Patents Represented by Attorney, Agent or Law Firm Marianne Fuierer
  • Patent number: 6711237
    Abstract: A contour collimator for radiation therapy has a plurality of diaphragm elements that are movable with respect to each other by means of drive units. The diaphragm elements of the invention are supported only on the side near the drive units for ease of movement. This allows larger contour collimators to be constructed having relatively heavy diaphragm elements while retaining relatively small motors.
    Type: Grant
    Filed: January 16, 2002
    Date of Patent: March 23, 2004
    Assignee: Deutsches Krebsforschungszentrum Stiftung des Offentlichen Rechts
    Inventors: Wolfgang Schlegel, Otto Pastyr, Gernot Echner, Karl-Heinz Hover, Jurgen Richter
  • Patent number: 6699656
    Abstract: The present invention relates to &bgr;-hCG, particularly &bgr;-hCG proteins having a sequence of amino acids 41-54, 45-54, 47-53, 45-57 and 45-58 and analogs and derivatives thereof. The invention further relates to methods of treatment and prevention of HIV infection by administration of a therapeutic compound of the invention. Such therapeutic compounds include hCG, &bgr;-hCG and &bgr;-hCG peptides, analogs and derivatives of hCG, &bgr;-hCG and &bgr;-hCG peptides, and nucleic acids encoding hCG, &bgr;-hCG and &bgr;-hCG peptides. In a preferred embodiment, &bgr;-hCG peptides, particularly &bgr;-hCG peptides of amino acids 47-53, 45-57 or 45-58 are administered to a subject for treatment or prevention of HIV infection in that subject. The invention also provides methods for screening hCG preparations for activity in treating or preventing HIV infection. Pharmaceutical compositions and methods of administration of Therapeutics are also provided.
    Type: Grant
    Filed: November 20, 2001
    Date of Patent: March 2, 2004
    Assignee: University of Maryland Biotechnology Institute
    Inventors: Robert C. Gallo, Joseph Bryant, Yanto Lunardi-Iskandar
  • Patent number: 6699834
    Abstract: The present invention relates to peptides of one or more portions of the human chorionic gonadotropin &bgr;-chain as well as methods for treatment of cancer, using human chorionic gonadotropin, employing the &bgr;-chain of human chorionic gonadotropin, peptides containing a sequence of one or more portions of the &bgr;-chain of human chorionic gonadotropin and derivatives and analogues thereof. The invention further relates to fractions of sources and or preparations of human chorionic gonadotropin, such as fractions of human early pregnancy urine, which fractions have anti-cancer activity. The present invention further relates to pharmaceutical compositions for treating cancer.
    Type: Grant
    Filed: September 29, 2000
    Date of Patent: March 2, 2004
    Assignee: University of Maryland Biotechnology Institute
    Inventors: Robert C. Gallo, Joseph Bryant, Yanto Lunardi-Iskandar
  • Patent number: 6696547
    Abstract: The invention relates to a protein for regulating apoptosis and to a nucleic acid encoding the protein. The protein and nucleic acids are useful in the regulation of apoptosis, and in methods for diagnosing or detecting apoptosis. The invention also relates to antibodies directed against the protein.
    Type: Grant
    Filed: December 8, 2000
    Date of Patent: February 24, 2004
    Assignee: Deutsches Krebsforschungszentrum Stiftung des Offentlichen Rechts
    Inventors: Marcus Peter, Peter Krammer
  • Patent number: 6694173
    Abstract: A method and system for non-contact laser photoablation to be utilized during vision corrective surgery. Multiple pulses of electromagnetic energy are impinged onto target tissue to ablate and generate an acoustic pressure wave while concurrently processing signals produced by the acoustic pressure wave. A representative pattern can be provided to guide the surgeon through distinct tissue layers encountered in cornea resculpting surgery. Cluster analysis may be utilized to process the acoustic wave signals to generate the representative pattern. Specifically, the representative cluster pattern provides the surgeon with a tool to discern, with increased precision, the tissue layer being ablated and reduces the likelihood of invading a deeper layer of tissue that should not be removed.
    Type: Grant
    Filed: November 10, 2000
    Date of Patent: February 17, 2004
    Inventors: Thomas Bende, Benedikt J. Jean
  • Patent number: 6690056
    Abstract: A non-volatile storage cell manufactured in a standard CMOS process in silicon on insulator is described. The cell is manufactured in a standard single polysilicon layer CMOS process applied to silicon on insulator starting substrates. Two versions of the cell are described with distinct mechanisms for writing onto a floating polysilicon layer storage node. The basic cell comprises crossed N- and P- transistors which share a common channel region and a common floating gate over the channel. Current in the channel results in charge injection through the gate oxide and onto the polysilicon gate conductor where it is permanently stored. Since both N and P type transistors are available, charge of both polarities can be injected. Application of a voltage to either of the transistors results in a current or voltage which is used to perform the reading function. Multiple variations of the cell and its operation are also described along with unique applications of the cell.
    Type: Grant
    Filed: October 19, 1999
    Date of Patent: February 10, 2004
    Assignee: Peregrine Semiconductor Corporation
    Inventors: Ronald E. Reedy, James S. Cable
  • Patent number: 6678347
    Abstract: A method for quantitatively determining the phase composition of a sample mixture that comprises two or more textured polycrystalline materials, based on corrected and integrated x-ray diffraction intensities. The effect of texture has been analytically eliminated from such corrected and integrated x-ray diffraction intensities, based on the texture information obtained from the sample mixture.
    Type: Grant
    Filed: July 26, 2002
    Date of Patent: January 13, 2004
    Assignee: HyperNex, Inc.
    Inventors: Krzysztof J. Kozaczek, David S. Kurtz, Paul R. Moran, Roger I. Martin
  • Patent number: 6676739
    Abstract: The invention relates to a method for producing a cellulose solution in an aqueous amine oxide, preferably N-methyl-morpholine-N-oxide, for processing to form cellulosed moulded bodies according to the Lyocell method, whereby said solution has an increased thermal stability. Cellulose is suspended in an aqueous amine oxide and the suspension is converted into the cellulose solution. The inventive method is characterised in that the base use of the cellulose used for producing the solution and of the optionally used additives is detected in a dispersion in aqueous amine oxide solution and in that the cellulose solution is formed by adding a base quantity which matches the detected own consumption of the cellulose and optionally the additives. Cellulose solutions having a stability which is essentially independent from the provenance of the used cellulose can he formed.
    Type: Grant
    Filed: October 29, 2002
    Date of Patent: January 13, 2004
    Assignee: Thuringishces Institut fur Textil und Kunststoff-Forschung E.V.
    Inventors: Birgit Kosan, Christoph Michels, Ralf-Uwe Bauer, Michael Mooz, Frank-Gunter Niemz
  • Patent number: 6676680
    Abstract: A tamponade device for controlling post-partum hemorrhage includes an inner drain tube co-axially encircled by an inflatable balloon. The device is inserted into the uterine cavity, and the balloon is distended with a medium supplied with sufficient pressure and volume to apply even pressure along the surface of an interior uterine wall. With the application of such pressure, bleeding is stopped as evidenced by a cessation of blood draining from the inner drain tube. The inner tube includes a drainage port at an inserted end for draining blood and other fluids from the interior of the uterine cavity. An integral valve and medium insufflation and supply tubes operate to control inflation and deflation of the balloon. The supply tube co-axially encircles the drain tube to define a thin passageway between an inner surface of the supply tube and an outer surface of the drain tube. Perforations in the supply tube allow the medium to pass from this passageway in order to distend the balloon.
    Type: Grant
    Filed: June 25, 2002
    Date of Patent: January 13, 2004
    Assignee: Polyzen, Inc.
    Inventor: Paul R. Packer
  • Patent number: 6670623
    Abstract: A thermoregulation system for an ion implantation system to reduce the temperature in the ion implanter and components therein, or attached thereto, to a temperature at which an ion source material, used in the ion implanter, has a vapor pressure that yields a reduced concentration of vapors. Such arrangement markedly reduces the risk of exposure to harmful vapors from the ion source material.
    Type: Grant
    Filed: March 7, 2001
    Date of Patent: December 30, 2003
    Assignee: Advanced Technology Materials, Inc.
    Inventor: Michael C. Vella
  • Patent number: 6667506
    Abstract: Multiple variations of a variable capacitor or varactor 10 with built-in programmability; exhibiting high quality, Q, factors; manufactured in a standard CMOS process in silicon on insulator. The cell 10 is manufactured in a standard single polysilicon layer CMOS process applied to silicon on insulator 30 starting substrates. The variable capacitor cell 10 combined with a non-volatile mechanism for programming the tuning range of the varactor 10 results in a varactor 10 which can be tuned and adjusted in an on-chip and purely electronic fashion. The basic variable capacitor cell 10 comprises a floating gate MOS variable capacitor, CMOS, in series with a metal to floating gate fixed capacitor CM/FG.
    Type: Grant
    Filed: March 25, 2000
    Date of Patent: December 23, 2003
    Assignee: Peregrine Semiconductor Corporation
    Inventors: Ronald E. Reedy, James S. Cable
  • Patent number: 6663646
    Abstract: A balloon article, e.g., for an in vivo lumenal procedure, formed of a UV cross-linkable polyurethane material that is partially cross-linked to an extent providing a desired expansibility and/or compliant character to the balloon. The degree of cross-linking is selectively modified by the degree of UV exposure to which the balloon article is exposed, and/or the relative proportion of the cross-linking agent, to achieve corresponding product characteristics ranging from semi-compliant to non-compliant polyurethane film properties, including low creep/semi-compliant films.
    Type: Grant
    Filed: October 24, 2000
    Date of Patent: December 16, 2003
    Inventor: Tilak M. Shah
  • Patent number: 6660904
    Abstract: The invention provides transgenic animals comprising a lentiviral transgene, such as an HIV transgene. Also within the scope of the invention are cells and eggs from the transgenic animal. Further included are methods for identifying therapeutic compounds for preventing lentiviral infection and treating associated disease (e.g. AIDS).
    Type: Grant
    Filed: October 10, 2000
    Date of Patent: December 9, 2003
    Assignee: University of Maryland Biotechnology Institute
    Inventors: Joseph L. Bryant, William C. Reid, Harry G. Davis, Jr.
  • Patent number: 6643997
    Abstract: A method for adapting the volume of a collar bag (1) that is partially filled with bulk material, whereby the collar (3) of said bag is formed by two opposite-lying outwardly bent edge strips (5) and two opposite-lying inwardly bent second edge strips (7), to the volume of the bulk material contained in said bag (1). The invention is characterized in that the first edge strips (5) are pulled apart, whereby the wall of the bag is drawn out of the upper unfilled part of the bag over the folded edges (6) and into the collar (3) or the cross-section of the bag is reduced by pressing the opposite-lying larger parts of the wall. The invention also relates to the collar bag (1) and the device to carry out the above-mentioned method.
    Type: Grant
    Filed: October 19, 2001
    Date of Patent: November 11, 2003
    Assignee: Chronos Holdings Ltd.
    Inventors: Dieter Schwenke, Robert Oster, Jurgen Tegtmeyer
  • Patent number: 6629810
    Abstract: The invention relates to a protecting cap for the head of a screw that is screwed into a constructional part. A body (2:7) is arranged between the protecting cap (1) and the screw head (3) and produces a positive and a non-positive fit therebetween. The protecting cap protects the screw head from mechanical damage, soiling or corrosion.
    Type: Grant
    Filed: February 15, 2002
    Date of Patent: October 7, 2003
    Inventors: Sebastian Heintges, Lothar Schmitz
  • Patent number: 6623951
    Abstract: This invention relates to an HBV vector in which functional genes of HBV are at least partially deleted. In addition, this invention concerns a process for producing such an HBV vector as well as cells usable for this purpose.
    Type: Grant
    Filed: March 2, 1998
    Date of Patent: September 23, 2003
    Assignee: MondoGen GmbH
    Inventors: Peter Hofschneider, Peter Habenberger, Ludwig Weiss
  • Patent number: 6620416
    Abstract: The present invention relates to peptides of one or more portions of the human chorionic gonadotropin &bgr;-chain as well as methods for treatment and prevention of diseases, including HIV infection, using human chorionic gonadotropin, employing the &bgr;-chain of human chorionic gonadotropin, peptides containing a sequence of one or more portions of the &bgr;-chain of human chorionic gonadotropin and derivatives and analogues thereof. The invention further relates to fractions of sources and or preparations of human chorionic gonadotropin, such as fractions of human early pregnancy urine, which fractions have anti-HIV activity. The present invention further relates to pharmaceutical compositions for treating and/or preventing HIV infection.
    Type: Grant
    Filed: September 29, 2000
    Date of Patent: September 16, 2003
    Assignee: University of Maryland Biotechnology Institute
    Inventors: Robert C. Gallo, Joseph Bryant, Yanto Lunardi-Iskandar
  • Patent number: 6620256
    Abstract: An improved, non-plasma, static method for removing accumulated films and solid residues from interior surfaces of processing chambers used in thermal or plasma CVD treatment processes. The method includes introducing a reactive substance into a processing chamber while adjusting the pressure within the processing chamber to a predetermined level. The flow of the reactive substance into the processing chamber is terminated and the reactive substance is retained in the processing chamber to react with solid residues and form reaction products, following which the reaction products are subsequently removed from the processing chamber. Advantageously, terminating the flow of reactive substance into the processing chamber results in etching action that more effectively utilizes the cleaning agent and generates less hazardous materials.
    Type: Grant
    Filed: November 8, 2000
    Date of Patent: September 16, 2003
    Assignee: Advanced Technology Materials, Inc.
    Inventors: Jose Arno, Luping Wang, Glenn M. Tom
  • Patent number: 6612536
    Abstract: This invention relates to a remote shut-off valve, and in particular to a valve for the remote shutting-off of a fluid such as a main water supply. The remote shut-off valve comprises a diaphragm valve and a pilot valve which are connected together by way of flexible tubes so that that pilot valve can be located in a desired location remote from the diaphragm valve. Part of the flow channels between the diaphragm valve and the pilot valve, and also the flow channel to the control chamber of the diaphragm valve are located within the body of the diaphragm valve. Quick-release connectors can be provided to connect the flexible tubes to the pilot valve and to the diaphragm valve.
    Type: Grant
    Filed: January 14, 2002
    Date of Patent: September 2, 2003
    Inventor: Martin Walter Dalton
  • Patent number: 6613505
    Abstract: A method and composition for destruction of infectious prion proteins in tissue, by thermal/enzymatic treatment of the tissue with a prion-destructive protease. The method and composition are applicable to treatment of tissue containing or contaminated with prion protein strains associated with transmissible spongiform encephalopathy (TSE) and/or other prion protein-mediated diseases.
    Type: Grant
    Filed: April 12, 2001
    Date of Patent: September 2, 2003
    Assignee: BioResource International, Inc.
    Inventor: Jason C. H. Shih