Patents Represented by Attorney Marla J. Mathias
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Patent number: 5977066Abstract: Pharmaceutical compositions comprising a cyclosporin as active ingredient, a fatty acid triglyceride, a glycerol fatty acid partial ester or propylene glycol or sorbitol complete or partial ester, preferably, and a tenside having an HLB of at least 10.Type: GrantFiled: March 24, 1998Date of Patent: November 2, 1999Assignee: Novartis AGInventor: Thomas Cavanak
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Patent number: 5965592Abstract: Compounds of the formula ##STR1## and their salts, in which R.sub.1, is a C.sub.1 -C.sub.7 aliphatic hydrocarbon radical; X.sub.1 is --CO; X.sub.2 is a divalent aliphatic hydrocarbon radical which comprises an ethyl group and an alkylene of 2 to 6 carbon atoms; R.sub.2 is hydroxy, carboxy or alkoxycarbonyl in which alkoxy is from 1 to 7 carbon atoms; X.sub.3 is a divalent aliphatic hydrocarbon; R.sub.3 is carboxyl or 5-tetrazolyl; and the rings A and B independently of one another are otherwise unsubstituted; can be prepared in a known manner and may be used as active ingredients for medicaments.Type: GrantFiled: July 29, 1998Date of Patent: October 12, 1999Assignee: Novartis CorporationInventors: Peter Buhlmayer, Franz Ostermayer, Tibur Schmidlin
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Patent number: 5962014Abstract: Pharmaceutical compositions comprising a cyclosporin, e.g. Ciclosporin or ?Nva!.sup.2 -Ciclosporin, in "microemulsion pre-concentrate" and microemulsion form. The compositions typically comprise (1.1) a C.sub.1-5 alkyl or tetrahydrofurfuryl di- or partial-ether of a low molecular weight mono- or poly-oxy-alkane diol, e.g. Transcutol or Glycofurol, as hydrophilic component. Compositions are also provided comprising a cyclosporin and (1.1) and, suitably, also a saccharide monoester, e.g. raffinose or saccharose monolaurate. Dosage forms include topical formulations and, in particular, oral dosage forms.Type: GrantFiled: March 6, 1997Date of Patent: October 5, 1999Assignee: Novartis AGInventors: Birgit Hauer, Armin Meinzer, Ulrich Posanski, Friedrich Richter
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Patent number: 5962017Abstract: Pharmaceutical compositions comprising a cyclosporin, e.g. Ciclosporin or ?Nva!.sup.2 -Ciclosporin, in "microemulsion pre-concentrate" and microemulsion form. The compositions typically comprise (1.1) a C.sub.1-5 alkyl or tetrahydrofurfuryl di- or partial-ether of a low molecular weight mono- or poly-oxy-alkane diol, e.g. Transcutol or Glycofurol, as hydrophilic component. Compositions are also provided comprising a cyclosporin and (1.1) and, suitably, also a saccharide monoester, e.g. raffinose or saccharose monolaurate. Dosage forms include topical formulations and, in particular, oral dosage forms.Type: GrantFiled: February 17, 1998Date of Patent: October 5, 1999Assignee: Novartis GInventors: Birgit Hauer, Armin Meinzer, Ulrich Posanski, Friedrich Richter
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Patent number: 5925367Abstract: A composition for controlling harmful insects and representatives of the order Acarina, containing as biologically active components a) a substance that modifies the behavior of the pests and b) at least one pesticidally active compound, wherein the biologically active components are contained in a flowable or viscous non-hardening matrix that is resistant to water and weather, is protected against light and is suitable for distribution in the form of droplets or droplet-like units or spots that adhere to a substrate, by means of which matrix the behavior-modifying substance is protected against UV radiation and from which it is slowly released in a biologically effective amount over a prolonged period, and wherein the pesticidally active compound can be taken up in a pesticidally effective amount from the surface of the droplets or droplet-like units or spots by the pests to be controlled; as well as a method of controlling the said pests, especially plant-destructive insects.Type: GrantFiled: January 19, 1995Date of Patent: July 20, 1999Assignee: Ciba-Geigy CorporationInventors: Max Angst, Fran.cedilla.ois Gugumus, Gunther Rist, Manfred Vogt, Jean Rody
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Patent number: 5916589Abstract: Pharmaceutical compositions comprising a cyclosporin, e.g. Ciclosporin or ?Nva!.sup.2 -Ciclosporin, in "microemulsion pre-concentrate" and microemulsion form. The compositions typically comprise (1.1) a C.sub.1-5 alkyl or tetrahydrofurfuryl di- or partial-ether of a low molecular weight mono- or poly-oxy-alkane diol, e.g. Transcutol or Glycofurol, as hydrophilic component. Compositions are also provided comprising a cyclosporin and (1.1) and, suitably, also a saccharide monoester, e.g. raffinose or saccharose monolaurate. Dosage forms include topical formulations and, in particular, oral dosage forms.Type: GrantFiled: March 6, 1997Date of Patent: June 29, 1999Assignee: Novartis AGInventors: Birgit Hauer, Armin Meinzer, Ulrich Posanski, Friedrich Richter
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Patent number: 5866153Abstract: The invention relates to a process for the preparation of an aqueous suspension of microcapsules having a capsule wall of polyurea and encapsulating a water-immiscible pesticide, by dispersing a solution of a polyisocyanate in the sparingly water-soluble pesticide in water and subsequently reacting the dispersion with a polyamine, which process comprises effecting the dispersion of the solution of the polyisocyanate in the sparingly water-soluble pesticide in water and the subsequent reaction of the dispersion with the polyamine in the presence of at least one water-soluble or water-dispersible nonionic surfactant of a block copolymer having at least one hydrophobic block and at least one hydrophilic block.Type: GrantFiled: August 8, 1995Date of Patent: February 2, 1999Assignee: Novartis CorporationInventors: Hans Walter Hasslin, Michael James Hopkinson
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Patent number: 5866159Abstract: Pharmaceutical compositions comprising a cyclosporin, e.g. Ciclosporin or ?Nva!.sup.2 -Ciclosporin, in "microemulsion pre-concentrate" and microemulsion form. The compositions typically comprise (1.1) a C.sub.1-5 alkyl or tetrahydrofurfuryl di- or partial-ether of a low molecular weight mono- or poly-oxy-alkane diol, e.g. Transcutol or Glycofurol, as hydrophilic component. Compositions are also provided comprising a cyclosporin and (1.1) and, suitably, also a saccharide monoester, e.g. raffinose or saccharose monolaurate. Dosage forms include topical formulations and, in particular, oral dosage forms.Type: GrantFiled: March 6, 1997Date of Patent: February 2, 1999Assignee: Novartis AGInventors: Birgit Hauer, Armin Meinzer, Ulrich Posanski, Friedrich Richter
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Patent number: 5852012Abstract: Compounds of the formula ##STR1## in which A is an unsubstituted or mono- to tetrasubstituted, aromatic or non-aromatic, monocyclic or bicyclic heterocyclic radical, where one to two of the substituents of A can be selected from the group consisting of halo-C.sub.1 -C.sub.3 alkyl, cyclopropyl, halocyclopropyl, C.sub.2 -C.sub.3 alkenyl, C.sub.2 -C.sub.3 alkynyl, halo-C.sub.2 -C.sub.3 alkenyl, halo-C.sub.2 -C.sub.3 alkynyl, halo-C.sub.1 -C.sub.3 alkoxy, C.sub.1 -C.sub.3 alkylthio, halo-C.sub.1 -C.sub.3 alkylthio, allyloxy, propargyloxy, allylthio, propargylthio, haloallyloxy, haloallylthio, cyano and nitro, and one to four of the substituents of A can be selected from the group consisting of C.sub.1 -C.sub.3 alkyl, C.sub.1 -C.sub.3 alkoxy and halogen;R is hydrogen, C.sub.1 -C.sub.6 alkyl, phenyl-C.sub.1 -C.sub.4 alkyl, C.sub.3 -C.sub.6 cycloalkyl, C.sub.2 -C.sub.6 alkenyl or C.sub.2 -C.sub.6 alkynyl; andX is N--NO.sub.Type: GrantFiled: June 5, 1995Date of Patent: December 22, 1998Assignee: Novartis CorporationInventors: Peter Maienfisch, Laurenz Gsell
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Patent number: 5837290Abstract: The invention relates to a process for the preparation of an aqueous suspension of microcapsules having a capsule wall of polyurea and encapsulating a water-immiscible pesticide, by dispersing a solution of a polyisocyanate in the sparingly water-soluble pesticide in water and subsequently reacting the dispersion with a polyamine, which process comprises effecting the dispersion of the solution of the polyisocyanate in the sparingly water-soluble pesticide in water and the subsequent reaction of the dispersion with the polyamine in the presence of at least one water-soluble or water-dispersible nonionic surfactant of a block copolymer having at least one hydrophobic block and at least one hydrophilic block.Type: GrantFiled: June 5, 1995Date of Patent: November 17, 1998Assignee: Ciba-Geigy CorporationInventor: Hans Walter Hasslin
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Patent number: 5827984Abstract: An apparatus for simulating the effect of a living organism on the change in shape, the disintegration and dissolution behaviour and the active-ingredient release of a pharmaceutical dosage form, including a beaker-shaped container for accommodating a test medium and the pharmaceutical dosage form and an agitating device for agitating the test medium, which agitating device can be moved periodically in a reciprocating movement into and back out of the container, wherein the agitating device includes a piston-shaped head portion arranged on a piston rod, which head portion is provided with through-openings for the test medium and the distance of the piston-shaped head portion from the container floor can be altered periodically in accordance with the periodic reciprocating movement of the agitating device, wherein, the piston rod is suspended from a gallows-shaped boom or the piston rod passes through a bore in the gallows-shaped boom in such a manner that downward movement of the piston-shaped head portion arType: GrantFiled: February 6, 1996Date of Patent: October 27, 1998Assignee: Ciba Geigy CorporationInventors: Joel Sinnreich, Christian Bosshard
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Patent number: 5788991Abstract: One object of the invention, therefore, is to provide encapsulated biologically active solid microparticle agglomerates, each agglomerate comprising eitherIi) at least two closely associated microparticles, each microparticle being coated partially or completely by at least one discrete layer of a polymer, andii) at least one outer discrete coating layer of the same polymer which envelops the coated microparticles to form an agglomerate of closely associated microparticles, orIIi) a cluster of at least two closely associated microparticles, each microparticle being coated partially or completely by at least one layer of a polymer, the microparticles adhering together through the polymer to form said cluster, andii) at least one outer discrete coating layer of the same polymer which envelops said cluster to form a discrete agglomerate, wherein in types I and II an inter-phase boundary is formed between each particle and the first coating layer, between individual coating layers and between the outer agglomeratType: GrantFiled: September 29, 1995Date of Patent: August 4, 1998Assignee: Novartis CorporationInventors: Rudolf Nastke, Ernst Neuenschwander, Andreas Leonhardt
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Patent number: 5780500Abstract: Base-substituted debenz?b,f!oxepines of formula I ##STR1## wherein alk is a divalent aliphatic radical, R is an amino group that is unsubstituted or mono- or di-substituted by monovalent aliphatic and/or araliphatic radicals or disubstituted by divalent aliphatic radicals, and R.sub.1, R.sub.2, R.sub.3 and R.sub.4 are each, independently of the others, hydrogen, lower alkyl, lower alkoxy, halogen or trifluoromethyl, and pharmaceutically acceptable salts thereof, may be used as anti-neurodegenerative active ingredients of medicaments. The invention relates also to novel compounds of formula I.Type: GrantFiled: April 18, 1997Date of Patent: July 14, 1998Assignee: Novartis CorporationInventors: Claudia Betschart, Kaspar Zimmermann
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Patent number: 5780501Abstract: Base-substituted dibenz?b,f!oxepines of formula I ##STR1## wherein alk is a divalent aliphatic radical, R is an amino group that is unsubstituted or mono- or di-substituted by monovalent aliphatic and/or araliphatic radicals or disubstituted by divalent aliphatic radicals, and R.sub.1, R.sub.2, R.sub.3 and R.sub.4 are each, independently of the others, hydrogen, lower alkyl, lower alkoxy, halogen or trifluoromethyl, and pharmaceutically acceptable salts thereof, may be used as anti-neurodegenerative active ingredients of medicaments. The invention relates also to novel compounds of formula I.Type: GrantFiled: July 8, 1997Date of Patent: July 14, 1998Assignee: Novartis CorporationInventors: Claudia Betschart, Kaspar Zimmermann
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Patent number: 5773030Abstract: Internally cross-linked albumin microspheres their surface being modified by attachment of polyoxy(C.sub.-)alkylene chains having a terminal ether group, especially such containing pharmacologically active agents, usable for pharmaceutical compositions.Type: GrantFiled: September 29, 1995Date of Patent: June 30, 1998Assignee: Novartis CorporationInventors: Rudolf Nastke, Ernst Neuenschwander, Andreas Leonhardt
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Patent number: 5767069Abstract: Nonimmunosuppressant cyclosporin derivatives having cyclophilin-binding activity, for example, the compound, ?MeIle!.sup.4 -ciclosporin, are useful in inhibiting HIV-1 replication in treating AIDS and AIDS related disorders.Type: GrantFiled: April 24, 1995Date of Patent: June 16, 1998Assignee: Novartis AGInventors: Soo Young Ko, Hans Kobel, Brigitte Besemer-Rosenwirth, Dieter Seebach, Rene P. Traber, Roland Wenger, Pietro Bollinger
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Patent number: 5759561Abstract: A composition for controlling harmful insects and representatives of the order Acarina, containing as biologically active components a) a substance that modifies the behaviour of the pests and b) at least one pesticidally active compound, wherein the biologically active components are contained in a flowable or viscous non-hardening matrix that is resistant to water and weather, is protected against light and is suitable for distribution in the form of droplets or droplet-like units or spots that adhere to a substrate, by means of which matrix the behaviour-modifying substance is protected against UV radiation and from which it is slowly released in a biologically effective amount over a prolonged period, and wherein the pesticidally active compound can be taken up in a pesticidally effective amount from the surface of the droplets or droplet-like units or spots by the pests to be controlled; as well as a method of controlling the said pests, especially plant-destructive insects.Type: GrantFiled: June 6, 1995Date of Patent: June 2, 1998Assignee: Novartis CorporationInventors: Max Angst, Fran.cedilla.ois Gugumus, Gunther Rist, Manfred Vogt, Jean Rody
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Patent number: 5759997Abstract: Pharmaceutical compositions comprising a cyclosporin as active ingredient, a fatty acid triglyceride, a glycerol fatty acid partial ester or propylene glycol or sorbitol complete or partial ester, preferably, and a tenside having an HLB of at least 10.Type: GrantFiled: June 6, 1995Date of Patent: June 2, 1998Assignee: Novartis AGInventor: Thomas Cavanak
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Patent number: 5741512Abstract: Pharmaceutical compositions comprising a cyclosporin, e.g. Ciclosporin or ?Nva!.sup.2 -Ciclosporin, in "microemulsion pre-concentrate" and microemulsion form. The compositions typically comprise (1.1) a C.sub.1-5 alkyl or tetrahydrofurfuryl di- or partial-ether of a low molecular weight mono- or poly-oxy-alkane diol, e.g. Transcutol or Glycofurol, as hydrophilic component. Compositions are also provided comprising a cyclosporin and (1.1) and, suitably, also a saccharide monoester, e.g. raffinose or saccharose monolaurate. Dosage forms include topical formulations and, in particular, oral dosage forms.Type: GrantFiled: April 27, 1995Date of Patent: April 21, 1998Assignee: Novartis CorporationInventors: Birgit Hauer, Armin Meinzer, Ulrich Posanski, Friedrich Richter
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Patent number: 5739167Abstract: A salt of formula (I) where X denotes a group of formula (II), Y denotes a group of formula (III) and R denotes the residue of an aliphatic or cycloaliphatic sulphonic acid having at least 3 carbon atoms after removal of an --SO.sub.3 H group therefrom.Type: GrantFiled: November 30, 1994Date of Patent: April 14, 1998Assignee: Novartis CorporationInventors: Nicholas Lowther, Ian Francis Hassan, Ian Timothy William Matthews