Patents Represented by Attorney, Agent or Law Firm Mark E. Waddell
  • Patent number: 6069170
    Abstract: The invention relates to a cosmetic light-screening composition for protecting human skin or human hair against ultraviolett radiation containing at least one compound of formula I ##STR1## wherein R.sup.1 represents a C.sub.1-8 straight or branched alkyl chain, andR.sup.2 and R.sup.3 each independently represent a C.sub.1-8 straight or branched alkyl chain.
    Type: Grant
    Filed: July 24, 1998
    Date of Patent: May 30, 2000
    Assignee: Roche Vitamins Inc.
    Inventors: Alain Bringhen, Hans Ulrich Gonzenbach, Magali Pochon, Dominique Sidrac
  • Patent number: 6067842
    Abstract: An olfactometer has a sniffing port, a sample supply for generating a sample flow constituted by a carrier gas and sample head space from a saturation chamber and for supplying the sample flow to the sniffing port, a carrier gas supply, and mixer for predetermined dilution of the sample flow. The carrier gas supply includes mass flow controllers with variable flow rates disposed before the saturation chamber for providing variable carrier gas flow to the saturation chamber. A multiplicity of capillaries of different diameter connect the mixing means with the sniffing port via individual injectors. A computer may be interphased with the olfactometer to regulate the amount of sample and/or carrier gas in the sample flow.
    Type: Grant
    Filed: June 4, 1998
    Date of Patent: May 30, 2000
    Assignee: Roche Vitamins Inc.
    Inventors: Hansruedi Gygax, Christian Montagner, Norbert Neuner-Jehle
  • Patent number: 6069125
    Abstract: The invention relates to the use of cyclohexylidene phenyl acetonitrile as an odoriferous substance.
    Type: Grant
    Filed: April 14, 1998
    Date of Patent: May 30, 2000
    Assignee: Givaudan Roure (International) SA
    Inventor: Mario Pesaro
  • Patent number: 6066745
    Abstract: A process for the manufacture of d,1-.alpha.-tocopherol by the acid catalyzed condensation of trimethylhydroquinone with isophytol is provided, in which the condensation is carried out in the presence of not more than about 0.4 weight percent, based on the weight of isophytol, of a sulfur-containing acid catalyst such as sulfuric acid, methanesulphonic acid, ethanesulphonic acid, trifluoromethanesulphonic acid, p-toluenesulphonic acid, fluorosulphonic acid and mixtures thereof, and in a solvent which is ethylene or propylene carbonate or a mixture of both carbonates, or a mixture of one or both of the carbonates and a non-polar solvent.
    Type: Grant
    Filed: March 31, 1999
    Date of Patent: May 23, 2000
    Assignee: Roche Vitamins Inc.
    Inventors: Marcel Baak, Werner Bonrath, Paul Kreienbuhl
  • Patent number: 6066731
    Abstract: A process for the production of a Mannich reagent comprises reacting formaldehyde, especially paraformaldehyde, with a secondary amine in the complete or almost complete absence of a solvent. An alternative comprises reacting a diaminomethane produced from a secondary amine, formaldehyde, especially paraformaldehyde, as well as water with one another in about equimolar amounts. The invention is also concerned with a process for the aminomethylation of .delta.-tocopherol or of tocopherol mixtures containing this and comprises using a Mannich reagent which has been produced in the above manner. After completion of this aminomethylation process excess Mannich reagent can be separated by distillation and can be reacted with water and formaldehyde, especially paraformaldehyde, in order to regenerate further Mannich reagent suitable for use in the aminomethylation, this regeneration representing a further aspect of the invention. Finally, the invention includes certain novel bis(aminomethyl)-.gamma.-tocopherols.
    Type: Grant
    Filed: March 22, 1996
    Date of Patent: May 23, 2000
    Assignee: Roche Vitamins Inc.
    Inventors: Robert Karl Muller, Heinz Schneider
  • Patent number: 6063937
    Abstract: The present invention provides a method of making alkali metal and alkaline earth metal salts of L-ascorbic acid 2-monophosphate comprising reacting a L-ascorbic acid 2-polyphosphate under alkaline conditions with an alkali metal or alkaline earth metal salt of L-ascorbic-acid in concentrated aqueous solution. The amount of the L-ascorbic acid salt is in molar excess of the polyphosphate and the pH value of the reaction medium is maintained in the range of from about 8 to about 11 wherein the reaction is carried out until substantially all of the polyphosphate has been consumed and only L-ascorbic acid 2-monophosphate salt is present. A further aspect of the present invention comprises spray drying the mixture obtained after completion of the reaction, cooling and dilution to a suitable viscosity.
    Type: Grant
    Filed: March 17, 1998
    Date of Patent: May 16, 2000
    Assignee: Roche Vitamins Inc.
    Inventors: Alain Dlubala, Paul Nosberger
  • Patent number: 6060267
    Abstract: A process for the enzymatic production of vitamin B.sub.6 which includes incubating 1-deoxy-D-threo-pentulose and 4-hydroxy-L-threonine with an enzyme system that is cell free or essentially cell free and prepared from the cells of a microorganism belonging to the genus Rhizobium, Sinorhizobium, Flavobacterium, Chryseobacterium, Lactobacillus, Arthrobacter, Bacillus, Klebsiella, Escherichia, Pseudomonas, Stenotrophomonas, Enterobacter, Serratia, Corynebacterium, Brevibacterium, Exiguobacterium, Saccharomyces, Yamadazyma, Pichia or Candida, in the presence of NADP.sup.+, NAD.sup.+, ATP. Manganese and magnesium ions stimulate the above reaction. This process affords high yields of vitamin B.sub.6, a vitamin essential for the nutrition of animals, plants and microorganisms, and which is also useful as a medicine or food additive. In addition, an enzyme reaction system for producing vitamin B.sub.6 and a process for making the enzyme reaction system are also provided.
    Type: Grant
    Filed: April 14, 1999
    Date of Patent: May 9, 2000
    Assignee: Roche Vitamins, Inc.
    Inventors: Tatsuo Hoshino, Masaaki Tazoe
  • Patent number: 6057136
    Abstract: The invention generally provides the genes of the biotin biosynthetic operon of Bacillus subtilis, and closely related species thereof, and well as constructions useful for high level production of biotin.
    Type: Grant
    Filed: July 8, 1996
    Date of Patent: May 2, 2000
    Assignee: Roche Vitamins Inc.
    Inventors: Stanley Grant Bower, John B. Perkins, R. Rogers Yocum, Janice G. Pero
  • Patent number: 6043210
    Abstract: The invention is related to novel thiamacrolides, especially musk odorants, having extremely low threshold values, their use in functional perfumery such as fine perfumery, as well as to the preparation of thiamacrolide compounds.
    Type: Grant
    Filed: January 29, 1998
    Date of Patent: March 28, 2000
    Assignee: Givaudan Roure (International) SA
    Inventors: Jerzy A. Bajgrowicz, Georg Frater, Philip Kraft
  • Patent number: 6040475
    Abstract: This invention is concerned with the synthesis of 3-(1-acetoxy-1-methylethyl)-6-oxo-heptanal; 3-(1-acetoxy-1-methylethyl)-2-formyl-1-methyl-cyclopentanol; 5-[2-hydroxy-5-(1-hydroxy-1-methylethyl)-2-methyl-2-cyclopentyl]-3-methyl- penta-2,4-dien-1-ol and 2,7,11-trimethyl-13-[2-hydroxy-5-(1-hydroxy-1-methylethyl)-2-methyl-cyclop entyl]-trideca-2,4,6,8,10,12-hexaenal which are useful as intermediates for the synthesis of lycopene metabolites.
    Type: Grant
    Filed: May 12, 1999
    Date of Patent: March 21, 2000
    Assignee: Roche Vitamins Inc.
    Inventors: Hanspeter Pfander, Bruno Traber
  • Patent number: 6037147
    Abstract: This invention is directed to cytochrome c.sub.551 polypeptides and polynucleotides encoding the polypeptides.
    Type: Grant
    Filed: March 31, 1998
    Date of Patent: March 14, 2000
    Assignee: Roche Vitamins Inc.
    Inventors: Akira Asakura, Tatsuo Hoshino, Masako Shinjoh, Noribumi Tomiyama
  • Patent number: 6033649
    Abstract: Photostable, cosmetic light-screening composition, comprising, in a cosmetically acceptable vehicle containing at least one fatty phase, about 0.1 to about 5%, in particular about 1 to about 3% by weight, of a dibenzoylmethane type UV-A screening agent and at least about 0.5%, in particular about 0.5 to about 4.5% by weight, of a .alpha.-cyano-.beta.,.beta.-diphenyl-acrylate stabilizer, the mole ratio of the acrylate to the dibenzoylmethane derivative being less than 0.8, if the amount of the dibenzoylmethane is 1% or more, and, optionally, at least one conventional UV-B filter.
    Type: Grant
    Filed: December 4, 1996
    Date of Patent: March 7, 2000
    Assignee: Roche Vitamins Inc.
    Inventors: Hans Ulrich Gonzenbach, Gilbert Pittet
  • Patent number: 6030645
    Abstract: The invention is concerned with a flowable dry particle consisting of at least one oleophilic substance as the active ingredient present in a matrix of at least one carrier material and a coating. The coating consists of calcium silicate or of a mixture of calcium silicate with one or more mixture components, with the mixture components being microcrystalline cellulose, magnesium silicate, magnesium oxide, stearic acid, calcium stearate, magnesium stearate, silicon dioxide, kaolin and/or hydrogenated vegetable oil.
    Type: Grant
    Filed: February 20, 1998
    Date of Patent: February 29, 2000
    Assignee: Roche Vitamins Inc.
    Inventors: Jean-Claude Tritsch, Johann Ulm
  • Patent number: 6018075
    Abstract: A process for the manufacture of a .gamma.-acetoxy-tiglic aldehyde by reacting a .gamma.-bromotiglic aldehyde or a .gamma.-chlorotiglic aldehyde with sodium acetate or potassium acetate in an organic solvent in the presence of a phase transfer catalyst.
    Type: Grant
    Filed: May 12, 1999
    Date of Patent: January 25, 2000
    Assignee: Roche Vitamins Inc.
    Inventors: Bruno Burdet, Paul Nosberger, August Ruttimann
  • Patent number: 6008034
    Abstract: The present invention relates to the production of HPO lyase proteins in hosts via recombinant expression of said proteins. Recombinant HPO lyase proteins, DNA sequences encoding these proteins, vectors containing these DNA sequences and hosts containing these vectors are provided, along with methods for recombinantly producing such proteins, DNA sequences, vectors and hosts. Also provided are processes for producing green note compounds.
    Type: Grant
    Filed: April 7, 1997
    Date of Patent: December 28, 1999
    Assignee: Givaudan-Roure (International) SA
    Inventors: Alex Hausler, Konrad Lerch, Andreas Muheim, Natasha Silke
  • Patent number: 6001554
    Abstract: Multiple micro-encapsulations of a high concentration oleophilic substance using heat to set the primary particle renders the composition suitable for the production of free-flowing powders or beadlets. Microencapsulation involves forming an emulsion out of the oleophilic substance and a polymer, and then use heat setting and/or cross-linking the polymer encapsulates the oleophilic composition. This process is then repeated with a second polymer or third polymer, and with or without cross-linked via the same or different mechanism to further protect the oleophilic substance.
    Type: Grant
    Filed: January 16, 1998
    Date of Patent: December 14, 1999
    Assignee: Roche Vitamins Inc.
    Inventors: Stasia Boyle, Kuei-Tu Chang
  • Patent number: 6002047
    Abstract: The present invention is concerned with a process for the catalytic hydrogenation of organic compounds on a catalyst of amorphous metal alloys and in a solvent, with the hydrogenation being carried out under near-critical or supercritical conditions of the solvent. The amorphous metal alloys can be produced by the shock cooling of alloy melts having eutectic solidification points. By hydrogenation at hydrogen partial pressures between 5 and 400 bar there is obtained outstanding space-time yields with high long-term stability of the catalytic activity.
    Type: Grant
    Filed: October 28, 1997
    Date of Patent: December 14, 1999
    Assignee: Roche Vitamins Inc.
    Inventors: Michael Jansen, Claus Rehren
  • Patent number: 5986113
    Abstract: A process for the manufacture of polyene esters or polyene acids comprises reacting a polyene O,O-dialkylacetal of di(O,O-dialkylacetal) with a vinylketene acetal or analogue thereof in the presence of a Lewis acid, hydrolyzing the reaction mixture depending on the vinylketene acetal used, subsequently cleaving alcohol under strongly basic conditions from the polyene derivative produced at this stage and, where the desired ester or carboxy group is still not present, performing the respective conversion. Certain intermediates in this process form a further aspect of the invention. The final products are primarily carotenoids which can be used appropriately, e.g. as colorants and pigments for foodstuffs, animal products etc.
    Type: Grant
    Filed: March 26, 1998
    Date of Patent: November 16, 1999
    Assignee: Roche Vitamins Inc
    Inventor: August Ruttimann
  • Patent number: 5981233
    Abstract: A process is disclosed for manufacturing a xylanase-rich enzyme complex by cultivating a xylanase-producing microorganism of the genus Trichoderma in a nutrient medium involves cultivating said microorganism in a nutrient medium containing a pre-treated thin stillage of rye as both the xylanase inductor and the carbon source. Pre-treatment of the thin stillage comprises removing the solid constituents of the thin stillage of rye, concentrating the non-volatile components by evaporation of water and other volatile substances, and autoclaving the thin stillage of rye concentrate resulting therefrom. De-oiled soya meal or soya meal liquor can be used as an additional xylanase inductor and as a nitrogen source. Addition of the de-oiled soya meal or soya meal liquor to the pre-treated thin stillage of rye further increases the xylanase production. The enzyme complexes so manufactured can be used immediately in the animal feedstuff industry such as poultry feeds.
    Type: Grant
    Filed: August 6, 1998
    Date of Patent: November 9, 1999
    Assignee: Roche Vitamins Inc.
    Inventor: Manfred Ringpfeil
  • Patent number: 5976512
    Abstract: The invention is concerned with compounds of formula I: ##STR1## which are useful as sun screening agents.
    Type: Grant
    Filed: February 17, 1998
    Date of Patent: November 2, 1999
    Assignee: Roche Vitamins Inc.
    Inventor: Ulrich Huber