Patents Represented by Attorney Linda E. Hall

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  • Endothelin receptor antagonists
    Patent number: 6022886
    Abstract: Novel pyrroles, pyrazoles and triazoles, pharmaceutical compositions containing these compounds and their use as endothelin receptor antagonists are described.
    Type: Grant
    Filed: July 31, 1998
    Date of Patent: February 8, 2000
    Assignee: SmithKline Beecham Corporation
    Inventor: John Duncan Elliott
  • Endothelin receptor antagonists
    Patent number: 6020348
    Abstract: Novel pyridines, pyrimidines, pyrazines, pyridazines and triazines, pharmaceutical compositions containing these compounds and their use as endothelin receptor antagonists are described.
    Type: Grant
    Filed: July 31, 1998
    Date of Patent: February 1, 2000
    Assignee: SmithKline Beecham Corporation
    Inventor: John Duncan Elliott
  • Endothelin receptor antagonists
    Patent number: 6017952
    Abstract: This invention relates to derivatives of furan and thiophene, their composition, process of making and method of use as endothelin receptor antagonists.
    Type: Grant
    Filed: February 2, 1998
    Date of Patent: January 25, 2000
    Assignee: SmithKline Beecham Corporation
    Inventors: John Duncan Elliott, Aiming Gao, Jia-Ning Xiang
  • Indole derivatives as 5-HT receptor antagonist
    Patent number: 5990133
    Abstract: A compound of formula (I) or a salt thereof: ##STR1## wherein: P.sup.1 is pyridyl;P.sup.2 is phenyl;A is a bond or a chain of 1 to 5 atoms optionally substituted by C.sub.1-6 alkyl;R.sup.1 and R.sup.2 groups are each independently hydrogen, C.sub.1-6 alkyl optionally substituted by NR.sup.12 R.sup.13, C.sub.2-6 alkenyl, C.sub.2-6 alkynyl, cyano, halogen, CF.sub.3, NR.sup.12 R.sup.13, CHO, OCF.sub.3, COR.sup.14, CH.sub.2 OR.sup.14 or OR.sup.14 where R.sup.12, R.sup.13 and R.sup.14 are independently hydrogen or C.sub.1-6 alkyl;n and m are independently 0, 1 or 2;R.sup.3 is hydrogen or C.sub.1-6 alkyl;R.sup.4 is a group of formula (i): ##STR2## in which: R.sup.6 and R.sup.7 are independently hydrogen, C.sub.1-6 alkyl optionally substituted by one or more fluorine atoms, C.sub.1-6 alkylthio, C.sub.1-6 alkoxy or halogen.
    Type: Grant
    Filed: October 16, 1997
    Date of Patent: November 23, 1999
    Assignee: SmithKline Beecham p.l.c.
    Inventors: Laramie Mary Gaster, Paul Adrian Wyman, Keith Raymond Mulholland, David Thomas Davies, David Malcolm Duckworth, Ian Thomson Forbes, Graham Elgin Jones
  • Endothelin receptor antagonists
    Patent number: 5985886
    Abstract: Novel indane and indene derivatives are described which are endothelin receptor antagonists.
    Type: Grant
    Filed: June 16, 1998
    Date of Patent: November 16, 1999
    Assignee: SmithKline Beecham Corporation
    Inventors: John Duncan Elliott, Deborah Lynne Bryan
  • Heterocyclic compounds possessing 5HT.sub.2C receptor antagonist activity
    Patent number: 5972937
    Abstract: The invention relates to heterocyclic families of compounds having pharmacological activity, in particular possessing 5HT.sub.2C receptor antagonist activity processes for their preparation, to compositions containing them and to their use in the treatment of CNS disorders.
    Type: Grant
    Filed: September 16, 1997
    Date of Patent: October 26, 1999
    Assignee: SmithKline Beecham p.l.c.
    Inventors: Laramie Mary Gaster, Paul Adrian Wyman, Keith Raymond Mulholland, David Thomas Davies
  • Endothelin receptor antagonists
    Patent number: 5968971
    Abstract: Novel furans and thiophenes, pharmaceutical compositions containing these compounds and their use as endothelin receptor antagonists are described.
    Type: Grant
    Filed: July 31, 1998
    Date of Patent: October 19, 1999
    Assignee: SmithKline Beecham Corporation
    Inventor: John Duncan Elliott
  • Endothelin receptor antagonists
    Patent number: 5969151
    Abstract: This is a continuation of application Ser. No. 08/718,562, filed Sep. 30, 1996, which is a 371 of International Application No. PCT/US96/12581, filed Aug. 2, 1996; which claims the benefit of priority from the following provisional applications: 60/001,792, filed Aug. 2 1995 and 60/010,982, filed Feb. 1, 1996.
    Type: Grant
    Filed: July 23, 1998
    Date of Patent: October 19, 1999
    Assignee: SmithKline Beecham Corporation
    Inventors: Juan Ignacio Luengo, John Duncan Elliott
  • Endothelin receptor antagonists
    Patent number: 5958968
    Abstract: Novel pyrroles, pyrazoles and triazoles, pharmaceutical compositions containing these compounds and their use as endothelin receptor antagonists are described.
    Type: Grant
    Filed: January 8, 1999
    Date of Patent: September 28, 1999
    Assignee: SmithKline Beecham Corporation
    Inventors: Juan Ignacio Luengo, John Duncan Elliott
  • Endothelin receptor antagonists
    Patent number: 5942516
    Abstract: Novel pyridines, pyrimidines, pyrazines, pyridazines and triazines, pharmaceutical compositions containing these compounds and their use as endothelin receptor antagonists are described.
    Type: Grant
    Filed: September 27, 1996
    Date of Patent: August 24, 1999
    Inventors: John Duncan Elliott, Deborah Lynne Bryan
  • Carbonyl compounds
    Patent number: 5932771
    Abstract: Carbonyl compounds corresponding to formulae (1a) and (1b) ##STR1##
    Type: Grant
    Filed: May 8, 1998
    Date of Patent: August 3, 1999
    Assignee: SmithKline Beecham Corporation
    Inventors: Thomas Markert, Ulf-Armin Schaper, Volker Porrmann, Werner Faber, Theo ten Pierik
  • Cyclopentene derivatives as endothelin receptor antagonists
    Patent number: 5929116
    Abstract: Novel cyclopentane derivatives are described which are endothelin receptor antagonists.
    Type: Grant
    Filed: October 13, 1995
    Date of Patent: July 27, 1999
    Assignee: SmithKline Beecham Corporation
    Inventors: John Duncan Elliott, Deborah Lynne Bryan
  • Endothelin receptor antagonists
    Patent number: 5929106
    Abstract: Dihydroisoindole compounds of formula (I), wherein the substituents are as defined herein, are disclosed as being useful as endothelin receptor antagonists. The compounds are applied in the treatment of cardiovascular and renal diseases.
    Type: Grant
    Filed: October 27, 1997
    Date of Patent: July 27, 1999
    Assignee: SmithKline Beecham Corporation
    Inventors: John Duncan Elliott, Robert Gene Franz, M. Amparo Lago, Aiming Gao
  • Pyridil carboxamides as 5HT2B/2C receptor antagonists
    Patent number: 5922733
    Abstract: Novel heterocyclic compounds having pharmacological activity, processes for their preparation, to compositions containing them and to their use in the treatment of CNS disorders are disclosed.
    Type: Grant
    Filed: June 30, 1997
    Date of Patent: July 13, 1999
    Assignee: SmithKline Beecham p.l.c.
    Inventors: Ian Thomson Forbes, Graham Elgin Jones, Francis David King, Peter Ham, David Thomas Davies, Angela Moghe
  • Use of ?R-(Z)!-.alpha.-(methoxyimino)-.alpha.-(1-azabicyclo ?2.2.2.!oct-3-yl)acetonitrile to reduce amyloid .beta.A4 formation in alzheimer's disease
    Patent number: 5891887
    Abstract: A method of enhancing amyloid precursor protein processing along a non-amyloidogenic pathway in patients suffering from, or at risk of developing, Alzheimer's disease and a method of treatment or prophylaxis of Alzheimer's disease by reducing .beta.A4 production in patients suffering from, or at risk of developing, Alzheimer's disease comprising administering to the patient an effective, non-toxic amount of an acetonitrile compound, use of the compound in preparation of a medicament for use in the method and a composition for use in the method.
    Type: Grant
    Filed: April 25, 1997
    Date of Patent: April 6, 1999
    Inventors: Roger Edward Markwell, Julie Hawkins, Carol Wendy Gray
  • Benzo- and pyridopyran derivatives having anxiolytic and anti-convulsant activity
    Patent number: 5889044
    Abstract: Benzopyran-3-ols having anxiolytic and anticonvulsant activity are claimed.
    Type: Grant
    Filed: May 31, 1995
    Date of Patent: March 30, 1999
    Assignee: SmithKline Beecham p.l.c.
    Inventors: John Morris Evans, Mervyn Thompson, Neil Upton
  • CNS-active pyridinylurea derivatives
    Patent number: 5866586
    Abstract: The invention relates to heterocyclic compounds of formula (I) having pharmacological activity, processes for their preparation, to compositions containing them and to their use in the treatment of CNS disorders, wherein P represents phenyl, a quinoline or isoquinoline residue, or a 5 -membered or 6 -membered aromatic heterocyclic ring containing up to three heteroatoms selected from nitrogen, oxygen or sulphur; R.sup.3 is a group of formula (i) or (ii).
    Type: Grant
    Filed: April 17, 1997
    Date of Patent: February 2, 1999
    Assignee: SmithKline Beecham p.l.c.
    Inventors: Ian Thomson Forbes, Graham Elgin Jones
  • Endothelin receptor antagonists
    Patent number: 5834469
    Abstract: The invention concerns compounds of the following formulae: ##STR1## wherein the variables are defined in the specification. The compounds are useful as endothelin receptor antagonists.
    Type: Grant
    Filed: June 7, 1995
    Date of Patent: November 10, 1998
    Assignee: SmithKline Beecham Corporation
    Inventors: John Duncan Elliott, Jack Dale Leber
  • Hemoregulatory peptides for stimulating the myelopoietic system
    Patent number: 5830867
    Abstract: The invention provides compounds of the general formula (I):A.sup.1 --B.sup.1 --X.sup.1 --(CH.sub.2).sub.m --(CON(R.sub.1)).sub.r --(CH.sub.2).sub.s --Y.sup.1 --(CH.sub.2).sub.s --(N(R.sub.1)CO).sub.r --(CH.sub.2).sub.n --X.sup.1 --B.sup.1 --A.sup.1The compounds of this invention are also illustrated by the Formula (II):A.sup.2 --B.sup.2 --X.sup.2 --(CH.sub.2).sub.m --(N(R.sub.1)CO).sub.r --(CH.sub.2).sub.s --Y.sup.2 --(CH.sub.2).sub.s --(CON(R.sub.1)).sub.r --(CH.sub.2).sub.n --X.sup.2 --B.sup.2 --A.sup.2The compounds have hemoregulatory activities and can be used to stimulate haematopoiesis and for the prevention and treatment of viral, fungal and bacterial infectious diseases.
    Type: Grant
    Filed: January 30, 1996
    Date of Patent: November 3, 1998
    Assignees: SmithKline Beecham Corporation, Nycomed Pharma AS
    Inventors: Pradip Kumar Bhatnagar, Dirk Heerding, Peter Martin Fischer
  • Endothelin receptor antagonists
    Patent number: 5817653
    Abstract: Novel compounds of the formula: ##STR1## are disicosed which are endothelin receptor antagonists.
    Type: Grant
    Filed: April 12, 1996
    Date of Patent: October 6, 1998
    Assignee: SmithKline Beecham Corporation
    Inventors: John Duncan Elliott, John Gerald Gleason, David Taylor Hill