Abstract: In a supersonic nozzle incorporating injectors and a combustion chamber as part of an expander cycle rocket engine, the oxidizer is injected in two streams. One of the streams, preferably a small fraction of the total, is injected into an upstream or preburner section of the combustion chamber and the other to a downstream or main section of the chamber. The preburner combustion gas is cooled in a substantially uniform manner to a moderate temperature by cooling the bulk of the gas rather than cooling only the gas in a boundary layer adjacent to the chamber wall. The combustion gas produced in the downstream section is hotter, and heat from that gas is drawn through the chamber wall into a jacket. The limited combustion in the preburner permits the use of a cooling element with highly intimate heat exchange construction, extracting a high level of energy from the preburner gas without damage to the cooling element and an overall improvement in the regenerative cooling.

Abstract: Carbon steels of high performance are disclosed that contain a three-phase microstructure consisting of grains of ferrite fused with grains that contain dislocated lath structures in which laths of martensite alternate with thin films of austenite. The microstructure can be formed by a unique method of austenization followed by multi-phase cooling in a manner that avoids bainite and pearlite formation and precipitation at phase interfaces. The desired microstructure can be obtained by casting, heat treatment, on-line rolling, forging, and other common metallurgical processing procedures, and yields superior combinations of mechanical and corrosion properties.

Abstract: Fossil fuels are combined with an aqueous liquid and a dialkyl ether to form an aqueous-organic reaction medium which is passed through an ultrasound chamber on a continuous flow-through basis. The emerging mixture separates spontaneously into aqueous and organic phases, from which the organic phase is readily isolated as the desulfurized fossil fuel.

Abstract: This disclosure describes a processing approach for the rapid and efficient in-situ polymerization of specially prepared precursor mixtures to achieve near-net-shape production of objects/articles with exact dimensions. The process relies on the use of polymerizable compositions comprised of a mixture of a dead polymer, a reactive plasticizer and an initiator, which compositions are semi-solid-like prior to curing and induce low shrinkage upon curing as a result of their partially polymerized nature prior to processing. The partially polymerized nature of the precursor mixtures also allows extremely impact-resistant objects/articles to be fabricated. Other desirable engineering property attributes can similarly be achieved via the judicious blending of starting ingredients in formulating the polymerizable (curable) mixtures.

Abstract: The invention relates to a method for solid-phase microextraction and analysis of substances in a carrier fluid, in which a collector is brought into contact with the stirred fluid containing the substances for a sufficient time and is then subjected to a solid-phase extraction directed at at least one substance adhering to the collector, and desorbed substances are transported for analysis by means of a carrier gas, in which the carrier fluid containing the substances is stirred in a receptacle of a magnetic stirrer by means of a coated magnetic stirring element as the collector, and/or the carrier fluid is made to move intimately relative to the collector by means of ultrasound, and then the stirring element is placed in a solid-phase extraction device.

Abstract: A convergent-divergent rocket nozzle is formed by joining two coaxially aligned conical sections at a throat plane, each diverging outward from the throat plane. Coolant channels formed in the wall of the nozzle are arranged in spirals around the nozzle axis. Preferably, the conical sections are formed from platelet laminates rolled into conical form with a single spiral seam, and at least one of the conical sections is a composite of two or more component conical sections separately formed and then joined in a nested arrangement with the seams not superimposed. A further preferred construction is one in which the convergent end of one conical section is split radially into strips that are then spread apart to serve as bonding surfaces to bond to the other conical section.

Abstract: Heat is extracted from the combustion gas in a rocket engine combustion chamber by diverting portions of the gas through channels in the nozzle wall. The channels are layered between channels of coolant, which in expander cycle rocket engines is uncombusted fuel, to achieve intimate heat exchange between the combustion gas and the fuel. The combustion gas channels are relatively short, returning combustion gas thus cooled to the chamber interior. By drawing combustion gas from the chamber interior into the chamber wall, the cooling process no longer relies on the combustion gas boundary layer for heat transfer as in the prior art.

Abstract: Pore-free rubber articles are prepared by dip-molding in a dipping medium that includes a vulcanizing agent, then by immersing the dip former in a heated liquid bath that is chemically inert. A particularly effective liquid bath is molten inorganic salt. In addition, the tensile properties of an article of vulcanized rubber can be improved to an unusually effective degree by immersing the already vulcanized article in a solution of a vulcanizing agent to cause the rubber of the article to absorb or imbibe the vulcanizing agent from the solution, and then immersing the rubber and the imbibed vulcanizing agent in a heated liquid bath to increase the degree of vulcanization.

Abstract: Microarrays are imaged by an illumination and detection system that supplies excitation light through one or more optical fibers, each fiber transmitting excitation light from an excitation light source to a single spot in the microarray. Emission light from each spot is then collected by a collimating lens and converted to a signal that is compiled by conventional software into an image of the entire microarray. The optical fiber(s) and the collimating lens are arranged such that the direction of travel of the excitation light and the direction along which the emission light is collected are not coaxial, and preferably both are at an acute angle to the axis normal to the plane of the microarray.

Abstract: This disclosure describes a processing approach for the rapid and efficient in-situ polymerization of specially prepared precursor mixtures to achieve near-net-shape production of objects/articles with exact dimensions. The process relies on the use of polymerizable compositions comprised of a mixture of a reactive plasticizer and an initiator, optionally also including a dead polymer, which compositions are semi-solid-like and induce little shrinkage upon curing as a result of their partially polymerized nature prior to processing. The articles of the invention have a surface and an interior core, the composition of the surface material being distinct from the composition of the core material while at the same time the surface and the core are an integral, monolithic entity. In addition, the articles are dimensionally stable and exhibit high fidelity replication.

Abstract: A stack of very thin metal plates provides high surface area for catalytic decomposition of a fluid flowing axially from upstream to downstream through the stack. Each plate has flow-through passages of selected size and location to promote uniform flow and good surface contact with a catalyst surface on the plates. The downstream surface of each plate is etched to provide gaps between plates for lateral fluid flow. The plates are divided into groups separated by metering plates that promote more uniform flow from group to group.

Abstract: Carbon steels of high performance are disclosed that contain a three-phase microstructure consisting of grains of ferrite fused with grains that contain dislocated lath structures in which laths of martensite alternate with thin films of austenite. The microstructure can be formed by a unique method of austenization followed by multi-phase cooling in a manner that avoids bainite and pearlite formation and precipitation at phase interfaces. The desired microstructure can be obtained by casting, heat treatment, on-line rolling, forging, and other common metallurgical processing procedures, and yields superior combinations of mechanical and corrosion properties.

Abstract: This invention is directed to a process for the rapid in-situ curing of polymerizable materials to provide macromolecular networks and articles of manufacture that are “morphology-trapped”; that is, they exhibit a fixed phase morphology and/or molecular orientation that is locked in by the curing step. The process includes the steps of mixing together a dead polymer, a reactive plasticizer and an initiator to give a polymerizable composition; further processing the mixture in order to achieve a desired phase morphology and/or molecular orientation of the polymeric constituents; shaping the polymerizable composition into a desired geometry; and exposing the polymerizable composition to a source of polymerizing energy, without mixing, to give a final product with the desired phase morphology and/or molecular orientation locked in place.

Abstract: In pre-cast slab gel cassettes, the formation of pathways in which proteins can migrate between the gel and the walls of the cassette to form shadow bands is avoided by the application of a coating of a nonionic amphiphilic polymer to the cassette walls. The coating also prevents the gel from sticking to the walls when the gel is to be removed from the cassette after electrophoresis.

Abstract: This invention is directed to a process for the rapid in-situ curing of polymerizable materials to provide macro-molecular networks and articles of manufacture that are “morphology-trapped”; that is, they exhibit a fixed phase morphology and/or molecular orientation that is locked in by the curing step. The process includes the steps of mixing together a dead polymer or a prepolymer, a reactive plasticizer or a diulent, and an initiator to give a polymerizable composition; further processing the mixture in order to achieve a desired phase morphology and/or moelcular orientation of the polymeric constitutents; shaping the polymerizable composition into a desired geometry; and exposing the polymerizable composition to a source of polymerizing energy, without mixing to give a final product with the desired phase morphology and/or moelcular orientation locked in place.

Abstract: Unit dosage form tablets for the delivery of pharmaceuticals are formed of the pharmaceutical dispersed in a solid unitary matrix that is formed of a combination of poly(ethylene oxide) and hydroxypropyl methylcellulose. The combination offers unique benefits in terms of release rate control and reproducibility while allowing both swelling of the tablet to effect gastric retention and gradual disintegration of the tablet to clear the tablet from the gastrointestinal tract after release of the drug has occurred.

Abstract: Ethers and esters of cyanohydrins that contain optically detectable moieties are highly effective for detecting, monitoring, and measuring the activity of enzymes that cause the cleavage of certain types of substrates. The cyanohydrins function as proaldehydes and proketones, spontaneously converting to aldehydes and ketones, respectively, which provide a large increase in optical detectability relative to both the starting esters and ethers and the cyanohydrins.

Abstract: Carbon steels of high performance are disclosed that contain dislocated lath structures in which laths of martensite alternate with thin films of austenite, but in which each grain of the dislocated lath structure is limited to a single microstructure variant by orienting all austenite thin films in the same direction. This is achieved by careful control of the grain size to less than ten microns. Further improvement in the performance of the steel is achieved by processing the steel in such a way that the formation of bainite, pearlite, and interphase precipitation is avoided.

Abstract: A shocking chamber for performing electroporation is constructed in the form of a base and a hinged lid which when lowered forms an enclosure with the base that fully encloses a cuvette and impresses a high voltage across the cuvette, the voltage connection becoming disengaged upon the simple raising of the lid. The base contains two pairs of electrical leads, one pair engaging the cuvette with spring-loaded contacts that provide electrical connections to the cuvette while helping to secure the cuvette in place, and the other pair joined to high-voltage terminals. A shunt built into the lid bridges the two pairs of leads in the base when the lid is closed and pivots out of the way to clear all leads when the lid is opened. These and other features of the construction provide the user with a safe and secure means of forming the high-voltage electrical connections used in electroporation in an apparatus that can be operated with one hand.

Abstract: The invention describes formulations that include either metformin, sulfonylurea or a biguanide-sulfonylurea combination as one active ingredient in addition to specific, other active ingredients. The compositions and dosage forms of the invention are clinically useful as methods for increasing the effectiveness, efficiency and safety of the included biguanide (metformin) and/or sulfonylurea in the prevention and treatment of insulin resistance and diabetes mellitus. The carefully chosen additional active ingredients of the invention are designed in a modular fashion to prevent and rectify adverse events associated with insulin resistance syndrome and diabetes mellitus, and those adverse incidences associated with the concurrent use of metformin and/or the sulfonylureas. When clinically administered, the invention will provide therapeutic levels of metformin and of a sulfonylurea, alone or in combination, and broaden their usefulness.