Patents Represented by Attorney, Agent or Law Firm Mark R. Daniel
  • Substituted 1,2,4-triazolin-3-one compounds bearing acidic functional groups as balanced angiotensin II antagonists
    Patent number: 5436259
    Abstract: Novel substituted 1,2,4-triazolin-3-ones of the formula (I) are useful as angiotensin II antagonists.
    Type: Grant
    Filed: November 18, 1993
    Date of Patent: July 25, 1995
    Assignee: Merck & Co., Inc.
    Inventors: Wallace T. Ashton, Prasun K. Chakravarty, Linda L. Chang
  • Cyclohexapeptide with basic nitrogen containing alkylamide groups
    Patent number: 5430018
    Abstract: Certain aminoalkyl substituted amides which have a cyclohexapeptidyl group and which are found to have antibiotic activity with physical properties suitable for use in therapeutic compositions are described.
    Type: Grant
    Filed: October 17, 1991
    Date of Patent: July 4, 1995
    Assignee: Merck & Co., Inc.
    Inventor: Robert A. Zambias
  • 3-acylaminobenzodiazepines
    Patent number: 5428157
    Abstract: 3-Acylamino-5-Aminobenzo[1,5]diazepines are useful in the treatment of arrhythmia.
    Type: Grant
    Filed: November 22, 1993
    Date of Patent: June 27, 1995
    Assignee: Merck & Co., Inc.
    Inventors: John J. Baldwin, David A. Claremon, Jason M. Elliott, Nigel Liverton, David C. Remy, Harold G. Selnick
  • Lipopeptide derivatives
    Patent number: 5428009
    Abstract: The present invention is directed to water-soluble derivatives of antibiotic lipopeptides. The derivatives have good solubility properties in aqueous medium, rendering them more useful as therapeutic agents.
    Type: Grant
    Filed: July 16, 1990
    Date of Patent: June 27, 1995
    Assignee: Merck & Co., Inc.
    Inventor: Milton L. Hammond
  • Methods of treating cardiac arrhythmia
    Patent number: 5428031
    Abstract: Benzodiazepine analogs have been found to be useful in treating cardiac abnormalities.
    Type: Grant
    Filed: November 22, 1993
    Date of Patent: June 27, 1995
    Assignee: Merck & Co., Inc.
    Inventors: Michael C. Sanguinetti, Joseph J. Lynch, Jr., Joseph J. Salata
  • Antiarrhythmic benzodiazepines
    Patent number: 5426185
    Abstract: Benzo-(1,5)-diazepine derivatives with an amide or urea function in the 3-position are useful in the treatment of arrhythmia.
    Type: Grant
    Filed: November 22, 1993
    Date of Patent: June 20, 1995
    Assignee: Merck & Co., Inc.
    Inventors: John J. Baldwin, David A. Claremon, Jason M. Elliott, Nigel Liverton, David C. Remy, Harold G. Selnick
  • Process for production of an antibiotic compound with Zalerion arboricola
    Patent number: 5426038
    Abstract: A process for producing an antibiotic compound which is normally a minor component in the cultivation of Z. arboricola to be the major product is described.
    Type: Grant
    Filed: February 14, 1994
    Date of Patent: June 20, 1995
    Assignee: Merck & Co, Inc.
    Inventors: Jimmy M. Fountoulakis, Prakash S. Masurekar, Louis Kaplan
  • Process for the preparation of imidazolutidine
    Patent number: 5424432
    Abstract: This invention relates to a method for the preparation of a compound of formula I: ##STR1## a key intermediate in the synthesis of a series of Angiotensin II receptor antagonists. The invention also relates to a selective reagent for conducting the Hofmann rearrangement, particularly in the formation of a pyridinoimidazolone, which is a percursor to the formation of an imidazopyfidine of formula I. This invention also relates to a method for the preparation of imidazolutidine, a key intermediate in the synthesis of 3-(2'-(N-benzoyl)sulfonamidobiphen-4-yl)-methyl-5,7 -dimethyl-2-ethyl-3H-imidazo[4,5-b]pyridine, using pyridinoimidazolone, an unreactive urea.
    Type: Grant
    Filed: May 26, 1994
    Date of Patent: June 13, 1995
    Assignee: Merck & Co., Inc.
    Inventors: Laura E. Fredenburgh, Robert D. Larsen, Ji Liu, Robert A. Reamer, Chris H. Senanayake, Thomas R. Verhoeven
  • Inhibitors of farnesyl-protein transferase
    Patent number: 5420334
    Abstract: The present invention is directed to compounds which inhibit farnesyl-protein transferase (FPTase) and the farnesylation of the oncogene protein Ras. The invention is further directed to chemotherapeutic compositions containing the compounds of this invention and methods for inhibiting famesyl-protein transferase and the famesylation of the oncogene protein Ras.
    Type: Grant
    Filed: April 4, 1994
    Date of Patent: May 30, 1995
    Assignee: Merck & Co., Inc.
    Inventors: Sheo B. Singh, Gerald F. Bills, Russell B. Lingham, Isabel Martin, Keith C. Silverman, Jack L. Smith
  • Inhibitors of farnesyl protein transferase or prodrugs thereof
    Patent number: 5420157
    Abstract: This invention relates to pharmaceutical compounds of structural formulae (I) and (II): ##STR1## and compositions and methods of treatment utilizing these compounds to inhibit farnesyl protein transferase and farnesylation of the oncogene protein Ras.
    Type: Grant
    Filed: December 16, 1991
    Date of Patent: May 30, 1995
    Assignee: Merck & Co., Inc.
    Inventors: Sheo B. Singh, Gerald F. Bills, Russell B. Lingham, Keith C. Silverman, Deborah L. Zink
  • Quinazolinones substituted with phenoxyphenylacetic acid derivatives
    Patent number: 5420133
    Abstract: Phenoxyphenylacetic acids and derivatives of general structural formula I ##STR1## have endothelin antagonist activity and are therefore useful in treating cardiovascular disorders, such as hypertension, postischemic renal failure, vasospasm, cerebral and cardiac ischemia, myocardial infarction, inflammatory diseases, Raynaud's disease, and endotoxic shock, and asthma.
    Type: Grant
    Filed: March 19, 1993
    Date of Patent: May 30, 1995
    Assignee: Merck & Co., Inc.
    Inventors: Daljit S. Dhanoa, Kenneth J. Fitch, Daniel F. Veber, Thomas F. Walsh, David L. Williams, Jr.
  • Substituted triazolinones, triazolinethiones, and triazolinimines as angiotensin II antagonists
    Patent number: 5411980
    Abstract: There are disclosed new substituted triazolinone, triazolinethione, and triazolinimine compounds which are useful as angiotensin II antagonists. These compounds have the general formula: ##STR1## wherein G is R.sup.
    Type: Grant
    Filed: December 21, 1992
    Date of Patent: May 2, 1995
    Assignee: Merck & Co., Inc.
    Inventors: Wallace T. Ashton, Linda L. Chang, Malcolm MacCoss, Prasun K. Chakravarty, William J. Greenlee, Arthur A. Patchett, Kelly Flanagan
  • Heterocyclic compounds bearing acidic functional groups as angiotensin II antagonists
    Patent number: 5412097
    Abstract: Heterocyclic compounds of structural formula: ##STR1## wherein A, B, C, and D are independently carbon atoms or nitrogen atoms are angiotensin II antagonists useful in the treatment of hypertension and congestive heart failure.
    Type: Grant
    Filed: September 2, 1992
    Date of Patent: May 2, 1995
    Assignee: Merck & Co., Inc.
    Inventors: Prasun K. Chakravarty, William J. Greenlee, Dooseop Kim, Nathan B. Mantlo, Arthur A. Patchett, Ralph A. Rivero
  • 2-(3-pyridyl)-carbapenem antibacterial agents
    Patent number: 5409920
    Abstract: Carbapenems of the formula ##STR1## are useful antibacterial agents.
    Type: Grant
    Filed: October 5, 1990
    Date of Patent: April 25, 1995
    Assignee: Merck & Co., Inc.
    Inventors: Ravindra N. Guthikonda, Frank P. DiNinno
  • Solution preparation system
    Patent number: 5402834
    Abstract: Solutions are prepared by accurately dispensing and weighing concentrated solutions of salts, acids and bases as well as water or organic solvent, and mixing to achieve homogeneity. The final solution may be stored or used directly from the system.
    Type: Grant
    Filed: November 25, 1992
    Date of Patent: April 4, 1995
    Assignee: Merck & Co., Inc.
    Inventors: Michael D. Levin, William F. Richardson, Alan B. Todtenkopf
  • Spirocycles
    Patent number: 5403846
    Abstract: Compounds of the general formula: ##STR1## or a pharmaceutically acceptable salt, hydrate or crystal form enantiomer, diastereomer or mixtures thereof are Class III antiarrhythmic agents.
    Type: Grant
    Filed: November 22, 1993
    Date of Patent: April 4, 1995
    Assignee: Merck & Co., Inc.
    Inventors: John J. Baldwin, David A. Claremon, Gerald S. Ponticello, Harold G. Selnick
  • Quinazolinones substituted with phenoxyphenylacetic acid derivatives
    Patent number: 5401745
    Abstract: Phenoxyphenylacetic acids and derivatives of general structural formula I ##STR1## have endothelin antagonist activity and are therefore useful in treating cardiovascular disorders, such as hypertension, postischemic renal failure, vasospasm, cerebal and cardiac ischemia, myocardial infarction, inflammatory diseases, Raynaud's disease, and endotoxic shock, and asthma.
    Type: Grant
    Filed: March 19, 1993
    Date of Patent: March 28, 1995
    Assignee: Merck & Co., Inc.
    Inventors: Scott W. Bagley, Prasun K. Chakravarty, Anna Chen, Daljit S. Dhanoa, Kenneth J. Fitch, William J. Greenlee, Elizabeth M. Naylor, James R. Tata, Thomas F. Walsh, David L. Williams, Jr.
  • Bridged biphenyl carbapenem antibacterial compounds
    Patent number: 5401735
    Abstract: Carbapenems of the formula: ##STR1## are disclosed as useful antibacterial agents.
    Type: Grant
    Filed: August 2, 1993
    Date of Patent: March 28, 1995
    Assignee: Merck & Co., Inc.
    Inventor: Frank P. Dininno
  • Biologically active compounds
    Patent number: 5399587
    Abstract: The present invention relates to novel potassium channel agonists which are useful in activating the calcium activated Maxi-K potassium channel in mammalian neuronal and smooth muscle tissue. The claimed compounds are of the general formula: ##STR1## In addition, a novel microbiological process for producing the claimed compounds is described.
    Type: Grant
    Filed: December 13, 1993
    Date of Patent: March 21, 1995
    Assignee: Merck & Co., Inc.
    Inventors: Maria L. Garcia, Robert A. Giacobbe, Otto D. Hensens, Gregory J. Kaczorowski, Seok H. Lee, Owen B. McManus, Deborah L. Zink
  • Single use fluid dispensing container
    Patent number: D359680
    Type: Grant
    Filed: January 25, 1994
    Date of Patent: June 27, 1995
    Assignee: Merck & Co., Inc.
    Inventor: Arthur L. Lifshey