Patents Represented by Attorney, Agent or Law Firm Lucy X. Yang
  • Pyrrolo[2,3-]pyrimidine compounds
    Patent number: 8133899
    Abstract: Described herein is pyrrolo{2,3-d}pyrimidine compounds, their use as Janus Kinase (JAK) inhibitors, pharmaceutical compositions containing this compounds, and methods for the preparation of these compounds.
    Type: Grant
    Filed: August 17, 2009
    Date of Patent: March 13, 2012
    Assignee: Pfizer Inc.
    Inventors: Mark J. Mitton-Fry, Pamela J. Berlinski, Matthew J. Birchmeier, Jerry W. Bowman, Andrea Joy Gonzales, Steven Glenn Kamerling, Donald Wayne Mann
  • Substituted arylpyrazoles
    Patent number: 7902232
    Abstract: This invention relates to a combination product comprising a range of 1-aryl-4 -cyclopropylpyrazoles in which there is at least one fluorine attached to the cyclopropyl ring, and one o more further therapeutic agents, particularly anti-parasitic agents.
    Type: Grant
    Filed: June 6, 2006
    Date of Patent: March 8, 2011
    Assignee: Pfizer Limited
    Inventors: Denis Billen, Nathan Anthony Logan Chubb, David Morris Gethin, Kim Thomas Hall, Lee Richard Roberts, Nigel Derek Arthur Walshe
  • Substituted imidazoles
    Patent number: 7547718
    Abstract: This invention relates to a range of alpha substituted 2-benzyl substituted imidazole compounds and pharmaceutically acceptable salts and solvates thereof, to compositions comprising such compounds, processes for their synthesis and their use as parasiticides.
    Type: Grant
    Filed: November 26, 2007
    Date of Patent: June 16, 2009
    Assignee: Pfizer Limited
    Inventors: Nathan Anthony Logan Chubb, Mark Roger Cox, Jerome Sebastien Dauvergne, Richard Andrew Ewin, Christelle Lauret
  • Substituted imidazoles
    Patent number: 7544706
    Abstract: This invention relates to a range of alpha substituted 2-benzyl substituted imidazole compounds and pharmaceutically acceptable salts and solvates thereof, to compositions comprising such compounds, processes for their synthesis and their use as parasiticides.
    Type: Grant
    Filed: November 26, 2007
    Date of Patent: June 9, 2009
    Assignee: Pfizer Limited
    Inventors: Nathan Anthony Logan Chubb, Mark Roger Cox, Jerome Sebastien Dauvergne, Richard Andrew Ewin, Christelle Lauret
  • Substituted arylpyrazoles
    Patent number: 7514464
    Abstract: This invention relates to a combination product comprising a compound of formula I wherein X, R1, R2, R3, R4, R5, R6, R7 and R9 are as described herein, and one or more further biologically active compounds as described herein, particularly anti-parasitic agents.
    Type: Grant
    Filed: June 15, 2005
    Date of Patent: April 7, 2009
    Assignee: Pfizer Limited
    Inventors: Denis Billen, Nathan Anthony Logan Chubb, David Morris Gethin, Kim Thomas Hall, Lee Richard Roberts, Nigel Derek Arthur Walshe
  • Antimicrobial 1-aryl dihydropyridone compounds
    Patent number: 7105547
    Abstract: The present invention provides antibacterial agents of formula I, or a pharmaceutically acceptable salt thereof.
    Type: Grant
    Filed: October 3, 2003
    Date of Patent: September 12, 2006
    Assignee: Pharmacia and Upjohn Company
    Inventors: Mikhail Fedor Gordeev, Upinder Singh, Dinesh Vinoobhai Patel, Paul Dennis May
  • Antimicrobial dihydrothiazine and dihydrothiopyran oxazolidinones
    Patent number: 7101874
    Abstract: The present invention provides a compound of formula I or a pharmaceutically acceptable salt thereof wherein Y is —S(?O)n—, —S(?NR8)—, or —S(?NR8)(?O)—; Z is —NHC(?O)R1, —NHC(?S)R1, —NH-het1, —O-het1, —S-het1, or -het2. The compounds of formula I are useful as antibacterial agents.
    Type: Grant
    Filed: February 22, 2005
    Date of Patent: September 5, 2006
    Assignee: Pharmacia and Upjohn Company
    Inventors: Mikhail F. Gordeev, Adam Renslo, Gary W. Luehr, Stuart Lam, Neil E. Westlund, Dinesh Vinoobhai Patel
  • Process to prepare oxazolidinones
    Patent number: 7087784
    Abstract: The present invention relates to a one-step process to prepare pharmacologically active 2-oxo-5-oxazolidinylmethylacetamides.
    Type: Grant
    Filed: March 25, 2004
    Date of Patent: August 8, 2006
    Assignee: Pharmacia & Upjohn
    Inventors: William R. Perrault, Bruce Allen Pearlman, Delara B. Godrej
  • Amide-containing compound having improved solubility and method of improving the solubility of an amide-containing compound
    Patent number: 7049443
    Abstract: The present invention is directed to novel amide-containing compounds which have an improved solubility and a method of improving the solubility of amide-containing compounds. The amide-containing compounds include oxazolidinone compounds and the bioavailability of these oxazolidinone compounds is improved by improving the solubility thereof.
    Type: Grant
    Filed: July 12, 2002
    Date of Patent: May 23, 2006
    Assignee: Pharmacia & Upjohn Company
    Inventor: Jackson B. Hester, Jr.
  • Indolone oxazolidinones and derivatives thereof
    Patent number: 7012088
    Abstract: The present invention provides antibacterial agents of formula I described herein and intermediates for their preparation.
    Type: Grant
    Filed: January 22, 2004
    Date of Patent: March 14, 2006
    Assignee: Pharmacia & Upjohn Company
    Inventor: Toni-Jo Poel
  • Difluorothioacetamides of oxazolidinones as antibacterial agents
    Patent number: 6927229
    Abstract: The present invention describes difluororthioacetamide oxazolidinones of formula I: R is —CH2— or —CH2CH2—; R2 and R3 are independently —H or —F; X is —CH—; Y is —SO—, —SO2—, or —SONR4—; and R4 is —H or —C1-4alkyl. These compounds are useful to treat infectives diseases caused by gram-positive and gram-negative bacteria.
    Type: Grant
    Filed: June 16, 2003
    Date of Patent: August 9, 2005
    Assignee: Pharmacia & Upjohn Company
    Inventors: Jackson Boling Hester, Jr., Wade J. Adams, Jeffrey Charles Stevens, Mikhail Fedor Gordeev, Upinder Singh, Carole Scott
  • N-Aryl-2-oxazolidinone-5-carboxamides and their derivatives
    Patent number: 6919329
    Abstract: The present invention provides antibacterial agents having the formulae I, II, and III described herein.
    Type: Grant
    Filed: February 24, 2003
    Date of Patent: July 19, 2005
    Assignee: Pharmacia & Upjohn Company
    Inventors: Richard Charles Thomas, Toni-Jo Poel, Michael Robert Barbachyn, Mikhail F. Gordeev, Gary W. Luehr, Adam Renslo, Upinder Singh
  • Heterocycle carboxamides as antiviral agents
    Patent number: 6903097
    Abstract: The present invention provides a compound of formula I which is useful as antiviral agents, in particular, as agents against viruses of the herpes family.
    Type: Grant
    Filed: December 18, 2002
    Date of Patent: June 7, 2005
    Assignee: Pharmacia & Upjohn Company
    Inventors: Fred L. Ciske, John R. Palmer, Mark E. Schnute, Valerie A. Vaillancourt
  • Process to prepare oxazolidinones
    Patent number: 6887995
    Abstract: The present invention relates to a one-step process to prepare pharmacologically active 2-oxo-5-oxazolidinylmethylacetamides.
    Type: Grant
    Filed: April 15, 2002
    Date of Patent: May 3, 2005
    Assignee: Pharmacia & Upjohn Company
    Inventors: William R. Perrault, Bruce Allen Pearlman, Delara B. Godrej
  • Antimicrobial dihydrothiazine and dihydrothiopyran oxazolidinones
    Patent number: 6884813
    Abstract: The present invention provides a compound of formula I or a pharmaceutically acceptable salt thereof wherein A is a structure i, ii, iii, or iv X is CR7; Y is —S(?O)n—, —S(?NR8)—, or —S(?NR8)(?O)—; Z is —NHC(?O)R1, —NHC(?S)R1, —NR-het1, —O-het1, —S-het1, or -het2; and n is independently 0, 1, or 2. The compounds of formula I are useful as antimicrobials against a number of human and veterinary pathogens.
    Type: Grant
    Filed: January 21, 2003
    Date of Patent: April 26, 2005
    Assignee: Pharmacia & Upjohn Company
    Inventors: Mikhail F. Gordeev, Adam Renslo, Gary W. Luehr, Stuart Lam, Neil E. Westlund, Dinesh V. Patel
  • Oxazolidinone photoaffinity probes
    Patent number: 6875871
    Abstract: Disclosed are novel compounds that are useful and effective as photoaffinity probes and methods of using oxazolidinone photoaffinity probes.
    Type: Grant
    Filed: February 6, 2003
    Date of Patent: April 5, 2005
    Assignee: Pharmacia & Upjohn Company
    Inventors: Lisa Marie Thomasco, Robert C. Gadwood
  • Oxazolidinone photoaffinity probes
    Patent number: 6861433
    Abstract: The present invention provides compounds of the formula: compositions comprising such compounds, and methods for using the same.
    Type: Grant
    Filed: December 15, 2000
    Date of Patent: March 1, 2005
    Assignee: Pharmacia & Upjohn Company
    Inventors: Lisa Marie Thomasco, Robert C. Gadwood
  • Antimicrobial thiadiazinone derivatives and their application for treatment of bacterial infections
    Patent number: 6828317
    Abstract: The present invention provides certain thiadiazinone derivatives of oxazolidinones of the following formula I: or pharmaceutically acceptable salts thereof that are antibacterial agents, pharmaceutical compositions containing them, methods for their use, and methods for preparing these compounds.
    Type: Grant
    Filed: February 4, 2003
    Date of Patent: December 7, 2004
    Assignee: Pharmacia & Upjohn Company
    Inventors: Gary W. Leuhr, Mikhail F. Gordeev, Dinesh V. Patel
  • Bicyclic isoxazolinones as antibacterial agents
    Patent number: 6825225
    Abstract: The present invention provides compounds of formula I useful as anti microbial agents wherein X, Y, R1, and n are as defined in thereof.
    Type: Grant
    Filed: November 14, 2001
    Date of Patent: November 30, 2004
    Assignee: Pharmacia & Upjohn Company
    Inventors: Michael J. Genin, Michael Robert Barbachyn, Jackson B. Hester, Jr., Paul D. Johnson, Fred L. Ciske
  • Oxazinocarbazoles for the treatment of CNS diseases
    Patent number: 6821970
    Abstract: The present invention provides oxazinocarbazole derivatives having a ring connecting position 8 (C-8) and position 9 (N-9), and more specifically, provides compounds of formula (I) wherein R1, R2, R3 and R4 are described herein. These compounds are 5-HT ligands, and are useful for treating diseases wherein modulation of 5-HT activity is desired.
    Type: Grant
    Filed: May 16, 2002
    Date of Patent: November 23, 2004
    Assignee: Pharmacia & Upjohn Company
    Inventor: Ruth Elizabeth TenBrink