Patents Represented by Attorney, Agent or Law Firm Limbach & Limbach LLP
  • Patent number: 6281191
    Abstract: New compositions and methods for treating patients suffering from hepatitis-C, AIDS, aberrant apoptosis which include N-acetyl-D-glucosaminyl(&bgr;-1-4)-N-Acetyl-muramyl-L-ananyl-D-isoglutamine (GMDP) of at least 98% purity and provided either alone, as an active ingredient of blastolysine, or in combination with an aminosugar such as N-acetyl-glucosamine(NAG). The high purity GMDP has a decreased amount immunogenic impurities and demonstrates cell protection as opposed to solely immunostimulatory effects, while a synergistic cell protective effect is exhibited when GMDP in combined with NAG. The new compositions modulate FasL mediated apoptosis while simultaneously stimulating TNF-&agr; production and further selectively inhibiting TNF-&agr; receptor p55 (TNFR1), providing a treatment for patients suffering from hepatitis-C, AIDS or aberrant apoptosis.
    Type: Grant
    Filed: May 13, 1999
    Date of Patent: August 28, 2001
    Inventors: Vladimir I. Slesarev, Todor Dimitrov
  • Patent number: 6277077
    Abstract: A catheter including an elongated body member, an ultrasound transducer located on the elongated body member, and dampening means for forming an ultrasound dampening region adjacent to a portion of the ultrasound transducer, is disclosed. The ultrasound transducer is configured to transmit or receive an ultrasound signal. The ultrasound dampening region is configured to improve uniformity of said ultrasound signal in three-dimensional space. Preferably, the dampening means includes air or a material containing air.
    Type: Grant
    Filed: November 16, 1998
    Date of Patent: August 21, 2001
    Assignee: Cardiac Pathways Corporation
    Inventors: Axel F. Brisken, N. Parker Willis
  • Patent number: 6269473
    Abstract: A software modeling environment is presented that supports the development and execution of software that can be dynamically configured. This is achieved by introducing a design-time object modeling construct called a dynamically configurable type (DCT) that supports the subdivision of an object into a plurality of subsets of semantics and allows dynamic merging of these semantic subsets together in different combinations in order to allow the resultant object to exhibit different semantics over time to serve different purposes. Specific process modeling constructs are included which take advantage of this semantic merging capability. Also included are other supporting design-time and run-time constructs and services. One embodiment of the present invention allows this software modeling environment to be integrated into a standard software development environment, enhancing the modeling capabilities already present.
    Type: Grant
    Filed: March 23, 1998
    Date of Patent: July 31, 2001
    Assignee: Evolve Software, Inc.
    Inventors: Erik Freed, Brian Anderson, Thomas James Noyes, Richard John Saville
  • Patent number: 6254617
    Abstract: An anastomosis is performed using a mounting structure mounted on the outside of at least one vessel. The mounting structure includes a flexible mounting structure that is attached to the vessel by a special instrument. A graft vessel is attached to the mounting structure either directly or by means of another mounting structure attached to the graft vessel. Tools for attaching a mounting structure to a vessel are disclosed, and a tool for attaching two mounting structures together is also disclosed. Methods for carrying out the anastomosis according to the invention are also disclosed.
    Type: Grant
    Filed: November 27, 1998
    Date of Patent: July 3, 2001
    Assignee: Origin Medsystems, Inc.
    Inventors: Paul A. Spence, Warren P. Williamson, IV, George Christakis
  • Patent number: 6245319
    Abstract: Agents for enhancing the contrast in a diagnostic ultrasound procedure comprise colloidal dispersions of the liquid-in-liquid type, i.e., emulsions or microemulsions, in which the dispersed liquid phase is a liquid having a boiling point below the temperature of the animal to be imaged and which therefore undergoes a phase change from a dispersed liquid to a highly echogenic dispersed gaseous foam or kugelschaum following administration to the animal. The liquid state of the dispersed phase allows one to manufacture extremely stable, pharmaceutically acceptable emulsions with particle sizes typically below 1000 nm. The gaseous state at body temperature yields highly echogenic microbubbles, typically below 10,000 nm in diameter, which are effective as ultrasound contrast agents. Intravenous, intraarterial, oral, intraperitoneal, and intrauterine dosage forms, methods of administration, and imaging techniques are described.
    Type: Grant
    Filed: March 24, 2000
    Date of Patent: June 12, 2001
    Assignee: Sonus Pharmaceuticals, Inc.
    Inventor: Steven C. Quay
  • Patent number: 6241742
    Abstract: An anastomosis is performed using a mounting structure mounted on the outside of at least one vessel. The mounting structure includes a flexible mounting structure that is attached to the vessel by a special instrument. A graft vessel is attached to the mounting structure either directly or by means of another mounting structure attached to the graft vessel. Tools for attaching a mounting structure to a vessel are disclosed, and a tool for attaching two mounting structures together is also disclosed. Methods for carrying out the anastomosis according to the invention are also disclosed.
    Type: Grant
    Filed: December 24, 1998
    Date of Patent: June 5, 2001
    Assignee: Origin Medsystems, Inc.
    Inventors: Paul A. Spence, Warren P. Williamson, IV, George Christakis
  • Patent number: 6236236
    Abstract: An apparatus and method of communicating signals between a 2.5 volt internal circuit and both 3.3 and 5 volt external circuits using a P-well. The apparatus includes a circuit having a P-well control circuit and a number of NMOS transistors. The P-well control circuit is configured to receive a P-well control signal and an external signal, and in accordance therewith selectively generate a P-well voltage. The NMOS transistors are coupled to the P-well control circuit. At least one of the NMOS transistors has a bulk region configured to receive the P-well voltage. The NMOS transistors are further configured to receive a 5 volt signal and in accordance therewith selectively generate a 2.5 volt signal. The NMOS transistors are still further configured to receive a 3.3 volt signal and in accordance therewith selectively generate a 2.5 volt signal.
    Type: Grant
    Filed: June 2, 1999
    Date of Patent: May 22, 2001
    Assignee: National Semiconductor Corporation
    Inventor: Deng-Yuan David Chen
  • Patent number: 6231543
    Abstract: A dilation catheter having a catheter shaft with an inner lumen for receiving a guidewire and an inflatable balloon member located at the distal portion of the shaft in fluid communication with the inner lumen. The catheter includes a distal seal disposed within the inner lumen of the shaft. The distal seal allows for movement of the guidewire relative to the inner lumen, while also providing for a fluid tight seal around the guidewire, independent of fluid pressure within the lumen, thereby both restricting a patient's blood from passing into the inner lumen and restricting media from the inner lumen from passing into the patient's bloodstream. A valve is located along the catheter shaft and adapted to engage the guidewire and provide for a fluid tight seal around the guidewire when fluid under pressure is applied to the interior of the balloon member.
    Type: Grant
    Filed: April 15, 1999
    Date of Patent: May 15, 2001
    Assignee: Intella Interventional Systems, Inc.
    Inventors: Anant V. Hegde, Arlene L. Errazo
  • Patent number: 6228104
    Abstract: A surgical clamp having an elongate cavity to receive a replaceable pad. The pad includes a draw cord to draw the pad into place on the jaw. The pad is formed with an attachment member engagable in the elongate cavity of the jaw. The draw cord is preferably an extension of the attachment member.
    Type: Grant
    Filed: June 18, 1999
    Date of Patent: May 8, 2001
    Assignee: Novare Surgical Systems, Inc.
    Inventors: Thomas J. Fogarty, Thomas A. Howell, David Willis
  • Patent number: 6222383
    Abstract: A programmable logic array (PLA) AND plane receives data input signals from input registers and generates corresponding minterms. The minterms are OR-ed together to form a sum of products, which are provided to output latches and clocked out before the end of each clock cycle by an internal self-timed signal as PLA output data. The OR plane (or the AND plane, or both) includes NOR gates that include a plurality of NMOS transistors. Each NMOS transistor in a gate has its drain connected to a common NOR gate output node, its source connected to ground and its gate connected to receive a corresponding minterm from the AND plane.
    Type: Grant
    Filed: December 26, 1996
    Date of Patent: April 24, 2001
    Assignee: Micro Magic, INc.
    Inventors: David Minoru Murata, Mark Ronald Santoro, Lee Stuart Tavrow
  • Patent number: 6215750
    Abstract: A data recording apparatus is constructed by: an input unit for receiving first and second digital data in which a ratio of sector sizes is not equal to an integer ratio; a block segmenting unit for inserting first data nA and second data mB (n and m are integers of 2 or more and n≠m) when it is assumed that a sector size of first data is set to A and a sector size of second data is set to B and for forming data of a block structure; a recording processing unit for performing an error correction encoding and a digital modulation to the data of the block structure; and a recording unit for recording the recording data from the recording processing unit to a data recording medium.
    Type: Grant
    Filed: February 9, 1998
    Date of Patent: April 10, 2001
    Assignee: Sony Corporation
    Inventors: Yoichiro Sako, Tamotsu Yamagami
  • Patent number: 6214022
    Abstract: A plurality of embodiments of a distal perfusion device are disclosed, which device facilitates anastomosis constructions by maintaining a dry anastomosis site while simultaneously maintaining blood flow distally in the blood vessel to prevent ischemia and reduce overall patient trauma. The perfusion device is configured for installation into a blood vessel such as a left anterior descending coronary artery through an incision therein, to which is to be grafted a distal end of a blood vessel such as an internal mammary artery. The device includes a central member of selected configuration and material, terminating at either end thereof in respective selectively tapered end members. A lumen extending through the central member and end members, and selected perforations in the end members, maintain blood flow through the perfusion device.
    Type: Grant
    Filed: April 28, 1999
    Date of Patent: April 10, 2001
    Assignee: Cardiothoracic Systems, Inc.
    Inventors: Charles S. Taylor, Alfredo R. Cantu, Son M. Gia, Jeff A. Krolic, Robert G. Matheny, Amr Salahieh, Ivan Sepetka
  • Patent number: 6206561
    Abstract: A collapsible wire whisk including a handle and wire basket. The wire basket comprises a plurality of wires that are coupled to a wire holder slidably and twistably mounted within the handle. The handle is hollow and has a proximal end with two arcuate apertures through which the wires may be inserted. The wire holder is a hollow cylinder that has a plurality of holes circumferentially positioned on each end. Each end of each wire of the wire basket is threaded through one of the holes on each end of the wire holder. The wires are crimped both above and below the wire holder to keep the wire basket coupled to the wire holder, but the wires remain free to be twisted.
    Type: Grant
    Filed: March 8, 1999
    Date of Patent: March 27, 2001
    Assignee: Kuhn Rikon Corporation
    Inventor: Rolf Hefti
  • Patent number: 6208381
    Abstract: A convertible connector arrangement for a video camera includes first and second connector portions. One of the connectors is configured for analog signals and the other for digital signals. The first and second connectors are joined along one side thereof to be pivotally mounted by a mounting member in an installation body, or frame. The mounting member and the joined connectors are configured such that the two connectors are disposed at a predetermined angle in relation to one another. According to pivotal movement of the mounting member, one of the two connectors may be operably disposed in an opening provided in the installation body. The other connection is thus inoperably stored within the video camera or VTR body. A locking mechanism is further provided to assure secure mounting and operability. A video camera utilizing the convertible connector arrangement may thus be selectably converted for analog or digital operation in a secure and efficient manner.
    Type: Grant
    Filed: April 2, 1997
    Date of Patent: March 27, 2001
    Assignee: Sony Corporation
    Inventors: Takahiro Fukutani, Hiroyoshi Hamashima
  • Patent number: 6208878
    Abstract: A radio communication apparatus is disclosed, that comprises a receiving portion for receiving a radio signal transmitted from a base station, the radio signal including character codes, a display portion for displaying a character string corresponding to character codes received by the receiving portion on a plurality of lines, a detecting portion for detecting a particular character from the character string displayed on the display portion, and a display controlling portion for displaying a word just after the particular character at the beginning of the next line. According to the present radio communication apparatus , a word in a message composed of a character string is prevented from being displayed in a plurality of lines. Thus, a character string is displayed on the screen of the display portion in such a manner that the user can easily read the character string.
    Type: Grant
    Filed: July 22, 1998
    Date of Patent: March 27, 2001
    Assignee: Kabushiki Kaisha Toshiba
    Inventors: Kiyoshi Hattori, Munehisa Tomioka
  • Patent number: 6202304
    Abstract: A movable sheet overlying a wing is disclosed that creates laminar flow over its exposed surface. The movable sheet serves as an integral, retractable shield for protecting a suction support structure of a wing against contamination, and also serves as a movable, conductive substrate for deicing by means of electrical resistance or hot-gas heating. The invention includes a movable sheet that is mounted scroll-like on two motor-driven rollers. The sheet has a solid area without perforations that protects the suction support structure from contamination, and a porous area with perforations therethrough that allows boundary layer suction. The motor-driven rollers scroll the sheet to cover the suction support structure with either the solid area or the perforations of the sheet. Contact rollers at the edge of the sheet supply electrical current to resistively heat the sheet and melt any accumulated ice. The movable sheet can also be moved back and forth to dislodge the ice.
    Type: Grant
    Filed: January 7, 1997
    Date of Patent: March 20, 2001
    Inventor: Solomon Shatz
  • Patent number: 6202849
    Abstract: An evacuatable storage unit that includes a substantially rigid container having an open upper end, a flexible air tight liner attached to the inside of the container, and a port installed in a surface of the liner that allows air to pass out of the liner and prevents air from entering the liner. The liner has an upper portion that extends out beyond the open upper end of the container. The liner upper portion terminates in an opening for inserting compressible articles into the liner. The opening is closable to form an air tight seal. As air inside the liner is evacuated from the liner through the port (typically by using a household vacuum cleaner), the liner upper portion and compressible articles stored therein collapse into the container.
    Type: Grant
    Filed: July 7, 1999
    Date of Patent: March 20, 2001
    Inventor: David B. Graham
  • Patent number: 6205501
    Abstract: A method and apparatus for performing a control transfer on a Universal Serial Bus (USB) device. A USB device includes a memory space for reading and writing data transmitted over a USB network. The memory space is shared between a plurality of endpoints. A host initiates a control transfer by transmitting a SETUP token to a first endpoint. The endpoint must accept the SETUP token. If the first endpoint does not expect the SETUP token, or if another endpoint is active, the device stores the token until a buffer is allocated and the first endpoint is made active.
    Type: Grant
    Filed: January 7, 1998
    Date of Patent: March 20, 2001
    Assignee: National Semiconductor Corp.
    Inventors: David Brief, David J. Fensore, Kent Bruce Waterson, Gregory Lewis Dean
  • Patent number: 6200900
    Abstract: Capacitance between interconnects lines of a semiconductor device is reduced by providing air voids between the interconnects. The air voids are produced by depositing a dielectric over and partially between the pairs of interconnects and the substrate between them, and etching (preferably by sputter etch) in a controlled and coordinated manner so as to produce air voids in the dielectric between the interconnects. The tops of the air voids are below the level to which the uppermost surfaces of the interconnect is then exposed during subsequent processing so that the air voids remain intact during such subsequent processing.
    Type: Grant
    Filed: October 8, 1999
    Date of Patent: March 13, 2001
    Assignee: National Semiconductor Corporation
    Inventor: Vassili Victor Kitch
  • Patent number: 6197671
    Abstract: Disclosed is a MOS transistor having a polysilicon gate structure in which an overlying metal interconnect completely shorts the gate area. In one embodiment, the gate is formed from multiple fingers joined in a serpentine pattern and separated by oxide-filled spaces. Overlying the fingers and oxide-filled spaces is an interconnect comprising a first metal layer and a second metal layer. The first metal layer overlies the fingers and oxide-filled spaces and the second metal layer overlies the first metal layer. Both metal layers form a stack that simultaneously shorts the fingers. Also disclosed is a method of fabricating such a polysilicon gate structure in a MOS transistor using a series of masks. Once the gate and fingers are defined, a conformal oxide is deposited over the fingers and in the spaces between the fingers. The conformal oxide is anisotropically etched to produce a planarized profile of the fingers and oxide-filled spaces.
    Type: Grant
    Filed: August 12, 1998
    Date of Patent: March 6, 2001
    Assignee: National Semiconductor Corporation
    Inventor: Albert Bergemont