Abstract: This invention relates to a novel and improved process for preparing .alpha.-(trichloromethyl) benzyl alcohols, particularly, trichloromethyl-3-nitrobenzyl alcohol a key intermediate useful in the preparation of clorsulon (4-amino-6-(trichloroethenyl)-1,3-benzene-disulfonamide) via a base-catalyzed condensation reaction of benzaldehydes and chloroform.

Abstract: The instant invention is directed to a method of settling fine calcium carbonate solids from a suspension comprising water and calcium carbonate, comprising adding to said suspension an effective amount of an admixture comprising: (a) an anionic polyelectrolyte; and (b) an anionic surfactant, wherein said polyelectrolyte/surfactant ratio ranges from 10:1 to 1:5, by weight.

Abstract: The instant invention is directed to a method for suppressing dust comprising contacting the material being treated with an aqueous emulsion of a methacrylate polymer or a composition comprising a hydrophobic liquid and a methacrylate polymer. These emulsions and compositions may further comprise a wetting/penetrating surfactant.

Abstract: The instant invention is directed to a method of inhibiting the precipitation and deposition of alkaline earth metal scales in an aqueous system, comprising adding to said system an effective amount of (a) an anionic polyelectrolyte; and (b) an anionic surfactant, wherein said polyelectrolyte/surfactant ratio ranges from 1000:1 to 1:10, by weight.

Abstract: Novel 5-amino or substituted amino 1,2,3-triazoles are disclosed as having anticoccidial activity. The compounds are useful for controlling coccidiosis when administered in minor quantities to animals, in particular to poultry, usually in admixture with animal sustenance.

Abstract: Processes for preparing (S) or (R) epihalohydrin and an (S) substituted glycerol intermediate are disclosed.

Abstract: Novel substituted and unsubstituted 13-(alkoxy)methoxy derivatives of the avermectin aglycones are useful as anthelmintic and antiparasitic agents. The compounds are also useful as pesticides and insecticides against agricultural pests. Included herein are novel intermediates useful in the process for preparing said avermectin aglycone derivatives. Compositions of said derivatives and methods of administering said compositions are also disclosed.

Abstract: There are disclosed novel avermectin 8,9-cyclopropyl compounds (also referred to as 8,9-dihydro-8,9-methano avermectin compounds). The 8,9-cyclopropyl compounds are prepared by treating an avermectin compound with an iodohalomethane compound in the presence of an activated form of zinc. The avermectin 8,9-cyclopropyl compounds have utility as anti-parasitic agents and compositions for that use are also disclosed. The compounds are also highly potent insecticides against agricultural pests.

Abstract: There are disclosed novel avermectin and milbemycin compounds wherein the 13-position is oxidized to a keto function. The 13-keto derivatives are prepared from the 13-hydroxy compounds by oxidizing the 13-position with a suitable oxidizing agent. The avermectin and milbemycin 13-keto derivatives are active in their own right and also serve as intermediates in the preparation of 13-imino and 13-amino derivatives. The 13-keto, imino and amino compounds have utility as anti-parasitic agents and compositions for that use are also disclosed. The compounds are also highly potent insecticides against agricultural pests.

Abstract: A process is disclosed for obtaining manipulated proportions of the (+) and (-) enantiomers of [(6,7-dichloro-2,3-dihydro-2-methyl-1-oxo-2-phenyl-1H-inden-5-yl)oxy]aceti c acid by asymmetric chiral phase transfer catalysis.

Abstract: There is disclosed a series of macrolides isolated from the fermentation broth of a microorganism identified as MA-5000 which morphological analysis reveals to be a strain of Streptomyces hygroscopicus. The compound's structure is presented based upon analytical studies. The compound has antifungal activity.

Abstract: The invention relates to an assembly for preparing and dispensing a solution and to the stopper for such an assembly, said assembly comprising a first bottle containing a first liquid component, with an elongated head; a second bottle containing a second component, liquid or solid; a stopper for this second bottle presenting a recess whose shape is homologous of the head of the first bottle, and in which said head is for example screwed. The bottom of the recess is constituted by a membrane of deformable material comprising an axial orifice which is hermetically closed, in the absence of deformation of the membrane, by the natural radial constriction of the material of the membrane. By screwing the first bottle in the stopper, the membrane is axially deformed and the orifice is radially distended, thus allowing the two bottles to be placed in communication in reversible manner. The invention also relates to a process for making the stopper.

Abstract: This invention relates to an eyeglass frame mounted unit dose ophthalmic drug delivery device. A unit dose of ophthalmic medicament is provided by either a preloaded disposable microsyringe, preloaded disposable tip or manually loaded calibrated microsyringe rigidly mounted on a block which itself is slidably mounted to the eyeglass frame. The device allows for the insertion of ophthalmic medication into the inferior cul de sac of the eye.

Abstract: There are disclosed certain naphtho-[1,2-b]-quinolizium compounds which have antidiarrheal activity. The compounds reduce fluid accumulation caused by enterotoxins produced by bacteria such as Vibrio cholerae or Escherichia coli.

Abstract: A facile process for the preparation of certain tetrahydrofuro[3,4-b]pyridines is described. The compounds have pharmacological properties useful in the study and treatment of cardiovascular diseases.

Abstract: The instant invention is directed to an aqueous stable magnesium hydroxide suspension which is dispersible in oil, comprising a mixture of:(a) a 33 to 60, preferably 50 to 60, percent, by weight, aqueous slurry or paste of magnesium hydroxide; and(b) an alkyl benzene sulfonate emulsifier.The instant invention is also directed to a process for the preparation of an aqueous stable magnesium hydroxide suspension which is dispersible in oil, comprising mixing:(a) a 33 to 60, preferably 50 to 60, percent, by weight, aqueous slurry of magnesium hydroxide; and(b) an alkyl benzene sulfonate emulsifier.The instant invention is also directed to a process for inhibiting corrosion in fuel burning boilers comprising adding to the fuel a corrosion inhibiting amount of an aqueous stable magnesium hydroxide suspension which is dispersible in oil, comprising a mixture of:(a) a 33 to 60 percent, by weight, aqueous slurry or paste of magnesium hydroxide; and(b) an alkyl benzene sulfonate emulsifier.

Abstract: Eucalyptol is used to enhance skin permeation of bio-affecting agents.

Abstract: There is disclosed a novel combination of avermectin compounds and agricultural spray oil which has been found to be synergistic in such a manner as to allow for a drastic reduction in the amount of active ingredient which is fully effective and also a dramatic extension of the time period over which such a combination is fully effective. The synergistic combination is useful as an agricultural insecticide and miticide against a variety of insects and mites which infest a variety of plants.

Abstract: The instant invention is directed to a bioerodible poly(ortho ester) thermoplastic elastomer prepared from:(A) a diketene diacetal;(B) a long-chain non-polar, flexible diol containing 4 to 22 carbon atoms; and(C) a diol selected from the group consisting of:(i) diols containing at least one functional group which produces hydrogen bonding or other association, and(ii) rigid symmetrical diols.

Abstract: There are disclosed novel avermectin and milbemycin compounds wherein the 8a position is oxidized to a ketone group. The 8a-oxo compounds are prepared by oxidizing an avermectin or milbemycin compound. The avermectin and milbemycin 8a-oxo compounds have utility as anti-parasitic agents and compositions for that use are also disclosed. The compounds are also highly potent insecticides against agricultural pests.