Patents Represented by Attorney, Agent or Law Firm Margaret C. Bogosian
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Patent number: 7091489Abstract: A method of serially transferring annihilation information in a compact positron emission tomography (PET) scanner includes generating a time signal representing a time-of-occurrence of an annihilation event, generating an address signal representing a channel detecting the annihilation event, and generating a channel signal including the time and address signals. The method also includes generating a composite signal including the channel signal and another similarly generated channel signal concerning another annihilation event. An apparatus that serially transfers annihilation information includes a time signal generator, address signal generator, channel signal generator, and composite signal generator. The time signal is asynchronous and the address signal is synchronous to a clock signal. A PET scanner includes a scintillation array, detection array, front-end array, and a serial encoder.Type: GrantFiled: October 16, 2003Date of Patent: August 15, 2006Assignee: Brookhaven Science Associates, LLCInventors: David J. Schlyer, Paul O'Connor, Craig Woody, Sachin Shrirang Junnarkar, Veljko Radeka, Paul Vaska, Jean-Francois Pratte
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Patent number: 7076959Abstract: A magnetocaloric effect heterostructure having a core layer of a magnetostructural material with a giant magnetocaloric effect having a magnetic transition temperature equal to or greater than 150 K, and a constricting material layer coated on at least one surface of the magnetocaloric material core layer. The constricting material layer may enhance the magnetocaloric effect by restriction of volume changes of the core layer during application of a magnetic field to the heterostructure. A magnetocaloric effect heterostructure powder comprising a plurality of core particles of a magnetostructural material with a giant magnetocaloric effect having a magnetic transition temperature equal to or greater than 150 K, wherein each of the core particles is encapsulated within a coating of a constricting material is also disclosed.Type: GrantFiled: March 7, 2005Date of Patent: July 18, 2006Assignee: Brookhaven Science Associates, LLCInventor: Laura J. H. Lewis
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Patent number: 7074386Abstract: A method for capturing specified materials which includes contacting a microporous material with a hydrostatic fluid having at least one specified material carried therein, under pressure which structurally distorts the lattice sufficiently to permit entry of the at least one specified material. The microporous material is capable of undergoing a temporary structural distortion which alters resting lattice dimensions under increased ambient pressure and at least partially returning to rest lattice dimensions when returned to ambient pressure. The pressure of the fluid is then reduced to permit return to at least partial resting lattice dimension while the at least one specified material is therein. By this method, at least one specified material is captured in the microporous material to form a modified microporous material.Type: GrantFiled: November 25, 2002Date of Patent: July 11, 2006Assignee: Brookhaven Science Associates, LLCInventors: Thomas Vogt, Joseph A. Hriljac, Yongjae Lee
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Patent number: 7075030Abstract: An apparatus includes a plasma generator aligned with a beam generator for producing a plasma to shield an energized beam. An electrode is coaxially aligned with the plasma generator and followed in turn by a vortex generator coaxially aligned with the electrode. A target is spaced from the vortex generator inside a fluid environment. The electrode is electrically biased relative to the electrically grounded target for driving the plasma toward the target inside a vortex shield.Type: GrantFiled: August 30, 2004Date of Patent: July 11, 2006Assignee: Brookhaven Science Associates, LLCInventors: Ady Hershcovitch, Rory Dominick Montano
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Patent number: 7029921Abstract: An apparatus for continuous on-line measurement of chemical composition of aerosol particles with a fast time resolution is provided. The apparatus includes an enhanced particle size magnifier for producing activated aerosol particles and an enhanced collection device which collects the activated aerosol particles into a liquid stream for quantitative analysis by analytical means. Methods for on-line measurement of chemical composition of aerosol particles are also provided, the method including exposing aerosol carrying sample air to hot saturated steam thereby forming activated aerosol particles; collecting the activated aerosol particles by a collection device for delivery as a jet stream onto an impaction surface; and flushing off the activated aerosol particles from the impaction surface into a liquid stream for delivery of the collected liquid stream to an analytical instrument for quantitative measurement.Type: GrantFiled: October 24, 2002Date of Patent: April 18, 2006Assignee: Brookhaven Science Associates, LLCInventors: Yin-Nan E. Lee, Rodney J. Weber, Douglas Orsini
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Patent number: 7005525Abstract: Organometallic complexes are provided, which include a catalyst containing a transition metal, a ligand and a component having the formula GArF. ArF is an aromatic ring system selected from phenyl, naphthalenyl, anthracenyl, fluorenyl, or indenyl. The aromatic ring system has at least a substituent selected from fluorine, hydrogen, hydrocarbyl or fluorinated hydrocarbyl, G is substituted or unsubstituted (CH2)n or (CF2)n, wherein n is from 1 to 30, wherein further one or more CH2 or CF2 groups are optionally replaced by NR, PR, SiR2, BR, O or S, or R is hydrocarbyl or substituted hydrocarbyl, GArF being covalently bonded to either said transition metal or said ligand of said catalyst, thereby rendering said cationic organometallic complex liquid.Type: GrantFiled: December 9, 2003Date of Patent: February 28, 2006Assignee: Brookhaven Science Associates, LLCInventors: Vladimir K. Dioumaev, R. Morris Bullock
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Patent number: 6995260Abstract: The present invention is directed to low toxicity boronated compounds and methods for their use in the treatment, visualization, and diagnosis of tumors. More specifically, the present invention is directed to low toxicity carborane-containing 5, 10, 15, 20-tetraphenylporphyrin compounds and methods for their use particularly in boron neutron capture therapy (BNCT) and photodynamic therapy (PDT) for the treatment of tumors of the brain, head and neck, and surrounding tissue. The invention is also directed to using these carborane-containing tetraphenyl porphyrin compounds to methods of tumor imaging and/or diagnosis such as MRI, SPECT, or PET.Type: GrantFiled: May 20, 2004Date of Patent: February 7, 2006Assignee: Brookhaven Science Associates, LLCInventors: Haitao Wu, Michiko Miura
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Patent number: 6989443Abstract: The present invention is directed to low toxicity boronated compounds and methods for their use in the treatment, visualization, and diagnosis of tumors. More specifically, the present invention is directed to low toxicity carborane-containing 5, 10, 15, 20-tetraphenylporphyrin compounds and methods for their use particularly in boron neutron capture therapy (BNCT) and photodynamic therapy (PDT) for the treatment of tumors of the brain, head, neck, and surrounding tissue. The invention is also directed to using these carborane-containing tetraphenyl porphyrin compounds to methods of tumor imaging and/or diagnosis such as MRI, SPECT, or PET.Type: GrantFiled: June 28, 2004Date of Patent: January 24, 2006Assignee: Brookhaven Science Associates, LLCInventors: Haitao Wu, Michiko Miura
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Patent number: 6974893Abstract: The present invention relates to oleate hydroxylase genes, proteins, and methods of their use. The present invention also relates to methods of using the oleate hydroxylase genes and proteins, including in their expression in transgenic organisms and in the production of hydroxylated fatty acids.Type: GrantFiled: June 28, 2002Date of Patent: December 13, 2005Assignee: Brookhaven Science Associates, LLCInventors: John Shanklin, Edward J. Whittle
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Patent number: 6951640Abstract: The present invention covers halogenated derivatives of boronated phorphyrins containing multiple carborane cages having the formula which selectively accumulate in neoplastic tissue within the irradiation volume and thus can be used in cancer therapies including, but not limited to, boron neutron-capture therapy and photodynamic therapy. The present invention also covers methods for using these halogenated derivatives of boronated porphyrins in tumor imaging and cancer treatment.Type: GrantFiled: February 27, 2003Date of Patent: October 4, 2005Assignee: Brookhaven Science Associates, LLCInventors: Michiko Miura, Daniel N. Slatkin
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Patent number: 6939876Abstract: The present invention provides a composition for treating pain. The composition includes a pharmaceutically acceptable analgesic and a GABAergic agent, such as gamma vinyl GABA, effective in reducing or eliminating the addictive liability of the analgesic.Type: GrantFiled: April 18, 2002Date of Patent: September 6, 2005Assignee: Brookhaven Science Associates, LLCInventors: Stephen L. Dewey, Jonathan D. Brodie, Charles R. Ashby, Jr.
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Patent number: 6921733Abstract: The invention provides a homogenous catalyst for the production of methanol from purified synthesis gas at low temperature and low pressure which includes a transition metal capable of forming transition metal complexes with coordinating ligands and an alkoxide, the catalyst dissolved in a methanol solvent system, provided the transition metal complex is not transition metal carbonyl. The coordinating ligands can be selected from the group consisting of N-donor ligands, P-donor ligands, O-donor ligands, C-donor ligands, halogens and mixtures thereof.Type: GrantFiled: January 16, 2002Date of Patent: July 26, 2005Assignee: Brookhaven Science Associates, LLCInventor: Devinder Mahajan
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Patent number: 6906099Abstract: The present invention relates to the use of a composition that increases central nervous system GABA levels in a mammal, for the treatment of addiction to drugs of abuse and modification of behavior associated with addiction to drugs of abuse in said mammal.Type: GrantFiled: February 2, 2001Date of Patent: June 14, 2005Assignee: Brookhaven Science Associates, LLCInventors: Stephen L. Dewey, Jonathan D. Brodie, Charles R. Ashby, Jr.
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Patent number: 6835303Abstract: The sulfur content of a liquid hydrocarbon stream is reduced under mild conditions by contracting a sulfur-containing liquid hydrocarbon stream with transition metal particles containing the transition metal in a zero oxidation state under conditions sufficient to provide a hydrocarbon product having a reduced sulfur content and metal sulfide particles. The transition metal particles can be produced in situ by adding a transition metal precursor, e.g., a transition metal carbonyl compound, to the sulfur-containing liquid feed stream and sonicating the feed steam/transition metal precursor combination under conditions sufficient to produce the transition metal particles.Type: GrantFiled: September 21, 2001Date of Patent: December 28, 2004Assignee: Brookhaven Science Associates, LLCInventor: Devinder Mahajan
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Patent number: 6828349Abstract: The present invention provides a highly efficient method for treating substance addiction and for changing addiction-related behavior of a mammal suffering from substance addiction. The method includes administering to a mammal an effective amount of gamma vinylGABA or a pharmaceutically acceptable salt thereof. The present invention also provides a method of treatment of cocaine, morphine, heroin, nicotine, amphetamine, methamphetamine, or ethanol addiction by treating a mammal with an effective amount of gamma vinylGABA or a pharmaceutically acceptable salt thereof.Type: GrantFiled: November 9, 1998Date of Patent: December 7, 2004Assignee: Brookhaven Science AssociatesInventors: Stephen L. Dewey, Jonathan D. Brodie, Charles R. Ashby, Jr.
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Patent number: 6819113Abstract: The present invention is for a precision grid surveyor having a stationary unit and a roving unit. The stationary unit has a light source unit that emits a light beam and a rotator to project the light beam toward detectors on a roving unit. The roving unit moves over an area to be surveyed. Further the invention is for a method of mapping details of hidden underground iron pipelines, and more particularly the location of bell joints.Type: GrantFiled: July 8, 2002Date of Patent: November 16, 2004Assignee: Brookhaven Science AssociatesInventor: Udo von Wimmerspeg
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Patent number: 6803203Abstract: The present invention provides a method for detecting DNA-activated protein kinase (DNA-PK) activity in a biological sample.Type: GrantFiled: October 24, 2000Date of Patent: October 12, 2004Assignee: Brookhaven Science AssociatesInventors: Carl W. Anderson, Margery A. Connelly
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Patent number: 6794339Abstract: The present invention is a method of forming thick films of crystalline YBa2Cu3O7 that includes forming a precursor film comprising barium fluoride (BaF2), yttrium (Y) and copper (Cu). The precursor film is heat-treated at a temperature above 500° C. in the presence of oxygen, nitrogen and water vapor at sub-atmospheric pressure to form a crystalline structure. The crystalline structure is then annealed at about 500° C. in the presence of oxygen to form the crystalline YBa2Cu3O7 film. The YBa2Cu3O7 film formed by this method has a resistivity of from about 100 to about 600 &mgr;Ohm-cm at room temperature and a critical current density measured at 77 K in a magnetic field of 1 Tesla of about 1.0×105 Ampere per square centimeter (0.1 MA/cm2) or greater.Type: GrantFiled: September 12, 2001Date of Patent: September 21, 2004Assignee: Brookhaven Science AssociatesInventors: Harold Wiesmann, Vyacheslav Solovyov
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Patent number: 6789022Abstract: Disclosed is a method for detecting and quantifying clustered damages in DNA. In this method, a first aliquot of the DNA to be tested for clustered damages with one or more lesion-specific cleaving reagents under conditions appropriate for cleavage of the DNA to produce single-strand nicks in the DNA at sites of damage lesions. The number average molecular length (Ln) of double stranded DNA is then quantitatively determined for the treated DNA. The number average molecular length (Ln) of double stranded DNA is also quantitatively determined for a second, untreated aliquot of the DNA. The frequency of clustered damages (&PHgr;c) in the DNA is then calculated.Type: GrantFiled: April 18, 2001Date of Patent: September 7, 2004Assignee: Brookhaven Science Associates LLCInventor: Betsy M. Sutherland
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Patent number: 6759403Abstract: The present invention covers radiosensitizers containing as an active ingredient halogenated derivatives of boronated porphyrins containing multiple carborane cages having the structure which selectively accumulate in neoplastic tissue within the irradiation volume and thus can be used in cancer therapies including, but not limited to, boron neutron—capture therapy and photodynamic therapy. The present invention also covers methods for using these radiosensitizers in tumor imaging and cancer treatment.Type: GrantFiled: April 5, 2002Date of Patent: July 6, 2004Assignee: Brookhaven Science Associates, LLCInventors: Michiko Miura, Daniel N. Slatkin