Abstract: The present invention provides methods of selecting and uses of anti-arthropod vector vaccines to prevent Leishmaniasis. The present invention also provides compositions for vaccines to prevent Leishmaniasis.
Type:
Grant
Filed:
May 6, 2011
Date of Patent:
January 1, 2013
Assignee:
The United States of America as represented by the Secretary of the Department of Health and Human Services
Inventors:
Jesus G. Valenzuela, Yasmine Belkaid, Shaden Kamhawi, David Sacks, Jose M. C. Ribeiro
Abstract: Preparation of derivatives of ?-hydroxycarboxylic acid, including ?-hydroxycarboxylic acid esters, ?,?-unsaturated carboxylic acid, esters of ?,?-unsaturated carboxylic acid, and alkoxy derivatives.
Type:
Grant
Filed:
July 21, 2009
Date of Patent:
December 25, 2012
Assignee:
Cargill, Incorporated
Inventors:
Paraskevas Tsobanakis, Xiangsheng Meng, Timothy W. Abraham
Abstract: Spray dried solid dispersions comprising a sparingly soluble drug and hydroxypropylmethylcellulose acetate succinate (HPMCAS) provide increased aqueous solubility and/or biavailability in a use environment.
Type:
Grant
Filed:
July 20, 2012
Date of Patent:
December 25, 2012
Assignee:
Bend Research, Inc.
Inventors:
William J. Curatolo, Scott M. Herbig, James A. S. Nightingale
Abstract: An image of an anatomical structure can be analyzed to determine an enclosing three-dimensional boundary when the anatomical structure is filled with two substances, such as air and a fluid. Various techniques can be used to determine the enclosing boundary including: analyzing the virtual structure to segment the structure into air and fluid pockets, determining if there are multiple fluid pockets whose surface touches a single air-fluid boundary, determining a separate threshold for respective fluid pockets, resegmenting the virtual anatomical structure using the separate threshold for different fluid pockets, forming a hierarchical pocket tree which represents the relationship between the fluid and air pockets, pruning the pocket tree based on various criteria which corresponds to deleting those pruned portions from the virtual anatomical structure, and resegmenting the remaining virtual anatomical structure using one or more of fuzzy connectedness, two-dimensional gap filling, and level set segmentation.
Type:
Grant
Filed:
May 23, 2011
Date of Patent:
December 25, 2012
Assignee:
The United States of America as represented by the Secretary, Department of Health and Human Services
Abstract: Interferometers are provided for measuring the surface shape of an examined object or a transmitted wavefront through the examined object. An exemplary interferometer includes an area light source having a low spatial coherence property, and a light-guiding optical system configured to arrange the area light source and the examined object in an optically conjugate relation with each other.
Abstract: Techniques and tools are described for scalable video coding and decoding. For example, a 3D sub-band video encoder includes an embedded base layer codec as well as temporal sub-band transforms and spatial sub-band transforms. The placement of the base layer codec among the sub-band transforms and the role of the base layer codec in scalable video coding vary depending on implementation. In general, the base layer codec provides efficient compression at low bit rates and produces a base layer compressed video bit stream compatible with existing decoders. At the same time, the 3D sub-band video encoder provides spatial and temporal scalability options at higher bit rates, refining the base layer video. A corresponding 3D sub-band video decoder includes an embedded base layer decoder.
Abstract: The present invention provides: (1) antiviral agents that act by reducing or inhibiting the activity of SR proteins, more specifically, (i) antiviral agents that act by enhancing dephosphorylation of SR proteins, and (ii) antiviral agents that act by inhibiting proteins that phosphorylate SR proteins; (2) antiviral agents that act by inhibiting the expression of SR proteins, and (3) antiviral agents that act by activating proteins that antagonize SR proteins. The present invention also provides compounds that inhibit SRPKs, which phosphorylate SR proteins. Such compounds inhibit the activity of SR proteins and have antiviral activities. Various new viruses including SARS have emerged, and thus the present invention provides long-lasting broad-spectrum antiviral agents applicable to new viruses.
Abstract: A video bit stream with pictures comprising inter-coded content can be decoded upon receiving a channel start or file seek instruction. Pictures for beginning decoding and display of the bit stream can be selected based at least in part on one or more tuning parameters that set a preference between a latency of beginning to display video and possible defects in the displayed video. In some embodiments, to implement decoding upon a channel start or file seek, one or more types of data are generated for one or more pictures. For example, picture order counts are generated for pictures after a channel start or file seek operation. As another example, a decoder generates a frame number value that triggers re-initialization of a reference picture buffer before decoding after a channel start or file seek operation.
Type:
Grant
Filed:
July 17, 2009
Date of Patent:
December 25, 2012
Assignee:
Microsoft Corporation
Inventors:
Yongjun Wu, Gang Ji, Shyam Sadhwani, Naveen Thumpudi, Eric S. Christoffersen
Abstract: A local or remote server is configured to receive requests for text and other suggestions from a plurality of client applications. The local or remote server can format requests for delivery to one or more suggestion sources along with client contexts that specify client delivery, format, or other requests associated with the suggestion request. The local or remote server selects suggestion sources based on the client requests and the client contexts, and can combine suggestions returned from multiple sources as directed by client contexts. Requests associated with different clients can be directed to different suggestion sources, and user or client accepted suggestion histories can be stored for use in providing suggestions.
Type:
Grant
Filed:
April 2, 2010
Date of Patent:
December 25, 2012
Assignee:
Microsoft Corporation
Inventors:
Takanobu Murayama, Kenichi Morimoto, Chongming Ho, Eric Norman Badger, Drew Elliot Linerud, Kenneth R. Walters
Abstract: A remote control system is disclosed for controlling a remote animal collar of the type which includes one or more electrodes or sensors which protrude from the inside surface of the collar for contacting the neck of the animal and electronic devices located within the body of the collar to receive electronic control signals or sensor input and to generate a stimulus, which is transmitted to the animal through the electrodes or by a speaker or other devices on the collar. The remote control system uses a master and slave remote transmitter combination.
Abstract: A golf club comprises a shaft, a club head, and a connection assembly that allows the shaft to be easily disconnected from the club head. In particular embodiments, the connection assembly includes a removable hosel sleeve that allows a shaft to be supported a desired predetermined orientation relative to the club head. In this manner, the shaft loft and/or lie angle of the club can be adjusted without resorting to traditional bending of the shaft. In some embodiments, the club head has an adjustable sole piece that can be adjusted upwardly and downwardly relative to the sole of the club head, which is effective to adjust the face angle of the club head.
Type:
Grant
Filed:
December 23, 2009
Date of Patent:
December 25, 2012
Assignee:
Taylor Made Golf Company, Inc.
Inventors:
Nathan Sargent, Todd P. Beach, Kraig A. Willett
Abstract: There is disclosed a medical or dental hand-piece element comprising a coupling mechanism for a detachable connection of the hand-piece element to a drive unit, a tool receptacle that is or can be connected to the hand-piece element, and a drive element for transmitting a driving movement from the drive unit to the tool receptacle so that the tool receptacle can be set into a working movement, wherein the drive element comprises at least one rotatable shaft, and a generator for converting mechanical energy into electric energy, wherein the generator can be driven by the at least one rotatable shaft of the drive element.
Type:
Grant
Filed:
January 23, 2008
Date of Patent:
December 18, 2012
Assignee:
W&H Dentalwerk Bürmoos GmbH
Inventors:
Stefan Putz, Stephan Rauchenzauner, Norbert Schatz, Karl Schmiedlechner, Hannes Wagner
Abstract: This disclosure provides the identification of an eight base pair deletion in the 3?-untranslated region (UTR) of the striatin gene that is linked to arrhythmogenic right ventricular cardiomyopathy (ARVC) in Boxer dogs. Also provided are methods for detecting ARVC, methods of breeding Boxer dogs to reduce the prevalence or frequency of ARVC in a population, and methods of screening for a compound useful for treatment of ARVC.
Type:
Grant
Filed:
April 26, 2010
Date of Patent:
December 18, 2012
Assignee:
Washington State University Research Foundation
Abstract: A speaker virtualization system provides virtual surround sound using a pair of physical loudspeakers. A multiple surround audio channels input is processed using a combination of head related transfer functions and shaped reverberation to provide widening and front/back auditory clues without requiring any kind of interaural path cancellation. The system uses a 360 degree power-response head related transfer function to provide perceptual separation of the reverberant and direct paths, along with discrete, different reverberation for left and right rendering channels to provide envelopment. By eliminating interaural path cancellation, the speaker virtualization system also produces a wider virtual surround sound effect, without dependency on head position and facing.
Type:
Grant
Filed:
January 18, 2008
Date of Patent:
December 18, 2012
Assignee:
Microsoft Corporation
Inventors:
James D. Johnston, Qunli Li, Serge Smirnov
Abstract: A parts washer comprises a cabinet, a platform, a liquid distributor, a coupling, and a drive system. The platform is disposed inside the cabinet and supports articles that are required to be cleaned. The distributor is disposed inside the cabinet to one side of the platform and has one or more outlets that direct the liquid in a generally radial direction toward the platform. The coupling couples the distributor to an inside of the cabinet in a manner allowing at least 2°of freedom of motion of the distributor. More particularly, the coupling allows the distributor to move in a complex motion comprising a combination of tilting, rotation and up and down motion.
Abstract: A vaccine is disclosed that is protective against pathogenic bacterial species, typically staphylococcal species, and includes methods to prepare said vaccine and to culture pathogenic bacteria.
Type:
Grant
Filed:
July 23, 2007
Date of Patent:
December 18, 2012
Assignee:
Vaccine Research International PLC
Inventors:
Afshan Ahmad, Bruce Robert Gordon Skinner
Abstract: A new and distinct Campanula plant characterized by large bells of deep violet blue flowers, short flower stalks, multiple inflorescences, no seed set, and long bloom time (June through September with deadheading in Canby, Oreg.).
Abstract: A new and distinct Heuchera plant substantially as shown and described, characterized by deep purple black spring leaves, glossy purple black summer leaves, ruffled leaves, medium large plant size, and excellent vigor.
Abstract: A new and distinct cultivar of Tradescantia plant characterized by yellow gold to yellow green foliage, white flowers, a compact clumping habit, and excellent vigor.
Abstract: A new and distinct cultivar of Heuchera plant characterized by multicolored leaves with a heavy silver white veil, narrow wands of pink flowers, reblooming, and excellent tolerance to heat and humidity.