Abstract: A method for treating abstructive respiratory passage disorders which comprises the use of 5,11-dihydro-11-[[(1-methyl-4-piperidinyl)-amino]carbonyl]-6H-dibenz[b,e]a zepin-6-one; 5,11-dihydro-11-[(1-methyl-4-piperazinyl)acetyl]-6H-dibenz[b,e]azepin-6-on e, 5,11-dihydro-11-[(4-methyl-1-piperazinyl)acetyl]-6H-dibenz[b,e]azepin-6-on e, alone or in combination.
Type:
Grant
Filed:
November 17, 1989
Date of Patent:
April 30, 1991
Assignee:
Dr. Karl Thomae GmbH
Inventors:
Wolfgang Eberlein, Wolfhard Engel, Gerhard Mihm, Klaus Rudolf, Henri Doods, Norbert Mayer
Abstract: The invention relates to new sulphonamidoethyl compounds having valuable pharmacological properties, particularly anti-thrombotic properties, and which are also thromboxane antagonists.
Type:
Grant
Filed:
March 3, 1989
Date of Patent:
April 16, 1991
Assignee:
Dr. Karl Thomae GmbH
Inventors:
Armin Heckel, Josef Nickl, Erich Muller, Berthold Narr, Johannes Weisenberger, Wolfgang Eisert, Thomas Muller
Abstract: Amino acid derivatives of general formula ##STR1## (the definitions of the various symbols being explained in the specification) are suitable for treating high blood pressure and for cardioprotection. The new compounds are prepared and used in the usual way.
Type:
Grant
Filed:
September 6, 1989
Date of Patent:
April 16, 1991
Assignee:
Boehringer Ingelheim GmbH
Inventors:
Gerd Schnorrenberg, Otto Roos, Walter Losel, Ingrid Wiedemann, Wolfram Gaida, Wolfgang Hoefke, Dietrich Arndts, Ilse Streller
Abstract: Novel condensed diazepinone of general formula I are described, ##STR1## wherein B represents one of the divalent groups ##STR2## and X.sup.1, X.sup.2, A.sup.1, A.sup.2 and R.sup.1 to R.sup.10 are as defined in herein useful as vagal pacemakers for treating bradycardia and bradyarrhythmia. The novel diazepinones also have spasmolytic properties on peripheral organs, antiemetic properties and are capable of promoting cerebral blood flow.
Type:
Grant
Filed:
May 30, 1989
Date of Patent:
April 9, 1991
Assignee:
Karl Thomae GmbH
Inventors:
Wolfhard Engel, Wolfgang Eberlein, Gerhard Mihm, Gunther Trummlitz, Norbert Mayer, Adriaan De Jonge
Abstract: Disclosed herein is a combination of bacitracin and acyclovir or equivalent derivatives thereof. The combination, as well as bacitracin itself, are useful for treating herpes viral infections.
Type:
Grant
Filed:
November 25, 1988
Date of Patent:
March 26, 1991
Inventors:
Yves Langelier, Pierrette Gaudreau, Paul Brazeau
Abstract: The invention relates to a new process for the purification, by distillation, of thermolabile compounds wherein a thermolabile compound is introduced into a twin screw extruder which is heated, in at least one zone, to the boiling temperature of the compound. The volatilized compound is drawn off and condensed.
Type:
Grant
Filed:
October 23, 1987
Date of Patent:
February 5, 1991
Assignee:
Boehringer Ingelheim KG
Inventors:
Michael Aigner, Wolfgang Dersch, Dieter Reichert, Horst Schwall, Werner Warth
Abstract: Tetrahydrobenzothiazole derivatives of the formula ##STR1## wherein n is 1, 2 or 3 and R.sub.1, R.sub.2, R.sub.3, R.sub.4, R.sub.5 and R.sub.6 are defined substituents, said derivatives (I) being suitable as active compounds for treating parkinsonism or Parkinson's Disease.
Type:
Grant
Filed:
December 20, 1988
Date of Patent:
January 1, 1991
Assignee:
Boehringer Ingelheim KG
Inventors:
Claus Schneider, Herbert Merz, Rainer Sobotta, Rudolf Bauer, Joachim Mierau, Gunter Schingnitz
Abstract: By using .alpha.-mimetics, particularly compounds of general formulae I to III and the compounds listed in Table I, as feed additives in fattening animals, it has surprisingly been possible to improve the daily weight gain, the utilization of fodder and the ratio of muscle to fat in favour of the proportion of muscle and protein.
Type:
Grant
Filed:
October 25, 1988
Date of Patent:
November 13, 1990
Assignee:
Boehringer Ingelheim GmbH
Inventors:
Werner Bomann, Franz Esser, Ulrich Hamel, Helmut Stable
Abstract: The invention relates to resorbable homopolymers and copolymers which are substantially free from polymerization catalysts and processes for preparing them.
Abstract: Oxoquinazoline derivatives of formulae ##STR1## (the symbols are defined in the specification) are well-tolerated drugs for treating hyperuricaemia.
Abstract: Compounds of formula ##STR1## (the substituents R.sub.1, R.sub.2, R.sub.3, R.sub.4 and R.sub.5 are explained in the specification) may be prepared by conventional methods.Owing to their favorable activity profile the compounds may advantageously be used to treat certain heart and circulatory disorders.
Type:
Grant
Filed:
November 25, 1987
Date of Patent:
August 14, 1990
Assignee:
Boehringer Ingelheim KG
Inventors:
Herbert Koppe, Franz Esser, Walter Kobinge, Christian Lillie
Abstract: The invention relates to an improved process for the catalytic hydrogenation of DAHNP and a new process for preparing 2,4-diamino-5-formylamino-6-hydroxypyrimidine.
Abstract: The invention relates to a process for preparing enantiomerically pure S(+)-propan-1,2-diol and R(-)-propan-1,2-diol from L(-)-lactide or D(+)-lactide, respectively.
Abstract: Water-soluble dispersions of chlorthalidone are prepared by a process comprising:(a) forming a solution comprising a water soluble pharmaceutically acceptable polymeric carrier and a C.sub.1 -C.sub.4 alkanol,(b) dissolving chlorthalidone in the solution thus formed, and(c) removing the C.sub.1 -C.sub.4 alkanol from the solution by evaporation,the amount of said carrier being effective to suppress substantially the formation of the alkyl ether by-product from the reaction of chlorthalidone with the C.sub.1 -C.sub.4 alkanol. A preferred water soluble carrier is polyvinylpyrrolidone and a preferred C.sub.1 -C.sub.4 alkanol is methanol.
Type:
Grant
Filed:
November 8, 1985
Date of Patent:
June 12, 1990
Assignee:
Boehringer Ingelheim Pharmaceuticals, Inc.
Abstract: New condensed diazepinones of general formula I are described ##STR1## wherein B represents one of the divalent groups ##STR2## and X.sup.1, X.sup.2, A, R.sup.1 to R.sup.10 and Z are defined as in the specification.
Type:
Grant
Filed:
August 9, 1988
Date of Patent:
June 5, 1990
Assignee:
Dr. Karl Thomae GmbH
Inventors:
Wolfhard Engel, Gunter Trummlitz, Wolfgang Eberlein, Gerhard Mihm, Norbert Mayer, Adriaan De Jonge, Klaus Rudolf
Abstract: The present invention relates to new heteroaromatic amine derivatives of general formula ##STR1## wherein the substituents are defined hereinbelow, which have valuable pharmacological properties, particularly a heart rate lowering activity and a positive inotropic activity.
Type:
Grant
Filed:
November 25, 1987
Date of Patent:
March 27, 1990
Assignee:
Dr. Karl Thomae GmbH
Inventors:
Andreas Bomhard, Joachim Heider, Manfred Psiorz, Norbert Hauel, Berthold Narr, Klaus Noll, Christian Lillie, Walter Kobinger, Willi Diederen