Abstract: A system, method, and computer program product for executing a task via a communication network, including devices configured to establish the communication network, wherein each of the devices includes a database having a capability of the devices, wherein the devices are adapted for executing a pre-defined set of activities indicative of the task. The device further includes a resource module adapted to select an optimal capability among the devices for performing the task based on the capability of the devices and a decision module adapted to allocate the task among the devices based on the selection of the optimal capability among the devices. The device further includes an execution module adapted to perform the task in any of the devices based on the allocation of the optimal capability among the devices and wherein the application resource is exchanged among the devices prior to invoking the task.

Abstract: The present invention relates to a rosamine derivative compound, as described herein, having the following structure: Also disclosed are methods of making such compounds and for using them for detection and imaging.

Abstract: Methods, computer-readable storage media, and systems for applying a user defined operation on collected network data include defining a user defined operation (UDO). A network device is monitored for data relating to the UDO and data relating to the UDO is collected from the network device. The UDO is applied to the collected network data and a result is produced.

Abstract: A spring retainer (60) for a syringe (10) that has a barrel (40), a plunger (20), a spring (90) and a retractable needle (50) that can couple with the plunger for spring-driven retraction of the coupled needle and plunger. The spring retainer has first (70) and second (80) body members that cooperate to releasably maintain the spring in a compressed state until the plunger is coupled to the retractable needle after depression of the plunger to deliver the fluid contents of the syringe. Depression of the plunger triggers rotational disengagement of the first and second body members to allow decompression of the spring which forces retraction of the needle into the barrel. Rotational disengagement of the first and second body members also assists rotation of the plunger into a final, inoperable position.

Abstract: A multimedia capture and presentation system includes a plurality of imaging systems and one or more detection systems. The plurality of imaging systems capture image areas of a scene from at least partially different locations. The one or more detection systems determine a relative position of each of the plurality of imaging systems with respect to the different locations of the scene from where the image areas are captured. The relative position of each of the plurality of imaging systems and the captured image areas are used to generate a multimedia presentation of the scene. The control system adjusts the output of the captured image areas from the plurality of projection systems to conform to a display environment. The one or more detection systems determine another relative position of each of the plurality of imaging systems with respect to the display environment on which the image areas are displayed.

Abstract: The invention relates to iRNA agents, which preferably include a monomer in which the ribose moiety has been replaced by a moiety other than ribose that further includes a tether having one or more linking groups, in which at least one of the linking groups is a cleavable linking group. The tether in turn can be connected to a selected moiety, e.g., a ligand, e.g., a targeting or delivery moiety, or a moiety which alters a physical property. The cleavable linking group is one which is sufficiently stable outside the cell such that it allows targeting of a therapeutically beneficial amount of an iRNA agent (e.g., a single stranded or double stranded iRNA agent), coupled by way of the cleavable linking group to a targeting agent—to targets cells, but which upon entry into a target cell is cleaved to release the iRNA agent from the targeting agent. The inclusion of such a monomer can allow for modulation of a property of the iRNA agent into which it is incorporated, e.g.

Abstract: The present invention provides a nucleic acid synthesis method which involves the step of incubating a double-stranded nucleic acid template under conditions that ensure a complementary strand synthesis reaction using a primer as an origin. This method involves the step of placing a region, to which a primer capable of isothermally amplifying the template nucleic acid will anneal, in a condition that ensures base pairing, using an arbitrary primer. The arbitrary primer initiates the complementary strand synthesis reaction, using the double-stranded nucleic acid as a template and DNA polymerases catalyzing the complementary strand synthesis reaction which comprises the destabilization of the double-stranded nucleic acid and strand displacement, thereby providing a region that can undergo base pairing.

Abstract: This invention relates composition and methods for making and using chemically modified oligonucleotides agents for inhibiting gene expression.

Abstract: One aspect of the present invention relates to a ribonucleoside substituted with a phosphonamidite group at the 3?-position. In certain embodiments, the phosphonamidite is an alkyl phosphonamidite. Another aspect of the present invention relates to a double-stranded oligonucleotide comprising at least one non-phosphate linkage. Representative non-phosphate linkages include phosphonate, hydroxylamine, hydroxylhydrazinyl, amide, and carbamate linkages. In certain embodiments, the non-phosphate linkage is a phosphonate linkage. In certain embodiments, a non-phosphate linkage occurs in only one strand. In certain embodiments, a non-phosphate linkage occurs in both strands. In certain embodiments, a ligand is bound to one of the oligonucleotide strands comprising the double-stranded oligonucleotide. In certain embodiments, a ligand is bound to both of the oligonucleotide strands comprising the double-stranded oligonucleotide.

Abstract: The present invention relates to methods of treating and preventing Alzheimer's Disease or other tauopathies in a subject by administering a tau protein, its immunogenic epitopes, or antibodies recognizing the tau protein or its immunogenic epitopes under conditions effective to treat or prevent Alzheimer's Disease of other tauopathies. Also disclosed are methods of promoting clearance of aggregates from the brain of the subject and of slowing progression of tangle-related behavioral phenotype in a subject.

Abstract: A switched file system, also termed a file switch, is logically positioned between client computers and file servers in a computer network. The file switch distributes user files among multiple file servers using aggregated file, transaction and directory mechanisms. The file switch supports caching of a particular aggregated data file either locally in a client computer or in the file switch in accordance with the exclusivity level of an opportunistic lock granted to the entity that requested caching. The opportunistic lock can be obtained either on the individual data files stored in the file servers or on the metadata files that contain the location of each individual data files in the file servers. The opportunistic lock can be broken if another client tries to access the aggregated data file. Opportunistic locks allows client-side caching while preserving data integrity and consistency, hence the performance of the switched file system is increased.

Abstract: A retractable syringe includes a barrel, a collar mounted to the barrel, a retraction spring and a needle mount. The plunger includes a first plunger member and a second plunger member that are releasably coupled to initially compress the spring. The second plunger member further includes a seal to prevent fluid leakage between plunger and barrel. After depression of the plunger to deliver the syringe fluid contents, the first plunger member engages the needle mount with needle attached thereto and is rotatably uncoupled from the second plunger member to allow decompression of the retraction spring, which forces retraction of the first plunger member, needle mount and needle engaged therewith. The first plunger member and the collar include elements that co-operatively disable subsequent depression or withdrawal of the plunger. Following retraction of the first plunger member, the second plunger member and seal prevent refilling and re-use of the syringe.

Abstract: The present invention relates to a method of preparing a carbon nanotube-quantum dot conjugate having a high density of quantum dots (QDs) on its surface. This method involves providing a plurality of semiconductor quantum dots and providing a thiol-functionalized carbon nanotube having a plurality of terminal thiol groups on its surface. The plurality of semiconductor quantum dots are attached to the surface of the carbon nanotube under conditions effective to yield a carbon nanotube-quantum dot conjugate having a high density of quantum dots on its surface. The present invention also relates to a carbon nanotube-quantum dot conjugate having a high density of quantum dots on its surface. The present invention further relates to a photodetector device. This device includes a substrate and a nanocomposite layer. The nanocomposite layer includes a plurality of the carbon nanotube-quantum dot conjugates previously described.

Abstract: A TIRing condensing array includes a plurality of condensing elements with at least one of the condensing elements having a first section and a second section. The first section provides substantially total internal reflection of light entering at a base of the first section. The second section tapers from the first section towards an optical axis extending through the first and second sections. The first and second sections are configured so a half-power angle of the light output from the second section is less than the half-power angle of the light entering the first section. At least one of the condensing elements is optically and mechanically connected to at least one other of the condensing elements at an attachment area between the condensing elements.

Abstract: The present invention relates to a method of treating an inflammatory disorder in a subject with an effective amount of compound having the general formula (I) as described in the present application, under conditions effective to treat the inflammatory disorder. The present invention also relates to a method of inhibiting respiratory burst in neutrophils without inhibiting degranulation in or bacterial killing by the neutrophils by contacting neutrophils with the compounds described above.

Abstract: The present invention relates to the discovery, identification and characterization of a transient receptor potential channel, referred to herein as TRP8, which is expressed in taste receptor cells and associated with the perception of bitter and sweet taste. The invention encompasses TRP8 nucleotides, host cell expression systems, TRP8 proteins, fusion proteins, polypeptides and peptides, antibodies to the TRP8 protein, transgenic animals that express a TRP8 transgene, and recombinant “knock-out” animals that do not express TRP8. The invention further relates to methods for identifying modulators of the TRP8-mediated taste response and the use of such modulators to either inhibit or promote the perception of bitterness or sweetness. The modulators of TRP8 activity may be used as flavor enhancers in foods, beverages and pharmaceuticals.

Abstract: The present invention relates to the discovery, identification and characterization of a transient receptor potential channel, referred to herein as TRP8, which is expressed in taste receptor cells and associated with the perception of bitter and sweet taste. The invention encompasses TRP8 nucleotides, host cell expression systems, TRP8 proteins, fusion proteins, polypeptides and peptides, antibodies to the TRP8 protein, transgenic animals that express a TRP8 transgene, and recombinant “knock-out” animals that do not express TRP8. The invention further relates to methods for identifying modulators of the TRP8-mediated taste response and the use of such modulators to either inhibit or promote the perception of bitterness or sweetness. The modulators of TRP8 activity may be used as flavor enhancers in foods, beverages and pharmaceuticals.

Abstract: The present invention is a method for detecting DNA sequence differences including single nucleotide mutations or polymorphisms, one or more nucleotide insertions, and one or more nucleotide deletions. Labeled heteroduplex PCR fragments containing base mismatches are prepared. Endonuclease cleaves the heteroduplex PCR fragments both at the position containing the variation (one or more mismatched bases) and to a lesser extent, at non-variant (perfectly matched) positions. Ligation of the cleavage products with a DNA ligase corrects non-variant cleavages and thus substantially reduces background. This is then followed by a detection step in which the reaction products are detected, and the position of the sequence variations are determined.

Abstract: A system for accessing network services includes a plurality of resolvers including a root resolver and a secondary resolver, each resolver arranged to perform actions comprising determining a set of service locations based at least in part on the service and an address associated with a client. the system includes an intermediate device that manipulates scores returned by a set of resolvers of the plurality of resolvers, wherein the root resolver is further arranged to combine sets of the determined service locations and return a combined set of service locations to the client, and wherein at least one resolver of the plurality of resolvers employs an algorithm that is different from an algorithm employed by another resolver of the plurality of resolvers, wherein each algorithm is employed to determine scores of service locations, wherein the combined set of services locations comprises the scores of service locations.