Abstract: The instant invention is directed to a process for the continuous manufacturing of carbon molecular sieves having average effective pore diameters of from 2 to 15 Angstroms which comprises continuously feeding a charred naturally occurring substrate to a means for heating said substrate and heating said substrate under non-activation conditions, without the use of an externally added pore blocking substance, at a temperature range of about 900.degree. F. (482.degree. C.) to 2000.degree. F. (1093.degree. C.) for a time period of about 5 to 90 minutes.The instant invention is also directed to a carbon molecular sieve, useful for separating gas or liquid mixtures containing components of at least two different molecular diameters, molecular weights or molecular shapes which has the following physical characteristics:(a) an apparent density of from 0.60 to 0.70 g/cc,(b) an oxygen diffusivity (.times.10.sup.-8) of from 500 to 900 cm.sup.2 /sec,(c) an oxygen/nitrogen selectivity ratio of from 5.0 to 8.
Abstract: Novel 4-substituted-3-hydroxy-3-pyrroline-2,5-diones are disclosed which inhibit glycolic acid oxidase and thus are useful in the treatment and prevention of calcium oxalate renal lithiasis.
Abstract: This invention involves complexes of quinoline carboxylic acid derivatives with guanidine and guanidine carbonate. The complexes have a greater solubility and dissolution rate when compared to the parent quinoline carboxylic acid derivatives and thus are more effective anti bacterials than the parent acids.
Abstract: A forced draft crossflow evaporative heat exchange has a turbulent air-liquid interchange zone downstream from the air propulsion means and intermediate the air propulsion means and the heat exchange media. The media is inclined so the upper portion is closer to the air propulsion means than the lower portion.
Type:
Grant
Filed:
January 22, 1981
Date of Patent:
July 23, 1985
Assignee:
Baltimore Aircoil Company, Inc.
Inventors:
Robert E. Cates, Richard H. Harrison, Jr., Thomas P. Carter
Abstract: A contact body or evaporative heat and mass exchanger packing composed of a plurality of side-by-side thin sheets interlocked with one another. The sheets are grooved with a serpentine-like, continuously-variable, cross section form to produce a plurality of liquid and gas channels between the sheets. The sheets have integrally-formed knobs and sockets specifically located to provide up-spaced alternate sheet support without utilizing adhesives of any type. The sheets are preferably composed of a thermoplastic material of any desired length, being continuously pressure-vacuum formed from long sheet rolls. The groove crests abut adjacent sheets apices at continuously-variable spacings of both greater and lesser dimension than the basic edge spacing of the serpentine grooves. The flat crests or apices of grooves are also infinitely variable in width dimension while maintaining a constant sidewall groove angle.
Type:
Grant
Filed:
January 20, 1983
Date of Patent:
May 21, 1985
Assignee:
Baltimore Aircoil Company, Inc.
Inventors:
Thomas P. Carter, Edward N. Schinner, Richard H. Harrison, Jr., Robert E. Cates
Abstract: The instant invention is directed to a variable permeability liquid crystalline membrane, comprising a porous structure containing a polymeric liquid crystal which can undergo a phase change.The instant invention is also directed to a process for regulating the flow of solutes or permeants through a liquid crystalline membrane, comprising changing the phase of a polymeric liquid crystal supported by a porous structure.
Abstract: The instant invention is directed to a method of inhibiting and dispersing calcium oxide deposit formation in coal-fired lime kilns, comprising burning the coal in the presence of from 1 to 2 pounds/ton of coal of a blend of 80 to 95%, by weight, magnesium oxide and 5 to 20%, by weight, copperoxychloride.
Abstract: This invention relates to new organic compounds that are prodrugs of the antiviral agent Ara-A which is 9-(.beta.-D-arabinofuranosyl)adenine. These compounds by virtue of their high lipid solubility will penetrate the stratum cornium and on entry the enzymatic cleavage will regenerate the antiviral compound Ara-A.
Abstract: The invention relates to the use of an acid anhydride incorporated as a latentiated catalyst in poly(ortho ester) and other polymers such that upon exposure to aqueous environments the acid anhydride generates the corresponding acid which catalyzes the matrix erosion. The releasing rate of a loaded drug substance incorporated into or surrounded by the poly(ortho ester) or other polymers can be controlled in that the drug is released as the poly(ortho ester)s or other polymer is eroded by action of the acid anhydride incorporated therein.
Abstract: This invention relates to a unique drug delivery system for delivering drugs to a body cavity. The drug delivery system comprises a medicament and a polymer such that the drug delivery system is a liquid at room temperature but forms a semi-solid or gel at the body temperature in the body cavity.
Type:
Grant
Filed:
May 16, 1983
Date of Patent:
October 23, 1984
Assignee:
Merck & Co., Inc.
Inventors:
John L. Haslam, Takeru Higuchi, Arthur R. Mlodozeniec
Abstract: An osmotic drug (or other beneficial substance) delivery system comprises a compartment with one or more chambers in series formed by an external shell and chamber-dividing walls of a microporous material and successive overlayers of semipermeable membranes completely covering the outer shell of all but one chamber and substantially covering the outer shell of that one chamber, each successive overlayer completely covering all but one more chamber and substantially covering that one more chamber.
Abstract: This invention describes the application of selected polymers as novel drug delivery systems which use the body temperature and pH to induce a liquid to gel transition of the polymer which contains a drug or therapeutic agent therein. The goal of such a delivery system is to achieve a greater degree of bioavailability or sustained concentration of a drug.
Type:
Grant
Filed:
May 16, 1983
Date of Patent:
October 2, 1984
Assignee:
Merck & Co., Inc.
Inventors:
John L. Haslam, Takeru Higuchi, Arthur R. Mlodozeniec
Abstract: Present invention provides a unique drug delivery device for delivering drug by injection into a body. The drug delivery system comprises the drug and polymer which is a liquid at room temperature and a semi-solid or gel at the body temperature.
Type:
Grant
Filed:
May 16, 1983
Date of Patent:
October 2, 1984
Assignee:
Merck & Co., Inc.
Inventors:
John L. Haslam, Takeru Higuchi, Arthur R. Mlodozeniec
Abstract: This invention relates to a unique drug delivery system for application to the skin which drug delivery system is a liquid at room temperature, but when administered topically to the skin becomes a semi-solid or gel when warmed by the body.
Type:
Grant
Filed:
May 16, 1983
Date of Patent:
October 2, 1984
Assignee:
Merck & Co., Inc.
Inventors:
John L. Haslam, Takeru Higuchi, Arthur R. Mlodozeniec
Abstract: A method and drug form are provided for increasing the oral absorption of .beta.-lactam antibiotics such as the penicillins, cephalosporins and related chemical species by the oral administration of said .beta.-lactam antibiotics in a suitable pharmaceutically accepted excipient to which has been added a hydroxy aryl or hydroxy aralkyl acid or salt, amide or ester thereof. The hydroxyaryl or hydroxyaralkyl acid or salt, amide or ester thereof is present in the drug form in quantities sufficient to be effective in enhancing the rate of oral absorption of the .beta.-lactam antibiotic.
Abstract: A method and drug form for enhancing the rate of absorption of a rectally administered drug from the rectal compartment into the blood stream of a warm blooded animal. The method includes the steps of preparing a drug form capable of being rectally administered. The drug form comprises a therapeutically effective unit dosage amount of a selected drug of the type which is capable of being absorbed into the blood stream from the rectal compartment and hydroxy aryl or hydroxy aralkyl acids or salts, amides or esters thereof, the hydroxy aryl or hydroxy aralkyl acids or salts, amides or esters thereof being present in the drug form in a sufficient amount to be effective in enhancing the drug absorption rate, when rectally administering the drug form to warm blooded animals.
Type:
Grant
Filed:
June 25, 1981
Date of Patent:
August 7, 1984
Assignee:
Merck & Co., Inc.
Inventors:
Takeru Higuchi, Toshiaki Nishihata, Howard J. Rytting
Abstract: A method and drug form are provided for increasing the oral absorption of polar bioactive agents such as polypeptides by the oral administration of said polar bioactive agents in a suitable pharmaceutically accepted excipient to which has been added a hydroxyaromatic acid or salt as an adjuvant thereof. The adjuvant is present in the drug form in quantities sufficient to be effective in enhancing the rate of oral absorption of the polar bioactive agents.
Abstract: The instant invention is directed to a method of inhibiting the precipitation and deposition of scale in an aqueous system comprising adding an effective amount, preferably at least 0.1 ppm, of a carboxylic functional polyampholyte, or the salt thereof, to said aqueous system.
Abstract: A method and drug form are provided for increasing the oral absorption of glycosidic and related antibiotics such as macrolide, aminoglycoside, lincomycin and anthracycline antibiotics and related chemical species by the oral administration of said glycosidic and related antibiotics in a suitable pharmaceutically accepted excipient to which has been added a hydroxyaryl or hydroxyaralkyl acid or salt thereof. The hydroxyaryl or hydroxyaralkyl acid or salt thereof is present in the drug form in quantities sufficient to be effective in enhancing the rate of oral absorption of glycosidic and related antibiotic.