Patents Represented by Attorney, Agent or Law Firm Lucy X. Yang
  • Method for the preparation of oxazolidinones
    Patent number: 6774231
    Abstract: The present invention relates to a process for making a compound of structure 4 which comprises reacting a compound of structure 1 with vinyl sulfone in the presence of a Lewis-acid at a temperature in a range of from 40° C. to 170° C., wherein each R1 is independently H, fluoro, chloro or bromo.
    Type: Grant
    Filed: April 15, 2002
    Date of Patent: August 10, 2004
    Assignee: Pharmacia & Upjohn Company
    Inventors: Jiong Jack Chen, Cuong V. Lu
  • Heterocycle carboxamides as antiviral agents
    Patent number: 6730682
    Abstract: The present invention provides a compound of formula I which is useful as antiviral agents, in particular, as agents against viruses of the herpes family.
    Type: Grant
    Filed: June 22, 2001
    Date of Patent: May 4, 2004
    Assignee: Pharmacia & Upjohn Company
    Inventors: Mark E. Schnute, Valerie A. Vaillancourt
  • Substituted quinolinecarboxamides as antiviral agents
    Patent number: 6727248
    Abstract: The present invention discloses disubstiuted 4-oxo-1,4-dihydro-3-quinolinecarboxamide derivatives. The compounds are useful as antiviral agents, in particular, as agents against viruses of the herpes family.
    Type: Grant
    Filed: January 23, 2003
    Date of Patent: April 27, 2004
    Assignee: Pharmacia & Upjohn Company
    Inventors: Valerie A. Vaillancourt, Audris Huang
  • 4-oxo-1,4-dihydro[1,8]naphthyridine-3-carboxamides as antiviral agents
    Patent number: 6693114
    Abstract: A compound of formula III: or a pharmaceutically acceptable salt thereof wherein, the variables are as in the specification is provided. The compounds are particularly effective in the treatment or prevention of herpes viruses.
    Type: Grant
    Filed: May 20, 2002
    Date of Patent: February 17, 2004
    Assignee: Pharmacia & Upjohn Company
    Inventors: Valerie A. Vaillancourt, Atli Thorarensen
  • Pyridoquinoxaline antivirals
    Patent number: 6686356
    Abstract: The present invention provides a compound of formula I or a pharmaceutically acceptable salt thereof wherein R1 and R2 are as defined in the specification. The compounds are useful for the treatment of viral infections.
    Type: Grant
    Filed: December 19, 2002
    Date of Patent: February 3, 2004
    Assignee: Pharmacia & Upjohn Company
    Inventors: Joseph Walter Strohbach, Steven P. Tanis, Malcolm Wilson Moon
  • Method for treating herpes viruses
    Patent number: 6682892
    Abstract: The present invention relates to a method for selecting an anti-herpes viral compound and a method for selectively inhibiting herpesvrus in a human host in need of such treatment. The present invention relates to a method for selecting an anti-herpes viral compound and a method for selectively inhibiting herpesvrus in a human host in need of such treatment.
    Type: Grant
    Filed: July 12, 2001
    Date of Patent: January 27, 2004
    Assignee: Pharmacia & Upjohn Company
    Inventors: Fred L. Homa, Michael W. Wathen, Todd A. Hopkins, Darrell R. Thomsen
  • Pyrroloquinolones as antiviral agents
    Patent number: 6683181
    Abstract: The present invention provides a compound of formula I which is useful as antiviral agents, in particular, as agents against viruses of the herpes family.
    Type: Grant
    Filed: November 5, 2002
    Date of Patent: January 27, 2004
    Assignee: Pharmacia and Upjohn Comapny
    Inventors: Valerie A. Vaillancourt, Sandra Staley, Audris Huang, Richard Allen Nugent, Ke Chen, Sajiv K. Nair, James A. Nieman, Joseph Walter Strohbach
  • Oxazinoquinolones useful for the treatment of viral infections
    Patent number: 6673793
    Abstract: The present invention provides a compound of formula I which is useful as antiviral agents, in particular, as agents against viruses of the herpes family.
    Type: Grant
    Filed: June 28, 2001
    Date of Patent: January 6, 2004
    Assignee: Pharmacia & Upjohn Co.
    Inventors: Steven Ronald Turner, Suvit Thaisrivongs, Atli Thorarensen
  • 1-aryl-4-oxo-1,4-dihydro-3-quinolinecarboxamides as antiviral agents
    Patent number: 6653307
    Abstract: The present invention provides compounds of formula I which are useful as antiviral agents, in particular, as agents against viruses of the herpes family.
    Type: Grant
    Filed: June 5, 2001
    Date of Patent: November 25, 2003
    Assignee: Pharmacia & Upjohn Company
    Inventor: Mark E. Schnute
  • Oxazolidinone thioamides with piperazine amide substituents
    Patent number: 6642238
    Abstract: The present invention provides a compound of formula I which have potent activities against gram-positive and gram-negative bacteria.
    Type: Grant
    Filed: January 9, 2002
    Date of Patent: November 4, 2003
    Assignee: Pharmacia and Upjohn Company
    Inventor: Jackson B. Hester, Jr.
  • 4-oxo-1,4-dihydro-3-cinnolinecarboxamides as antiviral agents
    Patent number: 6624160
    Abstract: This invention provides compounds of formula I; which are useful as antiviral agents.
    Type: Grant
    Filed: March 15, 2001
    Date of Patent: September 23, 2003
    Assignee: Pharmacia & Upjohn Co.
    Inventors: Valerie A. Vaillancourt, Scott D. Larsen, Sajiv K. Nair
  • Heterocycle carboxamides as antiviral agents
    Patent number: 6624159
    Abstract: The present invention provides a compound of formula I which is useful as antiviral agents, in particular, as agents against viruses of the herpes family.
    Type: Grant
    Filed: June 22, 2001
    Date of Patent: September 23, 2003
    Assignee: Pharmacia & Upjohn Company
    Inventors: David John Anderson, Gordon L. Bundy, Fred L. Ciske, David R. Graber, Michael J. Genin, Thomas M. Judge, Malcolm Wilson Moon, Mark E. Schnute, Joseph Walter Strohbach, Suvit Thaisrivongs, Atli Thorarensen, Steven Ronald Turner, Valerie A. Vaillancourt, Allison J. Wolf
  • Thizaine oxazolidinone
    Patent number: 6605609
    Abstract: The present invention provides a thizaine oxazolidinone useful as antimicrobial.
    Type: Grant
    Filed: June 15, 2001
    Date of Patent: August 12, 2003
    Assignee: Pharmacia & Upjohn Company
    Inventors: Michael Robert Barbachyn, Gary Edward Zurenko
  • Heterocyle carboxamides as antiviral agents
    Patent number: 6562822
    Abstract: The present invention provides a compound of formula I which is useful as antiviral agents, in particular, as agents against viruses of the herpes family.
    Type: Grant
    Filed: June 22, 2001
    Date of Patent: May 13, 2003
    Assignee: Pharmacia & Upjohn Company
    Inventor: Mark E. Schnute
  • Oxazolidinone combinatorial libraries, compositions and methods of preparation
    Patent number: 6562844
    Abstract: Oxazolidinones and methods for their synthesis are provided. Also provided are combinatorial libraries comprising oxazolidinones, and methods to prepare the libraries. Further provided are methods of making biologically active oxazolidinones as well as pharmaceutically acceptable compositions comprising the oxazolidinones. The methods of library preparation include the attachment of oxazolidinones to a solid support. The methods of compound preparation in one embodiment involve the reaction of an iminophosphorane with a carbonyl containing polymeric support.
    Type: Grant
    Filed: December 28, 2001
    Date of Patent: May 13, 2003
    Assignee: Pharmacia & Upjohn Company
    Inventors: Mikhail F. Gordeev, Gary W. Luehr, Dinesh V. Patel, Zhi-Jie Ni, Eric Gordon
  • Heterocycle carboxamides as antiviral agents
    Patent number: 6559145
    Abstract: The present invention provides a compound of formula I which is useful as antiviral agents, in particular, as agents against viruses of the herpes family.
    Type: Grant
    Filed: June 22, 2001
    Date of Patent: May 6, 2003
    Assignee: Pharmacia & Upjohn Company
    Inventors: Fred L. Ciske, Michael J. Genin, Byung Hyun Lee, Mark E. Schnute, Valerie A. Vaillancourt
  • Substituted quinolinecarboxamides as antiviral agents
    Patent number: 6544990
    Abstract: The present invention discloses disubstiuted 4-oxo-1,4-dihydro-3-quinolinecarboxamide derivatives. The compounds are useful as antiviral agents, in particular, as agents against viruses of the herpes family.
    Type: Grant
    Filed: February 27, 2002
    Date of Patent: April 8, 2003
    Assignee: Pharmacia & Upjohn Company
    Inventors: Valerie A. Vaillancourt, Joseph Walter Strohbach, Audris Huang
  • Oxazolidinone antibacterial agents having a thiocarbonyl funtionality
    Patent number: 6537986
    Abstract: The present invention provides compounds of Formula 1 or pharmaceutical acceptable salts thereof wherein A, G and R1 are as defined in the claims which are antibacterial agents.
    Type: Grant
    Filed: March 30, 2001
    Date of Patent: March 25, 2003
    Assignee: Pharmacia & Upjohn Company
    Inventors: Jackson B. Hester, Jr., Eldon George Nidy, Salvatore Charles Perricone, Toni-Jo Poel
  • Oxazolidinone combinatorial libraries, compositions and methods of preparation
    Patent number: 6531470
    Abstract: Oxazolidinones and methods for their synthesis are provided. Also provided are combinatorial libraries comprising oxazolidinones, and methods to prepare the libraries. Further provided are methods of making biologically active oxazolidinones as well as pharmaceutically acceptable compositions comprising the oxazolidinones. The methods of library preparation include the attachment of oxazolidinones to a solid support. The methods of compound preparation in one embodiment involve the reaction of an iminophosphorane with a carbonyl containing polymeric support.
    Type: Grant
    Filed: August 30, 2000
    Date of Patent: March 11, 2003
    Assignee: Pharmacia & Upjohn Company
    Inventors: Mikhail F. Gordeev, Gary W. Luehr, Dinesh V. Patel, Zhi-Jie Ni, Eric Gordon
  • Self-emulsifying formulation for lipophilic compounds
    Patent number: 6531139
    Abstract: The present invention provides a novel pharmaceutical composition based on the use of a particular oil phase which comprises a lipophilic, pharmaceutically active agent, a mixture of diglyceride and monoglyceride in a ratio of from about 9:1 to about 6:4 by weight (diglyceride:monoglyceride) wherein the diglyceride and monoglyceride are mono- or di- unsaturated fatty acid esters of glycerol having sixteen to twenty-two carbon chain length, one or more pharmaceutically acceptable solvents, and one or more pharmaceutically acceptable surfactants. The composition is in a form of self-emulsifying formulation which provides high concentration and high oral bioavailability for lipophilic compounds.
    Type: Grant
    Filed: July 27, 1998
    Date of Patent: March 11, 2003
    Assignee: Pharmacia & Upjohn Company
    Inventors: Ping Gao, Walter Morozowich