Abstract: A method for the treatment of atherosclerosis and vascular injury using exochelins, and more particularly exochelins of Mycobacterium tuberculosis, to prevent vascular smooth muscle cell proliferation. Delivery of an effective amount of a desferri-Exochelins to a living organism such as an animal or a human by oral, intravenous or direct delivery to the site at which the effect is desired will protect blood vessels in a living organism from restenosis following angioplasty or vascular surgery and will prevent or slow the progression of atherosclerosis, systemic hypertension, radiation damage to the vasculature, stenosis or closure of bypass grafts to the coronary arteries or other blood vessels following a surgical procedure and various forms of pulmonary hypertension.
Abstract: An active matrix portion of an active matrix liquid crystal display is created by a process that fabricates silicon wafers containing a plurality of transistors in an array necessary for the display. A plurality of these wafers are aligned and affixed to a transparent substrate. All silicon other than the active circuits is removed. Transparent and conductive pads as well as vertical and horizontal driver lines are added directly onto the substrate and interconnect with the individual transistors. The resulting pixels are slightly undersize but will be in perfect alignment in rows and columns.
Abstract: A chemical transport process which is enhanced by a plasma formed in a substantially oxygen free hydrogen environment for formation of microcrystalline diamond films at a relatively low deposition temperature and a rate of about 1 .mu.m/hr. The process, performed at 80 to 180 Torr and a current density of about 1 amp/cm.sup.2 of substrate, can be scaled to deposit films on large areas. The invention further comprises doped diamond films produced by the process, said product having a well-faceted microcrystalline structure with x-ray diffraction pattern and Raman spectra indicative of a predominately diamond structure. The doped diamond films can function as n-type and p-type semiconductors.
Type:
Grant
Filed:
August 2, 1995
Date of Patent:
May 5, 1998
Assignee:
The Regents of the University of California
Inventors:
Rointan F. Bunshah, Hans J. Doerr, Shyankay Jou
Abstract: A vapor-air steam engine is described which operates at high pressure and utilizes a working fluid consisting of a mixture of compressed uncombusted air components, fuel combustion products and steam.In the new cycle described, working fluid is provided at constant pressure and temperatures. Combustion air is supplied adiabatically by one or more stages of compression. Fuel is injected at pressure as needed. At least about 40% to all of compressed air is burned. Inert liquid is injected at high pressure to produce steam and thus provide an inert high specific heat diluent vapor required for internal cooling of an internal combustion turbine or other type system.The use of extensive liquid injection inhibits the formation of pollutants, increases the efficiency and horsepower of an engine, and reduces specific fuel consumption. The new cycle may also be operated open or closed; in the latter case, the liquid may be recouped via condensation for regenerative reuse.
Abstract: A novel delivery system for delivering a fine fog of water through a plurality of nozzles to absorb heat through evaporation. The delivery system comprises the combination of a water supply tank, an air compressor, solenoid valve and an electronic control module for controlling the operation of valve and compressor to allow an operator to adjust the displacement rate of fog as well as providing the operator a choice between continuous, intermittent and pulsing operation.
Abstract: Exochelins can be used to prevent damage to living tissue from the formation or presence of the (.cndot.OH) radical. In particular, the invention is directed to the administration of exochelins to infarcted myocardium prior to or coincidental with reperfusion to prevent damage to myocardium from iron mediated free radical formation. Also presented is the chemical structure of exochelins and modified exochelins as well as other applications of these materials in the treatment and diagnosis of disease in mammals.
Type:
Grant
Filed:
February 3, 1995
Date of Patent:
February 24, 1998
Assignee:
The Regents of the University of California
Inventors:
Lawrence D. Horwitz, Marcus A. Horwitz, Bradford W. Gibson, Joseph Reeve
Abstract: A gamma ray detection and locating system comprising an array of scintillator crystals connected to a multichannel photomultiplier tube by discrete optical fibers, each fiber connecting a single crystal to a corresponding specific location on the face of the photomultiplier tube. Also described is an improved system for identifying the location of specific electrodes in the photomultiplier tube receiving electrons generated by photons flowing from the crystal along the fiber to the tube.
Type:
Grant
Filed:
August 7, 1995
Date of Patent:
February 17, 1998
Assignee:
The Regents of the University of California
Inventors:
Simon R. Cherry, Yiping Shao, Stefan B. Siegel, Robert W. Silverman
Abstract: An injectable or implantable material for soft tissue augmentation comprising a hydrogel containing both hydrophobic and hydrophilic domains is prepared by copolymerizing a hydrophilic monomer, such as water soluble N-vinylpyrrolidone with non-water soluble monomers, such as N-vinyl carbazole, its derivatives, or a non-water soluble derivative of N-vinylpyrrolidone. Also suitable for injection into direct contact with body tissue are hydrogels prepared by cross-linking polyvinylpyrrolidone. The hydrogel may be either solid or composed of particles. The hydrogel may also be enclosed within a flexible porous or nonporous envelope.
Type:
Grant
Filed:
October 16, 1996
Date of Patent:
February 3, 1998
Inventors:
James Marlow Christensen, Parviz Robert Ainpour
Abstract: Disclosed are compositions and methods for the treatment of male impotence, wherein erectile dysfunction is alleviated by administering a pharmaceutically acceptable formulation containing prostaglandin PGE.sub.2. An antidote for the effects of administration of the PGE.sub.2, or for treating priapism of other etiology, is also disclosed.
Abstract: A system for monitoring the physical and chemical properties of urine in the urinary bladder and functioning of the bladder. For example, the system can include sensors for pressure, temperature, pH, various different chemical constituents of urine, sodium, potassium, glucose, drug markers, drug metabolites, specific gravity, proteins, leukocyte esterase, nitrites, urobilinogen, whole or crenated blood cells, ketones, bilirubin, turbidity or color, the sensors being connected to transmission means for delivering signals representative of the properties detected by the sensors.
Type:
Grant
Filed:
December 15, 1995
Date of Patent:
January 6, 1998
Inventors:
Irvin M. Kalb, Robert H. Shaw, Michael J. Ram