Patents Represented by Attorney Merle J. Smith

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  • Certain tetrahydropyridine-2-carboxylic acids and pyrroline-2-carboxylic acids and derivatives thereof
    Patent number: 4154942
    Abstract: New compounds which have the general formula ##STR1## are useful as hypotensive agents.
    Type: Grant
    Filed: August 15, 1978
    Date of Patent: May 15, 1979
    Assignee: E. R. Squibb & Sons, Inc.
    Inventors: Miguel A. Ondetti, Sehsea I. Natarajan
  • Substituted acyl derivatives of amino acids
    Patent number: 4154936
    Abstract: New substituted acyl derivatives of amino acids which have the general formula ##STR1## are useful as angiotensin converting enzyme inhibitors.
    Type: Grant
    Filed: March 24, 1978
    Date of Patent: May 15, 1979
    Assignee: E. R. Squibb & Sons, Inc.
    Inventors: Miguel A. Ondetti, Frank L. Weisenborn
  • Sugarless candies
    Patent number: 4154867
    Abstract: A sugarless candy is provided which has improved flavor and sweetness and contains one or more natural sweeteners, namely, a hydrogenated starch hydrolysate, preferably in combination with a sugar alcohol, such as sorbitol, one or more fruit flavors, together with malic acid which serves as a flavor enhancer.
    Type: Grant
    Filed: December 12, 1977
    Date of Patent: May 15, 1979
    Assignee: Life Savers, Inc.
    Inventors: Deborah Aldrich, Walter Vink, Richard W. Deptula, Donald J. Muskus, Paul R. Fronczkowski, Marc Chrusch
  • Hydroxycarbamoylalkylacylpipecolic acid compounds
    Patent number: 4154937
    Abstract: New hydroxycarbamoylalkylacyl derivatives of pipecolic acid which have the general formula ##STR1## are useful as angiotensin converting enzyme inhibitors.
    Type: Grant
    Filed: June 26, 1978
    Date of Patent: May 15, 1979
    Assignee: E. R. Squibb & Sons, Inc.
    Inventors: David W. Cushman, Miguel A. Ondetti
  • Amino acid derivatives
    Patent number: 4154960
    Abstract: New substituted acyl derivatives of amino acids which have the general formula ##STR1## are useful as angiotensin converting enzyme inhibitors.
    Type: Grant
    Filed: June 29, 1978
    Date of Patent: May 15, 1979
    Assignee: E. R. Squibb & Sons, Inc.
    Inventors: Miguel A. Ondetti, Michael E. Condon
  • Relieving angiotension related hypertension with carboxyalkylacylamino acids
    Patent number: 4153725
    Abstract: New carboxyalkylacylamino acids which have the general formula ##STR1## are useful as angiotensin converting enzyme inhibitors.
    Type: Grant
    Filed: May 4, 1978
    Date of Patent: May 8, 1979
    Assignee: E. R. Squibb & Sons, Inc.
    Inventors: Miguel A. Ondetti, David W. Cushman
  • Hydrazino derivatives of 1H-pyrazolo(3,4-b)-pyridine-5-carboxamides
    Patent number: 4153796
    Abstract: Hydrazino derivatives of 1H-pyrazolo[3,4-b]-pyridine-5-carboxamides which have the general formula ##STR1## are useful as ataractic agents, anti-allergy agents or anti-bronchoconstrictor agents.
    Type: Grant
    Filed: July 10, 1978
    Date of Patent: May 8, 1979
    Assignee: E. R. Squibb & Sons, Inc.
    Inventor: Hans Hoehn
  • Phosphonoacyl prolines and related compounds
    Patent number: 4151172
    Abstract: New phosphonoacyl prolines and related compounds have the general formula ##STR1## wherein R.sub.1 and R.sub.2 each is hydrogen, lower alkyl, lower alkenyl, unsustituted or substituted phenyl-lower alkyl, or a metal ion;R.sub.3 is hydrogen or lower alkyl;R.sub.4 is hydrogen, lower alkyl, phenyl-lower alkyl or a metal ion; andN is 0 or 1.These compounds are useful as hypotensive agents.
    Type: Grant
    Filed: July 20, 1978
    Date of Patent: April 24, 1979
    Assignee: E. R. Squibb & Sons, Inc.
    Inventors: Miguel A. Ondetti, Edward W. Petrillo
  • Substituted amides and sulfonamides having antiinflammatory activity
    Patent number: 4151354
    Abstract: Compounds having the formula ##STR1## wherein R.sub.1 is alkyl, cycloalkyl or aryl; R.sub.2 is acyl or sulfonyl; R.sub.3 is a nitrogen containing heterocyclic group; A.sub.1 is a saturated bond or an alkylene group having 1 to 4 carbon atoms; and A.sub.2 is an alkylene group having 2 to 5 carbon atoms; have antiinflammatory activity.
    Type: Grant
    Filed: August 2, 1978
    Date of Patent: April 24, 1979
    Assignee: E. R. Squibb & Sons, Inc.
    Inventor: John Krapcho
  • [(1,1-DIOXO-1,2-BENZISOTHIAZOL-3-YL)AMINO]ALKANOIC ACIDS AND ESTERS THEREOF
    Patent number: 4148798
    Abstract: [(1,1-Dioxo-1,2-benzisothiazol-3-yl)amino]alkanoic acids, esters and salts thereof which have the general formula ##STR1## are useful as anti-inflammatory agents.
    Type: Grant
    Filed: February 3, 1978
    Date of Patent: April 10, 1979
    Assignee: E. R. Squibb & Sons, Inc.
    Inventors: Peter C. Wade, B. Richard Vogt
  • 4,5-Disubstituted-1-aminoalkyl cyclohexenes
    Patent number: 4149001
    Abstract: Compounds of the formula ##STR1## wherein R is hydrogen, ##STR2## lower alkyl, ##STR3## R.sub.1 and R.sub.2 are independently selected from hydrogen, lower alkyl, and cycloalkyl or R.sub.1 and R.sub.2 taken together with the nitrogen atom to which they are attached from a ring of the formula ##STR4## N IS 0 OR AN INTEGER FROM 1 TO 3; M IS AN INTEGER FROM 1 TO 3; R.sub.3 and R.sub.4 are independently selected from hydrogen and lower alkyl; X is hydrogen, halogen, lower alkyl, lower alkoxy, or nitro; and their salts; are disclosed. These compounds possess useful antiinflammatory properties.
    Type: Grant
    Filed: August 18, 1978
    Date of Patent: April 10, 1979
    Assignee: E. R. Squibb & Sons, Inc.
    Inventors: Joseph E. Sundeen, Frederic P. Hauck
  • Cyclohexanetetrol derivatives
    Patent number: 4147871
    Abstract: Compounds having the formula ##STR1## and the pharmaceutically acceptable salts thereof, wherein R.sub.1 is alkanoyl; R.sub.2 is alkyl; R.sub.3 is alkylamino, dialkylamino, a 1-piperazinyl group, 4-aryl-1,2,3,6-tetrahydro-1-pyridinyl, or N-alkyl-N-(pyridinylalkyl)amino; and n is 1, 2 or 3; have useful hypotensive activity.
    Type: Grant
    Filed: April 28, 1978
    Date of Patent: April 3, 1979
    Assignee: E. R. Squibb & Sons, Inc.
    Inventors: Frederic P. Hauck, Rita T. Fox
  • 3-(Heterocyclicalkylamino)benzisothiazole-1,1-dioxides
    Patent number: 4147698
    Abstract: Compounds having the formula ##STR1## wherein R.sub.1 is hydrogen, halogen, alkyl alkoxy or nitro; R.sub.2 is hydrogen, halogen or alkoxy; R.sub.3 is an imidazol-4-yl or indol-3-yl; and n is 1,2,3 or 4, have antiinflammatory activity.
    Type: Grant
    Filed: July 13, 1978
    Date of Patent: April 3, 1979
    Assignee: E. R. Squibb & Sons, Inc.
    Inventors: Peter C. Wade, B. Richard Vogt
  • Carboxyalkylacylamino acids
    Patent number: 4146639
    Abstract: New carboxyalkylacylamino acids which have the general formula ##STR1## are useful as angiotensin converting enzyme inhibitors.
    Type: Grant
    Filed: May 4, 1978
    Date of Patent: March 27, 1979
    Assignee: E. R. Squibb & Sons, Inc.
    Inventors: Miguel A. Ondetti, David W. Cushman
  • Amino acid derivatives
    Patent number: 4146611
    Abstract: A method for alleviating or reducing angiotensin related hypertension in hypertensive mammals comprises administering an effective amount of a compound having the general formula ##STR1## Intermediates for the preparation of such compounds are also included.
    Type: Grant
    Filed: October 31, 1977
    Date of Patent: March 27, 1979
    Assignee: E. R. Squibb & Sons, Inc.
    Inventors: Miguel A. Ondetti, Michael E. Condon
  • 17-Alkylthio (and arylthio) androsteno[17.alpha.,16.alpha.-b]benzopyran-3-ones and [16.alpha.,17.alpha.]naphthopyran-3-ones
    Patent number: 4146538
    Abstract: Steroids having the formula ##STR1## wherein X is -S-, ##STR2## R.sub.1 is alkyl, aryl or acyloxyalkyl; R.sub.2 is carbonyl or .beta.-hydroxymethylene; R.sub.3 is hydrogen or halogen; R.sub.4 is hydrogen, fluorine or methyl; R.sub.5 is hydrogen or alkyl; and R.sub.6 and R.sub.7 are the same or different and are hydrogen, halogen, alkyl or alkoxy, or R.sub.6 and R.sub.7 together with the benzene ring to which they are attached form a naphthalene group; can be used as antiinflammatory agents.
    Type: Grant
    Filed: February 27, 1978
    Date of Patent: March 27, 1979
    Assignee: E. R. Squibb & Sons, Inc.
    Inventors: Ravi K. Varma, Sam T. Chao
  • Carboxyalkylacylamino acids
    Patent number: 4146641
    Abstract: New carboxyalkylacylamino acids which have the general formula ##STR1## are useful as angiotensin converting enzyme inhibitors.
    Type: Grant
    Filed: May 4, 1978
    Date of Patent: March 27, 1979
    Assignee: E. R. Squibb & Sons, Inc.
    Inventors: Miguel A. Ondetti, David W. Cushman
  • Method of treating helminthiasis by parenteral administration of sulfide- and sulfoxide-derivatives of benzimidazoles
    Patent number: 4145431
    Abstract: A method is provided for treating or inhibiting helminthiasis by parenterally or topically administering sulfide or sulfoxide derivatives of benzimidazoles having the structure ##STR1## wherein R.sup.1 is lower alkyl or phenyl-lower alkyl, R.sup.2 and R.sub.3 may be the same or different and are hydrogen or lower alkyl, Z is ##STR2## or R.sup.4 --C.tbd.C--, R.sup.4, R.sup.5 and R.sup.6 may be the same or different and are hydrogen, lower alkyl, or phenyl, and m is 0 to 3, n is 0 to 3, m + n being .ltoreq. 5, and p is 0 or 1. Pharmaceutical compositions for use in the above method are also provided.
    Type: Grant
    Filed: February 16, 1978
    Date of Patent: March 20, 1979
    Assignee: E. R. Squibb & Sons, Inc.
    Inventors: Rudiger D. Haugwitz, Larry R. Cruthers
  • Method of treating helminthiasis by parenteral administration of sulfoxide derivatives of benzimidazoles
    Patent number: 4145433
    Abstract: A method is provided for treating or inhibiting helminthiasis by parenterally or topically administering sulfoxide derivatives of benzimidazoles having the structure ##STR1## wherein R.sup.1 is lower alkyl or phenyl-lower alkyl, R.sup.2 and R.sup.3 may be the same or different and are hydrogen or lower alkyl, R.sup.4 and R.sup.5 may be the same or different and are hydrogen, lower alkyl, lower alkoxy, halogen or nitro, and m is 0 to 3, n is 0 to 3, m + n being .ltoreq. 5. Pharmaceutical compositions for use in the above method are also provided.
    Type: Grant
    Filed: January 18, 1978
    Date of Patent: March 20, 1979
    Assignee: E. R. Squibb & Sons, Inc.
    Inventors: Rudiger D. Haugwitz, Larry R. Cruthers
  • 3,3-Dichloro-2-azetidinone derivatives having basic substituents
    Patent number: 4145541
    Abstract: Compounds having the formula ##STR1## wherein X is oxygen or sulfur; R.sub.1 is alkyl, cycloalkyl or aryl; R.sub.2 is a nitrogen containing heterocyclic group; A.sub.1 is a saturated bond or an alkylene group having 1 to 4 carbon atoms; and A.sub.2 is an alkylene group having 2 to 5 carbon atoms; have antiinflammatory activity.
    Type: Grant
    Filed: June 30, 1978
    Date of Patent: March 20, 1979
    Assignee: E. R. Squibb & Sons, Inc.
    Inventors: John Krapcho, Chester F. Turk