Patents Represented by Attorney, Agent or Law Firm Margaret C. Bogosian
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Patent number: 4780238Abstract: This invention relates to the preparation of new, naturally produced chelating agents as well as to the method and resulting chelates of desorbing cultures in a bioavailable form involving Pseudomonas species or other microorganisms. A preferred microorganism is Pseudomonas aeruginosa which forms multiple chelates with thorium in the range of molecular weight 100-1,000 and also forms chelates with uranium of molecular weight in the area of 100-1,000 and 1,000-2,000.Type: GrantFiled: June 11, 1985Date of Patent: October 25, 1988Assignee: The United States of America as represented by the United States Department of EnergyInventor: Eugene T. Premuzic
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Patent number: 4769225Abstract: The reversible reaction M+x/2 H.sub.2 .rarw..fwdarw.MH.sub.x, wherein M is a reversible metal hydride former that forms a hydride MH.sub.x in the presence of H.sub.2, generally used to store and recall H.sub.2, is found to proceed under an inert liquid, thereby reducing contamination, providing better temperature control, providing in situ mobility of the reactants, and increasing flexibility in process design. Thus, a slurry of particles of a metal hydride former with an inert solvent is subjected to a temperature and pressure controlled atmosphere containing H.sub.2, to store hydrogen and to release previously stored hydrogen. The direction of the flow of the H.sub.2 through the liquid is dependent upon the H.sub.2 pressure in the gas phase at a given temperature. When the actual H.sub.2 pressure is above the equilibrium absorption pressure of the respective hydride the reaction proceeds to the right, i.e., the metal hydride is formed and hydrogen is stored in the solid particles.Type: GrantFiled: February 22, 1985Date of Patent: September 6, 1988Assignee: The United States of America as represented by the United States Department of EnergyInventors: James J. Reilly, Edward W. Grohse, John R. Johnson, Warren E. Winsche, deceased
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Patent number: 4758345Abstract: The present invention relates to an anaerobic bacterial culture of Clostridium sp. ATCC No. 53464 which solubilizes lead oxide under anaerobic conditions in coal and industrial wastes and therefore presents a method of removing lead from such wastes before they are dumped into the environment. The rate of lead dissolution during logarithmic growth of the bacteria in 40 ml medium containing 3.32 .mu.moles of lead as lead oxide was 0.042 .mu.moles ml.sup.-1 hr.sup.-1. Dissolution of lead oxide by the bacterial isolate is due to the production of metabolites and acidity in the culture medium. The major metabolites are acetic, butyric and lactic acid. Clostridium sp. ATCC No. 53464 can be used in the recovery of strategic metals from ores and wastes and also for the production of lactic acid for commercial purposes. The process yields large quantities of lactic acid as well as lead complexed in a stable form with said acids.Type: GrantFiled: April 16, 1987Date of Patent: July 19, 1988Assignee: The United States of America as represented by the United States Department of EnergyInventors: Arokiasamy J. Francis, Cleveland Dodge, Krishnachetty Chendrayan, Helen L. Quinby
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Patent number: 4755375Abstract: Disclosed herein are a method and kit for the preparation of .sup.99m Tc labeled red blood cells using whole blood in a closed sterile system containing stannous tin in a form such that it will enter the red blood cells and be available therein for the reduction of technetium.Type: GrantFiled: April 17, 1986Date of Patent: July 5, 1988Assignee: Associated Universities, Inc.Inventors: Suresh C. Srivastava, John W. Babich, Rita Straub, Powell Richards
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Patent number: 4729954Abstract: Disclosed is recombinant plasmid pLS101, consisting essentially of a 2.0 Kb malM gene fragment ligated to a 4.4 Kb T.sub.c r DNA fragment, which is particularly useful for transforming Gram-positive bacteria. This plasmid contains at least four restriction sites suitable for inserting exogeneous gene sequences. Also disclosed is a method for plasmid isolation by penicillin selection, as well as processes for enrichment of recombinant plasmids in Gram-positive bacterial systems.Type: GrantFiled: February 19, 1985Date of Patent: March 8, 1988Assignee: The United States of America as represented by the United States Department of EnergyInventors: Sanford A. Lacks, Tanjore S. Balganesh
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Patent number: 4707322Abstract: Beryllium-7 labeled carbon particles made from the proton irradiation of carbon materials, preferably from dry carbon black are disclosed. Such particles are useful as gamma emitting radiotracers.Type: GrantFiled: April 29, 1985Date of Patent: November 17, 1987Assignee: The United States of America as represented by the United States Department of EnergyInventors: Powell Richards, Leonard F. Mausner, Thomas F. Prach
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Patent number: 4659395Abstract: This invention relates to a precoat, laminate, and method for ductile coatings on steel and non-ferrous metals which comprises applying a zinc phosphating coating solution modified by a solid polyelectrolyte selected from polyacrylic acid (PAA), polymethacrylic acid (PMA), polyitaconic acid (PIA), and poly-L-glutamic acid. The contacting of the resin with the phosphating solution is made for a period of up to 20 hours at about 80.degree. C. The polyelectrolyte or the precoat is present in about 0.5-5.0% by weight of the total precoat composition and after application, the precoat base is dried for up to 5 hours at about 150.degree. C. to desiccate. Also, a laminate may be formed where polyurethane (PU) is applied as an elastomeric topcoating or polyfuran resin is applied as a glassy topcoating. It has been found that the use of PAA at a molecular weight of about 2.times.10.sup.5 gave improved ductility modulus effect.Type: GrantFiled: November 5, 1985Date of Patent: April 21, 1987Assignee: The United States of America as represented by the United States Department of EnergyInventors: Toshifumi Sugama, Lawrence E. Kukacka, Neal R. Carciello
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Patent number: 4623634Abstract: A catalyst and process useful at low temperatures (below about 160.degree. C.) and preferably in the range 80.degree.-120.degree. C. used in the production of methanol from carbon monoxide and hydrogen is disclosed. The catalyst is used in slurry form and comprises a complex reducing agent derived from the component structure NaH--RONa--M(OAc).sub.2 where M is selected from the group consisting of Ni, Pd, and Co and R is a lower alkyl group containing 1-6 carbon atoms. This catalyst is preferably used alone but is also effective in combination with a metal carbonyl of a group VI (Mo, Cr, W) metal. The preferred catalyst precursor is Nic (where M=Ni and R=tertiary amyl). Mo(CO).sub.6 is the preferred metal carbonyl if such component is used. The catalyst is subjected to a conditioning or activating step under temperature and pressure, similar to the parameters given above, to afford the active catalyst.Type: GrantFiled: December 23, 1985Date of Patent: November 18, 1986Inventors: Richard S. Sapienza, William A. Slegeir, Thomas E. O'Hare, Devinder Mahajan
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Patent number: 4617386Abstract: Process for the production of 2-deoxy-2-fluoro-D-glucose and the corresponding .sup.18 F-compound in which methyl 4,6-O-benzylidine-3-O-methyl-2-O-trifluoromethanesulfonyl-.beta.-D-mannopy ranoside is reacted with a triflating reagent, the resulting compound reacted with CsHF.sub.2, RbF or the corresponding .sup.18 F-compounds, and thereafter the alkyl groups removed by hydrolysis.Type: GrantFiled: April 25, 1983Date of Patent: October 14, 1986Assignee: The United States of America as represented by the United States Department of EnergyInventors: David R. Elmaleh, Shlomo Levy, Chyng-Yann Shiue, Alfred P. Wolf
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Patent number: 4614749Abstract: A catalyst and process useful at low temperatures (below about 160.degree. C.) and preferably in the range 80.degree.-120.degree. C. used in the production of methanol from carbon monoxide and hydrogen is disclosed. The catalyst is used in slurry form and comprises a complex reducing agent derived from the component structure NaH--RONa--M(OAc).sub.2 where M is selected from the group consisting of Ni, Pd, and Co and R is a lower alkyl group containing 1-6 carbon atoms. This catalyst is preferably used alone but is also effective in combination with a metal carbonyl of a group VI (Mo, Cr, W) metal. The preferred catalyst precursor is Nic (where M=Ni and R=tertiary amyl). Mo(CO).sub.6 is the preferred metal carbonyl if such component is used. The catalyst is subjected to a conditioning or activating step under temperature and pressure, similar to the parameters given above, to afford the active catalyst.Type: GrantFiled: December 23, 1985Date of Patent: September 30, 1986Inventors: Richard S. Sapienza, William A. Slegeir, Thomas E. O'Hare, Devinder Mahajan
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Patent number: 4613623Abstract: A gas reaction process for the preferential production of methyl formate over the co-production of methanol wherein the reactant ratio of CO/H.sub.2 is upgraded and this reaction takes place at low temperatures of 50.degree.-150.degree. C. and moderate pressures of .gtoreq.100 psi.Type: GrantFiled: July 23, 1985Date of Patent: September 23, 1986Assignee: The United States of America as represented by the United States Department of EnergyInventors: Devinder Mahajan, William A. Slegeir, Richard S. Sapienza, Thomas E. O'Hare
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Patent number: 4602918Abstract: Coal-water mixes stabilized by the addition of portland cement which may additionally contain retarding carbohydrates, or borax are described.Type: GrantFiled: October 17, 1984Date of Patent: July 29, 1986Assignee: The United States of America as represented by the United States Department of EnergyInventors: Meyer Steinberg, Coimbatore R. Krishna
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Patent number: 4585581Abstract: There is disclosed a polymer blend of a highly conductive polymer and a solid polymer electrolyte that is designed to achieve better charge transfer across the conductive film/polymer electrolyte interface of the electrochemical photovoltaic cell. The highly conductive polymer is preferably polypyrrole or poly-N-p-nitrophenylpyrrole and the solid polymer electrolyte is preferably polyethylene oxide or polypropylene oxide.Type: GrantFiled: September 28, 1984Date of Patent: April 29, 1986Assignee: The United States of America as represented by the United States Department of EnergyInventor: Terje Skotheim
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Patent number: 4563197Abstract: A process for the production of economically significant amounts of ethyl and other hydrocarbon compounds, such as benzene, from coal is disclosed wherein coal is reacted with methane at a temperature in the approximate range of 500.degree. C. to 1100.degree. C. at a partial pressure less than about 200 psig for a period of less than 10 seconds. Ethylene and other hydrocarbon compounds may be separated from the product stream so produced, and the methane recycled for further production of ethylene. In another embodiment, other compounds produced, such as by-product tars, may be burned to heat the recycled methane.Type: GrantFiled: February 15, 1984Date of Patent: January 7, 1986Assignee: The United States of America as represented by the Department of EnergyInventors: Meyer Steinberg, Peter Fallon
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Patent number: 4561859Abstract: This invention describes a chemical process for desulfurizing coal, especially adaptable to the treatment of coal-water slurries, at temperatures as low as ambient, comprising treating the coal with aqueous titanous chloride whereby hydrogen sulfide is liberated and the desulfurized coal is separated with the conversion of titanous chloride to titanium oxides.Type: GrantFiled: April 18, 1985Date of Patent: December 31, 1985Assignee: The United States of America as represented by the United States Department of EnergyInventors: William A. Slegeir, Francis E. Healy, Richard S. Sapienza
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Patent number: 4555392Abstract: There is described a method of removing oxides of sulfur from the emissions of fossil fuel combustion by injecting portland cement into the boiler with the fuel, the combustion air, or downstream with the combustion gases. There is also described the cement products that result from this method.Type: GrantFiled: October 17, 1984Date of Patent: November 26, 1985Assignee: The United States of America as represented by the United States Department of EnergyInventor: Meyer Steinberg
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Patent number: 4540726Abstract: Quick setting polymer concrete compositions with excellent structural properties are disclosed; these polymer concrete compositions are mixtures of unsaturated polyesters and crosslinking monomers together with appropriate initiators and promoters in association with aggregate, which may be wet, and with a source of bivalent metallic ions.Type: GrantFiled: May 13, 1983Date of Patent: September 10, 1985Assignee: The United States of America as represented by the United States Department of EnergyInventors: Toshifumi Sugama, Lawrence E. Kukacka, William H. Horn
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Patent number: H74Abstract: Process for the production of 2-deoxy-2-fluoro-D-glucose and the corresponding .sup.18 F-compound by the reaction of acetyl hypofluorite or the corresponding .sup.18 F-compound with 3,4,6-tri-O-acetyl-D-glucal followed by hydrolysis. Process includes the production of the hypofluorite compound at ambient temperature.Type: GrantFiled: February 24, 1983Date of Patent: June 3, 1986Assignee: The United States of America as represented by The United States Department of EnergyInventors: Chyng-Yann Shiue, Piero A. Salvadori, Alfred P. Wolf, Joanna S. Fowler, Robert R. MacGregor
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Patent number: H505Abstract: A stable boronated (.sup.10 B-labeled) compound, sodium mercaptoundecahydrododecaborate is infused in the form of the disulfide dimer, [.sup.10 B]Na.sub.4 B.sub.24 H.sub.22 S.sub.2, at a dose of about 200 .mu.g .sup.10 B per gm body weight. The infusion is performed into the blood or peritoneal cavity of the patient slowly over a period of many days, perhaps one week or more, at the rate of roughly 1 .mu.g .sup.10 B per gm body weight per hour. Use of this particular boronated dimer in the manner or similarly to the manner so described permits radiotherapeutically effective amounts of boron to accumulate in tumors to be treated by boron neutron capture radiation therapy and also permits sufficient retention of boron in tumor after the cessation of the slow infusion, so as to allow the blood concentration of .sup.10 B to drop or to be reduced artificially to a radiotherapeutically effective level, less than one-half of the concentration of .sup.10 B in the tumor.Type: GrantFiled: March 11, 1986Date of Patent: August 2, 1988Assignee: The United States of America as represented by the United States Department of EnergyInventors: Daniel N. Slatkin, Peggy L. Micca, Ralph G. Fairchild
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Patent number: H545Abstract: The present invention involves labeling monoclonal antibodies with intermediate half-life radionuclides which decay to much shorter half-life daughters with desirable high energy beta emissions. Since the daughter will be in equilibrium with the parent, it can exert an in-situ tumoricidal effect over a prolonged period in a localized fashion, essentially as an "in-vivo generator". This approach circumvents the inverse relationship between half-life and beta decay energy. Compartmental modeling was used to determine the relative distribution of dose from both parent and daughter nuclei in target and non-target tissues. Actual antibody biodistribution data have been used to fit realistic rate constants for a model containing tumor, blood, and non-tumor compartments. These rate constants were then used in a variety of simulations for two generator systems, Ba-128/Cs-128 (t.sub.1/2 =2.4d/3.6m) and Pd-112/Ag-112 (t.sub.1/2 =0.9d/192m).Type: GrantFiled: October 30, 1987Date of Patent: November 1, 1988Assignee: The United States of America as represented by the United States Department of EnergyInventors: Leonard F. Mausner, Suresh G. Srivastava, Rita F. Straub