Patents Represented by Attorney Marla J. Mathias
  • Patent number: 5977066
    Abstract: Pharmaceutical compositions comprising a cyclosporin as active ingredient, a fatty acid triglyceride, a glycerol fatty acid partial ester or propylene glycol or sorbitol complete or partial ester, preferably, and a tenside having an HLB of at least 10.
    Type: Grant
    Filed: March 24, 1998
    Date of Patent: November 2, 1999
    Assignee: Novartis AG
    Inventor: Thomas Cavanak
  • Patent number: 5965592
    Abstract: Compounds of the formula ##STR1## and their salts, in which R.sub.1, is a C.sub.1 -C.sub.7 aliphatic hydrocarbon radical; X.sub.1 is --CO; X.sub.2 is a divalent aliphatic hydrocarbon radical which comprises an ethyl group and an alkylene of 2 to 6 carbon atoms; R.sub.2 is hydroxy, carboxy or alkoxycarbonyl in which alkoxy is from 1 to 7 carbon atoms; X.sub.3 is a divalent aliphatic hydrocarbon; R.sub.3 is carboxyl or 5-tetrazolyl; and the rings A and B independently of one another are otherwise unsubstituted; can be prepared in a known manner and may be used as active ingredients for medicaments.
    Type: Grant
    Filed: July 29, 1998
    Date of Patent: October 12, 1999
    Assignee: Novartis Corporation
    Inventors: Peter Buhlmayer, Franz Ostermayer, Tibur Schmidlin
  • Patent number: 5962017
    Abstract: Pharmaceutical compositions comprising a cyclosporin, e.g. Ciclosporin or ?Nva!.sup.2 -Ciclosporin, in "microemulsion pre-concentrate" and microemulsion form. The compositions typically comprise (1.1) a C.sub.1-5 alkyl or tetrahydrofurfuryl di- or partial-ether of a low molecular weight mono- or poly-oxy-alkane diol, e.g. Transcutol or Glycofurol, as hydrophilic component. Compositions are also provided comprising a cyclosporin and (1.1) and, suitably, also a saccharide monoester, e.g. raffinose or saccharose monolaurate. Dosage forms include topical formulations and, in particular, oral dosage forms.
    Type: Grant
    Filed: February 17, 1998
    Date of Patent: October 5, 1999
    Assignee: Novartis G
    Inventors: Birgit Hauer, Armin Meinzer, Ulrich Posanski, Friedrich Richter
  • Patent number: 5962014
    Abstract: Pharmaceutical compositions comprising a cyclosporin, e.g. Ciclosporin or ?Nva!.sup.2 -Ciclosporin, in "microemulsion pre-concentrate" and microemulsion form. The compositions typically comprise (1.1) a C.sub.1-5 alkyl or tetrahydrofurfuryl di- or partial-ether of a low molecular weight mono- or poly-oxy-alkane diol, e.g. Transcutol or Glycofurol, as hydrophilic component. Compositions are also provided comprising a cyclosporin and (1.1) and, suitably, also a saccharide monoester, e.g. raffinose or saccharose monolaurate. Dosage forms include topical formulations and, in particular, oral dosage forms.
    Type: Grant
    Filed: March 6, 1997
    Date of Patent: October 5, 1999
    Assignee: Novartis AG
    Inventors: Birgit Hauer, Armin Meinzer, Ulrich Posanski, Friedrich Richter
  • Patent number: 5925367
    Abstract: A composition for controlling harmful insects and representatives of the order Acarina, containing as biologically active components a) a substance that modifies the behavior of the pests and b) at least one pesticidally active compound, wherein the biologically active components are contained in a flowable or viscous non-hardening matrix that is resistant to water and weather, is protected against light and is suitable for distribution in the form of droplets or droplet-like units or spots that adhere to a substrate, by means of which matrix the behavior-modifying substance is protected against UV radiation and from which it is slowly released in a biologically effective amount over a prolonged period, and wherein the pesticidally active compound can be taken up in a pesticidally effective amount from the surface of the droplets or droplet-like units or spots by the pests to be controlled; as well as a method of controlling the said pests, especially plant-destructive insects.
    Type: Grant
    Filed: January 19, 1995
    Date of Patent: July 20, 1999
    Assignee: Ciba-Geigy Corporation
    Inventors: Max Angst, Fran.cedilla.ois Gugumus, Gunther Rist, Manfred Vogt, Jean Rody
  • Patent number: 5916589
    Abstract: Pharmaceutical compositions comprising a cyclosporin, e.g. Ciclosporin or ?Nva!.sup.2 -Ciclosporin, in "microemulsion pre-concentrate" and microemulsion form. The compositions typically comprise (1.1) a C.sub.1-5 alkyl or tetrahydrofurfuryl di- or partial-ether of a low molecular weight mono- or poly-oxy-alkane diol, e.g. Transcutol or Glycofurol, as hydrophilic component. Compositions are also provided comprising a cyclosporin and (1.1) and, suitably, also a saccharide monoester, e.g. raffinose or saccharose monolaurate. Dosage forms include topical formulations and, in particular, oral dosage forms.
    Type: Grant
    Filed: March 6, 1997
    Date of Patent: June 29, 1999
    Assignee: Novartis AG
    Inventors: Birgit Hauer, Armin Meinzer, Ulrich Posanski, Friedrich Richter
  • Patent number: 5866153
    Abstract: The invention relates to a process for the preparation of an aqueous suspension of microcapsules having a capsule wall of polyurea and encapsulating a water-immiscible pesticide, by dispersing a solution of a polyisocyanate in the sparingly water-soluble pesticide in water and subsequently reacting the dispersion with a polyamine, which process comprises effecting the dispersion of the solution of the polyisocyanate in the sparingly water-soluble pesticide in water and the subsequent reaction of the dispersion with the polyamine in the presence of at least one water-soluble or water-dispersible nonionic surfactant of a block copolymer having at least one hydrophobic block and at least one hydrophilic block.
    Type: Grant
    Filed: August 8, 1995
    Date of Patent: February 2, 1999
    Assignee: Novartis Corporation
    Inventors: Hans Walter Hasslin, Michael James Hopkinson
  • Patent number: 5866159
    Abstract: Pharmaceutical compositions comprising a cyclosporin, e.g. Ciclosporin or ?Nva!.sup.2 -Ciclosporin, in "microemulsion pre-concentrate" and microemulsion form. The compositions typically comprise (1.1) a C.sub.1-5 alkyl or tetrahydrofurfuryl di- or partial-ether of a low molecular weight mono- or poly-oxy-alkane diol, e.g. Transcutol or Glycofurol, as hydrophilic component. Compositions are also provided comprising a cyclosporin and (1.1) and, suitably, also a saccharide monoester, e.g. raffinose or saccharose monolaurate. Dosage forms include topical formulations and, in particular, oral dosage forms.
    Type: Grant
    Filed: March 6, 1997
    Date of Patent: February 2, 1999
    Assignee: Novartis AG
    Inventors: Birgit Hauer, Armin Meinzer, Ulrich Posanski, Friedrich Richter
  • Patent number: 5852012
    Abstract: Compounds of the formula ##STR1## in which A is an unsubstituted or mono- to tetrasubstituted, aromatic or non-aromatic, monocyclic or bicyclic heterocyclic radical, where one to two of the substituents of A can be selected from the group consisting of halo-C.sub.1 -C.sub.3 alkyl, cyclopropyl, halocyclopropyl, C.sub.2 -C.sub.3 alkenyl, C.sub.2 -C.sub.3 alkynyl, halo-C.sub.2 -C.sub.3 alkenyl, halo-C.sub.2 -C.sub.3 alkynyl, halo-C.sub.1 -C.sub.3 alkoxy, C.sub.1 -C.sub.3 alkylthio, halo-C.sub.1 -C.sub.3 alkylthio, allyloxy, propargyloxy, allylthio, propargylthio, haloallyloxy, haloallylthio, cyano and nitro, and one to four of the substituents of A can be selected from the group consisting of C.sub.1 -C.sub.3 alkyl, C.sub.1 -C.sub.3 alkoxy and halogen;R is hydrogen, C.sub.1 -C.sub.6 alkyl, phenyl-C.sub.1 -C.sub.4 alkyl, C.sub.3 -C.sub.6 cycloalkyl, C.sub.2 -C.sub.6 alkenyl or C.sub.2 -C.sub.6 alkynyl; andX is N--NO.sub.
    Type: Grant
    Filed: June 5, 1995
    Date of Patent: December 22, 1998
    Assignee: Novartis Corporation
    Inventors: Peter Maienfisch, Laurenz Gsell
  • Patent number: 5837290
    Abstract: The invention relates to a process for the preparation of an aqueous suspension of microcapsules having a capsule wall of polyurea and encapsulating a water-immiscible pesticide, by dispersing a solution of a polyisocyanate in the sparingly water-soluble pesticide in water and subsequently reacting the dispersion with a polyamine, which process comprises effecting the dispersion of the solution of the polyisocyanate in the sparingly water-soluble pesticide in water and the subsequent reaction of the dispersion with the polyamine in the presence of at least one water-soluble or water-dispersible nonionic surfactant of a block copolymer having at least one hydrophobic block and at least one hydrophilic block.
    Type: Grant
    Filed: June 5, 1995
    Date of Patent: November 17, 1998
    Assignee: Ciba-Geigy Corporation
    Inventor: Hans Walter Hasslin
  • Patent number: 5827984
    Abstract: An apparatus for simulating the effect of a living organism on the change in shape, the disintegration and dissolution behaviour and the active-ingredient release of a pharmaceutical dosage form, including a beaker-shaped container for accommodating a test medium and the pharmaceutical dosage form and an agitating device for agitating the test medium, which agitating device can be moved periodically in a reciprocating movement into and back out of the container, wherein the agitating device includes a piston-shaped head portion arranged on a piston rod, which head portion is provided with through-openings for the test medium and the distance of the piston-shaped head portion from the container floor can be altered periodically in accordance with the periodic reciprocating movement of the agitating device, wherein, the piston rod is suspended from a gallows-shaped boom or the piston rod passes through a bore in the gallows-shaped boom in such a manner that downward movement of the piston-shaped head portion ar
    Type: Grant
    Filed: February 6, 1996
    Date of Patent: October 27, 1998
    Assignee: Ciba Geigy Corporation
    Inventors: Joel Sinnreich, Christian Bosshard
  • Patent number: 5788991
    Abstract: One object of the invention, therefore, is to provide encapsulated biologically active solid microparticle agglomerates, each agglomerate comprising eitherIi) at least two closely associated microparticles, each microparticle being coated partially or completely by at least one discrete layer of a polymer, andii) at least one outer discrete coating layer of the same polymer which envelops the coated microparticles to form an agglomerate of closely associated microparticles, orIIi) a cluster of at least two closely associated microparticles, each microparticle being coated partially or completely by at least one layer of a polymer, the microparticles adhering together through the polymer to form said cluster, andii) at least one outer discrete coating layer of the same polymer which envelops said cluster to form a discrete agglomerate, wherein in types I and II an inter-phase boundary is formed between each particle and the first coating layer, between individual coating layers and between the outer agglomerat
    Type: Grant
    Filed: September 29, 1995
    Date of Patent: August 4, 1998
    Assignee: Novartis Corporation
    Inventors: Rudolf Nastke, Ernst Neuenschwander, Andreas Leonhardt
  • Patent number: 5780500
    Abstract: Base-substituted debenz?b,f!oxepines of formula I ##STR1## wherein alk is a divalent aliphatic radical, R is an amino group that is unsubstituted or mono- or di-substituted by monovalent aliphatic and/or araliphatic radicals or disubstituted by divalent aliphatic radicals, and R.sub.1, R.sub.2, R.sub.3 and R.sub.4 are each, independently of the others, hydrogen, lower alkyl, lower alkoxy, halogen or trifluoromethyl, and pharmaceutically acceptable salts thereof, may be used as anti-neurodegenerative active ingredients of medicaments. The invention relates also to novel compounds of formula I.
    Type: Grant
    Filed: April 18, 1997
    Date of Patent: July 14, 1998
    Assignee: Novartis Corporation
    Inventors: Claudia Betschart, Kaspar Zimmermann
  • Patent number: 5780501
    Abstract: Base-substituted dibenz?b,f!oxepines of formula I ##STR1## wherein alk is a divalent aliphatic radical, R is an amino group that is unsubstituted or mono- or di-substituted by monovalent aliphatic and/or araliphatic radicals or disubstituted by divalent aliphatic radicals, and R.sub.1, R.sub.2, R.sub.3 and R.sub.4 are each, independently of the others, hydrogen, lower alkyl, lower alkoxy, halogen or trifluoromethyl, and pharmaceutically acceptable salts thereof, may be used as anti-neurodegenerative active ingredients of medicaments. The invention relates also to novel compounds of formula I.
    Type: Grant
    Filed: July 8, 1997
    Date of Patent: July 14, 1998
    Assignee: Novartis Corporation
    Inventors: Claudia Betschart, Kaspar Zimmermann
  • Patent number: 5773030
    Abstract: Internally cross-linked albumin microspheres their surface being modified by attachment of polyoxy(C.sub.-)alkylene chains having a terminal ether group, especially such containing pharmacologically active agents, usable for pharmaceutical compositions.
    Type: Grant
    Filed: September 29, 1995
    Date of Patent: June 30, 1998
    Assignee: Novartis Corporation
    Inventors: Rudolf Nastke, Ernst Neuenschwander, Andreas Leonhardt
  • Patent number: 5767069
    Abstract: Nonimmunosuppressant cyclosporin derivatives having cyclophilin-binding activity, for example, the compound, ?MeIle!.sup.4 -ciclosporin, are useful in inhibiting HIV-1 replication in treating AIDS and AIDS related disorders.
    Type: Grant
    Filed: April 24, 1995
    Date of Patent: June 16, 1998
    Assignee: Novartis AG
    Inventors: Soo Young Ko, Hans Kobel, Brigitte Besemer-Rosenwirth, Dieter Seebach, Rene P. Traber, Roland Wenger, Pietro Bollinger
  • Patent number: 5759561
    Abstract: A composition for controlling harmful insects and representatives of the order Acarina, containing as biologically active components a) a substance that modifies the behaviour of the pests and b) at least one pesticidally active compound, wherein the biologically active components are contained in a flowable or viscous non-hardening matrix that is resistant to water and weather, is protected against light and is suitable for distribution in the form of droplets or droplet-like units or spots that adhere to a substrate, by means of which matrix the behaviour-modifying substance is protected against UV radiation and from which it is slowly released in a biologically effective amount over a prolonged period, and wherein the pesticidally active compound can be taken up in a pesticidally effective amount from the surface of the droplets or droplet-like units or spots by the pests to be controlled; as well as a method of controlling the said pests, especially plant-destructive insects.
    Type: Grant
    Filed: June 6, 1995
    Date of Patent: June 2, 1998
    Assignee: Novartis Corporation
    Inventors: Max Angst, Fran.cedilla.ois Gugumus, Gunther Rist, Manfred Vogt, Jean Rody
  • Patent number: 5759997
    Abstract: Pharmaceutical compositions comprising a cyclosporin as active ingredient, a fatty acid triglyceride, a glycerol fatty acid partial ester or propylene glycol or sorbitol complete or partial ester, preferably, and a tenside having an HLB of at least 10.
    Type: Grant
    Filed: June 6, 1995
    Date of Patent: June 2, 1998
    Assignee: Novartis AG
    Inventor: Thomas Cavanak
  • Patent number: 5741512
    Abstract: Pharmaceutical compositions comprising a cyclosporin, e.g. Ciclosporin or ?Nva!.sup.2 -Ciclosporin, in "microemulsion pre-concentrate" and microemulsion form. The compositions typically comprise (1.1) a C.sub.1-5 alkyl or tetrahydrofurfuryl di- or partial-ether of a low molecular weight mono- or poly-oxy-alkane diol, e.g. Transcutol or Glycofurol, as hydrophilic component. Compositions are also provided comprising a cyclosporin and (1.1) and, suitably, also a saccharide monoester, e.g. raffinose or saccharose monolaurate. Dosage forms include topical formulations and, in particular, oral dosage forms.
    Type: Grant
    Filed: April 27, 1995
    Date of Patent: April 21, 1998
    Assignee: Novartis Corporation
    Inventors: Birgit Hauer, Armin Meinzer, Ulrich Posanski, Friedrich Richter
  • Patent number: 5739167
    Abstract: A salt of formula (I) where X denotes a group of formula (II), Y denotes a group of formula (III) and R denotes the residue of an aliphatic or cycloaliphatic sulphonic acid having at least 3 carbon atoms after removal of an --SO.sub.3 H group therefrom.
    Type: Grant
    Filed: November 30, 1994
    Date of Patent: April 14, 1998
    Assignee: Novartis Corporation
    Inventors: Nicholas Lowther, Ian Francis Hassan, Ian Timothy William Matthews