Abstract: This invention consists of an ophthalmic dispensing tip formed by injection molding, which has a one-piece molded tip to be used with a mating cap, the tip having an internally molded breakaway barrier membrane inside the flow channel, and the cap having a shaped stud fitting inside the tip, so that the final clockwise half-turn of the cap pushes the stud against the barrier and displaces it, thereby creating a restricted path through which the contents are dispensed.

Abstract: A compound having the formula ##STR1## which is an anti-fungal agent is described. The producing organism Colletotricum accutatum is also described, along with a method of production.

Abstract: A compound of the formula I is disclosed. ##STR1## R.sup.13 represents hydrogen, NH.sub.2, C1-4 alkyl, C1-4 alkylamino or di(C1-4) alkylamino-;Y represents CH or N;Y" represents (a) CR.sup.y' R.sup.z' with R.sup.y' and R.sup.z' hydrogen, C1-6 alkyl, C.sub.3-8 cycloalkyl or C.sub.1-6 alkyl substituted with C.sub.3-8 cycloalkyl, or (b) N substituted with OR.sup.14 with R.sup.14 representing H, C.sub.1-4 alkyl or C.sub.1-4 alkyl substituted with COOH.Ar represents: ##STR2## One of R.sup.1 and R.sup.2 independently represent H, W as defined below or one of the groups (a) through (d) below, and the other represents H or W. Pharmaceutical compositions and methods of use are also included.

Abstract: The device comprises a receiving housing for receiving and maintaining the vial, this latter being comprised of a pocket (10) containing the product and a nozzle (11 ) in which is inserted a pump (8) which has a variable volume chamber (8000) controlled by a movable actuating member (85); the device according to the invention comprises a pushing means (42) capable of acting against this actuating member (85) through the wall of the casing so as to displace it in a so-called "forward" direction against a resilient release means, a locking means (46) capable of locking the pushing means (42) in a position in which it maintains the actuating member in a mobile state at the end of the "forward" stroke, and an unlocking control means (52) of said locking means (46).Device for distributing successive and precise doses of a fluid product, in particular medicinal or cosmetic, for instance for the instillation of an eye lotion.

Abstract: This invention is concerned with novel compounds represented by structural formulae I and II. ##STR1## which are useful in the treatment of cardiac arrhythmia.

Abstract: A carbapenem antibiotic of the formula I ##STR1## is disclosed. The variable X.sup..crclbar. represents a counterion. Pharmaceutical compositions and methods of use are also disclosed.

Abstract: Substituted heterocycles attached through a methylene bridge to novel substituted phenyl derivatives of the Formula I are useful as angiotensin II antagonists. ##STR1## wherein the substituents are as defined in the claims.

Abstract: This invention relates to compounds represented by formula I: ##STR1## which are agonists of angiotensin II. The invention is also concerned with the use of aforementioned agonists in the treatment of states meditated by angiotensin.

Abstract: The present invention is directed to a process of making 2-Aryl Carbapenems of Formula 1 from a compound of formula 2.

Abstract: Novel substituted quinazolinones of the formula (I) are useful as angiotensin II antagonists.

Abstract: The present invention is directed to a process of making 2-aryl carbapenems of formula 1 from a compound of formula A.

Abstract: A compound having the formula ##STR1## which is useful as an antifungal agent and for the treatment and control of several agricultural phytopathogens, including Phytophthora infestans, is disclosed.

Abstract: This invention concerns the short synthesis of 5,6-dihydro-(S)-4-(ethylamino)-(S)-6-[C.sup.3 H.sub.3 ]-4H-thieno [2,3-b]thiopyran-2-sulfonamide 7,7-dioxide and related non-radioactive and radioactive compounds. The key step is the regioselective and stereo-controlled methylation of the C-6 (.alpha.-sulfone) carbanion in the presence of the monoprotected sulfonamide anion.

Abstract: Compounds of the general structural formula: ##STR1## or a pharmaceutically acceptable salt, hydrate or crystal form thereof, wherein;X is O or CH.sub.2R.sup.1 is H if R.sup.2 is not H or if R.sup.2 is H then R.sup.1 is ##STR2## R.sup.2 is --H if R.sup.1 is not H or if R.sup.1 is H then R.sup.2 is; ##STR3## and R.sup.3 is ##STR4## are Class HI antiarrhythmic agents.

Abstract: Imidazobenzo-(1,5)-diazepine derivatives with an amide or urea function in the 3-position are useful in the treatment of arrhythmia.

Abstract: The present invention is directed to compounds which inhibit farnesyl-protein transferase (FTase) and the farnesylation of the oncogene protein Ras. The invention is further directed to chemotherapeutic compositions containing the compounds of this invention and methods for inhibiting farnesyl-protein transferase and treatment of cancer.

Abstract: There is disclosed a child resistant blister package comprising a conventional blister package having cavities containing unit doses of medication. The blister package is adapted to receive a locking member which is slidably secured to the blister package to effectively prevent children from accessing the medication therein and yet is readily, slidably removed from the blister package by an adult to access medication therefrom.

Abstract: Benzodiazepine derivatives with an amide or urea function in the 3-position are useful in the treatment of arrhythmia.

Abstract: Their is disclosed a novel solvent-depletion process for making an avermectin/zein composition and the composition itself, which has excellent photostability and unexpected bioavailability to foliar-feeding insects. The process consists of depleting a dilute acidic, basic or alcoholic solvent from an emulsified solution of avermectin, zein, and dilute solvent.

Abstract: The present invention is directed to compounds which inhibit farnesyl-protein transferase (FPTase) and the farnesylation of the oncogene protein Ras. The invention is further directed to chemotherapeutic compositions containing the compounds of this invention and methods for inhibiting farnesyl-protein transferase and the farnesylation of the oncogene protein Ras.