Patents Represented by Attorney, Agent or Law Firm Lauren L. Stevens
  • Patent number: 7851484
    Abstract: Provided are certain chemical entities, and methods of use to modulate skeletal myosin, skeletal actin, skeletal tropomyosin, skeletal troponin C, skeletal troponin I, skeletal troponin T, and skeletal muscle, including fragments and isoforms thereof, as well as the skeletal sarcomere, and methods of use in the treatment of muscle weakness and/or cachexia, as part of a rehabilitation or conditioning exercise regimen, or in the treatment of fraility, post-polio syndrome, obesity, sarcopenia, wasting syndrome, muscle spasm, and other indications.
    Type: Grant
    Filed: March 28, 2008
    Date of Patent: December 14, 2010
    Assignee: Cytokinetics, Inc.
    Inventors: Bradley P. Morgan, David J. Morgans, Jr., Gustave Bergnes, Alex Muci, Scott Collibee, Pu-Ping Lu, Luke W. Ashcraft, William F. Browne, IV, Marc Andrew Garard
  • Patent number: 6797484
    Abstract: The present invention provides high throughput screening system's for identifying compounds useful in the treatment of cellular proliferation disorders. The method can be performed in plurality simultaneously with fluorescence or absorbance readouts.
    Type: Grant
    Filed: April 19, 2002
    Date of Patent: September 28, 2004
    Assignee: Cytokinetics, Inc.
    Inventor: Christophe Beraud
  • Patent number: 6762043
    Abstract: The present invention provides high throughput screening systems for identifying compounds useful in the treatment of cellular proliferation disorders. The method can be performed in plurality simultaneously with fluorescence of absorbance readouts.
    Type: Grant
    Filed: March 6, 2002
    Date of Patent: July 13, 2004
    Assignee: Cytokinetics, Inc.
    Inventor: Christophe Beraud
  • Patent number: 6743599
    Abstract: Described herein are methods which identify candidate agents as binding to a protein or as a modulator of the binding characteristics or biological activity of a protein. Generally, the methods involve the use of ADP or phosphate. The assays can be used in a high throughput system to obviate the cumbersome steps of using gels or radioactive materials.
    Type: Grant
    Filed: March 25, 2002
    Date of Patent: June 1, 2004
    Assignee: Cytokinetics, Inc.
    Inventors: Jeffrey T. Finer, Fady Malik, Roman Sakowicz, Christopher Shumate, Kenneth Wood
  • Patent number: 6743897
    Abstract: The invention provides isolated nucleic acid and amino acid sequences of A. fumigatus profilin, methods of screening for A. fumigatus profilin modulators using biologically active A. fumigatus profilin, and kits for screening for A. fumigatus profilin modulators.
    Type: Grant
    Filed: November 27, 2000
    Date of Patent: June 1, 2004
    Assignee: Cytokinetics, Inc.
    Inventors: Corey E. Nislow, Kee Wong
  • Patent number: 6738716
    Abstract: A system for acquiring knowledge from cellular information. The system has a database comprising a database management module (“DBMS”). The system also has a variety of modules, including a population module coupled to the DBMS for categorizing and storing a plurality of features (e.g., cell size, distance between cells, cell population, cell type) from an image acquisition device into the database. The system has a translation module coupled to the DBMS for defining a descriptor from a set of selected features from the plurality of features. In a specific embodiment, the descriptor is for a known or unknown compound, e.g., drug. A prediction module is coupled to the DBMS for selecting one of a plurality of a descriptors from known and unknown compounds from the database based upon a selected descriptor from a selected compound. The selected compound may be one that is useful for treatment of human beings or the like.
    Type: Grant
    Filed: November 21, 2000
    Date of Patent: May 18, 2004
    Assignee: Cytokinetics, Inc.
    Inventors: James H. Sabry, Cynthia L. Adams, Eugeni A. Vaisberg, Anne M. Crompton
  • Patent number: 6706489
    Abstract: The invention provides isolated nucleic acid and amino acid sequences of HsKifC2, antibodies to HsKifC2, methods of screening for HsKifC2 modulators using biologically active HsKifC2, and kits for screening for HsKifC2 modulators.
    Type: Grant
    Filed: April 2, 2002
    Date of Patent: March 16, 2004
    Assignee: Cytokinetics, Inc.
    Inventors: Christophe Beraud, Richard Freedman
  • Patent number: 6680369
    Abstract: The invention provides isolated nucleic acid and amino acid sequences of HsKip3, antibodies to HsKip3, methods of screening for HsKip3a modulators using biologically active HsKip3, and kits for screening for HsKip3a modulators.
    Type: Grant
    Filed: June 15, 2001
    Date of Patent: January 20, 2004
    Assignee: Cytokinetics, Inc.
    Inventors: Christophe Beraud, Andrew Craven, Ming Yu, Roman Sakowicz, Umesh A. Patel, Katherine A. Davies
  • Patent number: 6664072
    Abstract: The invention provides isolated nucleic acid and amino acid sequences of HsKip3b, antibodies to HsKip3b, methods of screening for HsKip3b modulators using biologically active HsKip3b, and kits for screening for HsKip3b modulators.
    Type: Grant
    Filed: March 4, 2002
    Date of Patent: December 16, 2003
    Assignee: Cytokinetics, Inc.
    Inventors: Christophe Beraud, Richard Freedman
  • Patent number: 6649363
    Abstract: The invention provides isolated nucleic acid and amino acid sequences of HsKif12a, antibodies to HsKif12a, methods of screening for HsKif12a modulators using biologically active HsKif12a, and kits for screening for HsKif12a modulators.
    Type: Grant
    Filed: June 11, 2002
    Date of Patent: November 18, 2003
    Assignee: Cytokinetics, Inc.
    Inventors: Christophe Beraud, Richard Freedman
  • Patent number: 6651008
    Abstract: According to the present invention, computer based techniques for using information technology in therapeutics or drug discovery. In an exemplary embodiment, computer based techniques for determining information about the properties of substances based upon information about structure of living or non-living cells exposed to substances are provided. Computer software according to the present invention enables researchers and/or scientists to identify promising candidates in the search for new and better medicines or treatments using, for example, a cellular informatics database.
    Type: Grant
    Filed: November 21, 2000
    Date of Patent: November 18, 2003
    Assignee: Cytokinetics, Inc.
    Inventors: Eugeni A. Vaisberg, Cynthia L. Adams, James H. Sabry, Anne M. Crompton
  • Patent number: 6638754
    Abstract: The present invention provides high throughput screening systems for identifying compounds useful in the treatment of cellular proliferation disorders. The method can be performed in plurality simultaneously with fluorescence or absorbance readouts.
    Type: Grant
    Filed: March 29, 2002
    Date of Patent: October 28, 2003
    Assignee: Cytokinetics, Inc.
    Inventors: Christophe Beraud, Roman Sakowicz
  • Patent number: 6631331
    Abstract: A system for acquiring knowledge from cellular information. The system has a database comprising a database management module (“DBMS”). The system also has a variety of modules, including a population module coupled to the DBMS for categorizing and storing a plurality of features (e.g., cell size, distance between cells, cell population, cell type) from an image acquisition device into the database. The system has a translation module coupled to the DBMS for defining a descriptor from a set of selected features from the plurality of features. In a specific embodiment, the descriptor is for a known or unknown compound, e.g., drug. A prediction module is coupled to the DBMS for selecting one of a plurality of a descriptors from known and unknown compounds from the database based upon a selected descriptor from a selected compound. The selected compound may be one that is useful for treatment of human beings or the like.
    Type: Grant
    Filed: November 21, 2000
    Date of Patent: October 7, 2003
    Assignee: Cytokinetics, Inc.
    Inventors: James H. Sabry, Cynthia L. Adams, Eugeni A. Vaisberg, Anne M. Crompton
  • Patent number: 6630479
    Abstract: Quinazolinones of formulae 1a, 1b, 1c and 1d are disclosed. They are useful for treating cellular proliferative diseases and disorders associated with KSP kinesin activity.
    Type: Grant
    Filed: November 28, 2000
    Date of Patent: October 7, 2003
    Assignee: Cytokinetics, Inc.
    Inventors: Jeffrey T. Finer, Gustave Bergnes, Whitney W. Smith, John C. Chabala, Bainian Feng
  • Patent number: 6627408
    Abstract: The present invention provides high throughput screening Systems for identifying antifungal compounds. The method can be performed in plurality simultaneously with fluorescence or absorbance readouts.
    Type: Grant
    Filed: October 11, 2002
    Date of Patent: September 30, 2003
    Assignee: Cytokinetics, Inc.
    Inventors: Corey E. Nislow, Roman Sakowicz, Christophe Beraud
  • Patent number: 6617144
    Abstract: The invention provides isolated nucleic acid and amino acid sequences of HsKif16a, antibodies to HsKif16a, methods of screening for HsKif16a modulators using biologically active HsKif16a, and kits for screening for HsKif16a modulators.
    Type: Grant
    Filed: November 22, 2000
    Date of Patent: September 9, 2003
    Assignee: Cytokinetics, Inc.
    Inventors: Christophe Beraud, Richard Freedman
  • Patent number: 6617115
    Abstract: Described herein are methods that can be used for diagnosis and prognosis of cellular proliferation. Also described herein are methods that can be used to screen candidate bioactive agents for the ability to modulate cellular proliferation. Additionally, methods and molecular targets (genes and their products) for therapeutic intervention in cancers are described.
    Type: Grant
    Filed: October 27, 1999
    Date of Patent: September 9, 2003
    Assignee: Cytokinetics, Inc.
    Inventors: Kenneth W. Wood, Jeffrey T. Finer, Christophe Beraud, John Mak, Roman Sakowicz
  • Patent number: 6615141
    Abstract: A system for acquiring knowledge from cellular information. The system has a database comprising a database management module (“DBMS”). The system also has a variety of modules, including a population module coupled to the DBMS for categorizing and storing a plurality of features (e.g., cell size, distance between cells, cell population, cell type) from an image acquisition device into the database. The system has a translation module coupled to the DBMS for defining a descriptor from a set of selected features from the plurality of features. In a specific embodiment, the descriptor is for a known or unknown compound, e.g., drug. A prediction module is coupled to the DBMS for selecting one of a plurality of a descriptors from known and unknown compounds from the database based upon a selected descriptor from a selected compound. The selected compound may be one that is useful for treatment of human beings or the like.
    Type: Grant
    Filed: November 21, 2000
    Date of Patent: September 2, 2003
    Assignee: Cytokinetics, Inc.
    Inventors: James H. Sabry, Cynthia L. Adams, Eugeni A. Vaisberg, Anne M. Crompton
  • Patent number: 6613540
    Abstract: The present invention relates to protein modulators, especially modulators of kinesin bioactivities. The present invention provides methods for screening protein modulators, e.g., kinesin modulators that bind to a region of a kinesin and/or that modulate kinesin bioactivities. The present invention also provide methods and compositions for treatment of disorders mediated by abnormal cellular proliferation activities.
    Type: Grant
    Filed: June 18, 2002
    Date of Patent: September 2, 2003
    Assignee: Cytokinetics, Inc.
    Inventor: Roman Sakowicz
  • Patent number: 6610525
    Abstract: The invention provides isolated nucleic acid and amino acid sequences of HsKifC2, antibodies to HsKifC2, methods of screening for HsKifC2 modulators using biologically active HsKifC2, and kits for screening for HsKifC2 modulators.
    Type: Grant
    Filed: November 22, 2000
    Date of Patent: August 26, 2003
    Assignee: Cytokinetics, Inc.
    Inventors: Christophe Beraud, Richard Freedman