Abstract: The invention is directed to rubber mixtures comprising rubber, fillers, optionally further rubber auxiliaries and at least one organosilane of the general formula I: R1R2R3SiR4—SH??(I) wherein: R1 is methyl or ethyl, R2 is methoxy, ethoxy or —O—(Y—O)m—X where Y=a branched or unbranched, saturated or unsaturated divalent hydrocarbon group, X is a C1- to C9-alkyl group and m=1-40, R3 is methyl, ethyl or R2, and R4 is a branched or unbranched, saturated or unsaturated, aliphatic, aromatic or mixed aliphatic/aromatic divalent C1-C12 hydrocarbon group. The rubber mixtures according to the invention are prepared by mixing rubber, filler, optionally further rubber auxiliaries and at least one organosilane of the general formula I. The rubber mixtures can be used for the production of shaped articles.

Abstract: The present invention is directed to a device for providing transcutaneous electrical stimulation (TENS) to the finger of a patient at the same time that the finger is being punctured for the purpose of obtaining a blood sample. The device should reduce the pain associated with this procedure and should be of particular interest to diabetic patients that must perform repeated finger puncture procedures to monitor blood glucose levels.

Abstract: The invention relates to a method for production of D- and/or L-methionine via D- and/or L-homoserine with subsequent chemical transformation to give methionine.

Abstract: Hydrogen peroxide is produced by reacting hydrogen and oxygen in the presence of a noble metal catalyst in a liquid reaction medium, the reaction being performed in the presence of a sulfuric acid alkyl ester. In the presence of sulfuric acid alkyl esters the noble metal catalyst exhibits a high and lasting activity for the formation of hydrogen peroxide with an elevated selectivity of hydrogen peroxide formation relative to the hydrogen used. Solutions of hydrogen peroxide in methanol obtainable by the process are suitable for use for the epoxidation of olefins.

Abstract: The present invention is directed to multilayer pharmaceutical tablets in which an NSAID and a triptan are present in separate and distinct layers. The layers are in a side-by-side configuration, which allows the dissolution of triptan and NSAID to occur independently and immediately.

Abstract: The invention provides a process for the removal of polysulfanes from gas streams formed during H2S synthesis.

Abstract: The invention relates to amino acid-producing bacteria from the family Enterobacteriaceae, in particular from the species Escherichia coli, which contain a stop codon chosen from the group amber, ochre and opal in the nucleotide sequence for the coding region of the rpoS gene and a suppressor for a stop codon chosen from the group amber suppressor, ochre suppressor and opal suppressor. This invention also relates to a process for preparing amino acids, in particular L-threonine, using these bacteria.

Abstract: The invention relates to alleles of the glk gene from coryneform bacteria coding for glucokinases, and to processes for the production of L-lysine by fermentation using bacteria containing such alleles.

Abstract: The present invention is directed to methods of identifying women at increased risk of having ovarian cancer. Identification is based upon the extent to which biological samples derived from the women exhibit elevated levels of eosinophil-derived neurotoxin (EDN).

Abstract: The present invention is directed to recombinantly engineered mice that are deficient in the expression of both presenilin-1 and presenilin-2. The mice exhibit characteristics of age-dependent cognitive impairments and neurodegeneration similar to those seen in Alzheimer's disease patients. This presenilin-deficient mouse model can be used to screen compounds capable of slowing, preventing or reversing the progression of cognitive impairments and neurodegeneration. The invention is also directed to the development of treatments for Alzheimer's disease based on augmentation or restoration of presenilin function in the brain. On the basis of the findings described herein, the invention is further directed to the development of assays to detect functional presenilin deficiency in human individuals, preferably through analysis of presenilin substrates, which may provide biomarkers useful in the diagnosis of Alzheimer's disease.

Abstract: The invention relates to a process for the preparation of L-amino acids, especially L-lysine, L-valine, L-homoserine and L-threonine, by fermenting a microorganism of the genus Escherichia which has a mutation or deletion in the gene encoding aspartate ammonium lyase (aspA).

Abstract: Pyrogenically prepared surface-modified silicon dioxide-titanium dioxide mixed oxides are prepared by spraying pyrogenically prepared silicon dioxide-titanium dioxide mixed oxides with a surface-modifying agent. The surface-modified pyrogenically prepared silicon dioxide-titanium dioxide mixed oxides can be used in sun protection formulation.

Abstract: The present invention relates to a screening process for hydantoin racemases and to novel hydantoin racemases, to the nucleic acid sequences coding therefor and to a proces for mutagenesis. Hydantoin racemases are of interest in connection with the production of enantiomerically enriched amino acids from racemic hydantoins.

Abstract: The invention is directed to the preparation of organic or aqueous-organic hydrogen peroxide solutions by direct synthesis from a non-explosive gaseous mixture containing hydrogen and oxygen. The process is carried out in the presence of a noble metal catalyst, using a reaction medium containing a halide and a strong acid. It can be performed in a stainless steel reactor without corrosion occurring to the reactor material if, during the reaction, the surface of the stainless steel is, at no place, in permanent contact with the gaseous mixture passing through the reactor.

Abstract: The invention concerns a process for the preparation of hydrogen peroxide by the anthraquinone cyclic process. The process includes a regeneration stage in which working solution is regenerated by being brought into contact with an aqueous solution containing an alkyl anthrahydroquinone and/or an alkyl tetrahydroanthrahydroquinone in deprotonated form. The working solution regenerated in the regeneration stage is returned to the cyclic process.

Abstract: The present invention is directed to methods of treating or preventing angiomyolipomas by administering interferon gamma. It also encompasses methods for assessing the risk of a patient developing angiomyolipomas based upon interferon gamma expression.

Abstract: Organopolysiloxanes which contain a fragrance alcohol Y—OH bonded via a betaine ester group having the structure —N+R1R2—CH2—C(O)OY, cleave off the fragrance alcohol under acid conditions and are resistant to hydrolysis in the neutral and weakly basic range. The organopolysiloxanes adhere to textile fibres, skin or hair and are suitable as perfume components for textile treatment agents and personal care products.

Abstract: The invention relates to recombinant microorganisms which, in comparison to the starting organism, have a higher concentration or activity of a D-amino acid oxidase, of an L-amino acid dehydrogenase, of an NADH cosubstrate regenerating enzyme and, if necessary, of a catalase. The invention also includes methods for preparing L-amino acids from D-amino acids using of these microorganisms.

Abstract: The invention relates to mutants and alleles of the coryneform bacterium mqo gene which encodes malate quinone oxidoreductases which contain any amino acid apart from L-serine at position 111, or a comparable position, in the amino acid sequence, and to processes for fermentatively preparing amino acids, preferably L-lysine, L-tryptophan and L-proline, using bacteria which comprise these alleles.

Abstract: The present invention is directed to diagnostic methods based upon the expression of the protein prostasin. In particular, it is concerned with assays performed on women to determine their risk of ovarian cancer.