Patents Represented by Attorney, Agent or Law Firm Mary E. Gormley
  • Tocols as adjuvant in vaccine
    Patent number: 5650155
    Abstract: Oil based vaccines often cause serious local side effects at the site of administration and/or have a high viscosity which make said vaccines difficult to handle. Vaccines comprising as an adjuvant a stable emulsion of tocols in water do not display these undesired effects and induce good immune responses.
    Type: Grant
    Filed: October 7, 1994
    Date of Patent: July 22, 1997
    Assignee: AKZO Nobel N.V.
    Inventors: Lammert Cornelius, Eric Onno Rijke
  • Actinobacillus pleuropneumoniae subunit vaccine
    Patent number: 5648081
    Abstract: The present invention is concerned with vaccines effective in protecting pigs against porcine pleuropneumonia. Said vaccines comprising a hemolysin and/or macrophage toxin and a 42 kD OMP preparation derived from Actinobacillus pleuropneumoniae (App) cells induce a complete and heterologous protection against App infection.
    Type: Grant
    Filed: January 3, 1995
    Date of Patent: July 15, 1997
    Assignee: Akzo Nobel N.V.
    Inventor: Johannes Franciscus van den Bosch
  • Eimeria tenella vaccine
    Patent number: 5637487
    Abstract: The invention is concerned with a polypeptide of Eimeria tenella which can be used for the immunization of chickens against coccidiosis.The invention also relates to a nucleic acid sequence encoding such a polypeptide. Said nucleic acid sequence is especially useful for the preparation of vector vaccines.
    Type: Grant
    Filed: December 21, 1989
    Date of Patent: June 10, 1997
    Assignee: Akzo Nobel N.V.
    Inventors: Arno Vermeulen, Rein Dijkema, Jacobus J. Kok, Paul Van Den Boogaart
  • Method for the diagnosis of HIV using antibodies to prosomes
    Patent number: 5635345
    Abstract: This invention is directed to a method useful in the diagnosis of HIV. The method involves reacting monoclonal antibodies to particular prosomal proteins with certain blood cell types obtained from a sample, and observing an increase or decrease in the levels of the prosomal proteins on the cell's surface.
    Type: Grant
    Filed: February 25, 1994
    Date of Patent: June 3, 1997
    Assignee: Akzo Nobel N.V.
    Inventors: Klaus Scherrer, Jean P. Bureau, Faycal Bey
  • Aqueous colloidal dispersion for diagnostic tests
    Patent number: 5635405
    Abstract: An aqueous colloidal dispersion for diagnostic or immunodiagnostic tests, comprising non-polymer nuclei surrounded by a hydrophilic copolymer that contains functional groups, a method for the detection of a specifically binding substance or immunochemically active component in a test fluid, and test kit containing the aqueous colloidal dispersion.
    Type: Grant
    Filed: June 7, 1995
    Date of Patent: June 3, 1997
    Assignee: Akzo Nobel N.V.
    Inventor: Wilfridus M. Brouwer
  • Non-shedding live herpesvirus vaccine
    Patent number: 5626850
    Abstract: The present invention is concerned with a genetically modified live herpesvirus vaccine of which the live herpesviruses are not shed into the environment by a vaccinated animal. This can he achieved by deleting a gene encoding a gD homolog, such as gp50 of pseudorabies virus, and propagating this deletion mutant in a cell line expressing the gene product. The reduced shedding characteristic of such a vaccine is particularly advantageous in a vector vaccine. The present invention also concerns a quadruple mutant pseudorabies virus vaccine, and a live cell bound vaccine containing gp50 mutant pseudorabies virus and cells which do not complement the mutation.
    Type: Grant
    Filed: March 28, 1994
    Date of Patent: May 6, 1997
    Assignee: Akzo Nobel N.V.
    Inventors: Nicolaas Visser, Petrus A. M. van Woensel, Thomas C. Mettenleiter
  • Non-A non-B sequences
    Patent number: 5620843
    Abstract: A peptide within a non-A non-B hepatitis virus genome reacts with antibodies found in individuals infected with non-A non-B hepatitis virus. The peptide is described along with the nucleic acid which encodes this peptide, antibodies directed against the peptide, as well as vectors, host cells and kits comprising these products. Also described are methods of detection of non-A non-B hepatitis using these products.
    Type: Grant
    Filed: June 26, 1992
    Date of Patent: April 15, 1997
    Assignee: Akzo Nobel N.V.
    Inventors: Jan A. Hellings, Johannes J. Wilhelmus de Haard
  • Coccidiosis poultry vaccine
    Patent number: 5614195
    Abstract: This invention relates to novel Eimeria proteins with immunogenic properties as well as to DNA sequences encoding these proteins. These proteins can be administered to poultry thereby protecting the birds against coccidiosis. In addition the DNA encoding these proteins can be used for the preparation of a vector vaccine against coccidiosis.
    Type: Grant
    Filed: June 2, 1995
    Date of Patent: March 25, 1997
    Assignee: Akzo Nobel N.V.
    Inventors: Janene M. Bumstead, Paul P. J. Dunn, Fiona M. Tomley, Arnoldus N. Vermeulen
  • Vaccine against streptococcus suis infection
    Patent number: 5612042
    Abstract: The present invention relates to a polypeptide of the bacterium Streptococcus suis with a molecular weight of about 54 kD, capable of inducing neutralising antibodies against Streptococcus suis. The invention also relates to a vaccine against Streptococcus suis infection, and a method for the preparation of such a vaccine.
    Type: Grant
    Filed: May 13, 1994
    Date of Patent: March 18, 1997
    Assignee: Akzo Nobel NV
    Inventor: Antonius A. C. Jacobs
  • Production of infectious bursal disease virus in mammalian cell line
    Patent number: 5602022
    Abstract: A method of producing infectious bursal disease virus comprising culturing infectious bursal disease virus in a mammalian cell line for two to ten days.
    Type: Grant
    Filed: November 20, 1992
    Date of Patent: February 11, 1997
    Assignee: Akzo Nobel, N.V.
    Inventors: Piet Van Der Marel, Pieter G. Mooren
  • Coccidiosis vaccine
    Patent number: 5602033
    Abstract: The present invention is concerned with a polypeptide of Eimeria which can be used for the immunization of poultry against coccidiosis. Furthermore, the invention comprises a DNA fragment of Eimeria coding for said polypeptide.
    Type: Grant
    Filed: June 27, 1989
    Date of Patent: February 11, 1997
    Assignee: Akzo Nobel N.V.
    Inventors: Arno Vermeulen, Rein Dijkema, Jacobus J. Kok
  • Immunoreactive peptides of apo(a)
    Patent number: 5597908
    Abstract: The present invention relates to peptides immunoreactive with anti-apolipoprotein(a) antibodies and to their use in raising monoclonal and polyclonal antibodies, in immunoassays and of their corresponding oligonucleotides as probes and primers in nucleic acid methodology.
    Type: Grant
    Filed: June 1, 1995
    Date of Patent: January 28, 1997
    Assignee: Akzo Nobel N.V.
    Inventors: W. C. Taddei-Peters, Sandra M. Butler
  • Monoclonal antibodies to hepatitis C virus
    Patent number: 5595868
    Abstract: The invention concerns a hybridoma cell line that produces a monoclonal antibody having binding specificity for epitopes on Hepatitis C virus (HCV) core protein and a monoclonal antibody produced by the hybridoma cell line as well.
    Type: Grant
    Filed: August 14, 1995
    Date of Patent: January 21, 1997
    Assignee: Akzo Nobel N.V.
    Inventors: Winand J. A. Habets, Miriam F. H. M. Klein-Rot, Theodorus A. M. Oosterlaken, Sing H. Yap
  • CTAA 81AV78, the antigen recognized by human monoclonal antibody 81AV78
    Patent number: 5595738
    Abstract: A lipid antigen found in colon, breast, lung, ovarian and pancreatic human adenocarcinomas identified by reactivity with human monoclonal antibody 81AV78, and the use of the antigen in vaccines.
    Type: Grant
    Filed: December 6, 1993
    Date of Patent: January 21, 1997
    Assignee: Akzo Nobel N.V.
    Inventors: Nicholas Pomato, Janet H. Ransom
  • Substituted 2.beta.-morpholino-androstane derivatives
    Patent number: 5593983
    Abstract: The invention is related to substituted 2.beta.-morpholino-androstane derivatives, bonded at their 2.beta.-position to the nitrogen of a group of formula I ##STR1## wherein R represents one to four substituents, each one independently selected from (1-4C) alkyl, phenyl and benzyl, or two at the same carbon atom being together --(CH.sub.2).sub.n -- wherein n is 2-6; and Y is O or S, or a pharmaceutically acceptable salt thereof. These steroids are very potent intravenous anaesthetics. The compounds have fast onset times and ideal `sleep duration` vs. `recovery to full coordination` profiles.
    Type: Grant
    Filed: December 1, 1994
    Date of Patent: January 14, 1997
    Assignee: Akzo Nobel N.V.
    Inventor: Alexander C. Campbell
  • Poultry vaccine against E. coli air sac inflammation and septicaemia
    Patent number: 5593679
    Abstract: The present invention is concerned with vaccines effective in protecting poultry against E. coli septicaemia, which contain or can cause the production of fimbriae of the F11 type or an immunogenic section thereof, or antibodies against these.
    Type: Grant
    Filed: April 5, 1994
    Date of Patent: January 14, 1997
    Assignee: Akzo Nobel N.V.
    Inventor: Johannes F. van den Bosch
  • Method for preparing aqueous suspension for diagnostic tests
    Patent number: 5583056
    Abstract: The invention relates to an aqueous suspension for diagnostic or immunodiagnostic tests, comprising non-polymer nuclei surrounded by a hydrophilic copolymer that contains functional groups, and also to a method for the preparation of this suspension. The method involves adding a monomer mixture to a colloidal dispersion of non-polymer particles, the monomer mixture being so chosen that the resultant copolymer has a charge of identical sign to that of the original dispersion. The invention also relates to a method for the detection of a specifically binding substance or immunochemically active component in a test fluid, and to a reagent and a test kit to be used when employing said detection methods.
    Type: Grant
    Filed: May 12, 1995
    Date of Patent: December 10, 1996
    Assignee: Akzo Nobel N.V.
    Inventor: Wilfridus M. Brouwer
  • Method for modifying the cell, tissue or host tropism of microorganisms; recombinant microorganisms obtained in this way and use thereof in medicine and veterinary medicine
    Patent number: 5580564
    Abstract: The invention relates to a microorganism having a modified cell, tissue or host tropism whereby at least one gene of the microorganism, preferably an essential gene, is brought under the control of a nucleotide sequence specific for the cell, the tissue or the host. The specific nucleotide sequence can be a promoter sequence and/or enhancer sequence, which can be inducible. The invention is also directed at the use of such a recombinant microorganism for the provision of protection against the corresponding natural microorganism.
    Type: Grant
    Filed: December 22, 1994
    Date of Patent: December 3, 1996
    Assignee: Akzo Nobel N.V.
    Inventors: Koenraad L. Glazenburg, Robertus J. M. Moormann
  • In vivo binding pair pretargeting
    Patent number: 5578289
    Abstract: A method for in-vivo targeting a functional moiety in a patient by administering a targeting moiety coupled to an affinity component, wherein the targeting moiety has affinity for binding sites in a target area, and administering a binding partner to the affinity component coupled to a functional moiety to localize the functional moiety in the target area. Preferably the targeting moiety is an antibody and the functional moiety is a radiometal when performing in vivo imaging or therapy. The affinity component may be a novel methotrexate analog.
    Type: Grant
    Filed: November 4, 1993
    Date of Patent: November 26, 1996
    Assignee: Akzo N.V.
    Inventors: Nicholas Pomato, Richard P. McCabe, Gregory A. Hawkins, Reinhard Bredehorst, Chong-Ho Kim, Carl-Wilhelm E. Vogel
  • Ornithobacterium rhinotracheale vaccine and method of immunization
    Patent number: 5576003
    Abstract: The present invention relates to a novel bacterial respiratory poultry disease and the identification of the causative agent Ornithobacterium rhinotracheale. A vaccine derived from this agent was effective in preventing the disease in chickens challenged with the virulent field strains.
    Type: Grant
    Filed: June 9, 1994
    Date of Patent: November 19, 1996
    Assignee: Akzo Nobel N.V.
    Inventors: Paul K. Storm, Paul C. M. van Empel