Patents Represented by Attorney, Agent or Law Firm Marcelo K. Sarkis
  • Process for the preparation of substantially pure stavudine and related intermediates useful in the preparation thereof
    Patent number: 6635753
    Abstract: There are disclosed novel Stavudine solvates as follows: Stavudine NN-dimethyllacetamide solvates; Stavudine NN-dimethylacrylamide solvates and Stavudine NN-dimethylpropionamide solvates and processes for producing Stavudine NN-dimethylacetamide solvates, Stavudine NN dimethylacrylamide solvates and Stavudine NN dimethylpropionamide solvates which results in pure Stavudine.
    Type: Grant
    Filed: September 30, 1998
    Date of Patent: October 21, 2003
    Assignee: Brantford Chemicals Inc.
    Inventors: Bruno K. Radatus, K. S. Keshava Murthy
  • Process for the preparation of nefazodone hydrochloride
    Patent number: 6596866
    Abstract: A process for the preparation of Nefazodone hydrochloride comprising direct conversion of semicarbazide dihydrochloride 3 into Nefazodone hydrochloride which process involves a reaction of triethyl orthopropionate in the presence of trimethylsilylchloride and hydrochloric acid.
    Type: Grant
    Filed: September 17, 2001
    Date of Patent: July 22, 2003
    Assignee: Brantford Chemicals Inc.
    Inventors: K. S. Keshava Murthy, Bhaskar Reddy Guntoori, Daqing Che
  • Preparation of derivative of 3-sulfonamido-4-phenylaminopyridine
    Patent number: 6593475
    Abstract: This invention relates to the preparation of 3-sulfonamido-4-arylaminopyridines by heating a 3-sulfonamido-4-aminopyridine with an aryl halide in the presence of an alkaline compound, a copper-containing agent and in the presence of a polar protic solvent.
    Type: Grant
    Filed: November 14, 2002
    Date of Patent: July 15, 2003
    Assignee: Brantford Chemicals Inc.
    Inventors: Carlos B. Zetina-Rocha, Bhaskar Reddy Guntoori, Stephen E. Horne
  • Efficient process for the preparation of lamotrigine and related 3,5-diamino-6-substituted-1,2,4-triazines
    Patent number: 6586593
    Abstract: A process for the manufacture of 3,5-diamino-6-substituted-1,2,4-triazines is disclosed which comprises the steps of: (a) reacting a compound of formula (II):  with aminoguanidine salts, (b) dehydrating the compound obtained to form a compound of formula IV,  and (c) cyclization of the compound of formula IV into a 3,5-diamino-6-substituted-1,2,4-triazine compound of formula I or into a hydrated form thereof.
    Type: Grant
    Filed: January 16, 2002
    Date of Patent: July 1, 2003
    Assignee: Brantford Chemicals Inc.
    Inventors: Bhaskar Reddy Guntoori, Daqing Che, K. S. Keshava Murthy
  • Pharmaceutical compositions comprising co-micronized fenofibrate
    Patent number: 6555135
    Abstract: A pharmaceutical composition for oral administration comprising a co-micronized mixture of fenofibrate and a solid excipient that is not a surfactant.
    Type: Grant
    Filed: April 7, 2000
    Date of Patent: April 29, 2003
    Inventor: Bernard Charles Sherman
  • Desktop soldering dispenser with automatic metering and feeding of soldering wire
    Patent number: 6550663
    Abstract: The present invention describes the precise metering of soldering material realized in a preferred desktop preferably portable device designated for hand-soldering in small and medium volume operations. It combines the fully automated process of precise metering of the soldering wire for high accuracy and quality soldering with the freedom of a hand-operated soldering process.
    Type: Grant
    Filed: May 31, 2001
    Date of Patent: April 22, 2003
    Inventor: Leonid Poletaev
  • Institutional towel
    Patent number: 6546965
    Abstract: A coloured institutional towel comprising ground warp, fill, and pile warped yarns, all of said yarns being colored by intimately draw blending a predetermined amount of pre-dyed polyester fiber with cotton fiber when the yarn is spun and twisted to thereby form a predetermined color for the institutional towel.
    Type: Grant
    Filed: December 26, 2000
    Date of Patent: April 15, 2003
    Assignee: Blair Mills, L.P.
    Inventors: David Eugene Hamby, Wilbur Mattison Rice
  • Pharmaceutical compositions comprising quinapril magnesium
    Patent number: 6531486
    Abstract: Solid pharmaceutical compositions comprising quinapril magnesium can be made by reacting a quinapril or an acid addition salt thereof with an alkaline magnesium compound in the presence of a solvent so as to convert the quinapril or quinapril acid addition salt to quinapril magnesium.
    Type: Grant
    Filed: June 7, 2001
    Date of Patent: March 11, 2003
    Assignee: Apotex Inc.
    Inventor: Bernard Charles Sherman
  • Process to manufacture simvastatin and intermediates
    Patent number: 6506929
    Abstract: A process is disclosed for the preparation of simvastatin which enables highly regio selective C-methylation of the 2′-position group of lovastatin without requiring protection/deprotection of 13-OH of lovastatin and lactone ring opening/closure.
    Type: Grant
    Filed: April 24, 2001
    Date of Patent: January 14, 2003
    Assignee: Apotex Inc.
    Inventors: Khashayar Karimian, Tim Fat Tam, Yong Tao, Yiwei Li, Gary Doucette
  • Controlled onset and sustained release dosage forms and the preparation thereof
    Patent number: 6500459
    Abstract: A pharmaceutical composition for controlled onset and sustained release of an active ingredient, said composition comprising: (i) a core comprising: (a) an active ingredient; (b) a hydrophilic carrier; (c) a hydrodynamic diffusion enhancer; and optionally (d) conventional pharmaceutically acceptable excipients selected from the group consisting of binders, fillers and lubricants and combinations thereof; and (ii) a functional coating membrane surrounding said core.
    Type: Grant
    Filed: July 21, 1999
    Date of Patent: December 31, 2002
    Inventors: Harinderpal Chhabra, Shyamal K. Sarkar
  • Process for the preparation of tetrahydrothieno[3,2-c]pyridine derivatives
    Patent number: 6495691
    Abstract: A process for the preparation of tetrahydrothieno[3,2-c]pyridine derivatives of general formula I: or their pharmaceutically acceptable salts, wherein the meaning of X is hydrogen, carboxyl, alkoxycarbonyl, aryloxycarbonyl, nitrile, or carbamoyl of formula wherein R1 and R2 can be individually or simultaneously hydrogen, alkyl or part of a heterocyclic structure; Z can be hydrogen, halogen, alkyl, aryl, aryloxy or alkoxy group.
    Type: Grant
    Filed: July 11, 2001
    Date of Patent: December 17, 2002
    Assignee: Brantford Chemicals Inc.
    Inventors: Stephen E. Horne, Gamini Weeratunga, Bogdan M. Comanita, Jaipal Reddy Nagireddy, Laura Kaye McConachie
  • Electric wheelchair drive system
    Patent number: 6494278
    Abstract: Motorized wheels in a wheelchair or other light vehicle are each mounted on an axle for limited rotation relative to a secondary connection to the frame of the vehicle which incorporates a sensor providing feedback which controls the motor according to torque sensed through the secondary connection. The motor and associated gearing and control circuitry are housed within a wheel hub of which a drum supporting a wheel rim is supported at its inner surface on multiple bearings spaced around its periphery.
    Type: Grant
    Filed: October 2, 2000
    Date of Patent: December 17, 2002
    Inventor: Ervin Weisz
  • Stabilized cefuroxime axetil
    Patent number: 6485744
    Abstract: Solid pharmaceutical compositions comprising cefuroxime axetil as active ingredient and a zinc salt as stabilizer.
    Type: Grant
    Filed: July 24, 2000
    Date of Patent: November 26, 2002
    Inventor: Bernard Charles Sherman
  • Pit form
    Patent number: 6477816
    Abstract: A pit form comprising two substantially parallel side members having two ends and a substituting perpendicular rear member extending between proximate the same ends of the side members in use, each of the side members and the rear member having compatible male and female engaging portions to interconnect said members to form said pit form.
    Type: Grant
    Filed: April 16, 1999
    Date of Patent: November 12, 2002
    Assignee: Frommelt Industries of Canada, Inc.
    Inventor: Joseph J. Di Biase
  • Retractable screen system
    Patent number: 6446696
    Abstract: A retractable screen is located within a frame portion of a window. The screen accumulates on and pays out from a spring biased roller located in said frame portion. The screen is fully retractable and for the most part hidden for viewing, egress or cleaning purposes, and is available as desired when moved to the operable position. The screening material utilized includes “T” shaped members for easy installation in compatible grooves provided with the handle and the roller.
    Type: Grant
    Filed: October 31, 1997
    Date of Patent: September 10, 2002
    Assignee: Preferred Engineering Products, Ltd.
    Inventors: John Robert Davies, Sean Davies, Sinnathamby Kupenthirarajan
  • Pharmaceutical composition comprising fenofibrate
    Patent number: 6444225
    Abstract: The bioavailability of fenofibrate is improved by making a solid dispersion of a disentegrant in the fenofibrate. Method of making said solid dispersion comprising melting the fenofibrate, blending the disintegrant into the melt, and resolidifying the mixture.
    Type: Grant
    Filed: September 16, 1998
    Date of Patent: September 3, 2002
    Inventor: Bernard Charles Sherman
  • Synthesis of pharmaceutically useful pyridine derivatives
    Patent number: 6437139
    Abstract: A process is provided for the preparation of compounds of formula I, useful in the preparation of compounds such as Omeprazole, Lansoprazole and Pantoprazole, wherein R1=H or CH3, R2=H or CH3, R3=Alkoxy (1-4C), OCH2CF3, Cyano, Hydrogen, Halogen, Acetoxy or Aryloxy, any electron withdrawing group or salts (organic or inorganic) of electron donating groups, R=Alkoxy, Hydroxy, Halogen, Activated ester, Tosylate, Mesylate, Thiol or Xanthyl, wherein the process for the preparation of compound of formula I employs a free radical reaction to functionalize the 2-position.
    Type: Grant
    Filed: June 23, 2000
    Date of Patent: August 20, 2002
    Assignee: PDi-Research Laboratories, Inc.
    Inventors: Michel Zoghbi, Liquin Chen
  • Useful form of anhydrous paroxetine hydrochloride
    Patent number: 6436956
    Abstract: Paroxetine hydrochloride anhydrous designated as Form IV having at least one, some or all of the following characteristics: a) Infrared spectra as shown in FIG. 1 and 2, b) A X-ray powder diffraction pattern as shown in Schedule “C”, c) A melting point of between about 80°0 C. to about 95° C.
    Type: Grant
    Filed: November 24, 1997
    Date of Patent: August 20, 2002
    Assignee: Brantford Chemicals Inc.
    Inventors: K. S. Keshava Murthy, Allan Rey, Gamini Weeratunga
  • Process for the preparation of Ramipril
    Patent number: 6407262
    Abstract: A process for separating diastereomeric mixtures of compounds of formula 1 and formula 2 wherein R1=H or R1 denotes a carboxyl-esterifying group selected from C1-C6 alkyl and C7-C8 aralkyl, by treating the mixture of 1 and 2 with a solvent or mixture of solvents to obtain a substantially pure compound of formula 1.
    Type: Grant
    Filed: November 23, 2001
    Date of Patent: June 18, 2002
    Assignee: Brantford Chemicals Inc.
    Inventors: Zhi-Xian Wang, Cameron McPhail
  • Roll up screen connector
    Patent number: D470749
    Type: Grant
    Filed: March 1, 1999
    Date of Patent: February 25, 2003
    Assignee: 420820 Ontario Limited
    Inventor: John Robert Davies