Patents Represented by Attorney Merle J. Smith

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  • Relieving hypertension with carboxyalkylacylamino acids
    Patent number: 4207336
    Abstract: New carboxyalkylacylamino acids which have the general formula ##STR1## are useful as angiotensin converting enzyme inhibitors.
    Type: Grant
    Filed: November 20, 1978
    Date of Patent: June 10, 1980
    Assignee: E. R. Squibb & Sons, Inc.
    Inventors: Miguel A. Ondetti, David W. Cushman
  • Relieving hypertension with carboxyalkylacylamino acids
    Patent number: 4207342
    Abstract: New carboxyalkylacylamino acids which have the general formula ##STR1## are useful as angiotensin converting enzyme inhibitors.
    Type: Grant
    Filed: November 20, 1978
    Date of Patent: June 10, 1980
    Assignee: E. R. Squibb & Sons, Inc.
    Inventors: Miguel A. Ondetti, David W. Cushman
  • Relieving hypertension with carboxyalkylacylamino acids
    Patent number: 4207337
    Abstract: New carboxyalkylacylamino acids which have the general formula ##STR1## are useful as angiotensin converting enzyme inhibitors.
    Type: Grant
    Filed: November 20, 1978
    Date of Patent: June 10, 1980
    Assignee: E. R. Squibb & Sons, Inc.
    Inventors: Miguel A. Ondetti, David W. Cushman
  • Thioalkanoylalkanoic acid compounds
    Patent number: 4206137
    Abstract: Thioalkanoylalkanoic acid compounds and salts thereof having the formula ##STR1## wherein R.sub.1, R.sub.2, R.sub.3 and R.sub.4 each is hydrogen or lower alkyl;R.sub.5 is hydrogen, lower alkanoyl, benzoyl or ##STR2## A and B each is hydrogen or join together as a polymethylene chain --(CH.sub.2).sub.n -- to complete a 4-, 5- or 6- membered cycloalkyl group, and m is 0 or 1,are angiotensin converting enzyme inhibitors and are useful as hypotensive agents.
    Type: Grant
    Filed: November 20, 1978
    Date of Patent: June 3, 1980
    Assignee: E. R. Squibb & Sons, Inc.
    Inventors: Michael E. Condon, Miguel A. Ondetti
  • Substituted acyl derivatives of amino acids
    Patent number: 4206121
    Abstract: New substituted acyl derivatives of amino acids which have the general formula ##STR1## are useful as angiotensin converting enzyme inhibitors.
    Type: Grant
    Filed: December 4, 1978
    Date of Patent: June 3, 1980
    Assignee: E. R. Squibb & Sons, Inc.
    Inventors: Miguel A. Ondetti, Frank L. Weisenborn
  • Derivatives of pyrrolidinecarboxaldehyde and piperidinecarboxaldehyde and intermediates therefor
    Patent number: 4206122
    Abstract: Derivatives of pyrrolidinecarboxaldehyde and piperidinecarboxaldehyde, and intermediates therefor, which have the general formula ##STR1## wherein R is hydrogen, lower alkanoyl or ##STR2## R.sub.1 is hydrogen or lower alkyl; R.sub.2 is hydrogen or hydroxy;R.sub.3 is hydroxymethyl, di(lower alkoxy)methyl or formyl;n is 1 or 2;and their bisulfite addition products, are useful as hypotensive agents.
    Type: Grant
    Filed: April 14, 1978
    Date of Patent: June 3, 1980
    Assignee: E. R. Squibb & Sons, Inc.
    Inventors: Sesha I. Natarajan, Miguel A. Ondetti
  • Relieving hypertension with carboxyalkylacylamino acids
    Patent number: 4206232
    Abstract: New carboxyalkylacylamino acids which have the general formula ##STR1## are useful as angiotensin converting enzyme inhibitors.
    Type: Grant
    Filed: November 20, 1978
    Date of Patent: June 3, 1980
    Assignee: E. R. Squibb & Sons, Inc.
    Inventors: Miguel A. Ondetti, David W. Cushman
  • 8H-Pyrazolo[1,5-a]pyrazolo[4',3':5,6]pyrido[3,4-e]pyrimidine
    Patent number: 4202899
    Abstract: New derivatives of 8H-pyrazolo[1,5-a]pyrazolo[4',3':5,6]-pyrido[3,4-e]pyrimidine have the general formula ##STR1## The compounds are useful as anti-inflammatory agents and central nervous system depressants.
    Type: Grant
    Filed: April 21, 1976
    Date of Patent: May 13, 1980
    Assignee: E. R. Squibb & Sons, Inc.
    Inventors: Theodor Denzel, Hans Hoehn
  • Relieving hypertension with carboxyalkylacylamino acids
    Patent number: 4200649
    Abstract: New carboxyalkylacylamino acids which have the general formula ##STR1## are useful as angiotensin converting enzyme inhibitors.
    Type: Grant
    Filed: November 20, 1978
    Date of Patent: April 29, 1980
    Assignee: E. R. Squibb & Sons, Inc.
    Inventors: Miguel A. Ondetti, David W. Cushman
  • Compounds for alleviating hypertension
    Patent number: 4199512
    Abstract: A method for alleviating or reducing angiotensin related hypertension in hypertensive mammals comprises administering to such hypertensive mammals an effective amount of an angiotensin converting enzyme inhibitor selected from a group of mercaptoacyl aminoacids.
    Type: Grant
    Filed: September 18, 1978
    Date of Patent: April 22, 1980
    Assignee: E. R. Squibb & Sons, Inc.
    Inventors: Miguel A. Ondetti, David W. Cushman
  • Mercaptoacyl derivatives of 4,5-dihydro-1H-pyrrole-2-carboxylic acids and 1,4,5,6-tetrahydropyridine-2-carboxylic acids
    Patent number: 4198515
    Abstract: New mercaptoacyl derivatives of 4,5-dihydro-1H-pyrrole-2-carboxylic acids and 1,4,5,6-tetrahydropyridine-2-carboxylic acids having the general formula ##STR1## are useful as hypotensive agents.
    Type: Grant
    Filed: December 8, 1978
    Date of Patent: April 15, 1980
    Assignee: E. R. Squibb & Sons, Inc.
    Inventors: Miguel A. Ondetti, Michael E. Condon
  • Mercaptoacylpiperazine carboxylic acid compounds
    Patent number: 4198509
    Abstract: The mercaptoacylpiperazine carboxylic acid compounds which have the formula ##STR1## wherein R, R.sub.3 and R.sub.4 each is hydrogen or lower alkyl;R.sub.1 is lower alkyl;R.sub.2 is hydrogen, lower alkanoyl, benzoyl or ##STR2## m is 0, 1 or 2; n is 1, 2 or 3, the sum of m+n being equal to 1, 2 or 3and salts thereof, are useful as hypotensive agents.
    Type: Grant
    Filed: October 30, 1978
    Date of Patent: April 15, 1980
    Assignee: E. R. Squibb & Sons, Inc.
    Inventors: Kathryn A. Losee, Jack Bernstein
  • Carboxyalkylacylamino acids
    Patent number: 4192882
    Abstract: New carboxyalkylacylamino acids which have the general formula ##STR1## are useful as angiotensin converting enzyme inhibitors. The compounds claimed in this application are those wherein R.sub.1 is 3-indolyl-lower alkylene.
    Type: Grant
    Filed: May 4, 1978
    Date of Patent: March 11, 1980
    Assignee: E. R. Squibb & Sons, Inc.
    Inventors: Miguel A. Ondetti, David W. Cushman
  • Carboxyalkylacyl substituted imidazolylamino acids
    Patent number: 4192881
    Abstract: New carboxyalkylacylamino acids which have the general formula ##STR1## are useful as angiotensin converting enzyme inhibitors.
    Type: Grant
    Filed: November 20, 1978
    Date of Patent: March 11, 1980
    Assignee: E. R. Squibb & Sons, Inc.
    Inventors: Miguel A. Ondetti, David W. Cushman
  • 2-Substituted-1H-benz[de]-isoquinoline-1,3(2H)-diones
    Patent number: 4180579
    Abstract: Compounds of the following formula ##STR1## wherein R.sup.1 and R.sup.2 are independently selected from hydrogen, halogen, lower alkyl, lower alkoxy, lower alkylthio, nitro, cyano, and trifluoromethyl, and R is selected from a triacetyl substituted pentose, pentose, a tetraacetyl substituted hexose, hexose, a hydroxy substituted cycloalkyl of 5 to 7 carbons, ##STR2## wherein n is 1 or 2 and R.sup.3 is hydrogen, an alkali metal or alkaline earth metal ion; are disclosed. These compounds possess useful anti-inflammatory activity.
    Type: Grant
    Filed: July 12, 1978
    Date of Patent: December 25, 1979
    Assignee: E. R. Squibb & Sons, Inc.
    Inventors: Peter C. Wade, Berthold R. Vogt
  • Method for alleviating hypertension
    Patent number: 4177277
    Abstract: A method for alleviating or reducing angiotensin related hypertension in hypertensive mammals comprises administering an effective amount of a compound having the general formula ##STR1## Intermediates for the preparation of such compounds are also included.
    Type: Grant
    Filed: September 15, 1978
    Date of Patent: December 4, 1979
    Assignee: E. R. Squibb & Sons, Inc.
    Inventors: Miguel A. Ondetti, Michael E. Condon
  • Substituted acyl derivatives of amino acids
    Patent number: 4176235
    Abstract: New substituted acyl derivatives of amino acids which have the general formula ##STR1## are useful as angiotensin converting enzyme inhibitors.
    Type: Grant
    Filed: December 4, 1978
    Date of Patent: November 27, 1979
    Assignee: E. R. Squibb & Sons, Inc.
    Inventors: Miguel A. Ondetti, Frank L. Weisenborn
  • Substituted acyl derivatives of amino acids
    Patent number: 4175199
    Abstract: New substituted acyl derivatives of amino acids which have the general formula ##STR1## are useful as angiotensin converting enzyme inhibitors.
    Type: Grant
    Filed: December 4, 1978
    Date of Patent: November 20, 1979
    Assignee: E. R. Squibb & Sons, Inc.
    Inventors: Miguel A. Ondetti, Frank L. Weisenborn
  • Substituted hydrazino derivatives of benzisothiazole-1,1-dioxides
    Patent number: 4174442
    Abstract: Compounds which have the general formula ##STR1## and those which can be obtained from them with a Vilsmeier type reagent and have the formula ##STR2## as well as salts thereof, are useful as anti-inflammatory agents.
    Type: Grant
    Filed: February 3, 1978
    Date of Patent: November 13, 1979
    Assignee: E. R. Squibb & Sons, Inc.
    Inventors: Peter C. Wade, Thomas P. Kissick
  • Dithio aminoacid derivatives
    Patent number: 4173704
    Abstract: A method for alleviating or reducing angiotensin related hypertension in hypertensive mammals comprises administering to such hypertensive mammals an effective amount of an angiotensin converting enzyme inhibitor selected from a group of mercaptoacyl aminoacids.
    Type: Grant
    Filed: May 26, 1978
    Date of Patent: November 6, 1979
    Assignee: E. R. Squibb & Sons, Inc.
    Inventors: Miquel A. Ondetti, David W. Cushman