Patents Represented by Attorney, Agent or Law Firm Margaret C. Bogosian
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Patent number: 6179897Abstract: The present invention provides a method for producing a metal vapor that includes the steps of combining a metal and graphite in a vessel to form a mixture; heating the mixture to a first temperature in an argon gas atmosphere to form a metal carbide; maintaining the first temperature for a period of time; heating the metal carbide to a second temperature to form a metal vapor; withdrawing the metal vapor and the argon gas from the vessel; and separating the metal vapor from the argon gas. Metal vapors made using this method can be used to produce uniform powders of the metal oxide that have narrow size distribution and high purity.Type: GrantFiled: March 18, 1999Date of Patent: January 30, 2001Assignee: Brookhaven Science AssociatesInventors: Walter Kunnmann, John Z. Larese
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Patent number: 6160195Abstract: A composition for converting asbestos-containing material, covering metal pipes or other metal surfaces, to non-regulated, environmentally benign-materials, and inhibiting the corrosion of the metal pipes or other metal surfaces. The composition comprises a combination of at least two multiple-functional group reagents, in which each reagent includes a Fluro acid component and a corrosion inhibiting compoment. A method for converting asbestos-containing material, covering metal pipes or other metal surfaces, to non-regulated, environmentally benign-materials, and inhibiting the corrosion of the metal pipes or other metal surfaces is also provided.Type: GrantFiled: January 22, 1999Date of Patent: December 12, 2000Assignee: Brookhaven Science AssociatesInventors: Toshifumi Sugama, Leon Petrakis
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Patent number: 6147787Abstract: A microphone for detecting sound pressure waves includes a laser resonator having a laser gain material aligned coaxially between a pair of first and second mirrors for producing a laser beam. A reference cell is disposed between the laser material and one of the mirrors for transmitting a reference portion of the laser beam between the mirrors. A sensing cell is disposed between the laser material and one of the mirrors, and is laterally displaced from the reference cell for transmitting a signal portion of the laser beam, with the sensing cell being open for receiving the sound waves. A photodetector is disposed in optical communication with the first mirror for receiving the laser beam, and produces an acoustic signal therefrom for the sound waves.Type: GrantFiled: December 12, 1997Date of Patent: November 14, 2000Assignees: Brookhaven Science Associates, Brookhaven National LaboratoryInventor: James T. Veligdan
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Patent number: 6125834Abstract: A cutting machine includes a gun barrel for receiving a projectile. A compression tube is disposed in flow communication with the barrel and includes a piston therein. A reservoir is disposed in flow communication with the tube and receives a first gas under pressure. A second gas fills the compression tube on a front face of the piston. And, the pressurized first gas is discharged into the tube on a back face of the piston to accelerate the piston through the tube for compressing the second gas, and in turn launching the projectile through the barrel to impact a workpiece.Type: GrantFiled: January 25, 1999Date of Patent: October 3, 2000Assignee: Brookhaven Science AssociatesInventors: Gaby Ciccarelli, Manomohan Subudhi, Robert E. Hall
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Patent number: 6124509Abstract: The present invention is a process for the catalytic hydrogenation of ketones and aldehydes to alcohols at low temperatures and pressures using organometallic molybdenum and tungsten complexes. The functional group is selected from groups represented by the formulas R(C.dbd.O)R' and R(C.dbd.O)H, wherein R and R' are selected from hydrogen or any alkyl or aryl group. The active catalyst for the process has the form: [CpM(CO).sub.2 (PR*.sub.3) L].sup.+ A.sup.-, where Cp=.eta..sup.5 -R.sup..tangle-solidup..sub.m C.sub.5 H.sub.5-m and R.sup..tangle-solidup. represents an alkyl group or a halogen (F, Cl, Br, I) or R.sup..tangle-solidup. =OR' (where R'=H, an alkyl group or an aryl group) or R.sup..tangle-solidup. =CO.sub.2 R' (where R'=H, an alkyl group or an aryl group) and m=0 to 5; M represents a molybdenum atom or a tungsten atom; R*.sub.3 represents three hydrocarbon groups selected from a cyclohexyl group (C.sub.6 H.sub.11), a methyl group (CH.sub.3), and a phenyl group (C.sub.6 H.sub.Type: GrantFiled: January 22, 1999Date of Patent: September 26, 2000Assignee: Brookhaven Science AssociatesInventors: Mark Voges, R. Morris Bullock
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Patent number: 6121053Abstract: A multiple protocol fluorometer measures photosynthetic parameters of phytoplankton and higher plants using actively stimulated fluorescence protocols. The measured parameters include spectrally-resolved functional and optical absorption cross sections of PSII, extent of energy transfer between reaction centers of PSII, F.sub.0 (minimal), F.sub.m (maximal) and F.sub.v (variable) components of PSII fluorescence, photochemical and non-photochemical quenching, size of the plastoquinone (PQ) pool, and the kinetics of electron transport between Q.sub.a and PQ pool and between PQ pool and PSI. The multiple protocol fluorometer, in one embodiment, is equipped with an excitation source having a controlled spectral output range between 420 nm and 555 nm and capable of generating flashlets having a duration of 0.125-32 .mu.s, an interval between 0.5 .mu.s and 2 seconds, and peak optical power of up to 2 W/cm.sup.2.Type: GrantFiled: December 10, 1997Date of Patent: September 19, 2000Assignee: Brookhaven Science AssociatesInventors: Zbigniew S. Kolber, Paul G. Falkowski
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Patent number: 6120941Abstract: A new family of aza-ether based compounds including linear, multi-branched and aza-crown ethers is provided. When added to non-aqueous battery electrolytes, the new family of aza-ether based compounds acts as neutral receptors to complex the anion moiety of the electrolyte salt thereby increasing the conductivity and the transference number of LI.sup.+ ion in alkali metal batteries.Type: GrantFiled: April 20, 1998Date of Patent: September 19, 2000Assignee: Brookhaven Science AssociatesInventors: Hung Sui Lee, Xiao-Oing Yang, James McBreen
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Patent number: 6100091Abstract: Disclosed is a methods for modifying the chain length and double bond positional specificities of a soluble plant fatty acid desaturase. More specifically, the method involves modifying amino acid contact residues in the substrate binding channel of the soluble fatty acid desaturase which contact the fatty acid. Specifically disclosed is the modification of an acyl-ACP desaturase. Amino acid contact residues which lie within the substrate binding channel are identified, and subsequently replaced with different residues to effect the modification of activity.Type: GrantFiled: March 25, 1999Date of Patent: August 8, 2000Assignee: Brookhaven Science AssociatesInventors: Edgar B. Cahoon, John Shanklin, Ylva Lindgvist, Gunter Schneider
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Patent number: 6057368Abstract: The present invention provides a highly efficient method for treating substance addiction and for changing addiction-related behavior of a primate suffering from substance addiction. The method includes administering to a primate an effective amount of a pharmaceutical composition including gamma vinylGABA. The present invention also provides a method of treatment of nicotine addiction by treating a patient with an effective amount of a composition including gamma vinylGABA.Type: GrantFiled: August 5, 1998Date of Patent: May 2, 2000Assignee: Brookhaven Science Associates LLCInventors: Stephen L. Dewey, Jonathan D. Brodie, Charles R. Ashby, Jr.
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Patent number: 6030549Abstract: The present invention provides a process of encapsulating depleted uranium by forming a homogenous mixture of depleted uranium and molten virgin or recycled thermoplastic polymer into desired shapes. Separate streams of depleted uranium and virgin or recycled thermoplastic polymer are simultaneously subjected to heating and mixing conditions. The heating and mixing conditions are provided by a thermokinetic mixer, continuous mixer or an extruder and preferably by a thermokinetic mixer or continuous mixer followed by an extruder. The resulting DUPoly shapes can be molded into radiation shielding material or can be used as counter weights for use in airplanes, helicopters, ships, missiles, armor or projectiles.Type: GrantFiled: August 4, 1997Date of Patent: February 29, 2000Assignee: Brookhaven Science AssociatesInventors: Paul D. Kalb, Jay W. Adams, Paul R. Lageraaen, Carl R. Cooley
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Patent number: 6022643Abstract: Novel fluorinated boron-based compounds which act as anion receptors in non-aqueous battery electrolytes are provided. When added to non-aqueous battery electrolytes, the fluorinated boron-based compounds of the invention enhance ionic conductivity and cation transference number of non-aqueous electrolytes. The fluorinated boron-based anion receptors include borane and borate compounds bearing different fluorinated alkyl and aryl groups.Type: GrantFiled: December 8, 1997Date of Patent: February 8, 2000Assignee: Brookhaven Science AssociatesInventors: Hung Sui Lee, Xia-Oing Yang, James McBreen, Caili Xiang
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Patent number: 6022522Abstract: Bicyclo[2.2.2]octane-2,3 diamine-N,N,N',N'-tetraacetic acids (BODTA) and bicyclo[2.2.1]heptane-2,3 diamine-N,N,N',N'-tetraacetic acid (BHDTA) are chelating agents useful in forming detectably labeled bioconjugate compounds for diagnostic and therapeutic purposes. New compounds and processes of forming BODTA and BHDTA are disclosed. Radioimmunoconjugates of the present invention show high and prolonged tumor uptake with low normal tissue uptakes.Type: GrantFiled: March 23, 1998Date of Patent: February 8, 2000Assignee: Brookhaven Science AssociatesInventors: Mark P. Sweet, Ronnie C. Mease, Suresh C. Srivastava
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Patent number: 6017902Abstract: The present invention provides new boron containing amino acid compounds and methods for making these compounds by contacting melphalan or another nitrogen mustard derivative and sodium borocaptate. The present invention also provides a method of treating a mammal having a tumor by administering to the mammal a therapeutically effective amount of the new boron containing amino acid compounds.Type: GrantFiled: February 25, 1999Date of Patent: January 25, 2000Assignee: Brookhaven Science AssociatesInventors: John D. Glass, Jeffrey A. Coderre
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Patent number: 6014239Abstract: An optical microphone includes a laser and beam splitter cooperating therewith for splitting a laser beam into a reference beam and a signal beam. A reflecting sensor receives the signal beam and reflects it in a plurality of reflections through sound pressure waves. A photodetector receives both the reference beam and reflected signal beam for heterodyning thereof to produce an acoustic signal for the sound waves. The sound waves vary the local refractive index in the path of the signal beam which experiences a Doppler frequency shift directly analogous with the sound waves.Type: GrantFiled: December 12, 1997Date of Patent: January 11, 2000Assignee: Brookhaven Science AssociatesInventor: James T. Veligdan
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Patent number: 6004532Abstract: The invention provides improved formulations of .sup.117m Sn (Sn.sup.4+) DTPA which allow higher doses of .sup.117m Sn (Sn.sup.4+) to be administered than were previously possible. Methods for making pharmaceutical compositions comprising .sup.117m Sn (Sn.sup.4+) DTPA in which the amount of unchelated DTPA is minimized are disclosed along with methods of using the improved formlulations, both for palliation of bone pain associated with cancer and for treatment of osseous tumors.Type: GrantFiled: June 8, 1998Date of Patent: December 21, 1999Assignee: Brookhaven Science AssociatesInventors: Suresh C. Srivastava, George E. Meinken
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Patent number: 6005158Abstract: A composition for converting asbestos-containing material to environmentally benign components is provided. The composition comprises a flouro acid decomposing agent which can be applied to either amosite-containing thermal insulation or chrysotile-containing fire-proof material or to any asbestos-containing material which includes of chrysotile and amosite asbestos. The fluoro acid decomposing agent includes FP(O)(OH).sub.2, hexafluorophosphoric acid, a mixture of hydrofluoric and phosphoric acid and a mixture of hexafluorophosphoric acid and phosphoric acid. A method for converting asbestos-containing material to environmentally benign components is also provided.Type: GrantFiled: May 26, 1998Date of Patent: December 21, 1999Assignee: Brookhaven Science Associates LLCInventors: Toshifumi Sugama, Leon Petrakis, Ronald P. Webster
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Patent number: 6002826Abstract: An optical system (20) projects light into a planar optical display (10). The display includes laminated optical waveguides (12) defining an inlet face (14) at one end and an outlet screen (16) at an opposite end. A first mirror (26) collimates light from a light source (18) along a first axis, and distributes the light along a second axis. A second mirror (28) collimates the light from the first mirror along the second axis to illuminate the inlet face and produce an image on the screen.Type: GrantFiled: August 28, 1998Date of Patent: December 14, 1999Assignee: Brookhaven Science AssociatesInventor: James T. Veligdan
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Patent number: 5968786Abstract: Disclosed is a method for the introduction of unidirectional deletions in a cloned DNA segment. More specifically, the method comprises providing a recombinant DNA construct comprising a DNA segment of interest inserted in a cloning vector, the cloning vector having an f1 endonuclease recognition sequence adjacent to the insertion site of the DNA segment of interest. The recombinant DNA construct is then contacted with the protein pII encoded by gene II of phage f1 thereby generating a single-stranded nick. The nicked DNA is then contacted with E. coli Exonuclease III thereby expanding the single-stranded nick into a single-stranded gap. The single-stranded gapped DNA is then contacted with a single-strand-specific endonuclease thereby producing a linearized DNA molecule containing a double-stranded deletion corresponding in size to the single-stranded gap. The DNA treated in this manner is then incubated with DNA ligase under conditions appropriate for ligation.Type: GrantFiled: December 18, 1998Date of Patent: October 19, 1999Assignee: Brookhaven Science AssociatesInventors: John J. Dunn, Mark A. Quesada, Matthew Randesi
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Patent number: 5935840Abstract: This application describes methods and expression constructs for producing activatable recombinant adenovirus proteinases. Purified activatable recombinant adenovirus proteinases and methods of purification are described. Activated adenovirus proteinases and methods for obtaining activated adenovirus proteinases are further included. Isolated peptide cofactors of adenovirus proteinase activity, methods of purifying and identifying said peptide cofactors are also described. Antibodies immunoreactive with adenovirus proteinases, immunospecific antibodies, and methods for preparing them are also described. Other related methods and materials are also described.Type: GrantFiled: May 5, 1995Date of Patent: August 10, 1999Assignee: Associated Universities, Inc.Inventors: Carl W. Anderson, Walter F. Mangel
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Patent number: 5928908Abstract: Disclosed is a method for the introduction of unidirectional deletions in a cloned DNA segment. More specifically, the method comprises providing a recombinant DNA construct comprising a DNA segment of interest inserted in a cloning vector, the cloning vector having an f1 endonuclease recognition sequence adjacent to the insertion site of the DNA segment of interest. The recombinant DNA construct is then contacted with the protein pII encoded by gene II of phage f1 thereby generating a single-stranded nick. The nicked DNA is then contacted with E. coli Exonuclease III thereby expanding the single-stranded nick into a single-stranded gap. The single-stranded gapped DNA is then contacted with a single-strand-specific endonuclease thereby producing a linearized DNA molecule containing a double-stranded deletion corresponding in size to the single-stranded gap. The DNA treated in this manner is then incubated with DNA ligase under conditions appropriate for ligation.Type: GrantFiled: November 10, 1997Date of Patent: July 27, 1999Assignee: Brookhaven Science AssociatesInventors: John J. Dunn, Mark A. Quesada, Matthew Randesi