Patents Represented by Attorney Linda E. Hall

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  • Hemoregulatory compounds
    Patent number: 6114357
    Abstract: Novel compounds of general formula (1), which have hemoregulatory activities and can be used to stimulate haematopoiesis and for the treatment of viral, fungal and bacterial infectious diseases.
    Type: Grant
    Filed: February 9, 1999
    Date of Patent: September 5, 2000
    Assignees: SmithKline Beecham Corporation, Nycomed Austria GmbH
    Inventors: Pradip Kumar Bhatnagar, Dirk Andries Heerding, Michael Hartmann, Johann Hiebl, Peter Kremminger, Franz Rovenszky
  • Endothelin receptor antagonists
    Patent number: 6114359
    Abstract: Novel pyrroles, pyrazoles and triazoles, pharmaceutical compositions containing these compounds and their use as endothelin receptor agonists are described.
    Type: Grant
    Filed: December 6, 1999
    Date of Patent: September 5, 2000
    Assignee: SmithKline Beecham Corporation
    Inventor: John Duncan Elliott
  • Substituted benzamide derivatives and their use as anticonvulsants
    Patent number: 6110934
    Abstract: This invention relates to substituted benzamido-heterocyclic compounds of general formula (I) having an alkoxy substituent at the C2 position of the benzamido group and various substituents at positions C4 and C5, being optionally substituted on the N atom of the heterocyclic system, and where the unsaturated ring of the heterocyclic system is a 5,6, 7 or 8-membered ring. Also to the use of these compounds as anticonvulsants in certain medical conditions, and to processes for making them.
    Type: Grant
    Filed: December 16, 1998
    Date of Patent: August 29, 2000
    Assignee: SmithKline Beecham p.l.c.
    Inventors: John David Harling, Barry Sidney Orlek, Mervyn Thompson
  • Hemoregulatory compounds
    Patent number: 6107309
    Abstract: The present invention relates to novel compounds which have hemoregulatory activities and can be used to stimulate hematopoiesis and for the treatment of viral, fungal and bacterial infectious diseases.
    Type: Grant
    Filed: December 4, 1998
    Date of Patent: August 22, 2000
    Assignees: SmithKline Beecham Corporation, Nycomed Austria GmbH
    Inventors: Pradip Kumar Bhatnagar, Dirk Andries Heerding, James Francis Callahan, Johann Hiebl, Michael Hartmann, Peter Kremminger, Franz Rovenszky
  • Endothelin receptor antagonists
    Patent number: 6096897
    Abstract: Novel pyrroles, pyrazoles and triazoles, pharmaceutical compositions containing these compounds and their use as endothelin receptor antagonists are described.
    Type: Grant
    Filed: June 29, 1999
    Date of Patent: August 1, 2000
    Assignee: SmithKline Beecham Corporation
    Inventors: Juan Ignacio Luengo, John Duncan Elliott
  • Endothelin receptor antagonists
    Patent number: 6087389
    Abstract: Novel indane and indene derivatives are described which are endothelin receptor antagonists.
    Type: Grant
    Filed: June 18, 1998
    Date of Patent: July 11, 2000
    Assignee: SmithKline Beecham Corporation
    Inventors: Russell Donovan Cousins, John Duncan Elliott, Maria Amparo Lago, Jack Dale Leber, Catherine Elizabeth Peishoff
  • Truncated gro and KC chemokines having enhanced bioactivity
    Patent number: 6080398
    Abstract: The present invention provides method of increasing the biological activity of KC, gro-.alpha., gro-.beta., and gro-.gamma. proteins, truncated and modified proteins characterized by having biological activity at least 1 log better than the full-length protein, and pharmaceutical compositions containing same.
    Type: Grant
    Filed: March 5, 1996
    Date of Patent: June 27, 2000
    Assignee: SmithKline Beecham Corporation
    Inventors: Louis Martin Pelus, Pradip Kumar Bhatnagar, Andrew Garrison King, Joanna Maria Balcarek
  • Stereoselective synthesis of endothelin receptor antagonists
    Patent number: 6080862
    Abstract: The present invention is directed to a synthetic route for preparing endothelium receptor antagonists of formulae (7B) and (7A) and to the chiral intermediates ##STR1##
    Type: Grant
    Filed: May 8, 1998
    Date of Patent: June 27, 2000
    Assignee: SmithKline Beecham Corporation
    Inventors: Robert John Mills, Conrad John Kowalski, Li-Jeng Ping, Kerry Joseph Gombatz
  • Hemoregulatory compounds
    Patent number: 6077857
    Abstract: The present invention relates to novel compounds which have hemoregulatory activities and can be used to stimulate hematopoiesis and for the treatment of viral, fungal and bacterial infectious diseases.
    Type: Grant
    Filed: May 12, 1998
    Date of Patent: June 20, 2000
    Assignee: SmithKline Beecham Corporation
    Inventors: Pradip Kumar Bhatnagar, Dirk Andries Heerding
  • Hemoregulatory compounds
    Patent number: 6077855
    Abstract: Novel compounds of the general formula (I) which have hemoregulatory activities and can be used to stimulate haematopoiesis and for the treatment of viral, fungal and bacterial infectious diseases.
    Type: Grant
    Filed: December 4, 1998
    Date of Patent: June 20, 2000
    Assignees: SmithKline Beecham Corporation, Nycomed Austria GmbH
    Inventors: Pradip Kumar Bhatnagar, Michael Hartmann, Johann Hiebl, Peter Kremminger, Franz Rovenszky
  • Hemoregulatory compounds
    Patent number: 6077856
    Abstract: Novel compounds of the general formula (I) which have hemoregulatory activities and can be used to stimulate haematopoiesis and for the treatment of viral, fungal and bacterial infectious diseases ##STR1##
    Type: Grant
    Filed: December 14, 1998
    Date of Patent: June 20, 2000
    Assignees: SmithKline Beecham Corporation, Nycomed Austria GmbH
    Inventors: Pradip Kumar Bhatnagar, Dirk Andries Heerding, Michael Hartmann, Johann Hiebl, Peter Kremminger, Franz Rovenszky
  • Endothelin receptor antagonists
    Patent number: 6075037
    Abstract: Pyrrolo[2,3-b]pyridine derivatives are described which are endothelin receptor antagonists.
    Type: Grant
    Filed: November 25, 1996
    Date of Patent: June 13, 2000
    Assignee: SmithKline Beecham Corporation
    Inventors: John Duncan Elliott, Jack Dale Leber
  • Hemoregulatory compounds
    Patent number: 6054465
    Abstract: The present invention relates to novel compounds of the Formula I which have hemoregulatory activities and can be used to stimulate hematopoiesis and for the treatment of viral fungal and bacterial infectious diseases.
    Type: Grant
    Filed: May 12, 1998
    Date of Patent: April 25, 2000
    Assignee: SmithKline Beecham Corporation
    Inventors: Pradip Kumar Bhatnagar, Dirk Andries Heerding
  • Endothelin receptor antagonists
    Patent number: 6051599
    Abstract: Novel furans and thiophenes, pharmaceutical compositions containing these compounds and their use as endothelin receptor antagonist are described.
    Type: Grant
    Filed: September 20, 1999
    Date of Patent: April 18, 2000
    Assignee: SmithKline Beecham Corporation
    Inventors: John Duncan Elliott, Aiming Gao
  • Hemoregulatory compounds
    Patent number: 6051584
    Abstract: Novel compounds of the general formula (I) which have hemoregulatory activities and can be used to stimulate haematopolesis and for the treatment of viral, fungal and bacterial infectious diseases ##STR1##
    Type: Grant
    Filed: November 23, 1998
    Date of Patent: April 18, 2000
    Assignees: SmithKline Beecham Corporation, Nycomed Austria GmbH
    Inventors: Pradip Kumar Bhatnagar, Michael Hartmann, Johann Hiebl, Peter Kremminger, Franz Rovenszky
  • Hemoregulatory compounds
    Patent number: 6046197
    Abstract: The present invention relates to novel compounds which have hemoregulatory activities and can be used to stimulate hematopoiesis and for the treatment of viral, fungal and bacterial infectious diseases.
    Type: Grant
    Filed: November 23, 1998
    Date of Patent: April 4, 2000
    Assignee: Smithkline Beecham Corporation
    Inventors: Pradip Kumar Bhatnagar, Dirk Andries Heerding, Stephen M. LoCastro
  • Hemoregulatory compounds
    Patent number: 6046198
    Abstract: The present invention relates to novel compounds which have hemoregulatory activities and can be used to stimulate hematopoiesis and for the treatment of viral, fungal and bacterial infectious diseases.
    Type: Grant
    Filed: November 13, 1998
    Date of Patent: April 4, 2000
    Assignee: SmithKline Beecham Corporation
    Inventors: Pradip Kumar Bhatnagar, Dirk Andries Heerding
  • Method of treating sepsis with chemokines
    Patent number: 6042821
    Abstract: The invention relates to the method of preventing and treating sepsis using chemokines selected from mature or modified KC [SEQ ID NO: 1], gro.alpha. [SEQ ID NO:2], gro.beta. [SEQ ID NO: 3] or gro.gamma. [SEQ ID NO: 4] or multimers thereof, alone or in conjunction with an anti-infective agent. This invention also relates to a new gro.beta. dimer chemokine.
    Type: Grant
    Filed: April 29, 1997
    Date of Patent: March 28, 2000
    Assignee: Smithkline Beecham Corporation
    Inventors: Peter Lawrence DeMarsh, Kyung Oh Johanson
  • Hemoregulatory compounds
    Patent number: 6030989
    Abstract: Novel compounds of general formula (I) which have hemoregulatory activities and can be used to stimulate haematopoiesis and for the treatment of viral, fungal and bacterial infectious diseases.
    Type: Grant
    Filed: November 23, 1998
    Date of Patent: February 29, 2000
    Assignee: SmithKline Beecham Corporation
    Inventors: Pradip Kumar Bhatnagar, Michael Hartmann, Johann Hiebl, Peter Kremminger, Franz Rovenszky
  • Endothelin receptor antagonists
    Patent number: 6030970
    Abstract: Novel to isooxazoles, oxazoles, thiazoles, isothiazoles and imidazoles, pharmaceutical compositions containing these compounds and their use as endothelin receptor antagonists are described.
    Type: Grant
    Filed: February 2, 1998
    Date of Patent: February 29, 2000
    Assignee: Smithkline Beecham Corporation
    Inventors: John Duncan Elliott, Juan Ignacio Luengo, Jia-Ning Xiang