Patents Represented by Attorney, Agent or Law Firm Margaret C. Bogosian
  • Patent number: 4533541
    Abstract: The radiopharmaceutical reagents of this invention and the class of Tin-117m radiopharmaceuticals are therapeutic and diagnostic agents that incorporate gamma-emitting nuclides that localize in bone after intravenous injection in mammals (mice, rats, dogs, and rabbits). Images reflecting bone structure or function can then be obtained by a scintillation camera that detects the distribution of ionizing radiation emitted by the radioactive agent. Tin-117m-labeled chelates of stannic tin localize almost exclusively in cortical bone. Upon intravenous injection of the reagent, the preferred chelates are phosphonate compounds, preferable, PYP, MDP, EHDP, and DTPA. This class of reagents is therapeutically and diagnostically useful in skeletal scintigraphy and for the radiotherapy of bone tumors and other disorders.
    Type: Grant
    Filed: August 25, 1983
    Date of Patent: August 6, 1985
    Assignee: The United States of America as represented by the United States Department of Energy
    Inventors: Suresh C. Srivastava, George E. Meinken, Powell Richards
  • Patent number: 4500508
    Abstract: Lymphocytes labelled with .beta.-emitting radionuclides are therapeutically useful, particularly for lymphoid ablation. They are prepared by incubation of the lymphocytes with the selected radionuclide-oxine complex.
    Type: Grant
    Filed: May 3, 1983
    Date of Patent: February 19, 1985
    Assignee: The United States of America as represented by the United States Department of Energy
    Inventors: Suresh C. Srivastava, Rashid A. Fawwaz, Powell Richards
  • Patent number: 4500674
    Abstract: This invention is concerned with a polymer concrete composition, which is a two-component composition useful with many bases including metal. Component A, the aggregate composition, is broadly composed of silica, silica flour, portland cement, and acrylamide, whereas Component B, which is primarily vinyl and acrylyl reactive monomers, is a liquid system. A preferred formulation emphasizing the major necessary components is as follows:______________________________________ Component A: Silica sand 60-77 wt. % Silica flour 5-10 wt. % Portland cement 15-25 wt. % Acrylamide 1-5 wt. % Component B: Styrene 50-60 wt. % Trimethylolpropane 35-40 wt. % trimethacrylate ______________________________________and necessary initiators, accelerators, and surfactants.
    Type: Grant
    Filed: May 29, 1984
    Date of Patent: February 19, 1985
    Assignee: The United States of America as represented by the United States Department of Energy
    Inventors: Jack J. Fontana, Walter Reams
  • Patent number: 4488943
    Abstract: There is disclosed a polymer blend of a highly conductive polymer and a solid polymer electrolyte that is designed to achieve better charge transfer across the conductive film/polymer electrolyte interface of the electrochemical photovoltaic cell. The highly conductive polymer is preferably polypyrrole or poly-N-p-nitrophenylpyrrole and the solid polymer electrolyte is preferably polyethylene oxide or polypropylene oxide.
    Type: Grant
    Filed: December 9, 1982
    Date of Patent: December 18, 1984
    Assignee: The United States of America as represented by the United States Department of Energy
    Inventor: Terje Skotheim
  • Patent number: 4476103
    Abstract: This invention relates to the formation of metal carbonyls from metal oxides and specially the formation of molybdenum carbonyl and iron carbonyl from their respective oxides. Copper is used here in admixed form or used in chemically combined form as copper molybdate. The copper/metal oxide combination or combined copper is utilized with a solvent, such as toluene and subjected to carbon monoxide pressure of 25 atmospheres or greater at about 150.degree.-260.degree. C. The reducing metal copper is employed in catalytic concentrations or combined concentrations as CuMoO.sub.4 and both hydrogen and water present serve as promoters. It has been found that the yields by this process have been salutary and that additionally the catalytic metal may be reused in the process to good effect.
    Type: Grant
    Filed: January 6, 1984
    Date of Patent: October 9, 1984
    Assignee: The United States of America as represented by the United States Department of Energy
    Inventors: Richard S. Sapienza, William A. Slegeir, Michael T. Foran
  • Patent number: 4463210
    Abstract: A process for the production of ethylene, benzene and carbon monoxide from particulated biomass such as wood by reaction with methane at a temperature of from 700.degree. C. to 1200.degree. C., at a pressure of from 20 psi to 100 psi for a period of from 0.2 to 10 seconds.
    Type: Grant
    Filed: June 1, 1983
    Date of Patent: July 31, 1984
    Assignee: The United States of America as represented by the United States Department of Energy
    Inventors: Meyer Steinberg, Peter Fallon
  • Patent number: 4460710
    Abstract: A method for synthesizing hydrocarbons from carbon monoxide and hydrogen by contacting said gases with a slurry of a catalyst composed of palladium or platinum and cobalt supported on a solid phase is disclosed. The catalyst is prepared by heating a heterogeneous component of the palladium or platinum deposited on the solid support in a solution of cobalt carbonyl or precursors thereof. The catalyst exhibits excellent activity, stability in air, and produces highly desirable product fractions even with dilute gaseous reactants.
    Type: Grant
    Filed: April 15, 1983
    Date of Patent: July 17, 1984
    Assignee: The United States of America as represented by the United States Department of Energy
    Inventors: Richard S. Sapienza, Michael J. Sansone, William A. R. Slegeir
  • Patent number: 4448762
    Abstract: A novel Ruthenium-transferrin complex, prepared by reacting iron-free human transferrin dissolved in a sodium acetate solution at pH 7 with ruthenium by heating at about 40.degree. C. for about 2 hours, and purifying said complex by means of gel chromotography with pH 7 sodium acetate as eluent. The mono- or di-metal complex produced can be used in nuclear medicine in the diagnosis and/or treatment of tumors and abscesses. Comparative results with Ga-67-citrate, which is the most widely used tumor-localizing agent in nuclear medicine, indicate increased sensitivity of detection and greater tumor uptake with the Ru-transferrin complex.
    Type: Grant
    Filed: November 3, 1980
    Date of Patent: May 15, 1984
    Assignee: The United States of America as represented by the United States Department of Energy
    Inventors: Powell Richards, Suresh C. Srivastava, George E. Meinken
  • Patent number: 4445102
    Abstract: An improved magnet which more easily provides a radially increasing magnetic field, as well as reduced fringe field and requires less power for a given field intensity. The subject invention comprises a pair of spaced, opposed magnetic poles which further comprise a pair of pole roots, each having a pole tip attached to its center. The pole tips define the gap between the magnetic poles and at least a portion of each pole tip is separated from its associated pole root. The separation begins at a predetermined distance from the center of the pole root and increases with increasing radial distance while being constant with azimuth within that portion. Magnets in accordance with the subject invention have been found to be particularly advantageous for use in large isochronous cyclotrons.
    Type: Grant
    Filed: November 19, 1981
    Date of Patent: April 24, 1984
    Assignee: The United States of America as represented by the United States Department of Energy
    Inventors: Craig E. Thorn, Chellis Chasman, Anthony J. Baltz
  • Patent number: 4442185
    Abstract: A photoelectric device is disclosed which comprises first and second layers of semiconductive material, each of a different bandgap, with a layer of dry solid polymer electrolyte disposed between the two semiconductor layers. A layer of a polymer blend of a highly conductive polymer and a solid polymer electrolyte is further interposed between the dry solid polymer electrolyte and the first semiconductor layer. A method of manufacturing such devices is also disclosed.
    Type: Grant
    Filed: June 9, 1982
    Date of Patent: April 10, 1984
    Assignee: The United States of America as represented by the United States Department of Energy
    Inventor: Terje Skotheim
  • Patent number: 4439414
    Abstract: The novel compounds 1-.sup.11 C-D-glucose, 1-.sup.11 C-D-mannose, 1-.sup.11 C-D-galactose, 2-.sup.11 C-D-glucose, 2-.sup.11 C-D-mannose and 2-.sup.11 C-D-galactose which can be used in nuclear medicine to monitor the metabolism of glucose and galactose can be rapidly prepared by reaction of the appropriate aldose substrate with an alkali metal .sup.11 C-labeled cyanide followed by reduction with a Raney alloy in formic acid.
    Type: Grant
    Filed: January 26, 1982
    Date of Patent: March 27, 1984
    Assignee: The United States of America as represented by the United States Department of Energy
    Inventors: Chyng-Yann Shiue, Alfred P. Wolf
  • Patent number: 4436717
    Abstract: The novel radioactive compound .sup.18 F-4-fluoroantipyrine having high specific activity which can be used in nuclear medicine in diagnostic applications, prepared by the direct fluorination of antipyrine in acetic acid with radioactive fluorine at room temperature and purifying said radioactive compound by means of gel chromatography with ethyl acetate as eluent is disclosed. The non-radioactive 4-fluoroantipyrine can also be prepared by the direct fluorination of antipyrine in acetic acid with molecular fluorine at room temperature and purified by means of gel chromotography with ethyl acetate eluent.
    Type: Grant
    Filed: May 29, 1981
    Date of Patent: March 13, 1984
    Assignee: The United States of America as represented by the United States Department of Energy
    Inventors: Chyng-Yann Shiue, Alfred P. Wolf
  • Patent number: 4436555
    Abstract: Rapid setting magnesium phosphate (Mg glass) cementitious materials consisting of magnesium phosphate cement paste, polyborax and water-saturated aggregate exhibiting rapid setting and high early strength characteristics. The magnesium glass cement is prepared from a cation-leachable powder and a bivalent metallic ion-accepting liquid such as an aqueous solution of diammonium phosphate and ammonium polyphosphate. The cation-leachable powder includes a mixture of two different magnesium oxide powders processed and sized differently which when mixed with the bivalent metallic ion-accepting liquid provides the magnesium glass cement consisting primarily of magnesium ortho phosphate tetrahydrate, with magnesium hydroxide and magnesium ammonium phosphate hexahydrate also present. The polyborax serves as a set-retarder.
    Type: Grant
    Filed: September 23, 1982
    Date of Patent: March 13, 1984
    Assignee: The United States of America as represented by the United States Department of Energy
    Inventors: Toshifumi Sugama, Lawrence E. Kukacka
  • Patent number: 4432088
    Abstract: A data transmission system includes a transmission medium which has a certain propagation delay time over its length. A number of data stations are successively coupled to the transmission medium for communicating with one another. Each of the data stations includes a transmitter for originating signals, each signal beginning with a carrier of a duration which is at least the propagation delay time of the transmission medium. Each data station also includes a receiver which receives other signals from other data stations and inhibits operation of the transmitter at the same data station when a carrier of another signal is received.
    Type: Grant
    Filed: April 30, 1981
    Date of Patent: February 14, 1984
    Assignee: The United States of America as represented by the United States Department of Energy
    Inventor: Robert Frankel
  • Patent number: 4409966
    Abstract: An apparatus and method for injecting a substance, such as a radiopharmaceutical, into the bloodstream of a subject. The apparatus comprises an injection means, such as a servo controlled syringe, a means for measuring the concentration of that substance in the subject's bloodstream, and means for controlling the injection in response to the measurement so that the concentration of the substance follows a predetermined function of time. The apparatus of the subject invention functions to inject a substance into a subject's bloodstream at a rate controlled by an error signal proportional to the difference between the concentration of the substance in the subject's bloodstream and the predetermined function.
    Type: Grant
    Filed: May 29, 1981
    Date of Patent: October 18, 1983
    Inventors: Richard M. Lambrecht, Gerald W. Bennett, Charles C. Duncan, Louis W. Ducote
  • Patent number: 4396539
    Abstract: A catalyst for the synthesis of hydrocarbons from carbon monoxide and hydrogen composed of palladium or platinum and cobalt supported on a solid phase is disclosed. The catalyst is prepared by heating a heterogeneous component of the palladium or platinum deposited on the solid support in a solution of cobalt carbonyl or precursors thereof. The catalyst exhibits excellent activity, stability in air, and produces highly desirable product fractions even with dilute gaseous reactants. The catalyst is preferably used in dilute slurry form, which is desirable from a heat transfer standpoint.
    Type: Grant
    Filed: August 14, 1981
    Date of Patent: August 2, 1983
    Inventors: Richard S. Sapienza, Michael J. Sansone, William A. R. Slegeir