Abstract: A pinless caster assembly comprising a first substantially "T"-shaped part and a second substantially ring-shaped solid part, said first and second parts interfitting with bearing elements and when interfit providing races for the bearing elements and the caster assembly, said first and second part being machined from solid material of predetermined metallurgical characteristics, said first part having disposed therewith a first one-half raceway, for receiving load-carrying bearings in use, and a second one-half raceway for receiving swivel bearings in use, said second part having disposed therewith a third one-half raceway for receiving load-carrying bearings in use for mating with the first one-half raceway disposed with the first part and thereby providing a load-carrying race of the caster assembly, said second part also having disposed therewith a fourth one-half raceway for receiving swivel bearings in use and for mating with the second one-half raceway disposed with the first part and thereby providing

Abstract: Pharmaceutical compositions from which effective non-toxic (to the patient) dosage amounts may be taken and applied to the skin and/or exposed tissue of a human, each effective dosage amount comprising pharmaceutical excipients suitable for topical application, an effective non-toxic dosage amount of a drug to treat and to assist to resolve a disease and/or condition of the skin and/or exposed tissue of a human and an effective non-toxic dosage amount of hyaluronic acid and/or salts thereof and/or homologues, analogues, derivatives, complexes, esters, fragments, and/or sub-units of hyaluronic acid sufficient to transport (to facilitate or cause the transport of) the drug, to a site in the skin including epidermis or exposed tissue of a disease or condition for percutaneous transport into the skin and/or exposed tissue to accumulate and remain there for a prolonged period of time and which is systemic independent acting.

Abstract: A cartridge for a valve housing having outlets, the cartridge comprising a stationary body sleeve for fixed insertion within the housing and having outlet ports permanently aligned with the outlets of the housing, a moveable substantially hollow stem sleeve inserted within the stationary body sleeve and having an opening selectively alignable with the ports of the stationary body sleeve, the body sleeve and hollow stem being connected to one another by a retaining ring which aligns and maintains the cartridge as a unit in the housing. The diverting valve may be installed as a deck mounted fixture in a tub, whirlpool, soaking bath, spa, roman tub, or the like wherein the tub spout is located below the flood line rim of the respective fixture wherein the diverting valve can be repaired by replacing the cartridge from the top of the valve by removing the handle and replacing the cartridge in its entirety.

Abstract: The present pump design with the elimination of a separate hydraulic fluid path from the cylinder dramatically improves the efficiency and pressure achieved by the pump by 15% as a result of reducing the number of chambers provided in the pump interior. It is, however, imperative for reasons not completely understood that in order for these efficiencies to be obtained that a reservoir of oil be located adjacent the main oil intake volume to ensure quick filling of the main oil intake volume as the piston cycles to its pressure stroke. This prevents cavitation of the pump.

Abstract: A method for the treatment of mucous membrane trauma disease or condition for the relief of pain associated therewith comprising administering topically an effective amount of a composition comprising an N.S.A.I.D. and a form of hyaluronic acid selected from hyaluronic acid, pharmaceutically acceptable salts thereof, fragments thereof and/or subunits thereof.

Abstract: A pharmaceutical composition is provided comprising a plurality of effective non-toxic dosage amounts of a composition for topical administration to the site of pathology and/or trauma of skin and/or exposed tissue of a human patient in need of treatment suffering from a disease or condition. Each such dosage amount comprises a therapeutically effective non-toxic (to the patient) dosage amount of a drug for the treatment of the disease and/or condition of the skin and/or exposed tissue at the site of the pathology and/or trauma and an effective non-toxic dosage amount of hyaluronic acid and/or salts thereof to transport (to facilitate or cause the transport of) the drug to the site of the pathology and/or trauma of the disease or condition.

Abstract: This invention relates to new stereoselective processes for preparing 3-substituted-4-aryl piperidines and methods for controlling the absolute stereochemistry at the C-3 and C-4 positions of the piperidine ring. Compounds of this type are key intermediates in the preparation of paroxetine, femoxetine, and other medicaments.

Abstract: A head assembly for a pultrusion process for pultruding pultrudable material is provided. The head assembly includes a floating adjustable assembly carrying a pultrusion die. The die has a center line disposed proximate the center line of the process and an entrance, and an exit. The material passing from the entrance to the exit of the die in forming an acceptable finished shape is maintained when formed with the center line of the exit of the die always remaining stationary and disposed proximate the center line of the process.

Abstract: A closure assembly includes a track and a slidable and pivotable closure member. The closure member is engaged with the track proximate first and second pivots adjacent the pivotable end of the member, the first and second pivots being interconnected by a multiple segment shaft (for example at least two portions) (for example telescoping) which provides for accurate installation, retention, removal, adjustment and alignment of the first and second pivots in a substantially parallel line for pivotally supporting the closure member so that it may be safely and securely pivoted away from the closure assembly.

Abstract: Topically applied transdermally quick penetrating compositions containing a drug and hyaluronic acid and/or salts thereof and methods of treating diseases and conditions employing said compositions.

Abstract: A combination for administration to a mammal which combination employs a therapeutically effective amount of a medicinal and/or therapeutic agent to treat a disease or condition and an amount of hyaluronic acid and/or salts thereof and/or homologues, analogues, derivatives, complexes, esters, fragments and subunits of hyaluronic acid sufficient to facilitate the agent's penetration through the tissue (including scar tissue) at the site to be treated, through the cell membranes into the individual cells to be treated.

Abstract: A shoe for movement in a track of a closure assembly the track having at least one engaging portion, the pivot shoe comprising a carrier portion having a bottom end for movement within the track, the shoe having clamping portions for clamping said at least one engaging portion of the track of the closure assembly the at least one engaging portion being disposed between the clamping portions of the shoe when the pivot shoe is installed in the closure assembly. The shoe also has an operating mechanism, the clamping portions being in engagement with said operating mechanism said operating mechanism being moveable from a first position to cause the clamping portions to engage the at least one engaging portion of the track wherein the closure member of the closure assembly is locked or secured in position, to a second position wherein the clamping portions disengages the at least one engaging portion of the track wherein the closure member of the closure assembly is free to move in the track.

Abstract: A combination for administration to a mammal which combination employs a therapeutically effective amount of a medicinal and/or therapeutic agent to treat a disease or condition and an amount of hyaluronic acid and/or salts thereof and/or homologues, analogues, derivatives, complexes, esters, fragments and subunits of hyaluronic acid sufficient to facilitate the agent's penetration through the tissue (including scar tissue) at the site to be treated, through the cell membranes into the individual cells to be treated.

Abstract: A process is provided for the manufacture of: where R is: ##STR1## comprising reacting: ##STR2## wherein R.sub.1 may be selected from H, Methyl, Ethyl and suitable lower alkyl groups, C.sub.n H.sub.2n+1 (where n is from 3 to 5) or any other suitable group and thereafter if desired converting the resultant product to a salt thereof.

Abstract: A topically applied transdermally penetrating systemic independent acting pharmaceutical combination and formulation for the treatment of a disease or condition of the skin and exposed tissue for example, basal cell carcinoma, the precancerous, often recurrent, actinic keratoses lesions, fungal lesions, "liver" spots and like lesions (found for the most part in the epidermis), squamous cell tumours, metastatic cancer of the breast to the skin, primary and metastatic melanoma in the skin, genital warts (condyloma acuminata) cervical cancer, and HPV (Human Papilloma Virus) including HPV of the cervix, psoriasis (both plaque-type psoriasis and nail bed psoriasis), corns on the feet and hair loss on the head of pregnant women, comprising, together with pharmaceutical excipients suitable for topical application, a therapeutically effective non-toxic amount of a drug which inhibits prostaglandin synthesis administered with, or carried in, an amount of hyaluronic acid and/or salts thereof and/or homologues, analogue

Abstract: A combination for administration to a mammal which combination employs a therapeutically effective amount of a medicinal and/or therapeutic agent to treat a disease or condition and an amount of hyaluronic acid and/or salts thereof and/or homologues, analogues, derivatives, complexes, esters, fragments and subunits of hyaluronic acid sufficient to facilitate the agent's penetration through the tissue (including scar tissue) at the site to be treated, through the cell membranes into the individual cells to be treated.

Abstract: A prosthesis for orienting a flacid penis in an orientation to accommodate sexual intercourse is provided. The prosthesis of the present invention does not interfere with the blood flow to the penis. A pair of continuous wire or rod shaped flexible members are formed separately and joined together to allow pivoting motion of the members with respect to one another in a pivoting relationship. The members are also coated with a flexible preferably soft latex like thermoplastic coating so as not to irritate the user. The prosthesis includes a the first engaging portion for engaging adjacent the glans of the penis, proximate the corona sulcus and the prosthesis also having laterally extending arms for engaging an area adjacent the public bone of the user for engaging with a securing strap to allow for the provision of various comfort positions.

Abstract: A pharmaceutical composition comprising a plurality of effective non-toxic dosage amounts of a composition for topical administration to the site of pathology and/or trauma of skin and/or exposed tissue of a human patient in need of treatment suffering from a disease or condition, each such dosage amount comprising a therapeautically effective non-toxic (to the patient) dosage amount of a drug for the treatment of the disease and/or condition of the skin and/or exposed tissue at the site of the pathology and/or trauma and an effective non-toxic dosage amount of hyaluronic acid and/or salts thereof and/or homologues, analogues, derivatives, complexes, esters, fragments, and/or sub-units of hyaluronic acid to transport (to facilitate or cause the transport of) the drug to the site of the pathology and/or trauma of the disease or condition.

Abstract: A process is provided for the preparation of 4-amino-1-hydroxybutylidene-1,1-bisphosphonic acid or salts thereof which comprises of:a) reacting 4-aminobutyric acid with phosphorous acid and phosphorus trichloride in the presence of a polyalkylene(glycol); andb) recovering said 4-amino-1-hydroxybutylidene-1,1-bisphosphonic acid or salts thereof.