Abstract: The invention relates to isolated nucleic acid molecules and to host cells comprising such nucleic acid molecules. Moreover, the invention relates to a polypeptide having PIM-3 activity and having a definite amino acid sequence, as well as to the use of PIM-3 as a screening agent for identifying anti-type 2 diabetes mellitus drugs and for preparing a medicament for the treatment of insulin resistance or type 2 diabetes mellitus.
Type:
Grant
Filed:
January 21, 2003
Date of Patent:
June 5, 2007
Assignee:
Sanofi-Aventis Deutschland GmbH
Inventors:
Marcus Korn, Guenter Mueller, Rudolf Schneider, Georg Tschank
Abstract: The invention relates to crystals of an insulin analog in which asparagine (Asn) in position B3 of the B chain is replaced by a naturally occurring basic amino acid residue and at least one amino acid residue in the positions B27, B28 or B29 of the B chain is replaced by another naturally occurring neutral or acidic amino acid residue, where phenylalanine (Phe) in position B1 of the B chain can optionally be absent, the crystals being present in the space group R3 (No. 146) with the cell axes A=81.5 ?±1 ? and C=33.3 ?±1 ?, their preparation and use, and a pharmaceutical composition comprising these crystals.
Abstract: The invention relates to a process for detecting or determining a C-peptide-containing impurity in a sample of recombinantly produced human insulin or a derivative thereof, by a non-radioactive assay, comprising the steps: (a) preparing a sample of recombinantly produced human insulin or a derivative thereof; (b) mixing the samples with dilution buffer; (c) adding a tracer to mixture (b); (d) adding antibody specific for the C-peptide impurity to mixture (c); (e) adding “C-peptide second antibody bead” having at least one label to mixture (d); and (f) detecting or determining the presence of the C-peptide-containing impurity.
Abstract: This invention relates to certain novel 2'-halomethylidene, 2'-ethenylidene and 2'-ethynyl cytidine, uridine and guanosine derivatives, and compositions thereof, which are useful in the treatment of patients afflicted with neoplastic or viral disease states.
Type:
Grant
Filed:
June 3, 1998
Date of Patent:
November 2, 1999
Assignee:
Merrell Pharmaceuticals Inc.
Inventors:
James R. McCarthy, Michael L. Edwards, Donald P. Matthews
Abstract: The present invention relates to methods and compositions using .DELTA..sup.16 unsaturated steroids which are useful as steroid C.sub.17-20 lyase inhibitors.
Type:
Grant
Filed:
May 6, 1998
Date of Patent:
November 2, 1999
Assignee:
Merrell Pharmaceuticals Inc.
Inventors:
Norton P. Peet, Joseph P. Burkhart, Cynthia A. Gates
Abstract: The present invention provides novel macrocyclic difluorostatone derivatives which are useful as antiviral agents. More specifically, these novel compounds are useful as inhibitors of retroviral proteases required for replication, particularly the HIV-1 and HIV-2 viral proteases, in the prevention or treatment of infection by the human immunodeficiency virus (HIV), and in the treatment of consequent pathological conditions such as the acquired immunodeficiency syndrome (AIDS) in mammals capable of being infected with HIV virus.
Abstract: This invention relates to novel statone antiviral analogs, to the processes and intermediates useful for their preparation and to their use as antiviral agents.
Type:
Grant
Filed:
May 19, 1998
Date of Patent:
September 7, 1999
Assignee:
Merrel Pharmaceuticals Inc.
Inventors:
Viviane Van Dorsselaer, Daniel Schirlin, Celine Tarnus
Abstract: Disclosed are novel unsaturated phosphonate derivatives of certain purines or pyrimidines useful as antiviral agents, methods useful for their preparation and use of these compounds as antiviral agents effective against DNA viruses, retroviruses and viruses involved in tumor formation.
Type:
Grant
Filed:
August 10, 1998
Date of Patent:
July 13, 1999
Assignee:
Merrell Pharmaceuticals Inc.
Inventors:
Patrick Casara, Jean-Fran.cedilla.ois Nave, Serge Halazy
Abstract: A process for preparing polyamines of the formula ##STR1## by selective introduction of the groups Z--CH.sub.2 -- at the terminal nitrogens from a polyamine having no nitrogen substituents by formation of bis-hexahydropyrimidine derivative, acylation, reduction of acyl group to give Z--CH.sub.2 --, and solvolysis.
Type:
Grant
Filed:
September 11, 1997
Date of Patent:
February 23, 1999
Assignee:
Merrell Pharmaceuticals Inc.
Inventors:
Paul T. Angell, John Martin, Peter B. Anzeveno
Abstract: Disclosed are novel unsaturated acetylene phosphonate derivatives of certain purines or pyrimidines useful as antiviral agents, methods useful for their preparation and use of these compounds as antiviral agents effective against DNA viruses, retroviruses and viruses involved in tumor formation.
Type:
Grant
Filed:
November 17, 1995
Date of Patent:
October 6, 1998
Assignee:
Merrell Pharmaceuticals Inc.
Inventors:
Patrick Casara, Jean-Fran.cedilla.ois Nave, Serge Halazy
Abstract: The present invention relates to a novel process for the preparation of 1-(3-trialkylsilylphenyl)-2,2,2-trifluoromethyl ethanones from 1-halo-3-trialkylsilanyl-benzenes. 1-(3-trialkylsilylphenyl)-2,2,2-trifluoromethyl ethanones are useful for the treatment of Alzheimer's disease and senile dementia. In addition, the present invention relates to a novel process for purifying 1-(3-trialkylsilylphenyl)-2,2,2-trifluoromethyl ethanones utilizing a novel extraction method.
Type:
Grant
Filed:
June 18, 1996
Date of Patent:
June 2, 1998
Assignee:
Hoechst Marion Roussel Inc.
Inventors:
Roberto Gandolfi, deceased, Dennis K. Klipa, Neal J. Fetner
Abstract: The present invention is directed toward a novel process of preparing 2'-exocyclic vinylfluoride derivatives of cytidine analogues for use as ribonucleotide reductase inhibitors.
Type:
Grant
Filed:
July 30, 1996
Date of Patent:
June 2, 1998
Assignee:
Merrell Pharmaceuticals Inc.
Inventors:
James R. McCarthy, Donald P. Matthews, Jeffrey S. Sabol, James R. McConnell, Richard E. Donaldson, Robert Duguid