Abstract: Covalently linked conjugates of oligonucleotides (ODNs) with a cyclopropapyrroloindole moiety or an analog thereof, selectively and efficiently alkylate and crosslink with nucleic acid sequences that are complementary to the base sequence of the ODN.

Abstract: A subminiature incandescent lamp has a substantially cylindrical base to which a glass envelope enclosing the interior of the lamp is sealed. A pair of contact wires or pins are made of a metal alloy that has substantially the same thermal expansion coefficient as the glass base. The contact pins are embedded and sealed to the glass base in a gas-tight manner, with a glass-to-metal seal. The contact pins extend below the base to provide external connections of the lamp to a power source. The pins also extend into the interior of the lamp, and provide electrical contact to a filament which is mounted between them. A filament support wire is anchored in the glass base at one end thereof and has a loop at its other end in which the mid-section of the filament rests and is mechanically supported.

Abstract: Compounds of Formula I ##STR1## wherein the symbols are as defined in the specification.

Abstract: A card game and method of playing the same played with a standard 52 card deck is disclosed, wherein each of several players is dealt three cards and is given the opportunity to stand pat or to exchange one card for another dealt by a non-player dealer with the object of achieving a hand having a high score based on a numerical point scoring system in which the lowest hand score is zero and the highest is ten. Each such score is then compared with that of a predesignated reference player or "banker" to distinguish winning hands from losing hands. In those jurisdictions in which it would be legal, the game may also include wagering by the players according to specific payout rules.

Abstract: An infusion catheter, for use in conjunction with a balloon dilatation catheter, comprises an elongate, flexible tube defining an infusion lumen, and an expansible infusion sleeve located near its distal end, the sleeve comprising an expansible network of spacer elements disposed between proximal and distal elastomeric sealing bands. When deployed at a treatment site in a blood vessel or other bodily passage, the elongate tube of the present invention concentrically surrounds the dilatation catheter, the infusion lumen being defined therebetween, with the infusion sleeve concentrically surrounding the balloon. The spacer elements of the expansible network create an axially-elongated, circumferential flow path or interstice between the balloon and the vessel wall when the balloon is inflated, the interstice being in fluid communication with the infusion lumen, through which a therapeutic fluid is delivered to the treatment site.

Abstract: Oligonucleotides containing 1-N-alkyl-6-thiopurine, 3-N-alkyl-4-thiopyrimidine and 5-N-alkyl-4-thiopyrazolopyrimidine bases and the corresponding 2'-O-alkylated or allylated nucleotides demonstrate potent antiviral activity in several assays, including the human immunodeficiency virus reverse transcriptase enzyme assay. The oligonucleotides of the invention contain approximately 5 to 99 nucleotide units, and may include, in addition to the above-noted N-alkylated and thiolated heterocyclic bases, the naturally occurring pyrimidine and purine bases.

Abstract: A display card for holding an item, wherein the item has an integral hinge joining a pair of molded item halves, each defining an interior surface, that are foldable along the hinge, wherein the card includes a bottom edge and an extended portion, contiguous with the bottom edge, configured for engaging the interior surface of one of the item halves when the item halves are folded together. In one embodiment, the integral hinge includes first and second hinge portions separated by a slot, and the extended portion includes a projection that is insertable through the slot. An aperture in the projection receives a post extending from the interior surface of one of the item halves. In other embodiments, the extended portion is insertable into a slot that is parallel to, or collinear with, the integral hinge, the extended portion including laterally-extending fingers that engage the interior of the item halves adjacent the ends of the slot.

Abstract: Oligonucleotides having approximately 8 to 18 nucleotide units and a 3'-tail which includes asteroid structure attached to the 3'-end through the A ring of the steroid skeleton and which form substantially stable duplexes at physiological temperature, have selective cytotoxic activity against certain tumor cell lines.

Abstract: A device for promoting hemostasis in a blood vessel puncture is employed with an introducer that accesses the puncture through an incision. The introducer has an open distal end positionable at the puncture, an external portion with an open proximal end, and an axial channel therebetween. The device includes a hollow catheter, dimensioned to pass through the introducer channel, having a distal end to which is attached an expansible compression element, which may be an inflatable balloon, a collapsible prong assembly, or a resilient foam pad. The compression element is collapsed when the distal end of the catheter is enclosed within the introducer. When the catheter and the introducer are located the desired distance from the puncture, the introducer is displaced axially relative to the catheter to expose the compression element to the subcutaneous tissue, whereupon the compression element is expanded.

Abstract: A syringe actuation device comprises an elastomeric element that is removably attachable to the outlet tip of a syringe, and to a grip member that allows the elastomeric element to be pulled distally along the syringe barrel to seat against the distal end of the syringe plunger. In first and second embodiments, the elastomeric element is attached between a grommet that fits around the outlet tip, and an end cap that engages the distal end of the plunger. When the grommet is seated around the outlet tip, and the end cap engages the distal end of the plunger with the plunger in its withdrawn position, the elastomeric element is stretched along the syringe, biasing the plunger toward its inserted position. As the elastomeric element restores itself to its unstretched configuration, it pushes the plunger into the syringe barrel.

Abstract: A parachute-type sail is connected with a tethering line to a water going vessel to provide motive power for the vessel. At least one swivel is disposed on the tether line between the vessel and the sail that allows the sail to roll when the vessel moves and the sail is in contact with the water's surface. The tether line may be raised or lowered relative to the horizon and may be moved around the compass to optimize position of the sail and thereby minimize the overturning vector and optimize the thrust balance for movement with neutral or substantially neutral rudder.

Abstract: A medical food having the below listed components is administered for several days as the sole source or as a substantial source of the daily caloric intake of a patient suffering from metabolic poisoning: 45 to 65% protein concentrate; 2.5 to 17.5% of grain syrup solids containing 50% dextran; 2.5 to 17.5% of grain syrup solids containing 50% of maltose; 3 to 12% of oil containing 20% of oleic acid, 1 to 11% medium chain triglycerides; magnesium ions; buffering agent; soluble calcium salt; ascorbic acid; 0.40 to 0.65% of .beta. carotene; D-.alpha.-tocopherol; chromium ions in the trivalent or hexavalent form, 0.008 to 0.022% glutathione, 0.08 to 0.22% N-acetylcysteine; L-lysine hydrochloride; 0.08 to 0.22% L-threonine, and 0.08 to 0.22% of L-cysteine.

Abstract: Micro-encapsulated lactobacilli bacteria are orally administered to mammals, including humans, to treat or prevent antibiotic associated or other chronic or acute diarrhea. Micro-encapsulated lactobacilli bacteria are topically administered to the skin to treat or prevent recurrent skin infections, and are administered intra-vaginally to treat or prevent vaginal yeast infections.

Abstract: Micro-encapsulated lactobacilli bacteria are orally administered to mammals, including humans, to treat or prevent antibiotic associated or other chronic or acute diarrhea. Micro-encapsulated lactobacilli bacteria are topically administered to the skin to treat or prevent recurrent skin infections, and are administered intra-vaginally to treat or prevent vaginal yeast infections.

Abstract: A medical food having the below listed components is administered for several days as the sole source or as a substantial source of the daily caloric intake of a patient suffering from metabolic poisoning: 45 to 65% protein concentrate; 2.5 to 17.5% of grain syrup solids containing 50% dextran; 2.5 to 17.5% of grain syrup solids containing 50% of maltose; 3 to 12% of oil containing 20% of oleic acid, 1 to 11% medium chain triglycerides; magnesium ions; buffering agent; soluble calcium salt; ascorbic acid; 0.40 to 0.65% of .beta. carotene; D-.alpha.-tocopherol; chromium ions in the trivalent or hexavalent form, 0.008 to 0.022% glutathione, 0.08 to 0.22% N-acetylcysteine; L-lysine hydrochloride; 0.08 to 0.22% L-threonine, and 0.08 to 0.22% of L-cysteine.

Abstract: An improved steering assembly for personal watercraft governs the positioning of a steering nozzle through a cable affixed to a steering shaft attached to handlebars gripped by the rider/operator of the watercraft. The steering shaft is mounted to the hull in a retainer member relative to which it is rotatable. The handlebars are shielded from the shocks and bumps occurring while the watercraft travels on rough water by a shock absorber that is mounted between the retainer member and the handlebars. The improved steering assembly significantly increases riding comfort and reduces operator fatigue.

Abstract: Micro-encapsulated lactobacilli bacteria are orally administered to mammals, including humans, to treat or prevent antibiotic associated or other chronic or acute diarrhea. Micro-encapsulated lactobacilli bacteria are topically administered to the skin to treat or prevent recurrent skin infections, and are administered intra-vaginally to treat or prevent vaginal yeast infections.

Abstract: A surface mount electronic device, attachable to a circuit board, comprises an insulating substrate having a top surface and a bottom surface; a plurality of metallized terminal pads on the bottom surface; and a plurality of leads, each attached to one of the terminal pads by a solder column. Each of the leads comprises a first substantially horizontal lead portion attached to one of the terminal pads by the solder column. A plurality of upturned prongs on the first substantially horizontal lead portion forms a pronged area configured to hold the solder column. A second substantially horizontal lead portion terminates in a free end for attachment to the circuit board. An upwardly curved intermediate lead portion connects the first and second substantially horizontal portions and underlies the bottom surface of the substrate.

Abstract: A syringe actuation device comprises an internally-threaded hollow outer sleeve with an open proximal end, and an externally-threaded hollow cylinder with a tapered internal diameter, that encloses a spring-biased piston, and that threads into the open distal end of the sleeve. The outer sleeve has a longitudinal opening parallel to its axis for receiving the fully-extended plunger of a pre-filled syringe, and a distal wall portion through which the barrel of the syringe extends. The cylinder contains a coil spring extending axially within its hollow interior, the spring having a proximal end seated against a proximal end wall of the cylinder, and a distal end attached to the proximal side of the piston. The piston is attached to the distal end of the spring so as to be pivotable from a canted orientation with respect to the cylinder's axis when the spring is compressed, to a substantially coaxial orientation with respect to the cylinder's axis when the spring is extended to a less compressed state.