Abstract: Disclosed are methods and compositions for targeting therapeutic proteins to the brain. Methods and compositions of the invention involve associating an IGF moiety with a therapeutic protein in order to target the therapeutic protein to the brain. Soluble fusion proteins that include an IGF targeting moiety are transported to neural tissue in the brain from blood. Methods and compositions of the invention include therapeutic applications for treating lysosomal storage diseases. The invention also provides nucleic acids and cells for expressing IGF fusion proteins.

Abstract: A product shipping and display carton includes a display box and a shipping sleeve. The display box has a removable panel portion below a top rail defining a product viewing window in the display box. The top rail positioned to hold elongated, tubular shaped product within the display box. The product viewing window having a length that is generally smaller than a length of elongated, tubular shaped product to be contained within the display box. The top rail adapted to hold elongated, tubular shaped product within the display box and to allow a customer to remove elongated, tubular shaped product from the display box by displacing part of the elongated, tubular shaped product outwardly through the product viewing window, and displacing the elongated, tubular shaped product in a second direction that is angled to a face of the product-restraining rail until the elongated, tubular shaped product clears the product-restraining rail.

Abstract: The system distributes workload amongst a plurality of pharmacy resources that are connected by a computer network. Work orders are queued at each pharmacy resource and redistributed based on existing workload distribution, capacity of pharmacy resources, and/or product demand.

Abstract: In a method for monitoring a control loop in a process plant, process gain data associated with a control loop may be collected. The collected process gain data may be used to determine an expected process gain behavior. For example, expected values of a process variable for given values of a load variable may be determined. As another example, expected changes in a process variable for given changes in a load variable may be determined. Then, during operation of the control loop, the process gain may be monitored. If the monitored process gain substantially deviates from the expected behavior, this may indicate an abnormal situation associated with the control loop.

Abstract: A method and apparatus for forming informational items such as outserts and booklets may include folding a sheet of paper having product information printed thereon by making a plurality of folds in the sheet of paper to form a first folded article; (b) making a fold in the first folded article to form a second folded article; (c) applying pressure at least about 30 psi and no greater than about 500 psi to the second folded article; and (d) making one or more folds in the second folded article to form an outsert using a third folding apparatus having a plurality of folding rollers having a nip therebetween and a movable blade member.

Abstract: To modify an existing printing press from its original length/cut off to a different cut off, a sub-frame may be mounted on an existing frame of a printing press. The sub-frame permits the relocation of bearing supports for various printing cylinders, such as, for example, the plate cylinders and blanket cylinders. In addition to mounting the sub-frame on the existing frame, new plate and blanket cylinders having different sizes than the plate and blanket cylinders used in the existing printing press may be mounted in the sub-frame to provide different printing lengths/cut offs. Suitable sleeves, such as the eccentric mounting sleeves may be provided as necessary in order to mount the cylinders to the sub-frame.

Abstract: A wide dispersion speaker system 1 comprises a cone type speaker unit 2, and a restricting element 10A. The restricting element 10A is provided with a center hole 11 at a center section thereof, and a peripheral hole 12 located outward relative to the center hole 11. The restricting element 10A has an annular sound travel inhibiting portion 19 positioned radially outward relative to the center hole 11 and radially inward relative to the peripheral hole 12. An outer end in a radial direction of the sound travel inhibiting portion 19 is positioned at a substantially middle point between an outer end in the radial direction of the center hole 11 and an outer end in the radial direction of the peripheral hole 12 or positioned radially outward relative to the substantially middle point.

Abstract: Disclosed is a method of manufacturing a flash memory device. In a flash memory device using a SA-STI scheme, a trench for isolation is buried with oxide. A field oxide film is then formed by means of a polishing process. Next, field oxide films of a cell region and a low-voltage transistor region are selectively etched by a given thickness. As EFH values of the cell region, the low-voltage transistor region and the high-voltage transistor region become same or similar, it is possible to secure stability of a subsequent process.

Abstract: In a color printhead, print elements for different colors print swaths of pixels in different colors side by side in a first traverse; the printhead and the surface to be printed are indexed, and in the next traverse, further swaths are printed with each new swath overlapping a previous swath in a different color.

Abstract: Provided is directed to a semiconductor memory device including a control path for enabling a sense generator signal for delaying time as long as a bitline sense amplifier operates in response to a row active signal and enabling a precharge signal according to the sense generator signal, wherein the control path includes: a first time control unit for varying an enabling time of the sense generator signal by each time, according to a special test mode signal for testing the semiconductor memory device and a specific column address; and a second time control unit for varying an enabling time of the precharge signal by each step, according to a special test mode signal for testing the semiconductor memory device and a specific column address.

Abstract: In order to minimize pollutants such as Nox, internal combustion engines typically include an exhaust gas recirculation (EGR) valve that can be used to redirect a portion of exhaust gases to an intake conduit, such as an intake manifold, so that the redirected exhaust gases will be recycled. It is desirable to have an EGR valve with fast-acting capabilities, and it is also desirable to have the EGR valve take up as little space as possible. An exhaust gas recirculation valve is provided that includes an exhaust passage tube, a valve element pivotally mounted within the exhaust passage tube, a linear actuator; and a gear train. The gear train includes a rack gear operatively connected to the linear actuator, and at least one rotatable gear meshing with the rack gear and operatively connected to the valve element to cause rotation of the valve element upon actuation of the linear actuator. The apparatus provides a highly compact package having a high-speed valve actuation capability.

Abstract: A process is provided for the production of titania rich slag from ilmenite. The ilmenite is fed together with carbonaceous reductant, and in the absence of fluxes, to the molten bath of a D.C. arc furnace. The molten bath of the furnace forms the anode and one or more electrodes in the roof of the furnace forms the cathode. A frozen lining is established and maintained between the refractory lining of the furnace and the molten bath and the process includes means to control the thickness of the frozen lining as well as the whole smelting process.

Abstract: The present invention relates to a method for preparing smooth-surface spherical microparticles which are completely or partially made of at least one water-insoluble linear polysaccharide. This method involves dissolving the at least one water-insoluble linear polysaccharide in a solvent or a mixture of solvents, introducing the solution into a precipitation agent or a mixture of precipitation agents, optionally cooling the mixture thus obtained, and separating the microparticles thus formed. The precipitation agent used consists of at least one water-soluble cellulose derivative. This invention also relates to microparticles obtained according to this method.

Abstract: The present invention relates to a gas flow-through line with a sound absorption effect. Thereby the wall (5) of the line (1) has through-going perforations (2) having a diameter of less than 1 mm. The invention can for example find employment in the air suction hoses of a turbocharger of an internal combustion engine.

Abstract: A discharge valve is disclosed for use in a vacuum toilet system having a waste receptacle defining an outlet and a sewer line placeable under partial vacuum. The discharge valve comprises a housing defining an inlet and an outlet, and a rotatable discharge valve member disposed in the housing for selectively establishing fluid communication between the inlet and the outlet. A periphery of the disk valve member being formed with a series of gear teeth. An actuator is provided having a rotatable spur gear adapted to engage the periphery of the discharge valve member.

Abstract: The present invention provides methods of treating adverse physiological effects associated with depressed reticuloendothelial system function comprising administering to a subject suffering from depressed reticuloendothelial system function an effective amount of a BPI protein product.