Patents Represented by Attorney Mark Dryer
  • Patent number: 6130217
    Abstract: This invention relates to certain heterocyclic compounds and their pharmaceutically acceptable salts, which are useful for sensitizing multidrug-resistant tumor cells to anticancer agents and multidrug resistant forms of malaria, tuberculosis, leishmania and amoebic dysentery to chemotherapeutants. The compounds and their pharmaceutically acceptable salts are also inhibitors of the active drug transport capability of P-glycoprotein which is encoded by the human MDR1 gene, as well as of certain other related ATP-binding-cassette transporters from eukaryotic and prokaryotic organisms (e.g., pfmdr from Plasmodium falciprum, and murine mdr1 and mdr3 gene products).
    Type: Grant
    Filed: September 20, 1995
    Date of Patent: October 10, 2000
    Assignee: Pfizer Inc
    Inventors: Lee Daniel Arnold, Jotham Wadsworth Coe, Takushi Kaneko, Mikel Paul Moyer
  • Patent number: 6057455
    Abstract: A process for preparing a compound of the formula ##STR1## wherein R.sup.1, m, o and p are described below, which comprises adding a base of the formula ##STR2## wherein R.sup.2, R.sup.3 and R.sup.4 are as described below, to a solution comprising a compound of the formula ##STR3## wherein R.sup.1, m, o and p are as described below, and a halonitromethane of the formula O.sub.2 NCH.sub.2 X, wherein X is a halogen atom dissolved in a non-aqueous inert solvent. The compounds of formula III are useful as intermediates in the syntheses of azabicyclo quinoline carboxylic acids, and their pharmaceutically acceptable salts and prodrugs, having antibacterial activity. This invention also relates to the base of formula IV wherein each R.sup.2 is butyl, R.sup.3 is hydrogen and each R.sup.4 is t-butyl.
    Type: Grant
    Filed: July 7, 1997
    Date of Patent: May 2, 2000
    Assignee: Pfizer, Inc.
    Inventor: Joel M. Hawkins
  • Patent number: 6017964
    Abstract: The present invention provides novel methods of increasing serum levels of testosterone comprising administering to a mammal in need of such treatment an effective amount of a compound of formula I ##STR1## wherein R.sup.1 and R.sup.2 may be the same or different provided that, when R.sup.1 and R.sup.2 are the same, each is a methyl or ethyl group, and, when R.sup.1 and R.sup.2 are different, one of them is a methyl or ethyl group and the other is hydrogen or a benzyl group; or a pharmaceutically acceptable salt thereof.
    Type: Grant
    Filed: December 9, 1998
    Date of Patent: January 25, 2000
    Assignee: Pfizer Inc.
    Inventors: David B. MacLean, David D. Thompson
  • Patent number: 5990125
    Abstract: The present invention relates to the use of certain NK-1 receptor antagonists (e.g., substance P receptor antagonists) to treat cancer patients, particularly cancer patients afflicted with a small cell lung carcinoma, APUDoma, astrocytoma, neuroendocrine tumor or extrapulmonary small cell carcinoma.
    Type: Grant
    Filed: January 17, 1997
    Date of Patent: November 23, 1999
    Assignee: Pfizer Inc.
    Inventor: Harry Ralph Howard
  • Patent number: 5977355
    Abstract: A process for the preparation of CCK antagonists of the formula ##STR1## wherein X, Y.sup.1 and Y.sup.2 are defined above and to novel intermediates used in the process.
    Type: Grant
    Filed: April 17, 1997
    Date of Patent: November 2, 1999
    Assignee: Pfizer Inc.
    Inventor: Frank J. Urban
  • Patent number: 5863917
    Abstract: The invention provides compounds of formula I, ##STR1## wherein R.sup.1 and R.sup.2 independently represent Cl or C.sub.1-6 alkyl;R.sup.3 represents XCO.sub.2 R.sup.4, XCONHSO.sub.2 R.sup.5, YNHSO.sub.2 R.sup.5 or XR.sup.6 ;R.sup.4 represents H or C.sub.1-6 alkyl (optionally substituted by aryl or heterocyclyl);R.sup.5 represents CF.sub.3, heterocyclyl or C.sub.1-6 alkyl (optionally substituted by aryl or heterocyclyl);R.sup.6 represents an acidic heterocycle;X represents a C.sub.1-6 alkyl diradical (optionally subsituted by aryl or heterocyclyl); andY represents a C.sub.2-6 alkyl diradical (optionally substituted by aryl or heterocyclyl); provided that when R.sup.1 and R.sup.2 each represent Cl, then R.sup.3 does not represent CH.sub.2 CO.sub.2 H, CH.sub.2 CO.sub.2 CH.sub.3, CH.sub.2 CH.sub.2 NHSO.sub.2 CF.sub.3 or 5-tetrazolylmethyl; and pharmaceutically acceptable salts thereof.The compounds are indicated as anxiolytics, anticonvulsants, analgesics and neuroprotectives.
    Type: Grant
    Filed: September 26, 1997
    Date of Patent: January 26, 1999
    Assignee: Pfizer, Inc.
    Inventors: Charles Eric Mowbray, Alan Stobie
  • Patent number: 5861402
    Abstract: A compound of the formula: ##STR1## and its pharmaceutically acceptable salts, wherein A.sup.1 and A.sup.2 are each halo or H; X.sup.1 is CH.sub.2, CO, SO or SO.sub.2 ; X.sup.2 is CH.sub.2 or CO; Y is piperazinyl-(CH.sub.2).sub.n --, 2,3,4,5,6,7-hexahydro-1H-1,4-diazepinyl-(CH.sub.2).sub.n --or --N(R.sup.5)--(CH.sub.2).sub.n -- wherein R.sup.5 is H or C.sub.1-4 alkyl, and n is 0, 1, 2, 3, or 4; R.sup.1 is selected from the following: (a) N-morpholino-C.sub.1-4 alkylphenyl, C.sub.1-4 alkoxycarbonyl, C.sub.2-5 acyl, dihydroimidazolyl, formamidino, guanidino or dihydroimidazolylamino, etc.; (b) hydrogen, C.sub.1-4 alkyl, etc.; (c) piperidinyl; (d) C.sub.5-14 cycloalkyl, bicycloalkyl or tricycloalkyl; (e) C.sub.7-14 azacyclo-, azabicyclo- or azatricyclo-alkyl; and (f) C.sub.7-10 bicycloalkenyl, benzo C.sub.5-7 cycloalkyl or heterocyclic, etc., with proviso that when Y is piperazinyl, at least one of A.sup.1 and A.sup.2 is H; X.sup.2 is CH.sub.2 ; and/or R.sup.1 is a group selected from group (a); R.sup.
    Type: Grant
    Filed: January 31, 1997
    Date of Patent: January 19, 1999
    Assignee: Pfizer Pharmaceuticals, Inc.
    Inventor: Takafumi Ikeda
  • Patent number: 5852038
    Type: Grant
    Filed: November 18, 1996
    Date of Patent: December 22, 1998
    Assignee: Pfizer Inc
    Inventors: Fumitaka Ito, Toshihide Kokura, Masami Nakane, Kunio Satake, Hiroaki Wakabayashi
  • Patent number: 5821245
    Abstract: A method of inhibiting cell growth in human small cell lung carcinoma comprising administering to a mammal in need of such treatment a cell growth inhibitory amount of a compound of the formula ##STR1##
    Type: Grant
    Filed: March 13, 1997
    Date of Patent: October 13, 1998
    Assignee: Pfizer Inc.
    Inventor: Harry R. Howard, Jr.
  • Patent number: 5782925
    Abstract: A knee implant rotational alignment apparatus comprising a non-implantable femoral trial component having substantially the same configuration as a femoral implant, a cooperating tibial articulating trial component having two parallel guide rails protruding from the upper surface thereof, which rails engage with grooves in the lower surface of the femoral trial component, which engagement prevents rotation of the femoral trial component relative to the tibial articulating trial component in a transverse plane but allows flexion and extension rotation of both components, a tibial trial baseplate having an outer periphery substantially identical to the outer periphery of a tibial implant baseplate of corresponding size, which baseplate accommodates a spring clip activator the rotation of which facilitates selection of the rotational alignment of the prosthesis.
    Type: Grant
    Filed: November 6, 1997
    Date of Patent: July 21, 1998
    Assignee: Howmedica Inc.
    Inventors: Carlos E. Collazo, Stuart L. Axelson, Donald G. Eckhoff
  • Patent number: 5720415
    Abstract: An apparatus for delivering fluid to a site at a controlled rate and pressure, which comprises a housing enveloping three interconnected chambers comprising a first end chamber, a connecting chamber and a second end chamber, an inlet port and an outlet port each located in a side wall of the connecting chamber, each of the inlet port and the outlet port being associated with a valve for opening and closing the respective port; a first piston positioned within the first end chamber and a second piston positioned within the second end chamber, each of said pistons having a head with an inwardly facing surface having a periphery which fits snugly within the corresponding end chamber to form a fluid-tight seal with the at least one side wall of the end chamber, wherein at least a portion of a side wall of the connecting chamber intrudes inwardly to provide a stop for the head of each piston; and a closure to close the open end of each end chamber.
    Type: Grant
    Filed: April 2, 1996
    Date of Patent: February 24, 1998
    Assignee: American Medical Systems, Inc.
    Inventor: Randy L. Morningstar
  • Patent number: 5672171
    Abstract: An apparatus for delivering laser energy to a target through a radiation-transmitting waveguide having a distal end terminating in a tip which is in contact with the target during delivery, while protecting the tip from heat damage, which apparatus comprises a waveguide for transmitting laser radiation and having a distal end terminating in a tip adapted to be placed in contact with the target to deliver laser energy directly to the target at the site of contact, and means for delivering a controlled small amount of liquid to the target adjacent to the tip, which small amount is just sufficient to limit the temperature at the target to not more than the failure temperature of the tip. An apparatus assembly for performing ILC incorporating a waveguide and a method for protecting the tip of a waveguide from damage is also disclosed.
    Type: Grant
    Filed: June 30, 1994
    Date of Patent: September 30, 1997
    Assignee: American Medical Systems, Inc.
    Inventors: W. Scott Andrus, Mark Polyak, Sidney F. Hauschild
  • Patent number: 5622259
    Abstract: A method for reducing discoloration in a discolored plastic material which has been subjected to sterilization by gamma radiation which includes exposing the plastic material to light having a wavelength within the range of 200 to 600 nm for a time sufficient to restore the original clarity. A sterilized pack for a medical device including plastic material in which the clarity has been restored by the method is also included.
    Type: Grant
    Filed: June 7, 1995
    Date of Patent: April 22, 1997
    Inventor: Jonathan M. Church
  • Patent number: 5618587
    Abstract: A vacuum rig apparatus for introducing a liquid into a space defined by a shaped article, which apparatus comprises a series of interconnected vessels attached through a port to a vacuum line, wherein one of the vessels is adapted to hold the shaped article and the apparatus is tiltable about a point midway along the vessel so that liquid from a reservoir flows into the vessel to surround the shaped article and fill the space therein when a vacuum is applied to the apparatus.
    Type: Grant
    Filed: December 7, 1994
    Date of Patent: April 8, 1997
    Assignee: Biomedical Sensors, Ltd.
    Inventors: David R. Markle, Barry C. Crane, Michael P. Irvine, Stuart P. Hendry, William Paterson
  • Patent number: 5596988
    Abstract: A multi-parameter catheter comprising sensors enveloped in a sheath made from a biphasic material comprising a layer of microporous hydrophobic substance having micropores which are filled with a hydrophilic substance which when hydrated forms a gel and allows the passage of water-bound ions, and an apparatus for introducing the catheter into a patient's blood vessel.
    Type: Grant
    Filed: December 7, 1994
    Date of Patent: January 28, 1997
    Assignee: Biomedical Sensors, Ltd.
    Inventors: David R. Markle, Barry C. Crane, Michael P. Irvine, Stuart P. Hendry, William Paterson
  • Patent number: 5553379
    Abstract: A malleable penile prosthesis adapted to be implanted in a corpus cavemosum of a penis comprising an elongated core which is bendable about its longitudinal axis with the capability of holding the configuration to which it is bent and is substantially rigid when in the unbent straight configuration, a sleeve of braided biocompatible material, having an inner surface and an outer surface, enveloping the core with the inner surface of the sleeve in contact with the core and the sleeve and core being accommodated within an outer tube of elastomeric material, which tube has a substantially rounded smooth outer surface and an inner surface having a profile formed of alternate grooves and ribs in a substantially helical arrangement. A method of forming a malleable prosthesis is also disclosed.
    Type: Grant
    Filed: July 13, 1995
    Date of Patent: September 10, 1996
    Assignee: American Medical Systems, Inc.
    Inventors: John W. Westrum, Jr., Mark S. Chace, Charles C. Kuyava
  • Patent number: 5553613
    Abstract: A device for the non-invasive measurement of the concentration of a specific analyte, particularly glucose, in arterial blood flowing in a patient's body part, which device comprises a solid first portion having a surface profile adapted to be held against the selected body part, a source of near infrared radiation mounted in a second portion associated with said first portion such that near infrared radiation is transmitted through or reflected from said body part, a third portion containing a detector and filters to receive radiation transmitted through or reflected from said body part, to select signals generated by the pulsatile component of the absorption spectrum and to provide a ratio representative of the desired concentration. A method for the determination of glucose concentration in arterial blood is also disclosed.
    Type: Grant
    Filed: August 17, 1994
    Date of Patent: September 10, 1996
    Assignee: Pfizer Inc.
    Inventor: Dawood Parker
  • Patent number: 5512054
    Abstract: A dual action syringe which comprises a hollow body defining a rear chamber and a front chamber, wherein the rear chamber has a greater internal cross-sectional area than the front chamber, a double action plunger mechanism comprising a primary plunger with a cross-section which matches the internal cross-section of the rear chamber and a secondary plunger telescopically mounted within the primary plunger and having a cross-section which matches the internal cross-section of the front chamber, the proximal end of the secondary plunger extending beyond the proximal end of the primary plunger and terminating in a handle which enables the plunger mechanism to be slidably moved relative to the hollow body.
    Type: Grant
    Filed: May 16, 1995
    Date of Patent: April 30, 1996
    Assignee: American Medical Systems, Inc.
    Inventor: Randy L. Morningstar
  • Patent number: 5512033
    Abstract: A malleable penile prosthesis adapted to be implanted in a corpus cavernosum of a penis comprising an elongated core which is bendable about its longitudinal axis with the capability of holding the configuration to which it is bent and is substantially rigid when in the unbent straight configuration, a sleeve of braided biocompatible material, having an inner surface and an outer surface, enveloping the core with the inner surface of the sleeve in contact with the core and the sleeve and core being accommodated within an outer tube of elastomeric material, which tube has a substantially rounded smooth outer surface and an inner surface having a profile formed of alternate grooves and ribs in a substantially helical arrangement. A method of forming a malleable prosthesis is also disclosed.
    Type: Grant
    Filed: August 8, 1994
    Date of Patent: April 30, 1996
    Assignee: American Medical Systems, Inc.
    Inventors: John W. Westrum, Jr., Mark S. Chace, Charles C. Kuyava
  • Patent number: 5511547
    Abstract: A stabilized bio-inert sensor for the determination of an analyte, especially pO.sub.2, pCO.sub.2 and pH, in a medium which comprises a chemical indicator sensitive to the analyte in association with a stabilizing substrate formed from a polymer which is inert to the medium and analyte and does not affect the sensitivity of the indicator, which polymer is a cross-linked, solid silicone rubber formed from a silicone carbinol having a molecular structure compatible with said indicator.
    Type: Grant
    Filed: February 16, 1994
    Date of Patent: April 30, 1996
    Assignee: Biomedical Sensors, Ltd.
    Inventors: David R. Markle, Misa V. Jovanovic