Abstract: Use of a compound for treating a respiratory disease in a mammal wherein the compound is a cannabinoid receptor modulator is disclosed. Compounds useful as cannabinoid receptor modulators for treating respiratory and non-respiratory leukocyte-activation associated diseases comprise compounds of formula (I),
in which A and B are nitrogen or carbon, provided only one of A and B is nitrogen; and R1-R6 are as defined in the specification, wherein R2 with R5 may form a ring, and/or two R4 groups may form a six-membered aryl or heteroaryl ring, optionally having a substituent R6 forming a ring with R3.
Type:
Grant
Filed:
February 8, 2001
Date of Patent:
November 25, 2003
Assignee:
Bristol-Myers Squibb Co.
Inventors:
Katerina Leftheris, Hong Wu, Stephen Wrobleski, Ping Chen, John Hynes, John Tokarski
Abstract: Tetrahydroisoquinoline analogs are provided which are modulators of chemokine receptor activity.
The tetrahdroisoquinoline analogs thereof have the structure
wherein R1, R2, R3, R3a, X1, X2, X3, X4, m, n and p are as described herein.
Type:
Grant
Filed:
November 7, 2002
Date of Patent:
November 18, 2003
Assignee:
Bristol-Myers Squibb Co.
Inventors:
Mark Alden Hermsmeier, David B. Rawlins, John Wityak
Abstract: The present invention discloses compounds useful in treating or preventing IMPDH-associated disorders, such as transplant rejection and autoimmune diseases, having the formula (I),
wherein X is —C(O)—, —C(S)—, or —S(O)2—; A is an optionally-substituted saturated or unsaturated monocyclic or bicyclic ring; B is a saturated or unsaturated monocyclic or bicyclic ring system having at least one substituent Q which is selected from R7 and R8; R7 is selected from (C0-C6)alkyl, (C2-C6)alkenyl and (C2-C6)alkynyl and R7 is substituted with
R8 is selected from (C0-C6)alkyl, (C2-C6)alkenyl and (C2-C6)alkynyl and R8 is substituted with
and Z1 through Z5 are as defined in the specification.
Type:
Grant
Filed:
May 23, 2002
Date of Patent:
September 9, 2003
Assignee:
Bristol-Myers Squibb Co.
Inventors:
Edwin J. Iwanowicz, Katerina Leftheris, Chunjian Liu, Toomas Mitt, Scott H. Watterson
Abstract: This invention pertains to the use of compounds containing amide or imide type functional groups to increase the rate of nitroxide mediated oxidation of alcohols, particularly primary and secondary alcohols. While suitable for oxidation of alcohol groups on a variety of substrates, it is particularly useful to oxidize cellulose, cellulose pulp or cellulose fiber such that it is commercially compatible with the traditional paper making process. Such co-catalysts may be used to increase the absolute amount of aldehyde groups on cellulose, cellulose pulp or cellulose fiber, thereby further increasing the inherent wet strength, temporary wet strength, and dry strength of paper made with such cellulose, cellulose pulp or cellulose fiber.
Type:
Grant
Filed:
May 19, 2000
Date of Patent:
April 1, 2003
Assignee:
National Starch and Chemical Ivnestment Holding
Corporation
Inventors:
A. Levent Cimecioglu, John S. Thomaides, Kraig A. Luczak, Danielle E. Harkins
Abstract: Compositions, particularly foodstuffs, were thickened by the inclusion of an effective amount of a stabilized waxy potato starch, particularly a stabilized, crosslinked waxy potato starch, more particularly a hydroxypropylated waxy potato distarch phosphate. Compositions which include the starch may be thickened using less starch than if other starches were used. Foodstuffs prepared using the starch were improved in that they have better flavor, texture, and appearance.
Type:
Grant
Filed:
September 23, 1997
Date of Patent:
December 3, 2002
Assignee:
National Starch and Chemical Investment Holding
Corporation
Inventors:
Roger Jeffcoat, William R. Mason, Joseph L. Emling, Chung-Wai Chiu
Abstract: Thermally-inhibited starches and flours which are functionally equivalent to chemically-crosslinked starches are prepared by a process which comprises the steps of dehydrating a granular starch or flour to anhydrous or substantially anhydrous (<1% moisture) and heat treating the dehydrated starch or flour for a time and at a temperature sufficient to inhibit the starch, (e.g., 120-180° C. for up to 20 hours). Preferably the pH of the starch is adjusted to neutral or greater (e.g., pH 8-9.5) prior to the dehydration. The dehydration may be a thermal dehydration carried out simultaneously with the heat treatment or a non-thermal dehydration carried out by extraction with a solvent (e.g., ethanol) or by freeze drying.
Type:
Grant
Filed:
March 2, 2001
Date of Patent:
September 17, 2002
Assignee:
National Starch and Chemical Investment Holding
Corporation
Inventors:
Chung-Wai Chiu, Eleanor Schiermeyer, David J. Thomas, Manish B. Shah, Douglas J. Hanchett, Roger Jeffcoat
Abstract: The present invention is directed to sago fluidity starch and the use thereof. Such fluidity starches exhibit exceptionally fast gelling properties, high gel strengths, and exceptional elasticity. These properties allow for significantly reduced processing times, including reduced hold times. Further, the higher gel strength allows for reduced starch levels without loss of final product gel strength integrity or texture.
Type:
Grant
Filed:
August 10, 1999
Date of Patent:
September 10, 2002
Assignee:
National Starch and Chemical Investment Holding
Corporation
Inventors:
Douglas J. Hanchett, Tunyawat Kasemsuwan, Joseph Light, Ai-Tsing Tan
Abstract: The present invention is directed to a process of preparing starch phosphate monoesters, optionally in the presence of oligosaccharides, having improved reaction efficiency and reduced side reactions. The invention also includes the improved starch phosphate monoester products, characterized by high viscosity and low level of residual salts, their use in food and the enhanced food compositions prepared from them.
Type:
Grant
Filed:
August 7, 2000
Date of Patent:
August 6, 2002
Assignee:
National Starch and Chemical Investment Holding
Corporation
Inventors:
Wolfgang Bindzus, Paul A. Altieri, James J. Kasica, Peter T. Trzasko
Abstract: Paper having improved retention properties made by the addition to the papermaking system of a combination of cationic starch and starch phosphate, the starch combination having a select net zeta potential.
Type:
Grant
Filed:
August 7, 2000
Date of Patent:
July 2, 2002
Assignee:
National Starch and Chemical Investment Holding
Corporation
Inventors:
Walter Maliczyszyn, Wolfgang Bindzus, Paul A. Altieri
Abstract: An aqueous, light weight paper laminating adhesive comprising a continuous aqueous phase of from about 15 to 50% by weight of polysaccharide material dispersed in water, the continuous phase polysaccharide material having a zero-shear viscosity of greater than 0.07 Pa·s when measured at 26% (+/−1% solids) and a shear rate of 0.1s−1; a shear-thinning index of 0.90 to 1.1; and bleed time of greater than 15 seconds. Also disclosed is another adhesive composition, which is particularly useful in non-contact spay applications and comprises the continuous phase polysaccharide phase described above as well as a second component comprising a water swellable, insoluble polysaccharide particulate phase.
Type:
Grant
Filed:
April 5, 1999
Date of Patent:
April 30, 2002
Assignee:
National Starch and Chemical Investment Holding
Corporation
Inventors:
James L. Eden, Eric M. Weisser, Daniel B. Solarek
Abstract: A paper coating comprising a hydrophobically modified starch having an amylose content of less than about 40% by weight. The coating provides the paper product with oil and grease resistant properties.
Type:
Grant
Filed:
July 7, 2000
Date of Patent:
April 16, 2002
Assignee:
National Starch and Chemical Investment Holding
Corporation
Inventors:
Victor L. Mackewicz, Robert L. Billmers, Douglas J. Hanchett
Abstract: This invention relates to paper comprising aldehyde modified cellulose pulp prepared using nitroxyl radical mediated oxidation and further containing selected additives comprising aldehyde functional polymers or polymers containing functionality capable of reacting with aldehyde groups and having improved strength properties. This invention further relates to paper made from aldehyde modified cellulose pulp where an hydroxyl group containing polymer is added to the paper to provide wet strength properties.
Type:
Grant
Filed:
December 3, 1999
Date of Patent:
April 9, 2002
Assignee:
National Starch and Chemical Investment Holding
Corporation
Inventors:
A. Levent Cimecioglu, John S. Thomaides, Kraig A. Luczak, Robert D. Rossi
Abstract: The use in papermaking of an amphoteric starch additive which contains a phosphate functional group and is made under anhydrous conditions while in a fluidized state, provides advantageous paper properties and improved wet end performance.
Type:
Grant
Filed:
August 7, 2000
Date of Patent:
April 2, 2002
Assignee:
National Starch and Chemical Investment Holding
Corporation
Abstract: A one-pass, non-tolerance dependent method for preparing paper size emulsions comprising an aqueous emulsion of a substituted cyclic dicarboxylic anhydride, a colloidal stabilizer, and a surfactant wherein the emulsion after one-pass through a dispersion system has an average particle size of less than 2 microns.
Type:
Grant
Filed:
December 15, 1998
Date of Patent:
October 2, 2001
Assignee:
National Starch & Chemical Investment Holding
Corporation
Inventors:
Michel D. Létourneau, Walter Maliczyszyn
Abstract: A biodegradable, water dispersible shaped core product useful in winding or rolling and storage of paper goods is provided by extruding starch which has a particle size of 800 to 1200 microns into an expanded, closed cell starch product.
Type:
Grant
Filed:
September 29, 1997
Date of Patent:
September 4, 2001
Assignee:
National Starch and Chemical Company Investment Holding
Corporation
Inventors:
Richard R. Rose, Beth C. Tormey, Paul A. Altieri
Abstract: A stable oil-in-water emulsion for use in cosmetic compositions comprising an oil phase which contains the combination of a polysaccharide such as animo-mullticarboxylate starch derivative and a dimethicone copolyol as emulsifier, and a water phase.
Type:
Grant
Filed:
May 10, 1999
Date of Patent:
August 21, 2001
Assignee:
National Starch & Chemical Co. Investment Holding
Corporation
Abstract: Stable, cold water soluble, ready for use starch aldehyde compositions and the method of preparation of such compositions wherein an aqueous dispersion of a converted starch acetal is hydrolyzed under acidic conditions to form the starch aldehyde which is then spray dried into a cold water soluble starch aldehyde powder.
Type:
Grant
Filed:
November 5, 1998
Date of Patent:
July 24, 2001
Assignee:
National Starch & Chemical Investment Holding
Corporation
Inventors:
A. Levent Cimecioglu, Bjork Ohlhorst, Daniel B. Solarek, Douglas J. Slate, James L. Eden