Patents Represented by Attorney Marla J. Mathias
  • Patent number: 5599771
    Abstract: 3-Aryluracil derivatives of formula I ##STR1## wherein W is a group of the formula ##STR2## wherein the bond to the ring nitrogen atom is made via the carbon atom; wherein R.sub.1 to R.sub.9 are as defined in claim 1, are suitable as active ingredients in weed control compositions.
    Type: Grant
    Filed: December 16, 1994
    Date of Patent: February 4, 1997
    Assignee: Ciba-Geigy Corporation
    Inventor: Jean Wenger
  • Patent number: 5597840
    Abstract: An agrochemical microemulsion composition for injection into trees, and the use of said composition for preventing and treating damage to trees from disease and pests or regulating tree growth. The composition includes a nonpolar agrochemical active ingredient, a water-miscible solvent, and an emulsifying agent. When the composition is diluted in water, the particle size of the active ingredient is between about 0.01 and about 0.1 microns.
    Type: Grant
    Filed: July 7, 1994
    Date of Patent: January 28, 1997
    Assignee: Ciba-Geigy Corporation
    Inventor: Carolyn E. Moore
  • Patent number: 5593962
    Abstract: The invention provides fibrillated calcitonin for use in treating calcium deficiency diseases.
    Type: Grant
    Filed: August 4, 1993
    Date of Patent: January 14, 1997
    Assignee: Ciba-Geigy Corporation
    Inventors: Tudor Arvinte, Amelia Cudd, Judith Phillips
  • Patent number: 5583128
    Abstract: The invention relates to the use of aromatase inhibitors for contraception in female primates and to a method for contraception in female primates using such substances and to the use of those substances for the preparation of pharmaceutical compositions for contraception in female primates.
    Type: Grant
    Filed: September 2, 1994
    Date of Patent: December 10, 1996
    Assignee: Ciba-Geigy Corporation
    Inventor: Ajay Bhatnagar
  • Patent number: 5578595
    Abstract: Novel 2-(2,2-difluorocyclopropyl)-acetic acid derivatives of formula I ##STR1## wherein A is oxygen or --NR.sub.1 --,B is C.sub.2 -C.sub.6 alkylene,D is oxygen, sulfur or --O--CH.sub.2 --,E is phenyl; phenyl substituted by from one to three substituents selected from the group halogen, C.sub.1 -C.sub.4 alkyl, C.sub.1 -C.sub.3 haloalkyl and C.sub.1 -C.sub.4 alkoxy; a five-membered aromatic heterocycle having from one to three hetero atoms selected from the group nitrogen, oxygen and sulfur; a five-membered aromatic heterocycle having from one to three hetero atoms selected from the group nitrogen, oxygen and sulfur that is substituted by one or two substituents selected from the group halogen, C.sub.1 -C.sub.4 alkyl and C.sub.1 -C.sub.3 haloalkyl; a six-membered aromatic heterocycle having from one to three nitrogen atoms; or a six-membered aromatic heterocycle having from one to three nitrogen atoms that is substituted by one or two substituents selected from the group halogen, C.sub.1 -C.sub.4 alkyl and C.
    Type: Grant
    Filed: March 21, 1995
    Date of Patent: November 26, 1996
    Assignee: Ciba-Geigy Corporation
    Inventor: Manfred B oger
  • Patent number: 5576009
    Abstract: A process for the preparation of microcapsules, which comprises rapidly stirring an aqueous solution of a precondensate of urea and a dialdehyde in the molar ratio of urea to dialdehyde of 1:1 to 1:2.5, into an acidified aqueous dispersion of a water-immiscible pesticide or a readily volatile water-immiscible solvent.
    Type: Grant
    Filed: August 22, 1994
    Date of Patent: November 19, 1996
    Assignee: Ciba-Geigy Corporation
    Inventors: Rudolf Nastke, Andreas Leonhardt, Ernst Neuenschwander
  • Patent number: 5571788
    Abstract: A stable aqueous solution of human calcitonin (hCT) which remains free of hCT fibrils for at least 24 hours at 25.degree. C. which comprises water, hCT and a cellulose derivative and/or an acid, the type of acid and the amount of acid being so chosen as to achieve said stability in the absence of a salt or a buffer.
    Type: Grant
    Filed: January 24, 1994
    Date of Patent: November 5, 1996
    Assignee: Ciba-Geigy Corporation
    Inventors: Tudor Arvinte, Katherine D. Ryman
  • Patent number: 5567840
    Abstract: P-substituted aminoalkylphosphinic acids of the formula ##STR1## wherein R denotes an optionally fluorinated methyl group, R.sub.1 denotes hydrogen, lower alkyl, lower alkoxy, hydroxy, halogen or a fluorinated methyl group and R.sub.2 and R.sub.3 denote hydrogen or R.sub.2 denotes hydroxy, lower alkoxy or halogen and R.sub.3 is hydrogen or R.sub.2 and R.sub.3 together represent an oxo group, and their pharmaceutically acceptable salts are active as GABA.sub.B -agonists and can be used in the treatment of spinal spasticity, multiple sclerosis and cerebral palsy, trigeminus neuralgia, drug withdrawal syndromes and/or conditions of pain. They can be manufactured by methods known per se and suitable such methods are described.
    Type: Grant
    Filed: June 5, 1995
    Date of Patent: October 22, 1996
    Assignee: Ciba-Geigy Corporation
    Inventors: Roger G. Hall, Ludwig Maier, Wolfgang Frostl
  • Patent number: 5561230
    Abstract: The invention relates to a process for the preparation of a compound of formula ##STR1## useful as intermediate for the preparation of pesticides, wherein R is hydrogen, C.sub.1 -C.sub.6 alkyl, C.sub.3 -C.sub.6 cycloalkyl, C.sub.1 -C.sub.4 alkyl substituted by from 1 to 10 halogen atoms or by from 1 to 3 radicals selected from the group consisting of C.sub.1 -C.sub.3 alkoxy, C.sub.1 -C.sub.3 alkylthio and phenyl, phenyl or phenyl substituted by from 1 to 3 radicals selected from the group consisting of halogen, methyl, ethyl, methoxy, methylthio and nitro, which comprises reacting with hydrazine hydrate a compound of formula ##STR2## wherein R.sub.1 is hydrogen, C.sub.1 -C.sub.4 alkyl, C.sub.3 -C.sub.6 cycloalkyl, C.sub.1 -C.sub.4 alkyl substituted by from 1 to 9 chlorine atoms, C.sub.1 -C.sub.3 alkoxy, C.sub.1 -C.sub.3 alkylthio, C.sub.1 -C.sub.3 alkylsulfinyl, C.sub.1 -C.sub.
    Type: Grant
    Filed: June 2, 1995
    Date of Patent: October 1, 1996
    Assignee: Ciba-Geigy Corporation
    Inventors: Ernst Beriger, Haukur Kristinsson
  • Patent number: 5559111
    Abstract: .delta.-Amino-.gamma.-hydroxy-.omega.-aryl-alkanoic acid amides of formula I ##STR1## and the salts thereof, have renin-inhibiting properties and can be used as antihypertensive medicinal active ingredients.
    Type: Grant
    Filed: April 4, 1995
    Date of Patent: September 24, 1996
    Assignee: Ciba-Geigy Corporation
    Inventors: Richard G oschke, J urgen K. Maibaum, Walter Schilling, Stefan Stutz, Pascal Rigollier, Yasuchika Yamaguchi, Nissim C. Cohen, Peter Herold
  • Patent number: 5556828
    Abstract: Mixtures of a herbicidally effective amount of a haloacetamide of formula I ##STR1## and, to antagonize the herbicide, an antidotally effective amount of a compound of formula IIR--CHYCl (II)wherein R is defined herein, suitable for controlling weeds in crops of cultivated plants, particularly maize.
    Type: Grant
    Filed: December 1, 1994
    Date of Patent: September 17, 1996
    Assignee: Ciba-Geigy Corporation
    Inventors: Jutta Glock, Elmar Kerber
  • Patent number: 5554738
    Abstract: Anionic disazo dyes useful for dyeing and printing textile materials, paper and leather and for the preparation of inks of the formula ##STR1## wherein D, R.sup.3, R.sup.4, M, R.sup.5 and R.sup.7 are defined as in the specification.
    Type: Grant
    Filed: October 18, 1991
    Date of Patent: September 10, 1996
    Assignee: Ciba-Geigy Corporation
    Inventors: Jean-Marie Adam, Adolf K aser
  • Patent number: 5545630
    Abstract: Compounds of the formula ##STR1## wherein R.sub.1 is C.sub.3 -C.sub.8 cycloalkyl, halo-C.sub.3 -C.sub.8 cycloalkyl, C.sub.3 -C.sub.8 cycloalkyl-C.sub.1 -C.sub.6 alkyl, halo-C.sub.3 -C.sub.8 cycloalkyl-C.sub.1 -C.sub.6 alkyl, --Si(R.sub.3).sub.3, --S--R.sub.4, --SO.sub.2 --R.sub.6 or --CO--R.sub.9 ;R.sub.2 is halogen, C.sub.1 -C.sub.4 alkyl or CF.sub.3, the substituents R.sub.2 being identical or different when n is 2;R.sub.3 each independently of the others is C.sub.1 -C.sub.6 alkyl, halo-C.sub.1 -C.sub.6 alkyl, C.sub.1 -C.sub.6 alkoxy or phenyl;R.sub.4 is aryl or heteroaryl each of which is unsubstituted or substituted;R.sub.6 is unsubstituted or substituted C.sub.1 -C.sub.10 alkyl, C.sub.2 -C.sub.6 alkenyl, C.sub.2 -C.sub.6 alkynyl, C.sub.1 -C.sub.20 alkoxy, C.sub.2 -C.sub.6 alkenyloxy, C.sub.2 -C.sub.6 alkynyloxy, C.sub.1 -C.sub.4 alkylthio, aryl, aryloxy or arylthio, or is optionally substituted amino;R.sub.9 is hydroxy, unsubstituted or substituted C.sub.1 -C.sub.10 alkyl, C.sub.2 -C.sub.6 alkenyl, C.
    Type: Grant
    Filed: June 5, 1995
    Date of Patent: August 13, 1996
    Assignee: Ciba-Geigy Corporation
    Inventors: Peter Maienfisch, Manfred B oger, Thomas Pitterna, Henry Szczepanski
  • Patent number: 5543520
    Abstract: There are disclosed N-(fluoroalkoxyphenyl)-2-pyrimidine-amine derivatives of formula I ##STR1## wherein R.sub.1 is isoquinolinyl, thienyl or 1H-pyrrolyl, and R.sub.2 is fluoro-substituted alkoxy containing up to 2 carbon atoms. These compounds can be used, inter alia, for the therapy of tumoral diseases.
    Type: Grant
    Filed: September 15, 1994
    Date of Patent: August 6, 1996
    Assignee: Ciba-Geigy Corporation
    Inventor: J urg Zimmermann
  • Patent number: 5532203
    Abstract: Mixtures of a herbicidally effective amount of a pyridylsulfonylurea of formula I, ##STR1## wherein R, R.sub.1, R.sub.2 and A are as defined in claim 1, and of a herbicide-antagonistically effective amount of a sulfamoylphenylurea of formula II, ##STR2## wherein R.sub.7 to R.sub.11 and A.sub.2 are as defined in claim 1, are very suitable for controlling weeds in crops of useful plants, especially maize and sugar cane.
    Type: Grant
    Filed: May 1, 1995
    Date of Patent: July 2, 1996
    Assignee: Ciba-Geigy Corporation
    Inventors: Werner Fory, Elmar Kerber, Manfred Hudetz
  • Patent number: 5529974
    Abstract: Mixtures comprising a herbicidally effective amount of a pyridylsulfonylurea of formula I ##STR1## wherein R.sub.1, R.sub.2, R.sub.3 and A are as defined in claim 1, and a herbicide-antagonistically effective amount of a sulfamoylphenylurea of formula II ##STR2## wherein R.sub.12 to R.sub.16 and A.sub.2 are as defined in claim 1, are very suitable for the control of weeds in crops of useful plants, especially maize.
    Type: Grant
    Filed: June 5, 1995
    Date of Patent: June 25, 1996
    Assignee: Ciba-Geigy Corporation
    Inventor: Elmar Kerber
  • Patent number: 5516529
    Abstract: An effervescent granulate consisting of a solid water-soluble acidic substance, potassium carbonate and/or potassium hydrogen carbonate and one or more water-insoluble substances that are capable of absorbing water, a pesticidal active ingredient concentrate that is in the form of effervescent tablets and contains the effervescent granulate, and the preparation of the effervescent granulate and of the pesticidal active ingredient concentrate are described.
    Type: Grant
    Filed: July 12, 1993
    Date of Patent: May 14, 1996
    Inventor: Jean-Michel Zellweger
  • Patent number: 5514795
    Abstract: The present invention relates to a process for the preparation of aminotriazine derivatives of the formula I ##STR1## by the solvolysis of compounds of the formula II ##STR2## in the presence of gaseous hydrogen chloride in an alcoholic medium. The compounds of formula I are useful as intermediates in the manufacture of insecticides.
    Type: Grant
    Filed: June 6, 1995
    Date of Patent: May 7, 1996
    Assignee: Ciba-Geigy Corporation
    Inventors: Thomas Rapold, Marcel Senn
  • Patent number: 5514816
    Abstract: The reaction of 2,2-difluorobenzo-1,3-dioxole with (a) an alkali metal or an alkali metal compound and then (b) a compound R.sup.1 -Z.sup.1 in which Z.sup.1 is a leaving group, or with an aldehyde produces compounds of formula I ##STR1## wherein R.sup.1 is --OH, --SH, --CHO, --CN, --COOH, --B(OH).sub.2, --COX, with X being C1 or Br, or is --COOR.sup.2, --SiR.sup.2.sub.3 or --B(OR.sup.2).sub.2, with R.sup.2 being a C.sub.1 -C.sub.12 alcohol moiety without the hydroxy group, wherein R.sup.1 is further --C.sub.n H.sub.2n COOR.sup.2, with n being an integer from 1 to 4, or linear or branched C.sub.1 -C.sub.12 hydroxyalkyl which is unsubstituted or is substituted by --F, --CN, C.sub.1 -C.sub.6 alkoxy, phenyl, fluorophenyl, C.sub.1 -C.sub.4 alkoxy-phenyl, C.sub.1 -C.sub.4 alkylthio-phenyl, C.sub.1 -C.sub.4 alkylphenyl, C.sub.1 -C.sub.4 fluoroalkyl-phenyl, nitrophenyl or by cyanophenyl, or wherein R.sup.1 is a benzyl alcohol which is unsubstituted or is substituted by F, C.sub.1 -C.sub.4 alkoxy, C.sub.1 -C.sub.
    Type: Grant
    Filed: May 12, 1995
    Date of Patent: May 7, 1996
    Assignee: Ciba-Geigy Corporation
    Inventors: Peter Ackermann, Hans-Ruedi Kanel, Bruno Schaub
  • Patent number: 5508402
    Abstract: A process for the preparation of substituted benzenes or benzenesulfonic acid and its derivatives comprising diazotisation of an aminobenzene or ortho-amino-benzenesulfonic acid derivative followed by homogeneous palladium-catalysed coupling with an olefine and heterogeneous palladium-catalysed hydrogenation of the olefinic substituent, wherein the homogeneous catalyst is reduced and precipitated as metal after the coupling in the reaction mixture and used as a heterogeneous palladium catalyst for the hydrogenation step. The process is particular suitable for the preparation N-benzenesulfon-N'-triazinyl-urea herbicides.
    Type: Grant
    Filed: May 26, 1995
    Date of Patent: April 16, 1996
    Assignee: Ciba-Geigy Corporation
    Inventors: Peter Baumeister, Gottfried Seifert, Heinz Steiner