Patents Represented by Attorney, Agent or Law Firm Mathews, Collins, Shepherd & Gould, P.A.
  • Patent number: 6429221
    Abstract: Novel imides are inhibitors of tumor necrosis factor &agr; and can be used to combat cachexia, endotoxic shock, and retrovirus replication. A typical embodiment is 2-Phthalimido-3-(3′,4′-dimethoxyphenyl)propane.
    Type: Grant
    Filed: December 30, 1994
    Date of Patent: August 6, 2002
    Assignee: Celgene Corporation
    Inventors: George W. Muller, Mary Shire, David I. Stirling
  • Patent number: 6379328
    Abstract: The present invention is related with an improved syringe having a novel piston design. The syringe comprises an outer tube or cylinder made of, for example, plastic material, narrowed at its outlet for fitting a detachable hollow needle. Inside the outer tube the novel piston is slidable fitted including at its forward end a coupling defined by a coupling bolt and a retaining head which form part of the piston body. To the coupling a rubber bulb is rotatably fitted including a longitudinal hole for allowing fluids flow from tube to the needle and from the piston to the tube. The forward end of the piston includes an orifice defining fluid communication between the inner volume of the hollow piston and the inner volume of the tube. During the operation the piston can be rotated so as to align the hole of said rubber bulb and said orifice of the piston forward end for defining a fluid channel from the syringe to the hollow needle.
    Type: Grant
    Filed: July 9, 1999
    Date of Patent: April 30, 2002
    Inventor: Fernando Horacio Mac Clay
  • Patent number: 6372944
    Abstract: In the purification of an easily polymerizable compound such as (meth)acrylic acid by the use of a purification column adapted to withdraw a liquid from the middle portion of the column, a novel liquid withdrawing tray adapted to prevent the compound from polymerization effectively and permit the purification to be stably performed for a long time, a purification column using this tray, and a method for purifications using this purification column are provided. The liquid withdrawing tray for the purification column is composed of a liquid receiving plate and a liquid withdrawing tube for withdrawing the liquid from the liquid receiving plate.
    Type: Grant
    Filed: September 22, 2000
    Date of Patent: April 16, 2002
    Assignee: Nippon Shokubai Co., Ltd.
    Inventors: Hajime Matsumoto, Takeshi Nishimura, Yukihiro Matsumoto, Sei Nakahara, Misao Inada
  • Patent number: 6362364
    Abstract: A method for the production of an esterified product which can prevent the occurrence of a gel-like substance during the separation and removal of the water formed by the reaction in the esterification reaction or during the expulsion of a dehydrating solvent by distillation after the esterification reaction by causing an antigelling agent to act on the distillate and consequently permits efficient production of the esterified product of high quality, and an apparatus therefor are to be provided.
    Type: Grant
    Filed: September 20, 1999
    Date of Patent: March 26, 2002
    Assignee: Nippon Shokubai Co., Ltd.
    Inventors: Tsuyoshi Hirata, Hiromichi Tanaka, Tsutomu Yuasa
  • Patent number: 6359054
    Abstract: Compositions and methods for intramuscular administration of polynucleotides, such as RNA, DNA, or derivatives thereof comprising polynucleotides and block copolymers of alkylethers. The invention also provides compositions and methods for stabilizing polynucleic acids and increasing the ability of polynucleic acids to cross cell membranes and act in the interior of a cell.
    Type: Grant
    Filed: January 8, 1999
    Date of Patent: March 19, 2002
    Assignee: Supratek Pharma Inc.
    Inventors: Pierre M. Lemieux, Alexander V. Kabanov, Valery Y. Alakov, Sergey V. Vinogradov
  • Patent number: 6357393
    Abstract: The present invention relates to a device for automatically controlling exhaust flow to a ventilated rack of animal cages when an air inlet system, such as an air supply blower, to the rack is not operating. Accordingly, the device can be used in a system that assures that the ventilation system is balanced when one or more of the ventilated racks are removed from their respective air supplies. The device includes a damper housing that is adapted to be connected between an exhaust outlet of the ventilated rack and an exhaust system. A movable damper is positioned within the damper housing and is moveable between an open position and a closed position. In the closed position, the device creates a partial obstruction to air flow in the connection.
    Type: Grant
    Filed: June 28, 2000
    Date of Patent: March 19, 2002
    Assignee: Allentown Caging Equipment Co., Inc.
    Inventors: Michael A. Coiro, Sr., Frank J. Herdt, Brian M. Bilecki
  • Patent number: 6354247
    Abstract: Apparatus to assist a person in controlling an animal, e.g. a dog, on a leash (2) attaches the leash to a loop (26) in the middle of a length of elasticised cord (“shock cord”), the ends (28) of which are attached just above the hocks of the rear legs of the dog. The shock cord runs freely through a central ring (16) on the back of the animal and then through guide rings (14) on each side of the body, these guide means being held in place by a harness (4) having straps (8, 10) around the body and chest of the animal. When the dog pulls on the leash a reactive tensile force is set up in the cord (6) which has the effect of resisting rearward movement of the hind legs and may even result in the dog sitting.
    Type: Grant
    Filed: June 30, 2000
    Date of Patent: March 12, 2002
    Inventor: Stuart John Andrews
  • Patent number: 6355811
    Abstract: Disclosed is polyoxypropylenepolyoxyethylene vitamin E, represented by formula (I). It is prepared by subjecting vitamin E to polyethoxylation and then, to polypropoxylation to a proper extent. The vitamin E is of superior anti-oxidation activity with water solubility. The bent chain of the polyoxypropylenepolyoxyethylene vitamin E increases the cross-sectional area of the whole molecule, making it difficult for the molecule to penetrate into the skin. It is very safe to apply to the skin. The polyoxypropylenepolyoxyethylene vitamin E has superb surface activity by forming close bilayer vesicle structures, like phospholipids or dialkyl surfactants, so it can be advantageously used in the cosmetic industry, the food industry and the medical industry. In said formula, R1 is —(OCH2CH2)m— wherein m is an integer of 0 to 150; R2 is (a) wherein n is an integer of 1 to 200; A is (b) or (c); B is —CH3 at the 5-, 7- or 8-position of vitamin E; and p is an integer of 1 or 3.
    Type: Grant
    Filed: December 1, 2000
    Date of Patent: March 12, 2002
    Inventors: Youngdae Kim, Keunja Park, Jungsoo Kim, Jisoo Kim
  • Patent number: 6353055
    Abstract: The invention provides compositions for stabilizing polynucleic acids and increasing the ability of polynucleic acids to cross cell membranes and act in the interior of a cell. In one aspect, the invention provides a polynucleotide complex between a polynucleotide and certain polyether block copolymers. Preferably, the polynucleotide complex will further include a polycationic polymer. The compositions can further include suitable targeting molecules and surfactants. In another aspect, the invention provides a polynucleotide complex between a polynucleotide and a block copolymer comprising a polyether block and a polycation block. In yet another aspect, the invention provides polynucleotides 10 that have been covalently modified at their 5′ or 3′ end to attach a polyether polymer segment.
    Type: Grant
    Filed: August 1, 1997
    Date of Patent: March 5, 2002
    Assignee: Supratek Pharma Inc.
    Inventors: Alexander Victorovich Kabanov, Valery Yulievich Alakov, Sergey V. Vingogradov
  • Patent number: 6338846
    Abstract: A recombinant baculovirus, which produces a recombinant polyhedra made up of a baculovirus polyhedrin (PH), a Bacillus thuringiensis crystal protein (CP) and jellyfish Aequorea victoria green fluorescent protein (GFP), is constructed by introducing a transfer vector carrying a fusion gene encoding a fusion protein in which the PH, the CP and the GFP are directly linked from N-terminal to C-terminal, in sequence, and a wild-type baculovirus into an insect cell, simultaneously, and culturing the cell. This baculovirus transfer vector pColorBtrus is constructed by synthesizing the GFP-coding DNA fragment from plasmid pGFP, the PH gene from wild-type Autographa californica Nucleopolyhedrovirus, and a Cry1Ac gene from plasmid pPN6.
    Type: Grant
    Filed: November 6, 1998
    Date of Patent: January 15, 2002
    Inventors: Seok-Kwon Kang, Yeon-Ho Je, Byung-Rae Jin, Hyun-Woo Park, Jong-Yul Roh, Jin-Hee Chang
  • Patent number: 6335349
    Abstract: Substituted 1,3-dioxo-2-(2,6-dioxopiperidin-3-yl)isoindolines and 1-oxo-2-(2,6-dioxo-piperidin-3-yl)isoindolines reduce the levels of TNF&agr; in a mammal and are useful in treating oncogenic conditions, inflammation, and autoimmune diseases. Typical embodiments are 1-oxo-2-(2,6-dioxo-3-methylpiperidin-3-yl)-4,5,6,7-tetrafluoroiso-indoline and 1,3-dioxo-2-(2,6-dioxo-3-methylpiperidin-3-yl)-4-aminoisoindoline.
    Type: Grant
    Filed: November 20, 2000
    Date of Patent: January 1, 2002
    Assignee: Celgene Corporation
    Inventors: George W. Muller, David I. Stirling, Roger Shen-Chu Chen
  • Patent number: 6333051
    Abstract: Copolymer networks having at least one cross-linked polyamine polymer fragment and at least one nonionic water-soluble polymer fragment, and compositions thereof, having at least one suitable biological agent.
    Type: Grant
    Filed: September 3, 1998
    Date of Patent: December 25, 2001
    Assignee: Supratek Pharma, Inc.
    Inventors: Alexander V. Kabanov, Sergey V. Vinogradov
  • Patent number: 6331585
    Abstract: The invention embraces a formulation to be combined with a resin and a hardener to produce a paint mixture useful for coating concrete and metal surfaces, such as aluminum, zinc, stainless steel, and steel. With the inventive formulation, the pot-life of the paint mixture may be extended to up to about eight hours, allowing for a much greater time period during which the paint, after mixing, can be applied to a surface being coated. The formulation comprises a mixture of a defoamer; titanium dioxide (TiO2); at least one of barite (BaSO4) or calcite (CaCO3); at least one of 1,2-propyleneglycol (propane-1,2-diol), a corrosive-inhibitor, such as L-4, and a retarder such as LOXANOL™; and a thickener. Other contemplated ingredients include slate, water, colorants, and dispersing additives.
    Type: Grant
    Filed: March 23, 1999
    Date of Patent: December 18, 2001
    Inventor: Michael Merkel
  • Patent number: 6326388
    Abstract: Substituted 1,3,4-oxadiazole compounds reduce the levels of TNF&agr; in a mammal. Typical embodiments are 2-[1-(3-cyclopentyloxy-4-methoxyphenyl)-2-(1,3,4-oxadiazol-2-yl)ethyl]-5-methylisoindoline-1,3-dione and 2-[1-(3-ethoxy-4-methoxyphenyl)-2-(1,3,4-oxadiazol-2-yl)ethyl]isoindoline-1,3-dione.
    Type: Grant
    Filed: December 21, 1999
    Date of Patent: December 4, 2001
    Assignee: Celgene Corporation
    Inventors: Hon-Wah Man, George W. Muller
  • Patent number: 6325071
    Abstract: The present invention relates to a dual bladed mascara application system having a dual bladed mascara applicator which is received in a cylindrical product container. A bottom blade has a channel formed adjacent a front edge thereof for receiving mascara. A top blade has a deflector rib positioned opposite the channel. The bottom blade can include teeth on the front edge. A wiper has a disc shape with two apertures to accept the applicator blades. A wiper housing receives the wiper and is rotatable in the product container. After use, the wiper housing can be locked to the product container.
    Type: Grant
    Filed: February 17, 2000
    Date of Patent: December 4, 2001
    Assignee: G.H.B. Enterprises
    Inventor: John Butcher
  • Patent number: D450905
    Type: Grant
    Filed: November 15, 2000
    Date of Patent: November 20, 2001
    Inventor: Claude Deroure
  • Patent number: D451403
    Type: Grant
    Filed: January 5, 2000
    Date of Patent: December 4, 2001
    Assignee: Les Vins Georges Duboeuf
    Inventors: Georges Duboeuf, Alain Vavro
  • Patent number: D452386
    Type: Grant
    Filed: July 12, 1999
    Date of Patent: December 25, 2001
    Assignee: CINNA
    Inventor: Pascal Mourgue
  • Patent number: D452580
    Type: Grant
    Filed: October 8, 1999
    Date of Patent: December 25, 2001
    Assignee: Roset S.A.
    Inventor: Arik Levy
  • Patent number: D462028
    Type: Grant
    Filed: October 28, 1999
    Date of Patent: August 27, 2002
    Assignee: Alain Roure Creations S.A.
    Inventor: Alain Roure