Patents Represented by Attorney, Agent or Law Firm Lauren L. Stevens
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Patent number: 7851484Abstract: Provided are certain chemical entities, and methods of use to modulate skeletal myosin, skeletal actin, skeletal tropomyosin, skeletal troponin C, skeletal troponin I, skeletal troponin T, and skeletal muscle, including fragments and isoforms thereof, as well as the skeletal sarcomere, and methods of use in the treatment of muscle weakness and/or cachexia, as part of a rehabilitation or conditioning exercise regimen, or in the treatment of fraility, post-polio syndrome, obesity, sarcopenia, wasting syndrome, muscle spasm, and other indications.Type: GrantFiled: March 28, 2008Date of Patent: December 14, 2010Assignee: Cytokinetics, Inc.Inventors: Bradley P. Morgan, David J. Morgans, Jr., Gustave Bergnes, Alex Muci, Scott Collibee, Pu-Ping Lu, Luke W. Ashcraft, William F. Browne, IV, Marc Andrew Garard
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Patent number: 6797484Abstract: The present invention provides high throughput screening system's for identifying compounds useful in the treatment of cellular proliferation disorders. The method can be performed in plurality simultaneously with fluorescence or absorbance readouts.Type: GrantFiled: April 19, 2002Date of Patent: September 28, 2004Assignee: Cytokinetics, Inc.Inventor: Christophe Beraud
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Patent number: 6762043Abstract: The present invention provides high throughput screening systems for identifying compounds useful in the treatment of cellular proliferation disorders. The method can be performed in plurality simultaneously with fluorescence of absorbance readouts.Type: GrantFiled: March 6, 2002Date of Patent: July 13, 2004Assignee: Cytokinetics, Inc.Inventor: Christophe Beraud
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Patent number: 6743599Abstract: Described herein are methods which identify candidate agents as binding to a protein or as a modulator of the binding characteristics or biological activity of a protein. Generally, the methods involve the use of ADP or phosphate. The assays can be used in a high throughput system to obviate the cumbersome steps of using gels or radioactive materials.Type: GrantFiled: March 25, 2002Date of Patent: June 1, 2004Assignee: Cytokinetics, Inc.Inventors: Jeffrey T. Finer, Fady Malik, Roman Sakowicz, Christopher Shumate, Kenneth Wood
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Patent number: 6743897Abstract: The invention provides isolated nucleic acid and amino acid sequences of A. fumigatus profilin, methods of screening for A. fumigatus profilin modulators using biologically active A. fumigatus profilin, and kits for screening for A. fumigatus profilin modulators.Type: GrantFiled: November 27, 2000Date of Patent: June 1, 2004Assignee: Cytokinetics, Inc.Inventors: Corey E. Nislow, Kee Wong
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Patent number: 6738716Abstract: A system for acquiring knowledge from cellular information. The system has a database comprising a database management module (“DBMS”). The system also has a variety of modules, including a population module coupled to the DBMS for categorizing and storing a plurality of features (e.g., cell size, distance between cells, cell population, cell type) from an image acquisition device into the database. The system has a translation module coupled to the DBMS for defining a descriptor from a set of selected features from the plurality of features. In a specific embodiment, the descriptor is for a known or unknown compound, e.g., drug. A prediction module is coupled to the DBMS for selecting one of a plurality of a descriptors from known and unknown compounds from the database based upon a selected descriptor from a selected compound. The selected compound may be one that is useful for treatment of human beings or the like.Type: GrantFiled: November 21, 2000Date of Patent: May 18, 2004Assignee: Cytokinetics, Inc.Inventors: James H. Sabry, Cynthia L. Adams, Eugeni A. Vaisberg, Anne M. Crompton
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Patent number: 6706489Abstract: The invention provides isolated nucleic acid and amino acid sequences of HsKifC2, antibodies to HsKifC2, methods of screening for HsKifC2 modulators using biologically active HsKifC2, and kits for screening for HsKifC2 modulators.Type: GrantFiled: April 2, 2002Date of Patent: March 16, 2004Assignee: Cytokinetics, Inc.Inventors: Christophe Beraud, Richard Freedman
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Patent number: 6680369Abstract: The invention provides isolated nucleic acid and amino acid sequences of HsKip3, antibodies to HsKip3, methods of screening for HsKip3a modulators using biologically active HsKip3, and kits for screening for HsKip3a modulators.Type: GrantFiled: June 15, 2001Date of Patent: January 20, 2004Assignee: Cytokinetics, Inc.Inventors: Christophe Beraud, Andrew Craven, Ming Yu, Roman Sakowicz, Umesh A. Patel, Katherine A. Davies
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Patent number: 6664072Abstract: The invention provides isolated nucleic acid and amino acid sequences of HsKip3b, antibodies to HsKip3b, methods of screening for HsKip3b modulators using biologically active HsKip3b, and kits for screening for HsKip3b modulators.Type: GrantFiled: March 4, 2002Date of Patent: December 16, 2003Assignee: Cytokinetics, Inc.Inventors: Christophe Beraud, Richard Freedman
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Patent number: 6649363Abstract: The invention provides isolated nucleic acid and amino acid sequences of HsKif12a, antibodies to HsKif12a, methods of screening for HsKif12a modulators using biologically active HsKif12a, and kits for screening for HsKif12a modulators.Type: GrantFiled: June 11, 2002Date of Patent: November 18, 2003Assignee: Cytokinetics, Inc.Inventors: Christophe Beraud, Richard Freedman
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Patent number: 6651008Abstract: According to the present invention, computer based techniques for using information technology in therapeutics or drug discovery. In an exemplary embodiment, computer based techniques for determining information about the properties of substances based upon information about structure of living or non-living cells exposed to substances are provided. Computer software according to the present invention enables researchers and/or scientists to identify promising candidates in the search for new and better medicines or treatments using, for example, a cellular informatics database.Type: GrantFiled: November 21, 2000Date of Patent: November 18, 2003Assignee: Cytokinetics, Inc.Inventors: Eugeni A. Vaisberg, Cynthia L. Adams, James H. Sabry, Anne M. Crompton
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Patent number: 6638754Abstract: The present invention provides high throughput screening systems for identifying compounds useful in the treatment of cellular proliferation disorders. The method can be performed in plurality simultaneously with fluorescence or absorbance readouts.Type: GrantFiled: March 29, 2002Date of Patent: October 28, 2003Assignee: Cytokinetics, Inc.Inventors: Christophe Beraud, Roman Sakowicz
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Patent number: 6631331Abstract: A system for acquiring knowledge from cellular information. The system has a database comprising a database management module (“DBMS”). The system also has a variety of modules, including a population module coupled to the DBMS for categorizing and storing a plurality of features (e.g., cell size, distance between cells, cell population, cell type) from an image acquisition device into the database. The system has a translation module coupled to the DBMS for defining a descriptor from a set of selected features from the plurality of features. In a specific embodiment, the descriptor is for a known or unknown compound, e.g., drug. A prediction module is coupled to the DBMS for selecting one of a plurality of a descriptors from known and unknown compounds from the database based upon a selected descriptor from a selected compound. The selected compound may be one that is useful for treatment of human beings or the like.Type: GrantFiled: November 21, 2000Date of Patent: October 7, 2003Assignee: Cytokinetics, Inc.Inventors: James H. Sabry, Cynthia L. Adams, Eugeni A. Vaisberg, Anne M. Crompton
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Patent number: 6630479Abstract: Quinazolinones of formulae 1a, 1b, 1c and 1d are disclosed. They are useful for treating cellular proliferative diseases and disorders associated with KSP kinesin activity.Type: GrantFiled: November 28, 2000Date of Patent: October 7, 2003Assignee: Cytokinetics, Inc.Inventors: Jeffrey T. Finer, Gustave Bergnes, Whitney W. Smith, John C. Chabala, Bainian Feng
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Patent number: 6627408Abstract: The present invention provides high throughput screening Systems for identifying antifungal compounds. The method can be performed in plurality simultaneously with fluorescence or absorbance readouts.Type: GrantFiled: October 11, 2002Date of Patent: September 30, 2003Assignee: Cytokinetics, Inc.Inventors: Corey E. Nislow, Roman Sakowicz, Christophe Beraud
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Patent number: 6617115Abstract: Described herein are methods that can be used for diagnosis and prognosis of cellular proliferation. Also described herein are methods that can be used to screen candidate bioactive agents for the ability to modulate cellular proliferation. Additionally, methods and molecular targets (genes and their products) for therapeutic intervention in cancers are described.Type: GrantFiled: October 27, 1999Date of Patent: September 9, 2003Assignee: Cytokinetics, Inc.Inventors: Kenneth W. Wood, Jeffrey T. Finer, Christophe Beraud, John Mak, Roman Sakowicz
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Patent number: 6617144Abstract: The invention provides isolated nucleic acid and amino acid sequences of HsKif16a, antibodies to HsKif16a, methods of screening for HsKif16a modulators using biologically active HsKif16a, and kits for screening for HsKif16a modulators.Type: GrantFiled: November 22, 2000Date of Patent: September 9, 2003Assignee: Cytokinetics, Inc.Inventors: Christophe Beraud, Richard Freedman
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Patent number: 6615141Abstract: A system for acquiring knowledge from cellular information. The system has a database comprising a database management module (“DBMS”). The system also has a variety of modules, including a population module coupled to the DBMS for categorizing and storing a plurality of features (e.g., cell size, distance between cells, cell population, cell type) from an image acquisition device into the database. The system has a translation module coupled to the DBMS for defining a descriptor from a set of selected features from the plurality of features. In a specific embodiment, the descriptor is for a known or unknown compound, e.g., drug. A prediction module is coupled to the DBMS for selecting one of a plurality of a descriptors from known and unknown compounds from the database based upon a selected descriptor from a selected compound. The selected compound may be one that is useful for treatment of human beings or the like.Type: GrantFiled: November 21, 2000Date of Patent: September 2, 2003Assignee: Cytokinetics, Inc.Inventors: James H. Sabry, Cynthia L. Adams, Eugeni A. Vaisberg, Anne M. Crompton
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Patent number: 6613540Abstract: The present invention relates to protein modulators, especially modulators of kinesin bioactivities. The present invention provides methods for screening protein modulators, e.g., kinesin modulators that bind to a region of a kinesin and/or that modulate kinesin bioactivities. The present invention also provide methods and compositions for treatment of disorders mediated by abnormal cellular proliferation activities.Type: GrantFiled: June 18, 2002Date of Patent: September 2, 2003Assignee: Cytokinetics, Inc.Inventor: Roman Sakowicz
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Patent number: 6610525Abstract: The invention provides isolated nucleic acid and amino acid sequences of HsKifC2, antibodies to HsKifC2, methods of screening for HsKifC2 modulators using biologically active HsKifC2, and kits for screening for HsKifC2 modulators.Type: GrantFiled: November 22, 2000Date of Patent: August 26, 2003Assignee: Cytokinetics, Inc.Inventors: Christophe Beraud, Richard Freedman