Patents Represented by Attorney Mary-Ellen M. Timbers
  • Patent number: 5011836
    Abstract: A method for treating abstructive respiratory passage disorders which comprises the use of 5,11-dihydro-11-[[(1-methyl-4-piperidinyl)-amino]carbonyl]-6H-dibenz[b,e]a zepin-6-one; 5,11-dihydro-11-[(1-methyl-4-piperazinyl)acetyl]-6H-dibenz[b,e]azepin-6-on e, 5,11-dihydro-11-[(4-methyl-1-piperazinyl)acetyl]-6H-dibenz[b,e]azepin-6-on e, alone or in combination.
    Type: Grant
    Filed: November 17, 1989
    Date of Patent: April 30, 1991
    Assignee: Dr. Karl Thomae GmbH
    Inventors: Wolfgang Eberlein, Wolfhard Engel, Gerhard Mihm, Klaus Rudolf, Henri Doods, Norbert Mayer
  • Patent number: 5011946
    Abstract: An improved process for the preparation of D,L-Lactide which can be used directly in polymerization reactions.
    Type: Grant
    Filed: May 25, 1990
    Date of Patent: April 30, 1991
    Assignee: Boehringer Ingelheim GmbH
    Inventors: Joachim Hess, Klaus R. Muller, Manfred Muller
  • Patent number: 5008290
    Abstract: The invention relates to new sulphonamidoethyl compounds having valuable pharmacological properties, particularly anti-thrombotic properties, and which are also thromboxane antagonists.
    Type: Grant
    Filed: March 3, 1989
    Date of Patent: April 16, 1991
    Assignee: Dr. Karl Thomae GmbH
    Inventors: Armin Heckel, Josef Nickl, Erich Muller, Berthold Narr, Johannes Weisenberger, Wolfgang Eisert, Thomas Muller
  • Patent number: 5008273
    Abstract: Amino acid derivatives of general formula ##STR1## (the definitions of the various symbols being explained in the specification) are suitable for treating high blood pressure and for cardioprotection. The new compounds are prepared and used in the usual way.
    Type: Grant
    Filed: September 6, 1989
    Date of Patent: April 16, 1991
    Assignee: Boehringer Ingelheim GmbH
    Inventors: Gerd Schnorrenberg, Otto Roos, Walter Losel, Ingrid Wiedemann, Wolfram Gaida, Wolfgang Hoefke, Dietrich Arndts, Ilse Streller
  • Patent number: 5006522
    Abstract: Novel condensed diazepinone of general formula I are described, ##STR1## wherein B represents one of the divalent groups ##STR2## and X.sup.1, X.sup.2, A.sup.1, A.sup.2 and R.sup.1 to R.sup.10 are as defined in herein useful as vagal pacemakers for treating bradycardia and bradyarrhythmia. The novel diazepinones also have spasmolytic properties on peripheral organs, antiemetic properties and are capable of promoting cerebral blood flow.
    Type: Grant
    Filed: May 30, 1989
    Date of Patent: April 9, 1991
    Assignee: Karl Thomae GmbH
    Inventors: Wolfhard Engel, Wolfgang Eberlein, Gerhard Mihm, Gunther Trummlitz, Norbert Mayer, Adriaan De Jonge
  • Patent number: 5006533
    Abstract: 3-Bromo-2,6-dimethoxybenzamides useful as neuroleptic agents are described.
    Type: Grant
    Filed: November 22, 1989
    Date of Patent: April 9, 1991
    Assignee: Boehringer Ingelheim GmbH
    Inventors: Rainer Sobotta, Adolf Langbein, Herbert Merz, Rudolf Bauer, Joachim Mierau
  • Patent number: 5002932
    Abstract: Disclosed herein is a combination of bacitracin and acyclovir or equivalent derivatives thereof. The combination, as well as bacitracin itself, are useful for treating herpes viral infections.
    Type: Grant
    Filed: November 25, 1988
    Date of Patent: March 26, 1991
    Inventors: Yves Langelier, Pierrette Gaudreau, Paul Brazeau
  • Patent number: 4997833
    Abstract: Aryloxy-aminoalkanes useful as antihypertensive agents are described and disclosed.
    Type: Grant
    Filed: July 5, 1989
    Date of Patent: March 5, 1991
    Assignee: Boehringer Ingelheim K G
    Inventors: KoHerbert, Franz Esser, Wolfram Gaida, Wolfgang Hoefke, Georg Speck
  • Patent number: 4990222
    Abstract: The invention relates to a new process for the purification, by distillation, of thermolabile compounds wherein a thermolabile compound is introduced into a twin screw extruder which is heated, in at least one zone, to the boiling temperature of the compound. The volatilized compound is drawn off and condensed.
    Type: Grant
    Filed: October 23, 1987
    Date of Patent: February 5, 1991
    Assignee: Boehringer Ingelheim KG
    Inventors: Michael Aigner, Wolfgang Dersch, Dieter Reichert, Horst Schwall, Werner Warth
  • Patent number: 4981862
    Abstract: Tetrahydrobenzothiazole derivatives of the formula ##STR1## wherein n is 1, 2 or 3 and R.sub.1, R.sub.2, R.sub.3, R.sub.4, R.sub.5 and R.sub.6 are defined substituents, said derivatives (I) being suitable as active compounds for treating parkinsonism or Parkinson's Disease.
    Type: Grant
    Filed: December 20, 1988
    Date of Patent: January 1, 1991
    Assignee: Boehringer Ingelheim KG
    Inventors: Claus Schneider, Herbert Merz, Rainer Sobotta, Rudolf Bauer, Joachim Mierau, Gunter Schingnitz
  • Patent number: 4970208
    Abstract: By using .alpha.-mimetics, particularly compounds of general formulae I to III and the compounds listed in Table I, as feed additives in fattening animals, it has surprisingly been possible to improve the daily weight gain, the utilization of fodder and the ratio of muscle to fat in favour of the proportion of muscle and protein.
    Type: Grant
    Filed: October 25, 1988
    Date of Patent: November 13, 1990
    Assignee: Boehringer Ingelheim GmbH
    Inventors: Werner Bomann, Franz Esser, Ulrich Hamel, Helmut Stable
  • Patent number: 4960866
    Abstract: The invention relates to resorbable homopolymers and copolymers which are substantially free from polymerization catalysts and processes for preparing them.
    Type: Grant
    Filed: January 24, 1989
    Date of Patent: October 2, 1990
    Assignee: Boehringer Ingelheim Zentrale
    Inventors: Dieter Bendix, Gunther Entenmann
  • Patent number: 4954505
    Abstract: Oxoquinazoline derivatives of formulae ##STR1## (the symbols are defined in the specification) are well-tolerated drugs for treating hyperuricaemia.
    Type: Grant
    Filed: September 25, 1989
    Date of Patent: September 4, 1990
    Assignee: Boehringer Ingelheim GmbH
    Inventors: Gerhard Rauber, Roland Stechert
  • Patent number: 4954516
    Abstract: The invention relates to the use of 1-benzyl-aminoalkyl-pyrrolidinones as antidepressants.
    Type: Grant
    Filed: July 20, 1989
    Date of Patent: September 4, 1990
    Assignee: Boehringer Ingelheim KG
    Inventors: Erich Lehr, Wolf-Dietrich Bechtel, Karin Boke-Kuhn, Claus Schneider, Gerhard Walther, Karl-Heinz Weber
  • Patent number: 4948812
    Abstract: Compounds of formula ##STR1## (the substituents R.sub.1, R.sub.2, R.sub.3, R.sub.4 and R.sub.5 are explained in the specification) may be prepared by conventional methods.Owing to their favorable activity profile the compounds may advantageously be used to treat certain heart and circulatory disorders.
    Type: Grant
    Filed: November 25, 1987
    Date of Patent: August 14, 1990
    Assignee: Boehringer Ingelheim KG
    Inventors: Herbert Koppe, Franz Esser, Walter Kobinge, Christian Lillie
  • Patent number: 4948890
    Abstract: The invention relates to an improved process for the catalytic hydrogenation of DAHNP and a new process for preparing 2,4-diamino-5-formylamino-6-hydroxypyrimidine.
    Type: Grant
    Filed: July 12, 1989
    Date of Patent: August 14, 1990
    Assignee: Boehringer Ingelheim KG
    Inventor: Heinrich Schneider
  • Patent number: 4945187
    Abstract: The invention relates to a process for preparing enantiomerically pure S(+)-propan-1,2-diol and R(-)-propan-1,2-diol from L(-)-lactide or D(+)-lactide, respectively.
    Type: Grant
    Filed: July 14, 1989
    Date of Patent: July 31, 1990
    Assignee: Karl Thomae GmbH
    Inventor: Klaus R. Muller
  • Patent number: 4933360
    Abstract: Water-soluble dispersions of chlorthalidone are prepared by a process comprising:(a) forming a solution comprising a water soluble pharmaceutically acceptable polymeric carrier and a C.sub.1 -C.sub.4 alkanol,(b) dissolving chlorthalidone in the solution thus formed, and(c) removing the C.sub.1 -C.sub.4 alkanol from the solution by evaporation,the amount of said carrier being effective to suppress substantially the formation of the alkyl ether by-product from the reaction of chlorthalidone with the C.sub.1 -C.sub.4 alkanol. A preferred water soluble carrier is polyvinylpyrrolidone and a preferred C.sub.1 -C.sub.4 alkanol is methanol.
    Type: Grant
    Filed: November 8, 1985
    Date of Patent: June 12, 1990
    Assignee: Boehringer Ingelheim Pharmaceuticals, Inc.
    Inventors: Nivedita Pandit, Stephen T. Horhota
  • Patent number: 4931436
    Abstract: New condensed diazepinones of general formula I are described ##STR1## wherein B represents one of the divalent groups ##STR2## and X.sup.1, X.sup.2, A, R.sup.1 to R.sup.10 and Z are defined as in the specification.
    Type: Grant
    Filed: August 9, 1988
    Date of Patent: June 5, 1990
    Assignee: Dr. Karl Thomae GmbH
    Inventors: Wolfhard Engel, Gunter Trummlitz, Wolfgang Eberlein, Gerhard Mihm, Norbert Mayer, Adriaan De Jonge, Klaus Rudolf
  • Patent number: 4912115
    Abstract: The present invention relates to new heteroaromatic amine derivatives of general formula ##STR1## wherein the substituents are defined hereinbelow, which have valuable pharmacological properties, particularly a heart rate lowering activity and a positive inotropic activity.
    Type: Grant
    Filed: November 25, 1987
    Date of Patent: March 27, 1990
    Assignee: Dr. Karl Thomae GmbH
    Inventors: Andreas Bomhard, Joachim Heider, Manfred Psiorz, Norbert Hauel, Berthold Narr, Klaus Noll, Christian Lillie, Walter Kobinger, Willi Diederen