Abstract: A method of providing a subject polypeptide variant with improved stability compared with a parent subject polypeptide, employing translation and selection using an RNA expression system, wherein two or more stability selection pressures are applied simultaneously during translation, two or more stability selection pressures are applied simultaneously during selecting, or at least one stability selection pressure is applied during translation and continues to be applied during selecting, and at least one further stability selection pressure is applied during selecting.

Abstract: Wave attenuation systems are disclosed. For example, a wave-attenuating panel can define a plane, a center-of buoyancy and a center-of-mass spaced from the center-of-buoyancy such that the panel is stably buoyant in a liquid with the plane oriented vertically. Wave attenuators are also disclosed. Such a wave attenuator can comprise a first row of support members extending vertically relative to a seabed and a second row of support members spaced from the first row. A vertically oriented, movable panel can be positioned between the first row and the second row, such that the panel is configured to rise and fall in a substantially vertical plane. Such wave attenuators can also comprise a second, fixed panel that remains submerged.

Abstract: The present disclosure relates to oligodeoxynucleotides that suppress an immune response. Methods are disclosed for preventing or treating inflammatory arthropathies by administering a therapeutically effective amount of a suppressive oligodeoxynucleotide.

Abstract: Apparatus for extracting a material from a body of liquid and methods therefore are disclosed. A transport member comprises at least one continuous loop configured to pass through a continuous orbit. The material sufficiently adheres to at least a portion of the at least one continuous loop. A scraping member urges against at least a portion of the continuous loop for removing at least some of any of the material adhered to the continuous loop. Such an apparatus can be a harvester that includes a frame having a first end and a second end. A first conveyor drum can be supported by the frame adjacent the first end and can have an outer surface for engaging the transport member. A second conveyor drum can be supported adjacent the second end and can have an outer surface for engaging the transport member.

Abstract: A golf club head having a high COR (maximum coefficient of restitution of at least 0.80) is durable and has desirable acoustic qualities. The club head includes a body portion, a striking face and a crown forming a hollow cavity of at least 150 cc. The body portion defines front and upper openings, and it includes a sole and a side section. The striking plate encloses the front opening. While partially assembled, final weighting and/or other attachment of other members to the inner surface of the club head can be preformed, as desired. The crown is secured to the body portion, enclosing the upper opening. A surface veil may also be provided about a junction of the crown and body. The striking plate and/or the crown are adhesively attached.

Abstract: Provided herein are compositions and related methods useful for free radical scavenging, with particular selectivity for mitochondria. The compounds comprise a nitroxide-containing group attached to a mitochondria-targeting group. The compounds can be cross-linked into dimers without loss of activity. Also provided herein are methods, for preventing, mitigating and treating damage caused by radiation. The method comprises delivering a compound, as described herein, to a patient in an amount and dosage regimen effective to prevent, mitigate or treat damage caused by radiation.

Abstract: Embodiments of compositions comprising materials satisfying the general formula AM1?xM?xM?yO3+y are disclosed, along with methods of making the materials and compositions. In some embodiments, M and M? are +3 cations, at least a portion of the M cations and the M? cations are bound to oxygen in trigonal bipyramidal coordination, and the material is chromophoric. In some embodiments, the material forms a crystal structure having a hexagonal unit cell wherein edge a has a length of 3.50-3.70 ? and edge c has a length of 10-13 ?. In other embodiments, edge a has a length of 5.5-7.0 ?. In particular embodiments, M? is Mn, and Mn is bonded to oxygen with an apical Mn—O bond length of 1.80 ? to 1.95 ?. In some embodiments, the material is YIn1?xMnxO3, x is greater than 0.0 and less than 0.75, and the material exhibits a surprisingly intense blue color.

Abstract: A method and system for managing at least one animal is disclosed. The method can include imaging, such as ultrasound imaging, a lung of a live animal, such as a ruminant or bovine. The imaging can be performed to determine a degree of respiratory damage from past respiratory illness. After imaging, information regarding respiratory damage can be used to select at least one aspect of the treatment, care or disposition of the animal. For example, the information can be used to select the amount or type of feed provided to the animal at a feedlot. The information also can be used to select how long the animal should be housed at the feedlot prior to slaughter. If an animal is diagnosed with a respiratory illness, information about its degree of respiratory damage from past respiratory illness also can be used to select the appropriate medical treatment or lack of treatment.

Abstract: Devices and methods are disclosed for holding an object, particularly a planar object. An exemplary device has a chuck and pressure-changing device. The chuck has an object-mounting surface and a deformable membrane coupled to the object-mounting surface such that conformational changes in the membrane produce corresponding changes in the object-mounting surface. The chuck has a first cavity separated by the membrane from the chuck cavity. The pressure-changing device is coupled to the first cavity to change pressure in the first cavity, relative to outside it, sufficiently to produce a conformational change of the membrane and a corresponding change in the object-mounting surface sufficient to reduce the force with which the object is being held to the object-mounting surface. The pressure change can be a pressure increase or decrease.

Abstract: A method and apparatus for testing a magnetic medium. The method comprises applying a magnetic field of a time-varying strength; directing a polarized optical beam towards a portion of the medium that is in the magnetic field, wherein the optical beam is reflected by a surface of the medium at a point of incidence in the magnetic field; moving the medium relative to the optical beam so as to cause the point of incidence to repeatedly traverse each of a plurality of sectors along a track on the surface; obtaining a series of Kerr signal measurements of the reflected optical beam; grouping measurements into ensembles such that the measurements in an individual ensemble are those obtained while the point of incidence was in a corresponding one of the sectors; and determining at least one magnetic property of at least one of the sectors from the measurements in the corresponding ensemble.

Abstract: This invention relates to methods and apparati for performing multiple simultaneous manipulations of biomolecules in a two-dimensional array, such as a gel, membrane, tissue biopsy, etc. Such manipulations particularly include assays and nucleic acid amplification protocols.

Abstract: A system includes one or more compacting wall retraction mechanisms for retracting one or more compacting walls of a compactable lightweight concrete block mold having at least two compacting walls. The compacting wall retraction mechanism(s) facilitate release of a compacted lightweight concrete block from the compactable lightweight concrete block mold. The system can include a mold feed conveyor, and a table for receiving the compactable lightweight concrete block mold from the mold feed conveyor. The system can include one or more tube extraction and re-insertion mechanisms for extracting or inserting tubes of a compactable mold. The system can include one or more end wall lock release mechanisms for releasing end walls to remove a molded block from the mold. Mold assembly and disassembly can be controlled by an electronic or computerized controller.

Abstract: A computing device has two or more software stacks, each stack simultaneously running a different operating system. Only one enabled operating system at a time has control of hardware resources of the computing device. Each disabled operating system has its device drivers disabled. The drivers may be disabled by stopping device driver messages to devices at a firmware layer unassociated with any operating system. The drivers may be disabled by having their associated operating system dynamically unload them when the operating system is disabled. In some instances, the drivers may be modified to include a “stop” control that tells the driver to stop communicating with its associated device, and a “resume” control that tells the driver to resume communication. When an operating system is disabled, the operating system may send a “stop” message to its device drivers. Drivers associated with messages passed between operating systems may remain enabled.

Abstract: Scaffold comprises a polymer defining macropores and comprising hydroxypropylcellulose partially substituted by a substituent comprising a self-crosslinkable group, which is crosslinked through the self-crosslinkable group. The macropores have an average pore size larger than 50 microns and are at least partially interconnected. In one method, bicontinuous emulsion comprising a continuous aqueous phase and a continuous polymer phase is formed. The polymer phase comprises hydroxypropylcellulose partially substituted by a substituent comprising a self-crosslinkable group, and is crosslinked through the self-crosslinkable group to form a polymer defining at least partially interconnected pores. In another method, phase separation is induced in a solution comprising a polymer precursor and water to form a bicontinuous emulsion comprising a continuous polymer phase and a continuous aqueous phase.

Abstract: In embodiments of the disclosed technology, diagnosis of a circuit is performed using compactor signatures (a technique referred to herein as “signature-based diagnosis”). Signature-based diagnosis typically does not require a test step that bypasses the compactor. Compactor signatures can be read from a compactor on a per-pattern basis, and an expected signature can be loaded into a compactor while an actual signature is being read from the compactor. Error functions can be used to describe relationships between errors in scan cell values and per-pattern compactor signatures, and the functions can be used to help generate a list of fault candidates in a circuit design.

Abstract: A golf club head includes a body defining an interior cavity. The body includes a sole positioned at a bottom portion of the golf club head, a crown positioned at a top portion, and a skirt positioned around a periphery between the sole and crown. The body has a forward portion and a rearward portion. The club head includes a face positioned at the forward portion of the body. The face defines a striking surface having an ideal impact location at a golf club head origin. Some embodiments of the club head form a club head for a fairway wood that has a high moment of inertia, a low center-of-gravity and a thin crown.

Abstract: The present invention provides pyrimidinediamine compounds useful for inhibiting kinase activity, including the activity of polo-like kinase 1 (PLK1). Also provided are pharmaceutical compositions comprising these compounds and methods of treating diseases associated with kinase activity, in particular enhanced PLK1 catalytic activity, such as diseases associated with abnormal cell proliferation, including neoplastic disorders.

Abstract: Disclosed herein is an electrochemical biosensor measuring device which comprises at least two photodiodes for emitting light beams at regular time intervals in a sequential manner, with the insertion of an electrochemical biosensor thereto, and a detector for sensing the emitted light beams, thereby identifying the production lot information recorded on a production lot information identification portion on the electrochemical biosensor. Thus, the device enjoys economic advantages of not requiring a high-priced optical filter in detecting the light absorbed through or reflected from the production identification information recorded in biosensor and a complicated software algorithm to recover the production lot information.

Abstract: Methods, apparatus, and systems for performing fault diagnosis are disclosed herein. In one exemplary embodiment, a failure log is received comprising entries indicative of compressed test responses to chain patterns and compressed test responses to scan patterns. A faulty scan chain in the circuit-under-test is identified based at least in part on one or more of the entries indicative of the compressed test responses to chain patterns. One or more faulty scan cell candidates in the faulty scan chain are identified based at least in part on one or more of the entries indicative of the compressed test responses to scan patterns. The one or more identified scan cell candidates can be reported. Computer-readable media comprising computer-executable instructions for causing a computer to perform any of the disclosed methods are also provided. Likewise, computer-readable media storing lists of fault candidates identified by any of the disclosed methods are also provided.