bound cells and particles completely fill successive cell-collection regions in the collection chamber.

Abstract: A lighting control system determines an optimal way to operate one or more lamps to achieve a desired light output and/or to control one or more parameters. The lighting control system includes a detection circuit and a control circuit. The control circuit performs a wide-scope scan and a narrow-scope scan to find the best way to operate the lamps. The wide-scope scan includes driving the lamp(s) using multiple output settings, evaluating the light output at each setting, and determining which setting produced the best results. The narrow-scope scan includes making small adjustments to the settings to better refine the light output. The detection circuit includes one or more sensors for providing measurements of the light output by the lamp(s) or of a controller parameter, such as power consumption, for each setting evaluated by the control circuit.

Abstract: An optical wall wash system including at least one module comprised of a 2 by 2 array of fixed elements, each element including a reflector and a refractor; a fixture, including light emitting diodes (LEDs) affixed thereto, for securing the at least one module, wherein there is a 1:1 correspondence between elements and LEDs and the fixture is rotated a first angular amount from nadir and towards a wall. Each of the elements within the at least one module is further oriented a different angular amount in relation to its underlying LED from each other element within the at least one module.

Abstract: An LED worklight having a center core and a first panel and a second panel coupled to the center core. The first panel includes a first array of LEDs mounted to a first circuit board disposed within a first opening formed within the first panel and a first lens disposed over the first array of LEDs. The second panel includes features similar to the first panel. The second panel is rotatable around the center core from a 0 degree closed orientation to about a 360 degree orientation, and is positionable at any intermediate angle therebetween. The LED worklight includes a retractable hook for mounting to an elevated object. The LED worklight also includes at least one magnet to mount the LED worklight to vertical/vertically angling surfaces. The array of LEDs mounted to the first panel and the second panel can be controlled independently of one another.

Abstract: An lighting fixture includes a reflector, a pedestal, and a lighting module. The reflector includes an opening formed therethrough and the pedestal is positioned in communication with the opening. The lighting module is coupled to the pedestal. In certain embodiments, the reflector is organically shaped and includes four parts, where each part is substantially S-shaped. The lighting module includes a frame and indirect LEDs that emit light toward the interior surface of the reflector. The indirect LEDs are positioned below the lowest portions of the reflector a are positioned at an angle with respect to a horizontal axis. The frame includes a cut-off wall that provides for a cut-off angle for the indirect LEDs and one or more fins. The frame and the pedestal provide thermal management for the LEDs. In certain embodiments, the lighting module also includes one or more of direct LEDs and an active cooling module.

Abstract: A method is provided for N-alkylation of acridine compounds, typically with a 1,3- propane sultone alkylating reagent, in ionic liquid solvents to provide the corresponding acridinium compounds in high yield.

Abstract: A system and a method for automatically segmenting and merging routing domains within a network. The system includes one or more gateway devices and a plurality of nodes segmented into one or more routing domains. Each of said plurality of nodes maintains a single gateway device from among said plurality of gateway devices as the node's primary gateway at any time. Each of said gateway devices possesses a gateway color attribute. Each of said plurality of nodes maintains a node color attribute value whose value is derived from the value of said gateway color attribute of then node's primary gateway. Each node's routing domain is determined by the node's color attribute value.

Abstract: A system for improving shape-based targeting by using interest level data is disclosed. According to one embodiment, a computer-implemented method comprises creating one or more trade zones, wherein creating a trade zone comprises grouping a set of parameters to deliver custom shapes, clustering the custom shapes according to offline data and geographic distribution of IP addresses, and mapping clusters of the custom shapes to IP addresses. Data indicating consumption of a content source is received, the content source having a plurality of tokens. The plurality of tokens is organized according to the one or more trade zones, wherein the one or more trade zones consume the tokens at a calculated rate and the calculated rate is analyzed to determine an interest associated with each trade zone. Targeting is based on a selected trade zone, wherein the selected trade zone is selected based upon a desired interest representative of a desired audience.

Abstract: Buffering data associated with a spatial publishing object data store at a buffer distance proximate a user presence in a spatial publishing object space. The buffer distance comprises a measure based at least in part on: capacity of a communications path between the data store and the user platform; availability of memory at the user platform; movement of a user presence through the space; traffic in the communications path; processing resources available; amount of objects within a distance of the user presence; amount of objects in the space; type of objects; proximity of objects to the user presence; and rate of the user presence movement in the space. Movement of the user presence in the space buffers data such that data for a proximate object is available in the buffer for presenting to the user when the user's presence is a predetermined distance from the proximate object.

Abstract: A method and system of virtual energy management display involves periodically receiving via a mesh local area network electronic data representing energy management-related information by a RF communication-enabled memory storage device coupled to an electronic display device within a home area network. Electronic data representing telemetry information is likewise periodically received by the RF communication-enabled memory storage device from at least one RF communication-enabled energy management-related device within the home area network. The electronic data is converted to a common format by an application running at least in part on the memory storage device and displayed on a screen associated with the display device.