Patents Represented by Attorney, Agent or Law Firm Linda M Buckley
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Patent number: 5075100Abstract: Disclosed is an iron colloid-labeled antibody wherein an iron colloid is bound to IgG or an antigen binding fragment thereof without a loss of antibody specificity. An iron colloid stabilized with cacodylic acid or the salt thereof (ferric cacodylate colloid) is preferable.This iron colloid-labeled antibody is prepared by mixing the iron colloid stabilized with cacodylic acid or the salt thereof with IgG or the antigen binding fragment thereof at a pH of about 7.4 to 7.5.The iron colloid-labeled antibody is used for the histochemical detection of specific constituents of cells or tissued under both a light microscope and an electron microscope, which gives distinct stained figures in each case.Type: GrantFiled: September 9, 1988Date of Patent: December 24, 1991Assignee: Wako Pure Chemical Industries, Ltd.Inventor: Satimaru Seno
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Patent number: 5035919Abstract: Disclosed herein are a refractory repairing material for repairing a brick comprising a mixture of 70 to 80 wt % of alumina having not more than 1 mm of grain size, which comprises 25 to 30 wt % of the above amount with a grain size not passing through a 325 mesh and 45 to 50 wt % of the above amount with a grain size passing through a 325 mesh; 1 to 7 wt % of carbonaceous material having a grain size passing through a 60 mesh; 1 to 5 wt % of magnesia having a grain size passing through a 325 mesh; and 10 to 25 wt % of aluminum phosphate, and a method of repairing a plate-like brick.Type: GrantFiled: August 30, 1990Date of Patent: July 30, 1991Assignees: Toshiba Ceramics Co., Ltd., Sumitomo Metal Indus., Ltd.Inventors: Takao Sugino, Toshio Kawamura, Masamichi Asai, Hiroshi Yamada, Kenichi Mukoyama, Akira Takahashi, Hiroshi Hikima
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Patent number: 4994235Abstract: Disclosed herein is a wear-resistance aluminum bronze alloy comprising 4 to 15 wt % of Al, 0.1 to 10 wt % of Cr and the balance Cu, and optionally containing not more than 6 wt % of Ni and not more than 15 wt % of Mn.Type: GrantFiled: November 3, 1989Date of Patent: February 19, 1991Assignee: Oiles CorporationInventors: Takehiro Shirosaki, Takashi Kikkawa, Hirotaka Toshima
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Patent number: 4983520Abstract: A modified protein (i) derived from a hepatitis B virus surface antigen P31 protein and (ii) having hepatitis B virus surface antigen activity and the ability to bind polymerized human serum albumin, wherein the modification comprises rendering at least one trypsin-like protease sensitive site of the hepatitis B virus surface antigen P31 protein insensitive. The modified protein can be used in the production of a vaccine for prevention of hepatitis B virus infections and as an antigen for diagnosis of hepatitis B virus infections.Type: GrantFiled: August 20, 1986Date of Patent: January 8, 1991Assignee: Takeda Chemical Industries, Ltd.Inventors: Fujisawa Yukio, Itoh Yasuaki, Nishimura Osamu, Fujii Tomoko
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Patent number: 4975312Abstract: The present invention is directed to the use of multiaxially oriented (e.g., biaxially) thermotropic polymers as a substrate material for the preparation of printed wire boards (PWB). In preferred embodiments, the PWB of the present invention comprises a generic, high density, organic multilayer PWB comprising XYDAR.RTM. and/or VECTRA.RTM. films, capable of being employed as a high density leadless perimeter and in grid array ceramic chip packages.Type: GrantFiled: June 20, 1988Date of Patent: December 4, 1990Assignee: Foster-Miller, Inc.Inventors: Richard W. Lusignea, James L. Racich, Andrew C. Harvey, Ruby R. Chandy
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Patent number: 4973515Abstract: Disclosed herein is a magnetic card comprising a monoaxially or biaxially stretched minute-cellular polyester film which has an apparent density of 0.4 to 1.3 g/cm.sup.3 and an opacifying power of 0.2 or more and a magnetic layer applied on at least one surface of said film.By using the polyester film containing small air bubbles as the base material of the magnetic card, flexibility, flatness and punching property, which were insufficient in a magnetic card using a conventional polyester film, are improved.Type: GrantFiled: September 9, 1988Date of Patent: November 27, 1990Assignee: Diafoil Company, Ltd.Inventors: Satoshi Otonari, Yoshinori Sato, Narihiro Masuda, Kazuyuki Akatsu
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Patent number: 4973442Abstract: This invention relates in general to the formation of thick films having a biaxial molecular orientation. Such films are prepared in accordance with the present invention from rod-like extended chain aromatic-heterocyclic ordered polymers. Such films have high tensile strength, modulus, and environmental resistance characteristics. A preferred ordered polymer for use in the present invention is poly (para--phenylenebenzo bisthiazole), (PBT), a compound having the structure: ##STR1## The present invention is also directed to methods and apparatus suitable for producing biaxially oriented films, coatings, and like materials from ordered polymers, preferably PBT.Type: GrantFiled: September 21, 1987Date of Patent: November 27, 1990Assignee: Foster Miller Inc.Inventors: Andrew C. Harvey, Richard W. Lusignea, Dirk M. Baars, Donald Bretches, Robert B. Davis
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Patent number: 4970180Abstract: Disclosed herein are a refractory repairing material for repairing a brick comprising a mixture of 70 to 80 wt % of alumina having not more than 1 mm of grain size, which comprises 25 to 30 wt % of the above amount with a grain size not passing through a 325 mesh and 45 to 50 wt % of the above amount with a grain size passing through a 325 mesh; 1 to 7 wt % of carbonaceous material having a grain size passing through a 60 mesh; 1 to 5 wt % of magnesia having a grain size passing through a 325 mesh; and 10 to 25 wt % of aluminum phosphate, and a method of repairing a plate-like brick.Type: GrantFiled: September 1, 1989Date of Patent: November 13, 1990Assignees: Toshiba Ceramics Co., Ltd., Sumitomo Metal Industries, Ltd.Inventors: Takao Sugino, Toshio Kawamura, Masamichi Asai, Hiroshi Yamada, Kenichi Mukoyama, Akira Takahashi, Hiroshi Hikima
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Patent number: 4966807Abstract: This invention relates in general to the formation of multiaxially (e.g., biaxially) oriented films from high molecular weight liquid crystalline thermotropic polymers (homopolymers, copolymers, and the like), wherein due to the processing conditions employed, the films have a controlled molecular orientation. The novel multiaxially oriented films of the present invention are preferably prepared from two commercially available thermotropic polymers, Datrco Manufacturing, Incorporated's XYDAR.RTM. LCP and Hoechst Celanese's VECTRA.RTM. LCP.Type: GrantFiled: June 13, 1988Date of Patent: October 30, 1990Assignee: Foster Miller, Inc.Inventors: Andrew C. Harvey, Richard W. Lusignea, James L. Racich
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Patent number: 4966806Abstract: This invention relates in general to the preparation of near zero CTE (coefficient of thermal expansion) film-based structural components from aromatic heterocyclic, molecularly oriented, or lyotropic liquid crystalline, polymers, and to the use of such near-zero CTE film based structural components for the preparation of space-based structural members, especially film-based components used in the construction of satellites, space craft, space stations, space-based mirrors, e.g., for the Strategic Defense Initiative, and the like.Type: GrantFiled: June 14, 1988Date of Patent: October 30, 1990Assignee: Foster Miller, Inc.Inventors: Richard W. Lusignea, William S. Stevenson, John F. McCoy, III
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Patent number: 4963428Abstract: This invention relates in general to the formation of multiaxially (e.g., biaxially) oriented films from high molecular weight lyotropic or thermotropic polymers (homopolymers, copolymers, and the like), wherein due to the processing conditions employed, the films have a controlled molecular orientation. The films of the present invention are preferably prepared from rod-like extended-chain, aromatic- heterocyclic polymers. These polymers generally fall into two classes; first, those that are modified in solution form, i.e., lyotropic liquid crystalline polymers; and second, those that are modSTATEMENT OF GOVERNMENT INTERESTFunding for the present invention was obtained from the Government of the United States by virtue of Contract Nos. F33615-83-C-5120 and N00164-87-C-0050, from the Departments of the Air Force and the Navy, respectively. Thus, the Government of the United States has certain rights in and to the invention claimed herein.Type: GrantFiled: June 13, 1988Date of Patent: October 16, 1990Assignees: Foster Miller, Inc., Albany International Research Company, Inc.Inventors: Andrew C. Harvey, Richard W. Lusignea, James L. Racich, Dirk M. Baars, Donald D. Bretches, Robert B. Davis
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Patent number: 4939235Abstract: This invention relates in general to the formation of thick films having a biaxial molecular orientation. Such films are prepared in accordance with the present invention from rod-like extended chain aromatic-heterocyclic ordered polymers. Such films have high tensile strength, modulus, and environmental resistance characteristics.A preferred ordered polymer for use in the present invention is poly (para - phenylenebenzo bisthiazole), (PBT), a compound having the structure: ##STR1## The present invention is also directed to methods and apparatus suitable for producing biaxially oriented films, coatings, and like materials from ordered polymers, preferably PBT.Type: GrantFiled: June 7, 1988Date of Patent: July 3, 1990Assignees: Foster-Miller, Inc., Albany International Research CompanyInventors: Andrew C. Harvey, Richard W. Lusignea, Dirk M. Baars, Donald D. Bretches, Robert B. Davis
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Patent number: 4876331Abstract: According to the present invention, a novel copolyester comprising 3-hydroxybutyrate unit, 3-hydroxyvalerate unit and 5-hydroxyvalerate unit; 3-hydroxybutyrate unit and 4-hydroxybutyrate unit; or 3-hydroxybutyrate unit, 4-hydroxybutyrate unit and 3-hydroxyvalerate unit is easily obtained.Further, since the copolyester according to the present invention has various excellent specific properties, it is extremely suitable as the biomedical materials such as suture material and fixation materials for bone fracture, and its application to various fields such as the slow-releasing system, etc. is expected.Type: GrantFiled: August 10, 1988Date of Patent: October 24, 1989Assignee: Mitsubishi Kasei CorporationInventor: Yoshiharu Doi
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Patent number: 4871595Abstract: The present invention is directed to the use of ordered polymers as a substrate material for the preparation of printed wire boards (PWB). In preferred embodiments, the PWB of the present invention comprises a generic, high density, organic multilayer PWB capable of being employed as a high density leadless perimeter and in grid array ceramic chip packages. Specific chip package density requirements are 0.020-in. centers with up to 300 input/outputs (I/Os) for perimeter type packages and 0.050-in. center grid array type packages with up to 240 I/Os per device. In its most preferred embodiments, the present invention is directed to a method of forming a PBT PWB substrate layer of 0.0025 in. or less in thickness. Another preferred aspect of the present invention concerns the discovery that a copper layer can be bonded to a PBT film substrate with a strength comparable to existing PWB materials.Type: GrantFiled: December 16, 1986Date of Patent: October 3, 1989Assignee: Foster Miller, Inc.Inventors: Richard W. Lusignea, William A. Stevenson
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Patent number: 4871784Abstract: The polyester film according to the present invention is produced by molding a composition comprising an aromatic polyester, 3 to 40 wt %, based on the amount of said polyester, of a crystalline polypropylene having a melt flow index of 0.2 to 120, and 0.001 to 3 wt %, based of the total amount of said polyester and said polypropylene, of a surface-active agent into a sheet; and stretching the thus obtained sheet at least one direction. The polyester film according to the present invention, which is obtained by the above process is low in the apparent specific gravity because of a large number of minute closed cells contained therein. Further, the polyester film according to the present invention shows a high opacifying power by adding a small amount of titanium oxide or without adding the titanium oxide, which have been added in a large amount. The polyester film can be used as the materials for printing plates and substrates in data devices.Type: GrantFiled: September 15, 1988Date of Patent: October 3, 1989Assignee: Diafoil Company, LimitedInventors: Satoshi Otonari, Yoshinori Sato, Narihiro Masuda, Tomoyuki Kotani
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Patent number: 4857396Abstract: A film is disclosed, which comprises an at least uniaxially stretched finely cellulated polyester film of a high surface roughness having an apparent specific gravity in the range of 0.4 to 1.3 and an opacifying power of not less than 0.2, and a coating applied to either or both of the opposite surfaces of the polyester film.The coating applied to the minute-cellular polyester film serves the purpose of improving the adhesive property of the polyester film.Type: GrantFiled: July 14, 1988Date of Patent: August 15, 1989Assignee: Daifoil Company, Ltd.Inventors: Satoshi Otonari, Yoshinori Sato, Narihiro Masuda, Tomoyuki Kotani
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Patent number: 4837379Abstract: The present invention provides fibrin-collagen tissue equivalents and methods of making and using such tissue equivalents. The present invention also provides methods of forming multi-layer tissue equivalents having improved adherence of the layers. The present invention further provides a method for joining tears in tissue equivalents.Type: GrantFiled: June 2, 1988Date of Patent: June 6, 1989Assignee: Organogenesis Inc.Inventor: Crispin B. Weinberg
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Patent number: 4835102Abstract: The present invention provides methods of, apparatus for, and kits for determining the interaction of tissue and at least one agent by use of at least one tissue equivalent. Tissue equivalent includes, but is not limited to, equivalents of epithelial tissue, connective tissue, cartilage, bone, blood, organs, glands and blood vessels, which are composed of living cells and extracellular matrix molecules, principally collagen. Agent includes, but is not limited to, various substances such as chemicals, cosmetics, pharmaceuticals, stimuli, e.g., light or physical injury; and tissue protective agents.Type: GrantFiled: March 31, 1987Date of Patent: May 30, 1989Inventors: Eugene Bell, Crispin Weinberg
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Patent number: 4833166Abstract: The present invention provides synthetic peptides and fragments and analogs thereof complementary to growth hormone releasing hormone, and antibodies raised against such peptides. The present invention also includes methods of using such peptides and antibodies.Type: GrantFiled: May 1, 1987Date of Patent: May 23, 1989Inventors: Clark E. Grosvenor, Balint Kacsoh
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Patent number: 4816388Abstract: Recombinant human prealbumin and a method for producing such human prealbumin through recombinant DNA techniques including preparation and isolation of a cDNA sequence coding for human prealbumin, construction of a cloning vector and an expression vector containing said cDNA sequence, and expression of human prealbumin in a prokaryotic cell transformed by said expression vector are disclosed. The invention further relates to the use of human prealbumin cDNA in the diagnosis by hybridization methodologies of medical conditions with which variant forms of prealbumin are associated. Also disclosed is a method for diagnosing some Type I familial amyloid polyneuropathies by a restriction endonuclease assay with an enzyme which recognizes the nucleotide base sequence 5'-ATGCAT-3'.Type: GrantFiled: October 30, 1985Date of Patent: March 28, 1989Assignee: Children's Medical Center CorporationInventors: Jean D. Sipe, Alexander S. Whitehead, Alan S. Cohen, Martha Skinner